Scholars@Duke
Peter Allen

Peter Allen

David C. Sabiston, Jr. Distinguished Professor of Surgery
Surgical Oncology

Scholarly Works - Conferences

Social Vulnerability as a Neighborhood-Level Determinant of Pancreatic Cancer Survivorship: A National Analysis of Veterans Affairs Patients.

Conference Ann Surg Oncol · February 2026 BACKGROUND: Veterans Affairs (VA) patients participate within the largest USA equal-access healthcare system, though still experience cancer mortality disparities by social determinants. The Social Vulnerability Index (SVI)-measuring community poverty, min ... Full text Link to item Cite

Abstract B074: scRNA-seq from FFPE tissue resolves the tumor microenvironment of intraductal papillary mucinous neoplasms

Conference Cancer Research · September 28, 2025 AbstractIntraductal papillary mucinous neoplasms (IPMN) are precancerous cysts representing the only radiographically identifiable precursor to pa ... Full text Cite

Abstract B125: Resolving PDAC cell subpopulations that seed metastatic recurrence

Conference Cancer Research · September 28, 2025 AbstractApproximately 40% of patients with pancreatic ductal adenocarcinoma (PDAC) receive no benefit from surgical resection and systemic chemoth ... Full text Cite

Perioperative and Oncologic Outcomes of Hepatic Arterial Infusion (HAI) Pump Chemotherapy for Patients with Unresectable Colorectal Liver Metastases at an Expanding HAI Program.

Conference Ann Surg Oncol · February 2025 BACKGROUND: Hepatic arterial infusion (HAI) is an established treatment for patients with unresectable colorectal liver metastases (uCRLM). Until recently, HAI was only performed at a limited number of centers. We previously reported early outcomes suggest ... Full text Link to item Cite

Uncovering the role of oncogenic HER2 variants as drivers of pancreatic cancer.

Conference Journal of Clinical Oncology · February 2025 772Background: The therapeutic resistance of pancreatic ductal adenocarcinoma (PDAC) to conventional cytotoxic therapy unders ... Full text Cite

Abstract B052: Single-cell and spatial analysis of the immune landscape unveils a subset of potentially tumor-reactive T cells in patients with localized PDAC

Conference Cancer Research · September 15, 2024 AbstractEven in its localized stages, pancreatic ductal adenocarcinoma (PDAC) is virtually incurable, characterized by early dissemination and disease recurrence. The liver is the most common site of metasta ... Full text Cite

Abstract C004: A window-of-opportunity trial using neoadjuvant hepatic artery chemotherapy for patients with localized pancreas cancer: Interim analysis of safety and feasibility

Conference Cancer Research · September 15, 2024 AbstractLess than 20% of patients diagnosed with pancreatic cancer will present with localized disease and receive both resection and systemic therapy. Within this group of patients, actual 10-year survival ... Full text Cite

Fragmented Care in Stage II and III Gastric and Esophageal Cancer

Conference ANNALS OF SURGICAL ONCOLOGY · March 2024 Link to item Cite

Abstract B022: A platform to characterize hepatic immunity reveals variation in hepatic infiltration of tumor expanded T cells in “localized” PDAC

Conference Cancer Research · January 16, 2024 AbstractEven in its earliest stages, pancreatic ductal adenocarcinoma (PDAC) is an essentially incurable disease due to the presence of disseminated, yet radiographically occult cancer cells in the setting o ... Full text Cite

Evolution in Management of Upfront Treatment For Desmoid Tumors

Conference ANNALS OF SURGICAL ONCOLOGY · March 2023 Link to item Cite

Multidimensional Immunophenotyping of Intraductal Papillary Mucinous Neoplasms Reveals Novel T Cell and Macrophage Signature.

Conference Ann Surg Oncol · November 2022 BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) are the only radiographically identifiable precursor to pancreatic adenocarcinoma, yet little is known about how these lesions progress to cancer. Inflammation has been associated with dysplastic ... Full text Link to item Cite

Robotic distal pancreatectomy, a novel standard of care? First benchmark values for surgical outcomes from 14 international expert centers

Conference British Journal of Surgery · May 31, 2022 AbstractObjectiveRobotic distal pancreatectomy (DP) is emerging as the preferred treatment for body and tail tumors of the pancreas. T ... Full text Cite

Perioperative and oncologic outcomes of hepatic artery infusion pump therapy at an expanding HAI program.

Conference Journal of Clinical Oncology · February 1, 2022 120 Background: Hepatic artery infusion (HAI) is a liver directed therapy to treat unresectable or resected colorectal liver metastases (CRLM) and unresectable intrahepatic cholangiocarcinoma (ICC). Historically, HAI has only bee ... Full text Cite

Abstract PO-002: Detection of chemotherapy-resistant pancreatic cancer using a glycan Biomarker

Conference Cancer Research · November 15, 2020 AbstractA subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. In this study, we evalua ... Full text Cite

CD226 Expression is Associated with Increased Survival in Pancreatic Cancer

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2020 Link to item Cite

A combined radiomics and cyst fluid inflammatory markers model to predict preoperative risk in pancreatic cystic lesions

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2020 This paper contributes to the burgeoning field of surgical data science. Specifically, multi-modal integration of relevant patient data is used to determine who should undergo a complex pancreatic resection. Intraductal papillary mucinous neoplasms (IPMNs) ... Full text Cite

Quantitative CT analysis for the preoperative prediction of pathologic grade in pancreatic neuroendocrine tumors

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Pancreatic neuroendocrine tumors (PanNETs) account for approximately 5% of all pancreatic tumors, affecting one individual per million each year.1 PanNETs are difficult to treat due to biological variability from benign to highly malignant, indo ... Full text Cite

Prediction of Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Resection: Validation of a Clinical Risk Score in an International Cohort.

Conference Ann Surg · October 2017 OBJECTIVE: This study aims to validate a previously reported recurrence clinical risk score (CRS). SUMMARY OF BACKGROUND DATA: Salvage transplantation after hepatocellular carcinoma (HCC) resection is limited to patients who recur within Milan criteria (MC ... Full text Link to item Cite

Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes.

Conference J Am Coll Surg · May 2017 BACKGROUND: Preoperative chemotherapy is a strategy for converting to resection and/or assessing disease biology before operation. The utility of such an approach in gallbladder carcinoma (GBCA) is unknown. This study evaluated outcomes of GBCA patients tr ... Full text Link to item Cite

Quantification of CT images for the classification of high- and low-risk pancreatic cysts

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017 Pancreatic cancer is the most lethal cancer with an overall 5-year survival rate of 7%1 due to the late stage at diagnosis and the ineffectiveness of current therapeutic strategies. Given the poor prognosis, early detection at a pre-cancerous st ... Full text Cite

Prospective Randomized Controlled Trial of Liberal Vs Restricted Perioperative Fluid Management in Patients Undergoing Pancreatectomy.

Conference Ann Surg · October 2016 OBJECTIVE: The aim of this study is to examine, by a prospective randomized controlled trial, the influence of liberal (LIB) vs restricted (RES) perioperative fluid administration on morbidity following pancreatectomy. SUMMARY OF BACKGROUND DATA: Randomize ... Full text Link to item Cite

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Conference Pancreas · September 2016 Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a 5-year survival rate of less than 10%. The Division of Cancer Prevention of the National Cancer Institute sponsored the Pancreatic Cancer Chemoprevention Tra ... Full text Link to item Cite

Recurrence Patterns and Disease-Free Survival after Resection of Intrahepatic Cholangiocarcinoma: Preoperative and Postoperative Prognostic Models.

Conference J Am Coll Surg · September 2016 BACKGROUND: Liver resection is the most effective treatment for intrahepatic cholangiocarcinoma. Recurrent disease is frequent; however, recurrence patterns are ill-defined and prognostic models are lacking. STUDY DESIGN: A primary cohort of 189 patients w ... Full text Link to item Cite

The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.

Conference Mod Pathol · September 2016 In 2010, the World Health Organization reclassified the entity originally described as intraductal oncocytic papillary neoplasm as the 'oncocytic subtype' of intraductal papillary mucinous neoplasm. Although several key molecular alterations of other intra ... Full text Link to item Cite

Postoperative Mortality after Liver Resection for Perihilar Cholangiocarcinoma: Development of a Risk Score and Importance of Biliary Drainage of the Future Liver Remnant.

Conference J Am Coll Surg · August 2016 BACKGROUND: Liver surgery for perihilar cholangiocarcinoma (PHC) is associated with postoperative mortality ranging from 5% to 18%. The aim of this study was to develop a preoperative risk score for postoperative mortality after liver resection for PHC, an ... Full text Link to item Cite

Texture analysis for survival prediction of pancreatic ductal adenocarcinoma patients with neoadjuvant chemotherapy

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016 Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States. The five-year survival rate for all stages is approximately 6%, and approximately 2% when presenting with distant disease.1 Only 10 ... Full text Cite

Recurrence Rate and Pattern of Perihilar Cholangiocarcinoma after Curative Intent Resection.

Conference J Am Coll Surg · December 2015 BACKGROUND: The aim of this study was to investigate the rate and pattern of recurrence after curative intent resection of perihilar cholangiocarcinoma (PHC). STUDY DESIGN: Patients were included from 2 prospectively maintained databases. Recurrences were ... Full text Link to item Cite

Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease.

Conference Ann Surg · December 2015 OBJECTIVES: To evaluate the association of tumor-associated neutrophils (TANs) with malignant progression in intraductal papillary mucinous neoplasms (IPMNs) and to study the cyst fluid from these lesions for biomarkers of the inflammation-carcinogenesis a ... Full text Link to item Cite

Early trends in serum phosphate and creatinine levels are associated with mortality following major hepatectomy.

Conference HPB (Oxford) · December 2015 BACKGROUND: Mortality after major hepatectomy remains high and is frequently related to post-hepatectomy liver failure (PHLF). Other than pre-existing liver disease and a small future liver remnant, few patient factors or early postoperative indicators ide ... Full text Link to item Cite

The accuracy of pre-operative imaging in the management of hepatic cysts.

Conference HPB (Oxford) · October 2015 BACKGROUND: Biliary cystic tumours (BCT) [biliary cystadenoma (BCA) and cystadenocarcinoma (BCAC)] warrant complete resection. Simple liver cysts (SLC) require fenestration when symptomatic. Distinguishing between BCT and atypical SLC with pre-operative im ... Full text Link to item Cite

Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?

Conference Ann Surg · September 2015 OBJECTIVES: The impact of margin width on overall survival (OS) in the context of other prognostic factors after resection for colorectal liver metastases is unclear. We evaluated the relationship between resection margin and OS utilizing high-resolution h ... Full text Link to item Cite

Hepatic parenchymal preservation surgery: decreasing morbidity and mortality rates in 4,152 resections for malignancy.

Conference J Am Coll Surg · April 2015 BACKGROUND: Liver resection is used to treat primary and secondary malignancies. Historically, these procedures were associated with significant complications, which may affect cancer-specific outcomes. This study analyzed the changes in morbidity and mort ... Full text Link to item Cite

Chemotherapy-induced splenic volume increase is independently associated with major complications after hepatic resection for metastatic colorectal cancer.

Conference J Am Coll Surg · March 2015 BACKGROUND: In patients with colorectal cancer liver metastases (CRCLM), chemotherapy-induced hepatic injury is associated with increased splenic volume, thrombocytopenia, and decreased long-term survival. The current study investigates the relationship be ... Full text Link to item Cite

American Joint Committee on Cancer staging for resected perihilar cholangiocarcinoma: a comparison of the 6th and 7th editions.

Conference HPB (Oxford) · December 2014 OBJECTIVES: This study was conducted to evaluate the prognostic value of, respectively, the 6th and 7th editions of the American Joint Committee on Cancer (AJCC) staging system for patients with resected perihilar cholangiocarcinoma (PHC). METHODS: Patient ... Full text Link to item Cite

Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases.

Conference Am J Surg Pathol · April 2014 BACKGROUND: In the pancreas, poorly differentiated neuroendocrine carcinomas include small cell carcinoma and large cell neuroendocrine carcinoma and are rare; data regarding their pathologic and clinical features are very limited. DESIGN: A total of 107 p ... Full text Link to item Cite

Does pre-operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase post-operative morbidity? A case-matched analysis

Conference HPB · January 1, 2013 Background Neoadjuvant chemoradiation therapy for locally unresectable and borderline resectable pancreatic cancer may allow some patients to a undergo a resection, but whether or not this increases post-operative morbidity remains unclear. Methods The pos ... Full text Cite

Five hundred patients with Merkel cell carcinoma evaluated at a single institution.

Conference Ann Surg · September 2011 OBJECTIVE: To identify factors associated with survival in Merkel cell carcinoma (MCC). BACKGROUND: Merkel cell carcinoma is a rare cutaneous neoplasm. Staging and treatment are based on studies, which incompletely characterize the disease. METHODS: Review ... Full text Link to item Cite

Extrahepatic cholangiocarcinoma: A comparison of patients with resected proximal and distal lesions

Conference HPB · October 1, 2008 Purpose. Disease-specific survival (DSS) for proximal bile duct cancer has been reported to be worse than for carcinoma of the distal duct. Methods. Review of two prospectively maintained databases identified 204 patients who underwent resection for extrah ... Full text Cite

Cystic lesions of the pancreas: selection criteria for operative and nonoperative management in 209 patients.

Conference J Gastrointest Surg · December 2003 Because of the inability to determine benign from malignant, many have recommended that all cystic lesions of the pancreas be resected. Patients evaluated between January 1995 and December 2000 for the ICD-9 diagnosis of pancreatic cyst (577.2) or benign n ... Full text Link to item Cite

Impact of steatosis on perioperative outcome following hepatic resection.

Conference J Gastrointest Surg · December 2003 Fatty liver disease may interfere with liver regeneration and is postulated to result in an adverse outcome for patients subjected to partial hepatectomy. This study examines the impact of steatosis on outcome following hepatic resection for neoplasms. All ... Full text Link to item Cite

Saphenous vein versus polytetrafluoroethylene carotid patch angioplasty.

Conference Am J Surg · August 1997 BACKGROUND: The optimal material for carotid patch angioplasty after endarterectomy remains uncertain. This study compares the early outcome and recurrent stenosis rates between saphenous vein (SV) and expanded polytetrafluoroethylene (ePTFE) carotid patch ... Full text Link to item Cite