Paul Michael Lantos

Journal article Zoonoses Public Health · February 2020 Featured Publication Staphylococcus sciuri is an occasional cause of human infection that has been described in the flora of numerous animal species and in environmental specimens. Here, we report a rare case of S. sciuri peritonitis in a dialysis patient who had exposure to p ... Full text Link to item Cite

A Bayesian Spatiotemporal Analysis of Pediatric Group A Streptococcal Infections.

Journal article Open Forum Infect Dis · December 2019 Featured Publication BACKGROUND: Pharyngitis due to group A Streptococcus (GAS) is a common pediatric infection. Physicians might diagnose GAS pharyngitis more accurately when given biosurveillance information about GAS activity. The availability of geographic GAS testing data ... Full text Link to item Cite

Misdiagnosis of Lyme Disease With Unnecessary Antimicrobial Treatment Characterizes Patients Referred to an Academic Infectious Diseases Clinic.

Journal article Open Forum Infect Dis · July 1, 2019 Featured Publication BACKGROUND: Although Lyme disease is the most common vector-borne infection in the United States, diagnostic accuracy within community settings is not well characterized. METHODS: A retrospective observational cohort study of patients referred to an academ ... Full text Link to item Cite

Beyond the Window: Patient Characteristics and Geographic Locations Associated with Late Prenatal Care in Women Eligible for 17-P Preterm Birth Prevention.

Journal article J Racial Ethn Health Disparities · June 2019 Featured Publication INTRODUCTION: To reduce the risk of recurrence, women with a history of spontaneous preterm birth (PTB) are recommended to receive 17-hydroxyprogesterone caproate (17-P) injections starting by the 20th week of pregnancy. In women eligible for 17-P, we aime ... Full text Link to item Cite

Positive 2-Tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the United States.

Journal article Pediatr Infect Dis J · May 2019 Featured Publication Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme-linked immunoassays, but ... Full text Link to item Cite

Geographic and Racial Disparities in Infant Hearing Loss.

Journal article Otolaryngol Head Neck Surg · December 2018 Featured Publication OBJECTIVE: Approximately 1 to 2 of every 1000 American newborns has hearing loss identified by newborn screening. This study was designed to determine if infant hearing loss is more common in socioeconomically disadvantaged communities. STUDY DESIGN: In th ... Full text Open Access Link to item Cite

Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy.

Journal article J Racial Ethn Health Disparities · August 2018 Featured Publication BACKGROUND: Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV is more common among socially disadvantaged groups, and geographically clusters in poor communities. The Area Deprivation Index (AD ... Full text Open Access Link to item Cite

Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia.

Journal article Acta Trop · January 2018 Featured Publication BACKGROUND: To better understand the epidemiology of tick-borne disease in Mongolia, a comprehensive seroprevalence study was conducted investigating exposure to Anaplasma spp. and spotted fever group (SFG) Rickettsia spp. in nomadic herders and their live ... Full text Link to item Cite

Geographic Disparities in Cytomegalovirus Infection During Pregnancy.

Journal article J Pediatric Infect Dis Soc · September 1, 2017 Featured Publication BACKGROUND: Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV is more common among socially disadvantaged groups, and it clusters geographically in poor communities. We conducted a geospatial a ... Full text Link to item Cite

Diagnostic Lumbar Puncture Among Children With Facial Palsy in a Lyme Disease Endemic Area.

Journal article J Pediatric Infect Dis Soc · June 1, 2017 Featured Publication We identified 620 children with peripheral facial palsy of which 211 (34%) had Lyme disease. The 140 children who had a lumbar puncture performed were more likely to be hospitalized (73% LP performed vs 2% no LP) and to receive parenteral antibiotics (62% ... Full text Link to item Cite

Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease.

Journal article Clin Infect Dis · April 15, 2017 Featured Publication BACKGROUND: The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enzyme immunoassay (EIA) followed by immunoglobulin M and immunoglobulin G Western blots, performs well in late-stage LD but is insensitive in patients with erythema ... Full text Link to item Cite

Increasing Nocardia Incidence Associated with Bronchiectasis at a Tertiary Care Center.

Journal article Ann Am Thorac Soc · March 2017 Featured Publication RATIONALE: Nocardia is a genus of pathogens that most commonly afflict immunocompromised hosts but may be an emerging infection among persons with bronchiectasis. OBJECTIVES: To examine the epidemiology and clinical presentation of adult patients with Noca ... Full text Link to item Cite

Geographic Expansion of Lyme Disease in Michigan, 2000-2014.

Journal article Open Forum Infect Dis · 2017 Featured Publication BACKGROUND: Most Lyme disease cases in the Midwestern United States are reported in Minnesota and Wisconsin. In recent years, however, a widening geographic extent of Lyme disease has been noted with evidence of expansion eastwards into Michigan and neighb ... Full text Open Access Link to item Cite

A fatal case of imported malaria in a non-endemic developing country - Mongolia, 2016

Journal article Asian Pacific Journal of Tropical Disease · January 1, 2017 Featured Publication This report describes the first case fatality of imported malaria in Mongolia. The infection was acquired in Central Africa and the patient died nine days after onset of symptoms, four days after hospitalization, illustrating the need for improved familiar ... Full text Cite

Are People Living Near Modern Swine Production Facilities at Increased Risk of Influenza Virus Infection?

Journal article Clin Infect Dis · December 15, 2016 Featured Publication BACKGROUND: Swine can harbor influenza viruses that are pathogenic to humans. Previous studies support an increased risk of human influenza cases among individuals with swine contact. North Carolina has the second-largest swine industry in the United Stat ... Full text Link to item Cite

False Positive Lyme Disease IgM Immunoblots in Children.

Journal article J Pediatr · July 2016 Featured Publication In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive ... Full text Link to item Cite

Lyme Disease Serology.

Journal article JAMA · April 26, 2016 Featured Publication Full text Open Access Link to item Cite

Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.

Journal article Open Forum Infect Dis · December 2015 Featured Publication Background. The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease be ... Full text Open Access Link to item Cite

The Excess Burden of Cytomegalovirus in African American Communities: A Geospatial Analysis.

Journal article Open Forum Infect Dis · December 2015 Featured Publication Background. Cytomegalovirus (CMV) is a common cause of birth defects and hearing loss in infants and opportunistic infections in the immunocompromised. Previous studies have found higher CMV seroprevalence rates among minorities and among persons with low ... Full text Open Access Link to item Cite

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.

Journal article Clin Infect Dis · November 1, 2015 Featured Publication BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS: We reviewed the medical records ... Full text Open Access Link to item Cite

The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children.

Journal article Pediatr Infect Dis J · November 2015 Featured Publication By using a Lyme enzyme-linked immunosorbent assay (ELISA), we demonstrated that high ELISA index values are strongly predictive of Lyme disease. In children with clinical presentations consistent with Lyme disease, ELISA index values ≥3.0 had a positive pr ... Full text Open Access Link to item Cite

Unorthodox alternative therapies marketed to treat Lyme disease.

Journal article Clin Infect Dis · June 15, 2015 Featured Publication BACKGROUND: Some patients with medically unexplained symptoms or alternative medical diagnoses suspect that they chronically suffer from the tick-borne infection Lyme disease. These patients are commonly targeted by providers of alternative therapies. This ... Full text Open Access Link to item Cite

Chronic Lyme disease.

Journal article Infect Dis Clin North Am · June 2015 Featured Publication Chronic Lyme disease is a poorly defined diagnosis that is usually given to patients with prolonged, unexplained symptoms or with alternative medical diagnoses. Data do not support the proposition that chronic, treatment-refractory infection with Borrelia ... Full text Open Access Link to item Cite

Laboratory testing for lyme neuroborreliosis--reply.

Journal article JAMA Neurol · January 2015 Featured Publication Full text Link to item Cite

Chronic coinfections in patients diagnosed with chronic lyme disease: a systematic review.

Journal article Am J Med · November 2014 Featured Publication PURPOSE: Often, the controversial diagnosis of chronic Lyme disease is given to patients with prolonged, medically unexplained physical symptoms. Many such patients also are treated for chronic coinfections with Babesia, Anaplasma, or Bartonella in the abs ... Full text Open Access Link to item Cite

Lyme disease: authentic imitator or wishful imitation?

Journal article JAMA Neurol · October 2014 Featured Publication Full text Open Access Link to item Cite

Detection of Bartonella species in the blood of veterinarians and veterinary technicians: a newly recognized occupational hazard?

Journal article Vector Borne Zoonotic Dis · August 2014 Featured Publication BACKGROUND: Bartonella species are important emerging pathogens in human and veterinary medicine. In the context of their daily activities, veterinary professionals have frequent animal contact and arthropod exposures. Detection of Bartonella spp. using tr ... Full text Open Access Link to item Cite

A systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme disease.

Journal article Clin Infect Dis · March 2014 Featured Publication BACKGROUND: Much of the controversy that surrounds Lyme disease pertains to whether it produces prolonged, treatment-refractory infection, usually referred to as chronic Lyme disease. Some have proposed that round morphologic variants of Borrelia burgdorf ... Full text Open Access Link to item Cite

Lyme disease vaccination: safety first - author's reply.

Journal article Lancet Infect Dis · January 2014 Featured Publication Full text Link to item Cite

Travelers with sickle cell disease.

Journal article J Travel Med · 2014 Featured Publication BACKGROUND: Sickle cell disease (SCD) is the most common genetic disease among persons with African ancestry. This article provides a background to SCD and reviews many important aspects of travel preparation in this population. METHODS: The medical litera ... Full text Open Access Link to item Cite

Empiric antibiotic treatment of erythema migrans-like skin lesions as a function of geography: a clinical and cost effectiveness modeling study.

Journal article Vector Borne Zoonotic Dis · December 2013 Featured Publication The skin lesion of early Lyme disease, erythema migrans (EM), is so characteristic that routine practice is to treat all such patients with antibiotics. Because other skin lesions may resemble EM, it is not known whether presumptive treatment of EM is appr ... Full text Open Access Link to item Cite

Rickettsial and Ehrlichial Diseases

Book section · September 3, 2013 Featured Publication Cite

Lyme disease vaccination: are we ready to try again?

Journal article Lancet Infect Dis · August 2013 Featured Publication Full text Open Access Link to item Cite

Lyme Borreliosis Coinfections with Anaplasma And Babesia

Journal article · July 12, 2011 Featured Publication Full text Cite

Chronic Lyme disease: the controversies and the science.

Journal article Expert Rev Anti Infect Ther · July 2011 Featured Publication The diagnosis of chronic Lyme disease has been embroiled in controversy for many years. This is exacerbated by the lack of a clinical or microbiologic definition, and the commonality of chronic symptoms in the general population. An accumulating body of ev ... Full text Open Access Link to item Cite

Lyme disease coinfections: Anaplasmosis and Babesiosis

Book section · June 7, 2011 Featured Publication Cite

Rickettsia rickettsii transmission by a lone star tick, North Carolina.

Journal article Emerg Infect Dis · May 2011 Featured Publication Only indirect or circumstantial evidence has been published to support transmission of Rickettsia rickettsii by Amblyomma americanum (lone star) ticks in North America. This study provides molecular evidence that A. americanum ticks can function, although ... Full text Open Access Link to item Cite

Response of the Infectious Diseases Society of America Lyme disease review panel to Johnson and Stricker

Journal article Clinical Infectious Diseases · November 1, 2010 Featured Publication Full text Open Access Cite

Final report of the Lyme disease review panel of the Infectious Diseases Society of America.

Journal article Clin Infect Dis · July 1, 2010 Featured Publication In April 2008, the Infectious Diseases Society of America (IDSA) entered into an agreement with Connecticut Attorney General Richard Blumenthal to voluntarily undertake a special review of its 2006 Lyme disease guidelines. This agreement ended the Attorney ... Full text Open Access Link to item Cite

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease.

Journal article Parasit Vectors · April 8, 2010 Featured Publication BACKGROUND: Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. ... Full text Open Access Link to item Cite

Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum.

Journal article Parasitology · January 2009 Featured Publication Plasmodium falciparum parasites use multiple ligand-receptor interactions to invade human erythrocytes. Variant expression levels of members of the PfRh and PfEBA ligand families are associated with the use of different erythrocyte receptors, defining inva ... Full text Open Access Link to item Cite

Shared features in the pathobiology of babesiosis and malaria.

Journal article Trends Parasitol · December 2007 Featured Publication The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of liv ... Full text Open Access Link to item Cite

Excess diagnosis of non-Hodgkin's lymphoma during spring in the USA.

Journal article Leuk Lymphoma · February 2007 Featured Publication A seasonal peak in hematologic malignancies may support hypotheses of infection-related precipitating events. Moderately increased incidence rates have been observed during the spring for leukemias and Hodgkin's disease but few studies have been conducted ... Full text Link to item Cite

Whispers from the Third Generation

Book section · 2004 Featured Publication Cite

Babesiosis

Book section · 2003 Featured Publication Cite

Ehrlichiosis in children.

Journal article Semin Pediatr Infect Dis · October 2002 Featured Publication Ehrlichia are obligate intracellular bacteria that belong to the family Rickettsiaceae. Human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) are the 2 ehrlichial diseases that are of greatest health concern in the United States. The ... Full text Link to item Cite

Babesiosis: similar to malaria but different.

Journal article Pediatr Ann · March 2002 Featured Publication Full text Link to item Cite