Scholars@Duke
Phillip James White

Phillip James White

Associate Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition

Featured Works

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

Journal article Cell Metab · June 5, 2018 Featured Publication Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that r ... Full text Link to item Cite

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.

Journal article Mol Metab · July 2016 Featured Publication OBJECTIVE: A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident diabetes and intervention outcomes. To better understand the role that this metabolite cluster plays in obes ... Full text Link to item Cite

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

Journal article Cell Metab · November 4, 2014 Featured Publication Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expres ... Full text Link to item Cite

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis.

Journal article Nat Med · June 2014 Featured Publication We previously demonstrated that low biosynthesis of ω-3 fatty acid-derived proresolution mediators, termed protectins, is associated with an impaired global resolution capacity, inflammation and insulin resistance in obese high-fat diet-fed mice. These fin ... Full text Link to item Cite