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John Robert Perfect

James B. Duke Distinguished Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Hanes House Rm 163, Trent Drive, Durham, NC 27710

Scholarly Works - Book sections


Cryptococcosis

Book section · January 1, 2025 Full text Cite

Cryptococcosis

Book section · September 14, 2023 Cryptococcosis is an infectious disease caused by the encapsulated fungi Cryptococcus neoformans and Cryptococcus gattii. Cryptococcal infection can develop in apparently immunocompetent hosts and these fungi have emerged as important opportunistic pathoge ... Full text Cite

Fungal Infections of the Central Nervous System

Book section · January 1, 2021 Fungal infections of the central nervous system (CNS) are life-threatening conditions that generally involve an immunosuppressive event. Many of these infections occur sporadically in the course of a serious underlying disease. However, outbreaks of CNS fu ... Full text Cite

Uncommon Yeasts and Molds Causing Human Disease

Book section · January 1, 2021 With advances in modern medicine, patients are now living with increasingly complex medical comorbidities, and often with increasingly fragile immunity. As a result, larger populations are susceptible to infections from once infrequently seen fungal opport ... Full text Cite

Management of Phaeohyphomycosis

Book section · February 13, 2019 This new edition of Antifungal Therapy aims at providing concise, practical, need-to-know information for busy physicians dealing with fungal infections, such as infectious disease physicians, transplant surgeons, dermatologists, and ... ... Cite

Management of Mucormycoses

Book section · February 13, 2019 This new edition of Antifungal Therapy aims at providing concise, practical, need-to-know information for busy physicians dealing with fungal infections, such as infectious disease physicians, transplant surgeons, dermatologists, and ... ... Cite

Fungi that infect humans

Book section · September 5, 2017 In its short history of a century and a half, of which the last half-century brought the most dramatic advances, scientific medicine has found ways to cure or to treat millions of ill people who 200 years ago would have died early. Paradoxically, these suc ... Full text Cite

Drug Resistance in Cryptococcosis

Book section · January 1, 2017 There are over 30 different Cryptococcus species (spp.), with C. neoformans and C. gattii being the two primary human pathogens responsible for the fungal disease, cryptococcosis. These encapsulated basidiomycetous yeasts have important differences in thei ... Full text Cite

Cryptococcosis

Book section · January 1, 2015 Cryptococcosis is an infectious disease caused by the encapsulated fungi Cryptococcus neoformans and Cryptococcus gattii Once a relatively uncommon cause of human disease, cryptococcal infection can develop in apparently immunocompetent hosts and has emerg ... Full text Cite

Fungal meningitis

Book section · April 21, 2014 Cite

The History of Cryptococcus and Cryptococcosis

Book section · January 1, 2014 This chapter considers over a century of clinical experience to examine the encapsulated yeast Cryptococcus, to identify the highlights of its maturation in identifying, understanding, diagnosing, and managing this major emerging fungal pathogen. In the ar ... Full text Cite

Fungal Molecular Pathogenesis: What Can It Do and Why Do We Need It?

Book section · January 1, 2014 As molecular studies are applied to study the pathogenesis of invasive mycoses, it is essential that the parameters of the host-parasite interactions are known. The issue of clinical antifungal drug resistance and the impact of molecular studies on these i ... Full text Cite

Cryptococcus neoformans: Latency and Disease

Book section · January 1, 2014 This chapter reviews the evidence of disease after acute infection and reactivation of latent infection, considering the newer epidemiological and serological studies and the older anatomical evidence. Cryptococcal meningitis was diagnosed in an HIV-infect ... Full text Cite

Cryptococcus neoformans: A Sugar-Coated Killer

Book section · January 1, 2014 The main principles for the genetic pathophysiology of cryptococcosis will probably be consistent among all three varieties. In this chapter the author considers the yeasts to be different varieties or serotypes. Seven major areas are examined to support t ... Full text Cite

Phaeohyphomycoses (brown-black moulds)

Book section · January 1, 2011 Phaeohyphomycosis, a term first introduced by Ajello and colleagues [1], is an encompassing clinical designation for a spectrum of infections caused by darkly pigmented moulds [2, 3]. In its simplest definition, phaeohyphomycosis is an infection caused by ... Full text Cite

Tourism implications of cryptococcus gattii in the southeastern USA

Book section · January 1, 2011 In 2007, the first confirmed case of Cryptococcus gattii was reported in the state of North Carolina, USA. An otherwise healthy human immunodeficiency virus (HIV) negative male patient presented with a large upper thigh cryptococcoma in February, which was ... Cite

Diagnosis of cryptococcosis

Book section · January 1, 2007 Cryptococcus neoformans is an encapsulated yeast that can cause life-threatening infectious diseases in both apparently immunocompetent and immunocompromised hosts in all areas of the world. This pathogenic yeast consists of four serotypes (A, B, C, and D) ... Cite

Rational use of antifungals for invasive fungal infections in the institutional setting

Book section · January 1, 2004 The incidence of invasive fungal infections (IFIs) is increasing at an alarming rate. In the past decade alone, Candida spp. have become the fourth leading cause of nosocomial bloodstream infections in the United States (1). The incidence of Aspergillus in ... Cite

Fungal infections in cancer patients

Book section · January 1, 2004 Cite