Scholars@Duke
Neil Allen Petry

Neil Allen Petry

Associate Professor Emeritus of Radiology
Radiology
Box 3304 Med Ctr, Durham, NC 27710
0023, Sub-Basement, Purple Zon, Duke Clinics, 200 Trent Drive, Durham, NC 27710

Scholarly Works

Licensing and regulatory control: radioactivity and radioactive materials

Book section · March 10, 2020 The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. ... Link to item Cite

Licensing and regulatory control: radiopharmaceutical oversight

Book section · March 10, 2020 The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. ... Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

Reply.

Journal article Muscle Nerve · October 2018 Full text Link to item Cite

Direct in vivo evidence of activated macrophages in human osteoarthritis.

Conference Osteoarthritis Cartilage · September 2016 OBJECTIVE: Through binding to folate receptor-β (FR-β), the new (99m)Tc-EC20 (Etarfolatide) imaging technique detects activated but not resting macrophages in vivo. The goal of this study was to investigate macrophage-related inflammation in osteoarthritis ... Full text Link to item Cite

Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.

Journal article Invest New Drugs · April 2016 D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel immunotoxin that reacts with wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFRvIII proteins overexpressed in glioblastomas. This study assessed the toxicity of intracerebral administration of D2 ... Full text Link to item Cite

Phase-1 clinical trial results of high-specific-activity carrier-free 123I-iobenguane.

Journal article J Nucl Med · May 2014 UNLABELLED: A first-in-human phase 1 clinical study was performed on 12 healthy adults with a high-specific-activity carrier-free formulation of (123)I-iobenguane. Clinical data are presented on the behavior of this receptor-targeting imaging agent. METHOD ... Full text Link to item Cite

First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer.

Journal article J Nucl Med · March 2013 Featured Publication UNLABELLED: This phase 1 study was performed to determine the pharmacokinetics and ability to visualize prostate cancer in bone, soft-tissue, and the prostate gland using (123)I-MIP-1072 and (123)I-MIP-1095, novel radiolabeled small molecules targeting pro ... Full text Link to item Cite

The future of USP monographs for PET drugs.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · March 2013 Featured Publication Full text Open Access Cite

Alumina Depyrogenates F 18 Fludeoxyglucose Injection during Purification Processes.

Journal article PDA journal of pharmaceutical science and technology · May 2012 Featured Publication Endotoxin indicators (EIs) and photometric bacterial endotoxin test (BET) assays were used to determine the capacity of alumina (Al(2)O(3)) for removing endotoxin from a parenteral solution. Fludeoxyglucose F 18 (FDG) Injection, USP, a radioactive imaging ... Full text Cite

Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Journal article Neurosurgery · September 2011 Featured Publication BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monito ... Full text Link to item Cite

Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine

Book section · March 30, 2011 The book contains essential information required by state and federal radiation licensing organizations for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. ... Cite

Operation of a radiopharmacy for a clinical trial.

Journal article Seminars in nuclear medicine · September 2010 Featured Publication Clinical investigations of radiopharmaceuticals are undertaken to advance promising compounds toward approval by the Food and Drug Administration (FDA) as "legend drugs." This FDA approval requires that the safety and efficacy of the investigational drug ( ... Full text Cite

Targeting Metastatic Prostate Cancer (PCa) Using I-123-MIP-1072 & I-123-MIP-1095: A Phase I Clinical Study in Patients

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · September 1, 2009 Link to item Cite

Targeting Metastatic Prostate Cancer (PCa) Using I-123-MIP-1072 & I-123-MIP-1095: A Phase I Clinical Study in Patients

Journal article EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · September 1, 2009 Featured Publication Link to item Cite

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Journal article Neuro Oncol · June 2008 Featured Publication The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombinant toxin (TP-38) targeting the epidermal growth factor receptor in patients with recurrent malignant brai ... Full text Link to item Cite

PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

Journal article AJR Am J Roentgenol · February 2008 Featured Publication OBJECTIVE: Copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g ... Full text Link to item Cite

A performance evaluation of 90Y dose-calibrator measurements in nuclear pharmacies and clinics in the United States.

Journal article Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · February 2008 Featured Publication A blind performance test was conducted to evaluate dose-calibrator measurements at nuclear pharmacies in the United States (US). Two test-sample geometries were chosen to represent those used for measurements of 90Y-ibritumomab tiuxetan (ZEVALIN). The radi ... Full text Cite

Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT.

Journal article Radiology · November 2007 Featured Publication PURPOSE: To prospectively determine feasibility of evaluating murine left ventricular (LV) function with electrocardiographically (ECG)-gated blood pool single photon emission computed tomography (SPECT). MATERIALS AND METHODS: All animal studies had insti ... Full text Link to item Cite

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.

Journal article Neurosurgery · February 2007 Featured Publication OBJECTIVE: Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known about the volume of distribution achieved within human brain tissue or how target anatomy and catheter positioning influence d ... Full text Link to item Cite

Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT.

Journal article Radiology · January 2007 PURPOSE: To determine the feasibility of in vivo localization and quantification of indium 111 (111In)-oxine-labeled bone marrow (BM) with high-resolution whole-body helical single photon emission computed tomography (SPECT) in an established murine model ... Full text Link to item Cite

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation.

Journal article Clin Cancer Res · November 15, 2006 PURPOSE: A noninvasive method to monitor intratumoral Doxil delivery in individual patients during targeted tumor therapy is important to predict treatment response. The purpose of this study was to determine if a small tracer dose of technetium-99m (99mTc ... Full text Link to item Cite

Explanations and unresolved issues pertaining to the development of the Nuclear Pharmacy Compounding Guidelines.

Journal article Journal of the American Pharmaceutical Association (Washington, D.C. : 1996) · September 2002 Featured Publication ObjectivesTo provide background information related to the development of the Nuclear Pharmacy Compounding Guidelines, to discuss regulatory complexities related to radiopharmaceutical compounding practice, and to summarize the gaps in the current ... Full text Cite

Abnormal Tl-201 myocardial scintigraphy associated with administration of sodium aurothiomalate

Journal article Clinical Nuclear Medicine · 1997 A patient with strikingly reduced Tl-201 myocardial retention after intramuscular administration of gold therapy (sodium aurothiomalate) is described. Following a routine Bruce protocol exercise test, postexercise scintigraphy was normal; an abnormal scan ... Full text Cite

Radioimmunotherapy of B-cell lymphoma with [131I]anti-B1 (anti-CD20) antibody.

Journal article The New England journal of medicine · August 1993 Featured Publication BackgroundMany patients with non-Hodgkin's lymphomas are not cured by current therapies, and new approaches to treatment are needed. As part of an ongoing phase 1 study, we examined the effect of radioimmunotherapy with 131I-labeled B-cell-specifi ... Full text Cite

Sestamibi in myocardial perfusion imaging [1]

Conference Journal of the American College of Cardiology · 1993 Cite

Determination of extent and location of coronary artery disease in patients without prior myocardial infarction by thallium-201 tomography with pharmacologic stress.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · December 1992 Seventy-six patients undergoing pharmacologic stress 201TI tomography and coronary angiography within 14 +/- 12 days were studied to determine how well coronary artery disease extent and location could be determined by this scintigraphic technique. No pati ... Cite

Comparison of technetium-99m sestamibi and thallium-201 retention characteristics in canine myocardium.

Journal article Journal of the American College of Cardiology · November 1992 ObjectivesThe aim of this study was to compare the myocardial retention of technetium-99m (Tc-99m) sestamibi and thallium-201 over a wide range of blood flow at different time points after tracer injection.BackgroundTechnetium-99m sestami ... Full text Cite

Technetium-99m-N1-(2-mercapto-2-methylpropyl)-N2-(2-propargylthio-2- methylpropyl)-1,2-benzenediamine (T691): preclinical studies of a potential new tracer of regional cerebral perfusion.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · October 1992 We report in vitro and in vivo preclinical studies of a new cerebral blood flow tracer, [99mTc]N1-(2-mercapto-2-methyl-propyl)-N2-(2- propargylthio-2-methylpropyl)-1,2-benzenediamine (T691). The tracer demonstrates excellent in vitro chemical stability and ... Cite

Synthesis, rodent biodistribution, dosimetry, metabolism, and monkey images of carbon-11-labeled (+)-2 alpha-tropanyl benzilate: a central muscarinic receptor imaging agent.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · March 1992 Muscarinic cholinergic receptors (mAChR) are abundant in the brain, and the mAChR system mediates many aspects of brain function. There is evidence of alterations in muscarinic binding in degenerative brain disorders. A muscarinic receptor radioligand, car ... Cite

Clinical experience with Tc-99m labeled (N2S2) anti-melanoma antibody fragments and single photon emission computed tomography.

Journal article Am J Physiol Imaging · 1992 We evaluated the imaging capability of murine Tc-99m-labeled antimelanoma Fab fragments in 12 patients with clinical stage II and III melanoma. Tc-99m-NRX118.7 antimelanoma Fab fragment, 10.0 to 27.2 mCi (370-1, 006 MBq), was injected IV 30 min after irrel ... Link to item Cite

The kinetics of copper-62-PTSM in the normal human heart

Journal article Journal of Nuclear Medicine · 1992 Copper-62-labeled pyruvaldehyde bis(N-4-methylthiosemicarbazone) copper(II) (PTSM) is a generator-produced myocardial perfusion tracer. Animal studies have shown high myocardial tissue extraction and prolonged retention. The aim of this study was to define ... Cite

The relationship between myocardial retention of Technetium-99m teboroxime and myocardial blood flow

Journal article Journal of the American College of Cardiology · 1992 Objectives. The aim of this study was to define the temporal changes in the relationship between technetium-99m teboroxime tissue retention and myocardial blood flow in a canine model. Background. Technetium-99m teboroxime is a new neutral lipophilic myoca ... Cite

Metastatic angiosarcoma with thrombocytopenia and intratumoral indium-111-platelet deposition.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · December 1991 A 66-yr-old woman with cutaneous angiosarcoma of the face presented with thrombocytopenia and metastases to the skeleton. Scintigraphic imaging with 111In-oxine-labeled autologous platelets demonstrated localization of radiolabeled platelets at sites of me ... Cite

Myocardial clearance kinetics of technetium-99m-SQ30217: a marker of regional myocardial blood flow.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · July 1990 SQ30217 is a new, technetium-99m-(99mTc) labeled perfusion agent introduced for cardiac imaging. To evaluate the myocardial tracer kinetics, 99mTc-SQ30217, was injected intracoronarily in open-chested dogs under baseline conditions and after administration ... Cite

Diagnostic accuracy and pitfalls of [iodine-131]6-beta-iodomethyl-19-norcholesterol (NP-59) imaging.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · April 1990 NP-59 concentrates in steroid hormone synthesizing tissues, enabling scintigraphic localization and characterization of endocrine dysfunction in the adrenal cortex and ovary. Studying 108 consecutive cases from 1982 to 1985 and using clinical, biochemical, ... Cite

Prognostication of recovery following stroke using the comparison of CT and technetium-99m HM-PAO SPECT.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · January 1990 This study investigated the possibility that a relationship between the anatomic defects observed on computed tomography (CT) and the functional defects observed on single photon emission computed tomography (SPECT) might be used as an outcome measure to p ... Cite

Platelet reactivity in human aortic grafts: a prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits.

Journal article Journal of vascular surgery · February 1989 Platelet-related phenomena at the blood-surface interface of randomly placed knitted Dacron (n = 6) and polytetrafluoroethylene (ePTFE) (n = 6) interposition aortic grafts were studied in patients undergoing abdominal aortic aneurysmectomy. Luminal accumul ... Full text Cite

SPECT imaging of moyamoya disease using 99mTc-HM-PAO. Comparison with computed tomography findings.

Journal article The Journal of computed tomography · October 1988 99mTc-HM-PAO was used to evaluate regional cerebral blood flow in a 26-year-old woman with Moyamoya disease. This patient had an 18-month history of recurrent neurologic deficits and had angiographic evidence of Moyamoya disease. She had used oral contrace ... Full text Cite

Blood flow imaging of a posterior circulation stroke. Use of technetium Tc 99m hexamethylpropyleneamine oxime and single photon emission computed tomography.

Journal article Archives of neurology · June 1988 Regional cerebellar perfusion was imaged using technetium Tc 99m hexamethylpropylene amine oxime and single photon emission computed tomography (HM-PAO-SPECT) in a patient with chronic left lateral medullary syndrome with contralateral weakness due to trau ... Full text Cite

Radiolabeled antibodies, albumin and antimony sulfide colloid: a comparison as lymphoscintigraphic agents.

Journal article International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology · January 1988 The kinetics of lymph node and systemic uptake of members of three different classes of lymphoscintigraphic agents were studied in normal laboratory rats. 99mTc antimony trisulfide colloid (TcSbC), 99mTc human serum albumin (TcHSA), 125I 5G6.4 (a murine Ig ... Full text Cite

Radiolabeled antibodies, albumin and antimony sulfide colloid: A comparison as lymphoscintigraphic agents

Journal article Nuclear Medicine and Biology · 1988 The kinetics of lymph node and systemic uptake of members of three different classes of lymphoscintigraphic agents were studied in normal laboratory rats. 99mTc antimony trisulfide colloid (TcSbC), 99mTc human serum albumin (TcHSA), 125I 5G6.4 (a murine Ig ... Cite

Treatment of established prosthetic vascular graft infection with antibiotics preferentially concentrated in leukocytes.

Journal article Surgery · July 1987 The efficacy of treating established vascular graft infections with rifampin and clindamycin (preferentially concentrated in leukocytes) and cefazolin (not concentrated in leukocytes) was studied in a canine model. Infrarenal aortic, 6 mm by 6 cm knitted D ... Cite

Iodine-123-4-amino-3-iodobenzylguanidine, a new sympathoadrenal imaging agent: comparison with iodine-123 metaiodobenzylguanidine.

Journal article Journal of nuclear medicine : official publication, Society of Nuclear Medicine · July 1986 Iodine-123-4-amino-3-iodobenzylguanidine ([123I]AIBG), an analog of 123I metaiodobenzylguanidine ([123I]MIBG), has an advantage in having a more rapid and simple synthesis. This, combined with animal data that suggested a greater affinity of the new radiop ... Cite

Nuclide imaging of vascular graft-platelet interactions: comparison of indium excess and technetium subtraction techniques.

Journal article The Journal of surgical research · April 1986 Indium-111-labeled platelet adherence to ePTFE thoracoabdominal vascular prostheses in a canine model (n = 10) was quantitated by (1) an indium-111 excess technique, contrasting graft radioactivity to that in a reference region, and (2) a technetium-99m su ... Full text Cite

Indium 111 platelet imaging for the detection of deep venous thrombosis and pulmonary embolism in patients without symptoms after surgery.

Journal article Surgery · July 1985 Indium 111 platelet imaging for the detection of deep vein thrombosis and pulmonary emboli was performed in 171 patients after abdominal and pelvic surgery. Fifteen patients were found to have inadequate circulating blood pools of indium 111 platelets, mak ... Cite

Phosphorus-32 therapy of cystic Grade IV astrocytomas: Technique and preliminary application

Journal article Journal of Nuclear Medicine · 1985 Instillation of [32P]chromic phosphate to cystic brain tumors was performed in six patients. Three patients had craniopharyngioma, two had Grade IV astrocytoma and one had Grade II astrocytoma. The cyst volumes ranged from 2 to 44 cc. A calculated dose of ... Cite

In vivo quantitation of regional cerebral blood flow in glioma and cerebral infarction: validation of the HIPDm-SPECT method.

Journal article AJNR Am J Neuroradiol · 1983 Iodine-123 labeled hydroxyiodopropyldiamine (HIPDm) is a diffusible indicator with an 85%-90% extraction fraction and stable retention in the brain for more than 2 hr. Equilibrium-phase imaging and quantitation using single-photon emission computed tomogra ... Link to item Cite

Muscarinic cholinergic receptor binding: In vivo depiction using single photon emission computed tomography and radioiodinated quinuclidinyl benzilate

Journal article Journal of Computer Assisted Tomography · 1982 An attempt was made to characterize, in vivo, specific binding to the muscarinic cholinergic receptor in the calf using the radioiodinated ligand quinuclidinyl benzilate (123I-OH-QNB) and single photon detection emission computed tomography (SPECT). The su ... Cite

Nonradioactive iodoantipyrine enhanced cranial computed tomography: Preliminary observations

Journal article Journal of Computer Assisted Tomography · 1980 Nonradioactive 4-iodoantipyrine, an iodinated indicator that freely diffuses across the blood-brain barrier, was serially imaged in vivo using computed tomography (CT). Prominent enhancement was immediately detected in the brain substance of the dog follow ... Cite

Effect of rubber closures on the stability of stannous ion in reagent kits for radiopharmaceuticals.

Journal article Journal of the Parenteral Drug Association · September 1979 Cite