Pelin Cayirlioglu Volkan
Associate Professor of Biology
The long-term goal in the lab is to understand the developmental processes that establish the basic organizational and functional principles of the neuronal circuits in the brain. We investigate how the neuronal circuits assemble, functionally mature, remodel in developmental and evolutionary time scales. To understand these processes the Volkan lab uses the olfactory system of the genetically tractable Drosophila melanogaster as a model organism and apply molecular, developmental and systems level approaches. Our research aims to answer three fundamental questions in developmental and evolutionary neurobiology using the Drosophila olfactory system: 1- What are the transcriptional and epigenetic networks that regulate cellular specification and diversity of olfactory receptor neurons? 2- How is sensory neuron function established during development and modulated with experience? 3- What are the molecular, developmental and functional changes underlying evolution of species-specific differences in odor-guided behaviors?
Current Appointments & Affiliations
- Associate Professor of Biology, Biology, Trinity College of Arts & Sciences 2019
- Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2011
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Investigator in the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2009
Contact Information
- 4313 French Family Science Center, Durham, NC 27708
- Box 90338, Durham, NC 27708-0338
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pelin.volkan@duke.edu
(919) 684-1150
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https://sites.duke.edu/volkanlab/
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2003
- M.S., Bogazici University (Turkey) 1997
- B.S., Bogazici University (Turkey) 1995
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Previous Appointments & Affiliations
- Assistant Professor of Biology, Biology, Trinity College of Arts & Sciences 2009 - 2019
- Recognition
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In the News
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FEB 10, 2021 -
MAY 22, 2020 -
FEB 5, 2020 -
JAN 8, 2019 Duke Research Blog -
FEB 3, 2016 -
JAN 7, 2014 Duke Research
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Awards & Honors
- Distinguished UNC Alumnus Award. UNC-CH. May 17, 2013
- Expertise
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Subject Headings
- Research
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Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Social experience dependent modification of gene regulation and circuit function awarded by National Institutes of Health 2022 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Role of insect olfactory receptors and cell adhesion molecules in circuit organization awarded by National Science Foundation 2020 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Sensing Dietary Amino Acids from Gut to Brain awarded by National Institutes of Health 2021 - 2023
- Epigenetic reprogramming of behaviors with sensory experience awarded by National Institutes of Health 2018 - 2023
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Collaborative Research: The impacts of the distribution of phenotypic effects and distribution of pleiotropic costs on the genetics of natural adaptations awarded by National Science Foundation 2015 - 2020
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Chromatin modulation in structural and functional refinement of olfactory circuits awarded by Whitehall Foundation, Inc. 2014 - 2016
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External Relationships
- Northwestern University
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Duan, Qichen, Rachel Estrella, Allison Carson, Yang Chen, and Pelin C. Volkan. “The effect of Drosophila attP40 background on the glomerular organization of Or47b olfactory receptor neurons.” G3 (Bethesda, Md.) 13, no. 4 (April 2023): jkad022. https://doi.org/10.1093/g3journal/jkad022.Full Text
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Deanhardt, Bryson, Qichen Duan, Chengcheng Du, Charles Soeder, Alec Morlote, Deeya Garg, Aishani Saha, Corbin D. Jones, and Pelin Cayirlioglu Volkan. “Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.” G3 (Bethesda, Md.), March 2023, jkad072. https://doi.org/10.1093/g3journal/jkad072.Full Text
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Duan, Qichen, and Pelin Cayirlioglu Volkan. “Ant Olfaction: Smells Like an Insect, Develops Like a Mammal.” Current Biology : Cb 30, no. 16 (August 2020): R950–52. https://doi.org/10.1016/j.cub.2020.06.074.Full Text
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Zhao, Songhui, Bryson Deanhardt, George Thomas Barlow, Paulina Guerra Schleske, Anthony M. Rossi, and Pelin C. Volkan. “Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling.” Science Advances 6, no. 21 (May 2020): eaba6913. https://doi.org/10.1126/sciadv.aba6913.Full Text
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Sethi, Sachin, Hui-Hao Lin, Andrew K. Shepherd, Pelin C. Volkan, Chih-Ying Su, and Jing W. Wang. “Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila.” Current Biology : Cb 29, no. 22 (November 2019): 3887-3898.e4. https://doi.org/10.1016/j.cub.2019.09.045.Full Text
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Barish, Scott, Sarah Nuss, Ilya Strunilin, Suyang Bao, Sayan Mukherjee, Corbin D. Jones, and Pelin C. Volkan. “Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila.” Plos Genetics 14, no. 8 (August 2018): e1007560. https://doi.org/10.1371/journal.pgen.1007560.Full Text
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Barish, Scott, and Pelin C. Volkan. “Preparing Developing Peripheral Olfactory Tissue for Molecular and Immunohistochemical Analysis in Drosophila.” Journal of Visualized Experiments : Jove, no. 136 (June 2018). https://doi.org/10.3791/57716.Full Text
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Pan, Jia Wern, Joi McLaughlin, Haining Yang, Charles Leo, Paula Rambarat, Sumie Okuwa, Anaïs Monroy-Eklund, Sabrina Clark, Corbin D. Jones, and Pelin Cayirlioglu Volkan. “Comparative analysis of behavioral and transcriptional variation underlying CO2 sensory neuron function and development in Drosophila.” Fly 11, no. 4 (October 2017): 239–52. https://doi.org/10.1080/19336934.2017.1344374.Full Text
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Pan, Jia Wern, Qingyun Li, Scott Barish, Sumie Okuwa, Songhui Zhao, Charles Soeder, Matthew Kanke, Corbin D. Jones, and Pelin Cayirlioglu Volkan. “Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species.” Scientific Reports 7, no. 1 (August 2017): 8804. https://doi.org/10.1038/s41598-017-08563-0.Full Text
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Barish, Scott, Qingyun Li, Jia W. Pan, Charlie Soeder, Corbin Jones, and Pelin C. Volkan. “Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates.” Scientific Reports 7 (January 2017): 40873. https://doi.org/10.1038/srep40873.Full Text
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Hueston, Catherine E., Douglas Olsen, Qingyun Li, Sumie Okuwa, Bo Peng, Jianni Wu, and Pelin Cayirlioglu Volkan. “Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons.” Plos Biology 14, no. 4 (April 2016): e1002443. https://doi.org/10.1371/journal.pbio.1002443.Full Text Open Access Copy
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Li, Q., S. Barish, S. Okuwa, and P. C. Volkan. “Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9 Mediated Protein Tagging (vol 5, pg 2809, 2015).” G3 Genes Genomes Genetics 6, no. 3 (March 1, 2016): 771–771.Link to Item
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Li, Qingyun, Scott Barish, Sumie Okuwa, Abigail Maciejewski, Alicia T. Brandt, Dominik Reinhold, Corbin D. Jones, and Pelin Cayirlioglu Volkan. “A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.” Plos Genetics 12, no. 1 (January 2016): e1005780. https://doi.org/10.1371/journal.pgen.1005780.Full Text Open Access Copy
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Barish, Scott, and Pelin Cayirlioglu Volkan. “Mechanisms of olfactory receptor neuron specification in Drosophila.” Wiley Interdisciplinary Reviews. Developmental Biology 4, no. 6 (November 2015): 609–21. https://doi.org/10.1002/wdev.197.Full Text
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Li, Qingyun, Scott Barish, Sumie Okuwa, and Pelin C. Volkan. “Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging.” G3 (Bethesda, Md.) 5, no. 12 (October 2015): 2809–16. https://doi.org/10.1534/g3.115.021857.Full Text Open Access Copy
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Barish, S., and P. C. Volkan. “Mechanisms of olfactory receptor neuron specification in Drosophila.” Wiley Interdisciplinary Reviews: Developmental Biology 4, no. 6 (2015): 609–21. https://doi.org/10.1002/wdev.197.Full Text
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Li, Qingyun, Tal Soo Ha, Sumie Okuwa, Yiping Wang, Qian Wang, S Sean Millard, Dean P. Smith, and Pelin Cayirlioglu Volkan. “Combinatorial rules of precursor specification underlying olfactory neuron diversity.” Current Biology : Cb 23, no. 24 (December 2013): 2481–90. https://doi.org/10.1016/j.cub.2013.10.053.Full Text
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Li, Qingyun, Tal Soo Ha, Dean Smith, and Pelin Cayirlioglu Volkan. “Molecular mechanisms governing the receptor choice in Drosophila pheromone circuits.” Journal of Neurogenetics 24 (December 1, 2010): 34–34.Link to Item
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Cayirlioglu, P. “Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems (Science (1256)).” Science 320, no. 5883 (June 20, 2008): 1588.
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Cayirlioglu, Pelin, Ilona Grunwald Kadow, Xiaoli Zhan, Katsutomo Okamura, Greg S. B. Suh, Dorian Gunning, Eric C. Lai, and S Lawrence Zipursky. “Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems.” Science (New York, N.Y.) 319, no. 5867 (February 2008): 1256–60. https://doi.org/10.1126/science.1149483.Full Text
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Jones, Walton D., Pelin Cayirlioglu, Ilona Grunwald Kadow, and Leslie B. Vosshall. “Two chemosensory receptors together mediate carbon dioxide detection in Drosophila.” Nature 445, no. 7123 (January 2007): 86–90. https://doi.org/10.1038/nature05466.Full Text
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Cinaroglu, Ayca, Yesim Ozmen, Anil Ozdemir, Ferruh Ozcan, Ceren Ergorul, Pelin Cayirlioglu, David Hicks, and Kuyas Bugra. “Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina.” Journal of Neuroscience Research 79, no. 3 (February 2005): 329–39. https://doi.org/10.1002/jnr.20363.Full Text
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Cayirlioglu, Pelin, William O. Ward, S Catherine Silver Key, and Robert J. Duronio. “Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells.” Molecular and Cellular Biology 23, no. 6 (March 2003): 2123–34. https://doi.org/10.1128/mcb.23.6.2123-2134.2003.Full Text
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Cayirlioglu, P., P. C. Bonnette, M. R. Dickson, and R. J. Duronio. “Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells.” Development (Cambridge, England) 128, no. 24 (December 2001): 5085–98. https://doi.org/10.1242/dev.128.24.5085.Full Text
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Loureiro, J. J., K. Akong, P. Cayirlioglu, A. E. Baltus, A. DiAntonio, and M. Peifer. “Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila.” Developmental Biology 235, no. 1 (July 2001): 33–44. https://doi.org/10.1006/dbio.2001.0292.Full Text
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Cayirlioglu, P., and R. J. Duronio. “Cell cycle: Flies teach an old dogma new tricks.” Current Biology : Cb 11, no. 5 (March 2001): R178–81. https://doi.org/10.1016/s0960-9822(01)00088-4.Full Text
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Book Sections
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Hueston, C., and P. C. Volkan. “Generation of neuronal diversity in the peripheral olfactory system in drosophila.” In Decoding Neural Circuit Structure and Function: Cellular Dissection Using Genetic Model Organisms, 399–418, 2017. https://doi.org/10.1007/978-3-319-57363-2_16.Full Text
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Conference Papers
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Volkan, Pelin C., Bryson Deanhardt, Songhui Zhao, Chengcheng Du, Aishani Saha, Charles Soeder, and Corbin Jones. “Chromatin Based Reprogramming of fru and dsx in Courtship Circuits with Social Experience and Pheromone Signaling.” In Chemical Senses, Vol. 46, 2021.Link to Item
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Volkan, Pelin C., Bryson Deanhardt, Songhui Zhao, Chengcheng Du, Aishani Saha, Charles Soeder, and Corbin Jones. “Chromatin Based Reprogramming of fru and dsx in Courtship Circuits with Social Experience and Pheromone Signaling.” In Chemical Senses, Vol. 46, 2021.Link to Item
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Duan, Qichen, Yetong Huang, Scott Barish, and Pelin C. Volkan. “Interacting Ig Superfamily Proteins Organize Axon Terminals of Olfactory Receptor Neurons Regulated by Olfactory Receptors in Drosophila.” In Chemical Senses, 44:E68–E68. OXFORD UNIV PRESS, 2019.Link to Item
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Pan, Jia W., Scott Barish, Tristan Li, Catherine Hueston, Doug Olsen, Songhui Zhao, Sayan Mukherjee, Corbin D. Jones, and Pelin C. Volkan. “Stability and plasticity in the Drosophila olfactory system across timescales.” In Chemical Senses, 42:E3–E3. OXFORD UNIV PRESS, 2017.Link to Item
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 385L: Integrative Neuroscience Laboratory 2023
- BIOLOGY 493: Research Independent Study 2023
- BIOLOGY 791T: Tutorial 2023
- NEUROSCI 385L: Integrative Neuroscience Laboratory 2023
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2023
- BIOLOGY 223: Cellular and Molecular Neurobiology 2022
- BIOLOGY 493: Research Independent Study 2022
- BIOLOGY 792: Research 2022
- NEUROSCI 223: Cellular and Molecular Neurobiology 2022
- NEUROSCI 495: Research Independent Study 3 2022
- BIOLOGY 223: Cellular and Molecular Neurobiology 2021
- BIOLOGY 293: Research Independent Study 2021
- BIOLOGY 385L: Integrative Neuroscience Laboratory 2021
- BIOLOGY 493: Research Independent Study 2021
- BIOLOGY 791T: Tutorial 2021
- BIOLOGY 792: Research 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- NEUROSCI 223: Cellular and Molecular Neurobiology 2021
- NEUROSCI 385L: Integrative Neuroscience Laboratory 2021
- NEUROSCI 493: Research Independent Study 1 2021
- NEUROSCI 494: Research Independent Study 2 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Constructing and Deconstucting the nervous system though time: Lessons from the Drosophila olfactory system. Genetics Department. Columbia University Medical School. October 6, 2015 2015
- Chromatin modulatory proteins and olfactory receptor signaling in establishment and maintenance of fruitless expression. Neurobiology of Drosophila. Cold Spring Harbor meeting. September 29, 2015 - October 3, 2015 2015
- Mechanisms of development and evolution of the olfactory system in Drosophilids. Pan-American Society for Evolutionary Developmental Biology. August 5, 2015 - August 9, 2015 2015
- A molecular network module governing sensory neuron diversification. Society of Developmental Biology Meeting. July 9, 2015 - July 13, 2015 2015
- A molecular network module governing sensory neuron diversification. Developmental Biology. Gordon Research Conferences. June 21, 2015 - June 26, 2015 2015
- Chromatin modulation in structural and functional refinement of fru+ ORN circuits in Drosophila. October 1, 2013 2013
- Chromatin modulation in structural and functional refinement of fru+ ORN circuits in Drosophila. June 1, 2013 2013
- Generating neuronal complexity in the olfactory system. May 17, 2013 2013
- From sensory receptors to functional neuronal networks: Assembly and remodeling of olfactory circuitry in Drosophila. November 16, 2012 2012
- From sensory receptors to functional neuronal networks: Assembly and remodeling of olfactory circuitry in Drosophila. November 1, 2012 2012
- FROM SENSORY RECEPTORS TO FUNCTIONAL NEURONAL NETWORKS: CONSTRUCTING AND DECONSTRUCTING THE OLFACTORY CIRCUITRY IN DROSOPHILA. November 18, 2011 2011
- From Sensory Receptors to Functional Neuronal Networks: Assembling the Olfactory Circuitry in Drosophila. December 3, 2010 2010
- Carbonated Insects. November 17, 2010 2010
- A microRNA pathway involved in the evolution of CO2 sensory circuit assembly in insects.. March 1, 2009 2009
- A microRNA pathway involved in the evolution of CO2 sensory circuit assembly in insects.. March 1, 2009 2009
- A microRNA pathway involved in the evolution of CO2 sensory circuit assembly in insects.. February 1, 2009 2009
- A microRNA pathway involved in the evolution of CO2 sensory circuit assembly in insects.. February 1, 2009 2009
- A microRNA pathway involved in the evolution of CO2 sensory circuit assembly in insects.. October 1, 2008 2008
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Outreach & Engaged Scholarship
- Unknown. Demonstration in Brain Awareness Week. December 18, 2012 2012
- FROM SENSORY RECEPTORS TO FUNCTIONAL NEURONAL NETWORKS: CONSTRUCTING AND DECONSTRUCTING THE OLFACTORY CIRCUITRY IN DROSOPHILA. UNDERGRADUATE HOWARD HUGHES PROGRAM. July 1, 2011 2011
- Unknown. Middle and High School outreach. July 1, 2011 2011
- FROM ASSEMBLY TO EVOLUTION: THE CO2 SENSORY CIRCUITRY IN DROSOPHILA. UNDERGRADUATE HOWARD HUGHES PROGRAM. June 15, 2010 2010
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Service to the Profession
- Advisor for Triangle Fly Symposium. 2015 2015
- Book Reviewer. Oxford Press. 2015 - 2015 2015
- Impostor syndrome lunch, invited faculty. 2015 2015
- Manuscript Reviewer/Referree. Genome Biology and Evolution. 2015 - 2015 2015
- Manuscript Reviewer/Referree. Insect Science. 2015 - 2015 2015
- Reviewer for journal. Journal of Comparative Physiology. 2015 - 2015 2015
- Reviewer for journal. Insect Molecular Biology. 2014 - 2015 2014 - 2015
- Reviewer for journal. Scientific Reports. 2014 - 2015 2014 - 2015
- Duke Fly Club. 2013 2013
- Session moderator. Drosophila Research Conference. 2013 2013
- Manuscript reviewer for "Genes and Development". December 18, 2012 2012
- Reviewer for journal. Plos Genetics. 2012 - 2015 2012 - 2015
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Service to Duke
- Graduate Thesis Committee. 2015 2015
- Graduate Thesis Committee. 2015 2015
- Graduate Thesis Committee. 2014 2014
- Graduate Thesis Committee. 2014 2014
- Performance Review Committee. 2014 2014
- Graduate Thesis Committee. 2013 2013
- Graduate Thesis Committee. 2013 2013
- Graduate Thesis Committee. 2013 2013
- Graduate Thesis Committee. 2013 2013
- Academic Advising. December 18, 2012 - December 18, 2012 2012
- Biology Department Strategic Planning Committee. December 18, 2012 2012
- Consortium of Neuroscience Graduate Programs faculty steering committee. December 18, 2012 2012
- Graduate Admissions Committee. December 18, 2012 2012
- Neuroscience Steering Committee. December 18, 2012 2012
- Biology Department Strategic Planning Committee. December 1, 2012 2012
- Session chair for Neural Development at the Drosophila Conference. March 1, 2012 - March 1, 2012 2012
- Academic Advising. February 21, 2012 - February 21, 2012 2012
- Biology Thesis Reader. February 21, 2012 - February 21, 2012 2012
- Graduate Thesis Committees. February 21, 2012 2012
- Graduate Thesis Committees. February 21, 2012 2012
- Biology Department Graduate Admissions Committee. December 13, 2011 2011
- Departmental Seminar Committee. February 21, 2011 2011
- Graduate Thesis Committees. February 21, 2011 2011
- Graduate Thesis Committees. February 21, 2011 2011
- Developmental and Stem Cell Biology Program Graduate Admissions Committee. February 1, 2011 2011
- Organizer. Curriculum Innovations. December 8, 2009 2009
- Graduate Thesis Committees. December 1, 2009 2009
- Graduate Thesis Committees. December 1, 2009 2009
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