Paula Sowon Lee | Scholars@Duke

Paula Sowon Lee
Associate Professor of Obstetrics and Gynecology

Teaching interests involve responsibilities as the Gynecologic Oncology Fellowship Program Director
Clinical interests involve sentinel lymph node techniques, radical surgeries, minimally invasive surgery including advanced laparoscopy and robotics
Scholarly interests involve global health initiatives, novel surgical techniques/therapies, palliative care

Current Research Interests

Palliative Care

Delivery of care in low and middle income countries for gyn malignancies and surgeries

Surgical techniques and technology

Current Appointments & Affiliations

Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

Box 3079 Med Ctr, Durham, NC 27710
DUMC Box 3079, Durham, NC 27710
paula.s.lee@duke.edu (919) 684-3765

Background
Education, Training, & Certifications
- Residency, Ob/Gyn, Duke University 2000 - 2004
- M.D., Tulane University 2000
Medical Licensure
- 200101084. North Carolina. 2022
Previous Appointments & Affiliations
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2020
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2019 - 2020
- Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2007 - 2019
- Clinical Associate in the Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2006 - 2007
- Clinical Associate in the Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Clinical Science Departments 2005 - 2006
Leadership & Clinical Positions at Duke
- Fellowship Director, Duke Gynecologic Oncology Fellowship
  
  Medical Director of Duke Gyn Oncology services in Wake County
Expertise
Subject Headings
Global Scholarship
- Expertise
  - Uganda (Country)
Research
Selected Grants
- PP LNM 01 FILM - A Randomized, Prospective, Open Label, Multicenter Study Assessing the Safety and Utility of PINPOINT® Near Infrared Fluorescence Imaging in the Identification of Lymph Nodes in Subjects with Uterine and Cervical Malignancies who are awarded by Novadaq Technologies Inc. 2016 - 2019
- A Pilot Study on H.O.P.E: Helping Ovarian Cancer Patients Cope with Disease Recurrence awarded by Foundation for Women's Cancer 2014 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth 127, no. 6 (December 2021): 917–28. https://doi.org/10.1016/j.bja.2021.08.012.
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  - Gatta, Luke A., Paula S. Lee, Jennifer B. Gilner, Jeremy M. Weber, LaMani Adkins, Julia R. Salinaro, Ashraf S. Habib, et al. “Placental uterine artery embolization followed by delayed hysterectomy for placenta percreta: A case series.” Gynecol Oncol Rep 37 (August 2021): 100833. https://doi.org/10.1016/j.gore.2021.100833.
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  - Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.
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  - VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97. https://doi.org/10.3233/JAD-201544.
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  - Watson, Catherine H., Lindsay Soo, Brittany A. Davidson, Laura J. Havrilesky, Paula S. Lee, Leah J. McNally, Rebecca A. Previs, Angeles Alvarez Secord, Andrew Berchuck, and Noah D. Kauff. “Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices.” Int J Gynecol Cancer 30, no. 10 (October 2020): 1583–88. https://doi.org/10.1136/ijgc-2020-001536.
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  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.
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  - Bixel, K., M. Vetter, B. Davidson, A. Berchuck, D. Cohn, L. Copeland, J. M. Fowler, et al. “Intraperitoneal chemotherapy following neoadjuvant chemotherapy and optimal interval tumor reductive surgery for advanced ovarian cancer.” Gynecol Oncol 156, no. 3 (March 2020): 530–34. https://doi.org/10.1016/j.ygyno.2019.12.016.
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  - Havrilesky, Laura J., Jui-Chen Yang, Paula S. Lee, Angeles Alvarez Secord, Jessie A. Ehrisman, Brittany Davidson, Andrew Berchuck, Kathleen M. Darcy, G Larry Maxwell, and Shelby D. Reed. “Patient preferences for attributes of primary surgical debulking versus neoadjuvant chemotherapy for treatment of newly diagnosed ovarian cancer.” Cancer 125, no. 24 (December 15, 2019): 4399–4406. https://doi.org/10.1002/cncr.32447.
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  - Havrilesky, L. J., J. C. Yang, P. S. Lee, A. A. Secord, J. A. Ehrisman, B. Davidson, A. Berchuck, K. M. Darcy, G. L. Maxwell, and S. D. Reed. “Patient Preferences for Attributes of Primary Surgical Debulking Versus Neoadjuvant Chemotherapy for Treatment of Newly Diagnosed Ovarian Cancer.” Obstetrical and Gynecological Survey 74, no. 12 (December 1, 2019): 718–19. https://doi.org/10.1097/OGX.0000000000000743.
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  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
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  - Veade, Ashley E., Jonathan Foote, Jessie Ehrisman, Gloria Broadwater, Brittany A. Davidson, Paula S. Lee, Angeles Alvarez Secord, Andrew Berchuck, and Laura J. Havrilesky. “Associations between lymphovascular space invasion, nodal recurrence, and survival in patients with surgical stage I endometrioid endometrial adenocarcinoma.” World J Surg Oncol 17, no. 1 (May 10, 2019): 80. https://doi.org/10.1186/s12957-019-1620-x.
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  - Watson, Catherine H., Micael Lopez-Acevedo, Gloria Broadwater, Amy H. Kim, Jessie Ehrisman, Brittany A. Davidson, Paula S. Lee, Fidel Valea, Andrew Berchuck, and Laura J. Havrilesky. “A pilot study of lower extremity lymphedema, lower extremity function, and quality of life in women after minimally invasive endometrial cancer staging surgery.” Gynecol Oncol 153, no. 2 (May 2019): 399–404. https://doi.org/10.1016/j.ygyno.2019.02.021.
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  - Lim, Stephanie L., Haley A. Moss, Angeles Alvarez Secord, Paula S. Lee, Laura J. Havrilesky, and Brittany A. Davidson. “Hysterectomy with sentinel lymph node biopsy in the setting of pre-operative diagnosis of endometrial intraepithelial neoplasia: A cost-effectiveness analysis.” Gynecol Oncol 151, no. 3 (December 2018): 506–12. https://doi.org/10.1016/j.ygyno.2018.09.020.
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  - Frumovitz, Michael, Marie Plante, Paula S. Lee, Samith Sandadi, James F. Lilja, Pedro F. Escobar, Lilian T. Gien, Diana L. Urbauer, and Nadeem R. Abu-Rustum. “Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial.” Lancet Oncol 19, no. 10 (October 2018): 1394–1403. https://doi.org/10.1016/S1470-2045(18)30448-0.
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  - Davidson, Brittany A., Jessie Ehrisman, Sara Abbott, Zach Harmon, Angeles A. Secord, Andrew Berchuck, Paula S. Lee, et al. “Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-grade Endometrial Cancer.” Int J Gynecol Pathol 37, no. 3 (May 2018): 252–55. https://doi.org/10.1097/PGP.0000000000000418.
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  - Foote, Jonathan, Micael Lopez-Acevedo, Gregory Samsa, Paula S. Lee, Arif H. Kamal, Angeles Alvarez Secord, and Laura J. Havrilesky. “Predicting 6- and 12-Month Risk of Mortality in Patients With Platinum-Resistant Advanced-Stage Ovarian Cancer: Prognostic Model to Guide Palliative Care Referrals.” Int J Gynecol Cancer 28, no. 2 (February 2018): 302–7. https://doi.org/10.1097/IGC.0000000000001182.
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  - Tanner, Edward, Allison Puechl, Kimberly Levinson, Laura J. Havrilesky, Abdulrahman Sinno, Angeles Alvarez Secord, Amanda N. Fader, and Paula S. Lee. “Use of a novel sentinel lymph node mapping algorithm reduces the need for pelvic lymphadenectomy in low-grade endometrial cancer.” Gynecol Oncol 147, no. 3 (December 2017): 535–40. https://doi.org/10.1016/j.ygyno.2017.10.020.
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  - Foote, Jonathan R., Micael Lopez-Acevedo, Adam H. Buchanan, Angeles Alvarez Secord, Paula S. Lee, Cynthia Fountain, Evan R. Myers, David E. Cohn, Shelby D. Reed, and Laura J. Havrilesky. “Cost Comparison of Genetic Testing Strategies in Women With Epithelial Ovarian Cancer.” J Oncol Pract 13, no. 2 (February 2017): e120–29. https://doi.org/10.1200/JOP.2016.011866.
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  - Lee, Paula S., Samantha Kempner, Michael Miller, Jennifer Dominguez, Chad Grotegut, Jessie Ehrisman, Rebecca Previs, et al. “Multidisciplinary approach to manage antenatally suspected placenta percreta: updated algorithm and patient outcomes.” Gynecol Oncol Res Pract 4 (2017): 11. https://doi.org/10.1186/s40661-017-0049-6.
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  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
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  - Natesan, D., O. I. Craciunescu, P. S. Lee, and J. P. Chino. “FDG Positron Emission Tomography (PET)/Computed Tomography Characteristics of Vulvar Cancer: Posttreatment PET Correlates With Clinical Outcomes.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): S52–53. https://doi.org/10.1016/j.ijrobp.2016.06.137.
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  - Ehrisman, Jessie, Angeles Alvarez Secord, Andrew Berchuck, Paula S. Lee, Nicola Di Santo, Micael Lopez-Acevedo, Gloria Broadwater, Fidel A. Valea, and Laura J. Havrilesky. “Performance of sentinel lymph node biopsy in high-risk endometrial cancer.” Gynecol Oncol Rep 17 (August 2016): 69–71. https://doi.org/10.1016/j.gore.2016.04.002.
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  - Fox, Karin A., Alireza A. Shamshirsaz, Daniela Carusi, Angeles Alvarez Secord, Paula Lee, Ozhan M. Turan, Christopher Huls, et al. “Conservative management of morbidly adherent placenta: expert review.” American Journal of Obstetrics and Gynecology 213, no. 6 (December 2015): 755–60. https://doi.org/10.1016/j.ajog.2015.04.034.
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  - Rimel, B. J., W. M. Burke, R. V. Higgins, P. S. Lee, C. V. Lutman, and L. Parker. “Improving quality and decreasing cost in gynecologic oncology care. Society of gynecologic oncology recommendations for clinical practice.” Obstetrical and Gynecological Survey 70, no. 9 (September 1, 2015): 570–71. https://doi.org/10.1097/01.ogx.0000470820.38134.12.
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  - Konecny, Gottfried E., Neil Finkler, Agustin A. Garcia, Domenica Lorusso, Paula S. Lee, Rodney P. Rocconi, Peter C. Fong, et al. “Second-line dovitinib (TKI258) in patients with FGFR2-mutated or FGFR2-non-mutated advanced or metastatic endometrial cancer: a non-randomised, open-label, two-group, two-stage, phase 2 study.” Lancet Oncol 16, no. 6 (June 2015): 686–94. https://doi.org/10.1016/S1470-2045(15)70159-2.
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  - Landrum, Lisa M., Stephanie Blank, Lee-may Chen, Linda Duska, Victoria Bae-Jump, Paula S. Lee, Lyuba Levine, Carolyn McCourt, Kathleen N. Moore, and Renata R. Urban. “Comprehensive care in gynecologic oncology: The importance of palliative care.” Gynecol Oncol 137, no. 2 (May 2015): 193–202. https://doi.org/10.1016/j.ygyno.2015.02.026.
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  - Rimel, B. J., William M. Burke, Robert V. Higgins, Paula S. Lee, Christopher V. Lutman, and Lynn Parker. “Improving quality and decreasing cost in gynecologic oncology care. Society of gynecologic oncology recommendations for clinical practice.” Gynecol Oncol 137, no. 2 (May 2015): 280–84. https://doi.org/10.1016/j.ygyno.2015.02.021.
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  - Campos, S. M., W. E. Brady, K. M. Moxley, R. E. O’Cearbhaill, P. S. Lee, P. A. DiSilvestro, J. Rotmensch, et al. “Corrigendum to: A phase II evaluation of Pazopanib in the treatment of recurrent or persistent carcinosarcoma of the uterus: A Gynecologic Oncology Group Study [Gynecol Oncol 133 (2014) 537-541].” Gynecologic Oncology 135, no. 3 (December 1, 2014): 624. https://doi.org/10.1016/j.ygyno.2014.08.011.
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  - Havrilesky, Laura J., Angeles Alvarez Secord, Jessie A. Ehrisman, Andrew Berchuck, Fidel A. Valea, Paula S. Lee, Stephanie L. Gaillard, et al. “Patient preferences in advanced or recurrent ovarian cancer.” Cancer 120, no. 23 (December 1, 2014): 3651–59. https://doi.org/10.1002/cncr.28940.
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  - Powell, Matthew A., Michael W. Sill, Paul J. Goodfellow, Doris M. Benbrook, Heather A. Lankes, Kimberly K. Leslie, Yvette Jeske, et al. “A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study.” Gynecol Oncol 135, no. 1 (October 2014): 38–43. https://doi.org/10.1016/j.ygyno.2014.07.083.
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  - Campos, Susana M., William E. Brady, Katherine M. Moxley, Roisin E. O’Cearbhaill, Paula S. Lee, Paul A. DiSilvestro, Jacob Rotmensch, et al. “A phase II evaluation of pazopanib in the treatment of recurrent or persistent carcinosarcoma of the uterus: a gynecologic oncology group study.” Gynecol Oncol 133, no. 3 (June 2014): 537–41. https://doi.org/10.1016/j.ygyno.2014.02.036.
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  - Zhang, Chelsea, Laura J. Havrilesky, Gloria Broadwater, Nicola Di Santo, Jessie A. Ehrisman, Paula S. Lee, Andrew Berchuck, et al. “Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients.” Gynecol Oncol 133, no. 2 (May 2014): 211–15. https://doi.org/10.1016/j.ygyno.2014.02.025.
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  - Lee, Paula S., and Angeles Alvarez Secord. “Targeting molecular pathways in endometrial cancer: a focus on the FGFR pathway.” Cancer Treat Rev 40, no. 4 (May 2014): 507–12. https://doi.org/10.1016/j.ctrv.2013.11.004.
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  - Lee, P. S., and A. A. Secord. “Targeting molecular pathways in endometrial cancer: A focus on the FGFR pathway.” Cancer Treatment Reviews 40, no. 4 (2014): 507–12.
  - Lopez-Acevedo, Micael, William J. Lowery, Ashlei W. Lowery, Paula S. Lee, and Laura J. Havrilesky. “Palliative and hospice care in gynecologic cancer: a review.” Gynecol Oncol 131, no. 1 (October 2013): 215–21. https://doi.org/10.1016/j.ygyno.2013.06.012.
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  - Lowery, William J., Ashlei W. Lowery, Jason C. Barnett, Micael Lopez-Acevedo, Paula S. Lee, Angeles Alvarez Secord, and Laura Havrilesky. “Cost-effectiveness of early palliative care intervention in recurrent platinum-resistant ovarian cancer.” Gynecol Oncol 130, no. 3 (September 2013): 426–30. https://doi.org/10.1016/j.ygyno.2013.06.011.
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  - Lopez-Acevedo, Micael, Laura J. Havrilesky, Gloria Broadwater, Arif H. Kamal, Amy P. Abernethy, Andrew Berchuck, Angeles Alvarez Secord, James A. Tulsky, Fidel Valea, and Paula S. Lee. “Timing of end-of-life care discussion with performance on end-of-life quality indicators in ovarian cancer.” Gynecol Oncol 130, no. 1 (July 2013): 156–61. https://doi.org/10.1016/j.ygyno.2013.04.010.
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  - Turner, Taylor, Angeles Alvarez Secord, William J. Lowery, Gregory Sfakianos, and Paula S. Lee. “Metastatic adenocarcinoma after laparoscopic supracervical hysterectomy with morcellation: A case report.” Gynecol Oncol Case Rep 5 (2013): 19–21. https://doi.org/10.1016/j.gynor.2013.03.002.
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  - Lopez-Acevedo, Micael, Chelsea Zhang, Angeles Alvarez Secord, Paula S. Lee, Laura Jean Havrilesky, and Andrew Berchuck. “Predictors of failure to perform pelvic peritoneal cytology in endometrial cancer staging surgery.” Journal of Clinical Oncology 30, no. 34 (December 1, 2012). https://doi.org/10.1200/jco.2012.30.34_suppl.201.
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  - Zhang, C., A. A. Secord, P. S. Lee, L. J. Havrilesky, and A. Berchuck. “Predictors of failure to perform pelvic peritoneal cytology in endometrial cancer staging surgery.” J Clin Oncol 30, no. 34_suppl (December 2012): 201. https://doi.org/10.1200/jco.2012.30.34_suppl.201.
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  - Secord, Angeles Alvarez, Deanna K. Teoh, William T. Barry, Miao Yu, Gloria Broadwater, Laura J. Havrilesky, Paula S. Lee, Andrew Berchuck, Johnathan Lancaster, and Robert M. Wenham. “A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer.” Clin Cancer Res 18, no. 19 (October 1, 2012): 5489–98. https://doi.org/10.1158/1078-0432.CCR-12-0507.
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  - Alvarez Secord, Angeles, Kathleen M. Darcy, Alan Hutson, Zhiqing Huang, Paula S. Lee, Elizabeth L. Jewell, Laura J. Havrilesky, Maurie Markman, Franco Muggia, and Susan K. Murphy. “The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.” Gynecol Oncol 123, no. 2 (November 2011): 314–19. https://doi.org/10.1016/j.ygyno.2011.08.003.
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  - Teoh, Deanna, Andrew Berchuck, Angeles Alvarez Secord, Paula S. Lee, William J. Lowery, Gregory P. Sfakianos, Fidel A. Valea, Evan R. Myers, and Laura J. Havrilesky. “Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer.” Gynecol Oncol 122, no. 3 (September 2011): 467–72. https://doi.org/10.1016/j.ygyno.2011.06.014.
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  - Barnett, Jason C., Laura J. Havrilesky, Amy E. Bondurant, Nicole D. Fleming, Paula S. Lee, Angeles Alvarez Secord, Andrew Berchuck, and Fidel A. Valea. “Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer.” Am J Obstet Gynecol 205, no. 2 (August 2011): 143.e1-143.e6. https://doi.org/10.1016/j.ajog.2011.03.012.
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  - Bernardini, Marcus Q., Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Gregory P. Sfakianos, Angeles Alvarez Secord, Susan K. Murphy, Edwin Iversen, Jeffrey R. Marks, and Andrew Berchuck. “Expression signatures of TP53 mutations in serous ovarian cancers.” Bmc Cancer 10 (May 26, 2010): 237. https://doi.org/10.1186/1471-2407-10-237.
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  - Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.” Int J Cancer 126, no. 6 (March 15, 2010): 1378–89. https://doi.org/10.1002/ijc.24797.
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  - Jewell, Elizabeth L., Kathleen M. Darcy, Alan Hutson, Paula S. Lee, Laura J. Havrilesky, Lisa A. Grace, Andrew Berchuck, and Angeles Alvarez Secord. “Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study.” Gynecol Oncol 115, no. 3 (December 2009): 424–29. https://doi.org/10.1016/j.ygyno.2009.07.035.
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  - Lee, Paula S., Amy Bland, Fidel A. Valea, Laura J. Havrilesky, Andrew Berchuck, and Angeles Alvarez Secord. “Robotic-assisted laparoscopic gynecologic procedures in a fellowship training program.” Jsls 13, no. 4 (October 2009): 467–72. https://doi.org/10.4293/108680809X12589998403921.
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  - Horne, Hisani N., Paula S. Lee, Susan K. Murphy, Miguel A. Alonso, John A. Olson, and Jeffrey R. Marks. “Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.” Mol Cancer Res 7, no. 2 (February 2009): 199–209. https://doi.org/10.1158/1541-7786.MCR-08-0314.
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  - Matsumura, Noriomi, Zhiqing Huang, Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Seiichi Mori, Jeffrey T. Chang, et al. “Yin yang 1 modulates taxane response in epithelial ovarian cancer.” Mol Cancer Res 7, no. 2 (February 2009): 210–20. https://doi.org/10.1158/1541-7786.MCR-08-0255.
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  - Bland, Amy E., Brian Calingaert, Angeles Alvarez Secord, Paula S. Lee, Fidel A. Valea, Andrew Berchuck, John T. Soper, and Laura Havrilesky. “Relationship between tamoxifen use and high risk endometrial cancer histologic types.” Gynecol Oncol 112, no. 1 (January 2009): 150–54. https://doi.org/10.1016/j.ygyno.2008.08.035.
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  - Lee, Paula S., Ryan Bakelaar, C Brennan Fitpatrick, Sarah C. Ellestad, Laura J. Havrilesky, and Angeles Alvarez Secord. “Medical and surgical treatment of placenta percreta to optimize bladder preservation.” Obstet Gynecol 112, no. 2 Pt 2 (August 2008): 421–24. https://doi.org/10.1097/AOG.0b013e31817e7966.
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  - Barnett, J. C., A. Bland, R. Whitaker, B. Calingaert, R. C. Bentley, P. S. Lee, P. C. Moorman, J. M. Schildkraut, and A. Berchuck. “The prognostic significance of p53 and cyclin E overexpression in ovarian cancer: A population-based study.” Gynecologic Oncology 108, no. 3 (March 2008): S125–S125.
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  - Schildkraut, Joellen M., Patricia G. Moorman, Amy E. Bland, Susan Halabi, Brian Calingaert, Regina Whitaker, Paula S. Lee, et al. “Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 17, no. 3 (March 2008): 585–93. https://doi.org/10.1158/1055-9965.epi-07-0596.
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  - Secord, Angeles Alvarez, Kathleen M. Darcy, Alan Hutson, Paula S. Lee, Laura J. Havrilesky, Lisa A. Grace, Andrew Berchuck, and Andrew Gynecologic Oncology Group study. “Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study.” Gynecol Oncol 106, no. 1 (July 2007): 221–32. https://doi.org/10.1016/j.ygyno.2007.03.021.
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  - Clarke-Pearson, D. L., M. A. Spillman, C. V. Lutman, and P. S. Lee. “Preoperative evaluation and postoperative management,” December 1, 2006, 233–48. https://doi.org/10.1016/B978-0-443-06691-7.50022-4.
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  - Gynecologic Oncology Group, Andrew, Angeles Alvarez Secord, Paula S. Lee, Kathleen M. Darcy, Laura J. Havrilesky, Lisa A. Grace, Jeffrey R. Marks, and Andrew Berchuck. “Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study.” Gynecol Oncol 101, no. 3 (June 2006): 390–97. https://doi.org/10.1016/j.ygyno.2006.02.014.
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  - Berchuck, Andrew, Edwin S. Iversen, Johnathan M. Lancaster, Jennifer Pittman, Jingqin Luo, Paula Lee, Susan Murphy, et al. “Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.” Clin Cancer Res 11, no. 10 (May 15, 2005): 3686–96. https://doi.org/10.1158/1078-0432.CCR-04-2398.
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- Conference Papers
  - Wong, J., P. Mulamira, J. Arizu, M. Nabwire, D. Driwaru, D. Mugabi, S. Nabulime, et al. “333 Standardization of caregiver and nursing perioperative care on gynecologic oncology wards in a resource-limited setting.” In Poster. BMJ Publishing Group Ltd, 2020. https://doi.org/10.1136/ijgc-2020-igcs.285.
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  - Puechl, A. M., S. Lim, L. A. Gatta, A. Lorenzo, A. N. Galanos, T. Truong, A. Berchuck, et al. “A systematic outpatient quality improvement intervention results in earlier goals of care conversations between high-risk gynecologic cancer patients and their providers.” In Gynecologic Oncology, 159:306–306. Elsevier BV, 2020. https://doi.org/10.1016/j.ygyno.2020.05.549.
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  - Puechl, A. M., K. C. Strickland, E. J. Tanner, T. Murdock, G. Broadwater, J. A. Ehrisman, P. S. Lee, A. A. Secord, and L. Havrilesky. “Association between isolated tumor cells and recurrence in stage I endometrial cancer.” In Gynecologic Oncology, 154:172–172. Elsevier BV, 2019. https://doi.org/10.1016/j.ygyno.2019.04.401.
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  - Gatta, L. A., I. V. Rodriguez, K. C. Strickland, J. B. Gilner, C. Grotegut, J. Ronald, M. Bashir, A. James, P. S. Lee, and A. A. Secord. “Novel management of morbidly adherent placenta: Preliminary outcomes assessment of 13-year experience with prospective multidisciplinary algorithm.” In Gynecologic Oncology, 154:15–15. Elsevier BV, 2019. https://doi.org/10.1016/j.ygyno.2019.04.041.
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  - Watson, Catherine H., Brittany Anne Davidson, Laura Jean Havrilesky, Paula S. Lee, Leah McNally, Haley Moss, Rebecca A. Previs, et al. “Management of high, moderate, and low penetrance ovarian cancer susceptibility gene mutations: An assessment of current practice patterns.” In Journal of Clinical Oncology, 37:1536–1536. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/jco.2019.37.15_suppl.1536.
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  - Frumovitz, M., M. Plante, P. S. Lee, S. Sandadi, J. F. Lilja, P. F. Escobar, L. T. Gien, M. F. Munsell, and N. R. Abu-Rustum. “The FILM Trial: A randomized phase III multicenter study assessing near infrared fluorescence in the identification of sentinel lymph nodes (SLN).” In Gynecologic Oncology, 149:7–7. Elsevier BV, 2018. https://doi.org/10.1016/j.ygyno.2018.04.023.
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  - Davidson, Brittany Anne, Jonathan Foote, Jessie Ehrisman, Jui-Chen Yang, Shelby D. Reed, Reed Johnson, Paula S. Lee, Angeles Alvarez Secord, Andrew Berchuck, and Laura Jean Havrilesky. “What factors drive the choice of a genetic test? A prospective study of the preferences of women with ovarian cancer.” In Journal of Clinical Oncology, 36:e13621–e13621. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e13621.
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  - Natesan, D., O. I. Craciunescu, P. S. Lee, and J. P. Chino. “FDG Positron Emission Tomography (PET)/Computed Tomography Characteristics of Vulvar Cancer: Posttreatment PET Correlates With Clinical Outcomes.” In International Journal of Radiation Oncology Biology Physics, 96:S52–53, 2016.
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  - Ehrisman, Jessie A., Sara Abbott, Zach Harmon, Angeles Alvarez Secord, Andrew Berchuck, Paula S. Lee, Fidel A. Valea, et al. “Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-Grade Endometrial Cancer.” In Modern Pathology, 29:282A-282A. NATURE PUBLISHING GROUP, 2016.
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  - Teoh, Deanna, William J. Lowery, Xiaoyin Jiang, Jessie Ehrisman, Paige Halvorson, Gloria Broadwater, Rex Bentley, et al. “Vaginal cuff thermal injury by mode of colpotomy at total laparoscopic hysterectomy: a randomized clinical trial.” In J Minim Invasive Gynecol, 22:227–33, 2015. https://doi.org/10.1016/j.jmig.2014.10.002.
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  - Havrilesky, Laura Jean, Angeles Alvarez Secord, Jessie A. Ehrisman, Andrew Berchuck, Fidel A. Valea, Paula S. Lee, Stephanie Gaillard, et al. “Relative influence of factors determining a woman’s preference for treatment options in ovarian cancer.” In Journal of Clinical Oncology, 32:5544–5544. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.5544.
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  - Havrilesky, L. J., A. A. Secord, J. Ehrisman, A. Berchuck, F. A. Valea, P. S. Lee, D. Cella, K. Weinfurt, A. P. Abernethy, and S. D. Reed. “Relative Influence of Factors Determining a Woman’s Preference for Treatment Options in Ovarian Cancer: A Discrete Choice Experiment.” In Value in Health, 17:A93–A93. Elsevier BV, 2014. https://doi.org/10.1016/j.jval.2014.03.539.
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  - Lee, P. S., V. Teaberry, A. E. Bland, Z. Huang, A Alvarez Secord, A. Berchuck, and S. K. Murphy. “MAL, a gene associated with survival in epithelial ovarian cancer, is epigenetically regulated.” In Gynecologic Oncology, 108:S125–S125. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008.
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  - Rubatt, J. M., K. M. Darcy, A. Hutson, S. M. Bean, L. J. Havrilesky, P. S. Lee, L. A. Grace, A. Berchuck, and A Alvarez Secord. “Prognostic relevance of microvessel density in previously untreated, advanced-stage epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.” In Gynecologic Oncology, 108:S20–S20. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008.
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Teaching & Mentoring
Advising & Mentoring
- Duke second year medical students
  Duke OBGYN residents
  Duke GynOnc fellows
  Uganda Gynonc fellows
  Uganda Gynonc faculty
Teaching Activities
- Developing gyn oncology curriculum including organizing rotating 3 year lecture series that includes 4 hours of didactics per month
  
  Preceptor in the Longitudinal Integrated Clerkship (LIC) program for Duke 2nd year medical students
  
  Surgical teaching to gynonc fellows and OBGYN residents
  
  Providing lectures, case-based presentations and discussions to gynonc fellows
  
  Providing monthly lectures to Uganda GynOnc Fellowship
Scholarly, Clinical, & Service Activities
Presentations & Appearances
- Global Oncology: Gynecologic Cancer Care in Uganda. Grand Rounds. Duke OBGYN. February 24, 2021 2021
Outreach & Engaged Scholarship
- Developer. Uganda Gynecologic Oncology Fellowship Program. Uganda Cancer Institute. November 2014 2014
Service to the Profession
Service to Duke
- Duke Cancer Institute. Wake County Physician Leadership Committee. 2017 2017
- Duke Hospital. Robotic Surgery Committee. 2008 2008
Academic & Administrative Activities
- 1. Fellowship Director: Since September 2016, my academic administration priority has been as Fellowship Program Director for our 3 year gynecologic oncology program. During this time, our fellowship accreditation transitioned from ABOG to ACGME. My duties include optimizing the learning and training environment for our three fellows. I maintain compliance to ACGME, organize a rotating three year didactic series, and provide routine feedback to fellows and faculty. Structured feedback occurs quarterly, including semiannual reviews with the fellows. Semiannual assessments occur with the gynonc faculty as well as a comprehensive annual program evaluation. When available, I attend monthly Duke GME meetings and complete the required ACGME annual program updates and ABOG reporting. I oversee the candidate recruitment process and our program accepts one fellow per year.
  2. Medical Director of Duke Raleigh/WakeCounty Gynecologic Oncology: Since 2016, my administrative activities include overseeing the clinical operations of our practice in Wake County and reporting directly to our Division Chief. Every quarter, I assist with ensuring accuracy of the Division's clinical schedule for our 8 faculty and 7 APPs. As clinical supervisor for the four advance practice practitioners in Raleigh (three nurse practitioners and one physician assistant), I provide direct supervision, feedback, and complete semiannual evaluations. I work closely with nursing administration and oversee our six person nursing team to maintain high quality patient care and effective team work at DWCCR. In May 2021, I am clinical supervisor to another NP who will run the newly opened sexual health clinic for cancer patients at Macon Pond.
  3. Wake County Physician Leadership Committee: With the announcement of Cancer Care Plus between Duke and WakeMed in 2017, my administrative activities as a member of this committee include developing the clinical infrastructure to provide gynecologic cancer care in Wake County. This entails participation in every other month strategic planning meetings with administration teams and networking meetings with Wake Med physicians.
Clinical Activities
- My gynecologic oncology practice consists of 80% clinical practice split between Duke University Hospital and Wake County locations. My outpatient clinics occur twice a week at the Duke Women’s Cancer Center in Raleigh. I operate twice a week: every Wednesday at Duke North and every other Monday at WakeMed Hospital Raleigh. I began operating at WakeMed Hospital since October 2017.
  
  Starting in August 2019, my clinical practice expanded to include Vidant Medical Center in Greenville, NC. This collaboration between Duke and Vidant Medical center was developed to provide ongoing access to gynecologic oncology care in this rural population setting. I provide outpatient gynecologic oncology services one to twice a month (every other Thursday) and operate twice a month at this site (every other Monday) with East Carolina University (ECU) OBGYN residents.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Medical Licensure

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Subject Headings

Global Scholarship

Expertise

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Advising & Mentoring

Teaching Activities

Presentations & Appearances

Outreach & Engaged Scholarship

Service to the Profession

Service to Duke

Academic & Administrative Activities

Clinical Activities