Overview
As Director of the Duke Medical Center Radiopharmacy, which is permitted by the North Carolina Board of Pharmacy, I am responsible for the procurement, formulation, quality control testing, and dispensing of all radiopharmaceuticals for diagnostic, therapeutic, and research purposes for use in patients in Duke Hospital. Service accomplishments in fiscal year 2011-2012 included providing all radiopharmaceuticals used for routine patient care at Duke Medical Center. In addition, the Radiopharmacy service participated in a wide variety of clinical research protocols undertaken by Duke investigators either by consultation regarding pharmaceutical formulation of research compounds or actually performing these formulations as a specialized service. The major accomplishment over the last several years was to move the Radiopharmacy operation into a new state of the art USP <797> compliant clean room environment. This new lab space is specifically designed to satisfy a wide variety of sterile radiopharmaceutical compounding needs for both routine patient care and clinical research well into the future. My general research interests focus on the development and clinical evaluation of diagnostic and therapeutic radiopharmaceuticals for patient care. Specific research interests focus on the clinical applications of 1.) Carbon C-11, Nitrogen N-13, Oxygen 0-15 and Fluorine F-18 labeled radiopharmaceuticals for Positron Emission Tomography (PET) based molecular imaging and 2.) Radiolabeling antibodies, small molecules and peptides with Gallium Ga-68 for diagnosis and therapeutic radionuclides for treatment of human cancers. Finally, I am interested in the development of radiopharmaceutical care models in nuclear medicine to optimize the patient's health related quality of life, and achieve positive clinical outcomes, within realistic economic expenditures.
Current Appointments & Affiliations
Associate Professor in Radiology
·
2022 - Present
Radiology,
Clinical Science Departments
Recent Publications
Licensing and regulatory control: radioactivity and radioactive materials
Chapter · March 10, 2020 The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. ... Link to item CiteLicensing and regulatory control: radiopharmaceutical oversight
Chapter · March 10, 2020 The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. ... Link to item CitePredictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.
Journal Article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item CiteRecent Grants
Cross-disciplinary Training in Medical Physics
Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2007 - 2013View All Grants
Education
Purdue University ·
1977
M.S.
Purdue University ·
1975
B.S.