Phuong Linh Doan | Scholars@Duke

Phuong Linh Doan
Assistant Professor of Medicine

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

595 Lasalle St, Snyderman Building, Box 103866, Durham, NC 27710
Duke Box 103866, Durham, NC 27710
phuong.doan@duke.edu (919) 613-2625

Background
Education, Training, & Certifications
- Fellowship, Hematology, Oncology, Cellular Therpay, Duke University School of Medicine 2007 - 2010
- Chief Medical Resident, University of North Carolina at Chapel Hill School of Medicine 2006 - 2007
- Resident, Internal Medicine, University of North Carolina at Chapel Hill School of Medicine 2003 - 2006
- M.D., University of North Carolina at Chapel Hill 2003
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Hematological Malignancies, Medicine 2010 - 2013
Recognition
Awards & Honors
- Duke Physician-Scientist Strong Start Award. Duke School of Medicine. April 2017
- MEDx Biomedical Research Award. Duke School of Medicine and School of Engineering. April 2017
Expertise
Subject Headings
Research
Selected Grants
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Role of ErbB Receptor Signaling in Regulating Normal and Leukemic Stem Cell Fate awarded by National Institutes of Health 2014 - 2019
- Endothelial Cell-Derived Extracellular Vesicles Mitigate Hematopoietic Injury Following Ionizing Radiation awarded by Columbia University 2017 - 2019
- Epidermal Growth Factor Regulates Leukemic Stem Cell Self-Renewal awarded by American Association for Cancer Research 2014 - 2016
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Piryani, SO, Kam, AYF, Kliassov, EG, Chen, BJ, Spector, NL, Chute, JP, Hsu, DS, Chao, NJ, and Doan, PL. "Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration." Stem Cells (Dayton, Ohio) 36, no. 2 (February 2018): 252-264. Full Text
  - Sundaramoorthy, P, Wang, Q, Zheng, Z, Jiao, Y, Chen, BJ, Doan, PL, Chao, NJ, and Kang, Y. "Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice." Stem Cell Research & Therapy 8, no. 1 (November 15, 2017): 263-null. Full Text
  - Racioppi, L, Lento, W, Huang, W, Arvai, S, Doan, PL, Harris, JR, Marcon, F, Nakaya, HI, Liu, Y, and Chao, N. "Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration." Cell Death & Disease 8, no. 10 (October 5, 2017): e3076-null. Full Text
  - Himburg, HA, Doan, PL, Quarmyne, M, Yan, X, Sasine, J, Zhao, L, Hancock, GV, Kan, J, Pohl, KA, Tran, E, Chao, NJ, Harris, JR, and Chute, JP. "Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms." Nature Medicine 23, no. 1 (January 2017): 91-99. Full Text
  - Yan, X, Himburg, HA, Pohl, K, Quarmyne, M, Tran, E, Zhang, Y, Fang, T, Kan, J, Chao, NJ, Zhao, L, Doan, PL, and Chute, JP. "Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration." Cell Reports 17, no. 6 (November 2016): 1584-1594. Full Text Open Access Copy
  - Quarmyne, M, Doan, PL, Himburg, HA, Yan, X, Nakamura, M, Zhao, L, Chao, NJ, and Chute, JP. "Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity." The Journal of Clinical Investigation 125, no. 1 (January 2015): 177-182. Full Text Open Access Copy
  - Himburg, HA, Yan, X, Doan, PL, Quarmyne, M, Micewicz, E, McBride, W, Chao, NJ, Slamon, DJ, and Chute, JP. "Pleiotrophin mediates hematopoietic regeneration via activation of RAS." The Journal of Clinical Investigation 124, no. 11 (November 2014): 4753-4758. Full Text
  - Doan, PL, and Chute, JP. "Ex vivo expansion of murine and human hematopoietic stem cells." Methods in molecular biology (Clifton, N.J.) 1185 (January 2014): 211-221. Full Text Open Access Copy
  - Doan, PL, and Chute, JP. "Ex vivo expansion of murine and human hematopoietic stem cells." Methods in Molecular Biology 1185 (2014): 211-221. Full Text Open Access Copy
  - Doan, PL, Himburg, HA, Helms, K, Russell, JL, Fixsen, E, Quarmyne, M, Harris, JR, Deoliviera, D, Sullivan, JM, Chao, NJ, Kirsch, DG, and Chute, JP. "Epidermal growth factor regulates hematopoietic regeneration after radiation injury." Nature Medicine 19, no. 3 (March 2013): 295-304. Full Text Open Access Copy
  - Doan, PL, Russell, JL, Himburg, HA, Helms, K, Harris, JR, Lucas, J, Holshausen, KC, Meadows, SK, Daher, P, Jeffords, LB, Chao, NJ, Kirsch, DG, and Chute, JP. "Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury." Stem Cells (Dayton, Ohio) 31, no. 2 (February 2013): 327-337. Full Text
  - Himburg, H, Harris, J, Ito, T, Daher, P, Russell, J, Quarmyne, M, Doan, P, Helms, K, Nakamura, M, Fixsen, E, Herradon, G, Reya, T, Chao, N, Harroch, S, and Chute, J. "Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche." Cell Reports 2, no. 6 (December 2012): 1774-1774. Full Text
  - Himburg, HA, Harris, JR, Ito, T, Daher, P, Russell, JL, Quarmyne, M, Doan, PL, Helms, K, Nakamura, M, Fixsen, E, Herradon, G, Reya, T, Chao, NJ, Harroch, S, and Chute, JP. "Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche." Cell Rep 2, no. 4 (October 25, 2012): 964-975. Full Text Link to Item
  - Morse, MA, Hanks, BA, Suhocki, P, Doan, PL, Liu, EA, Frost, P, Bernard, SA, Tsai, A, Moore, DT, and O'Neil, BH. "Improved time to progression for transarterial chemoembolization compared with transarterial embolization for patients with unresectable hepatocellular carcinoma." Clinical Colorectal Cancer 11, no. 3 (September 2012): 185-190. Full Text
  - Doan, PL, and Chute, JP. "The vascular niche: home for normal and malignant hematopoietic stem cells." Leukemia 26, no. 1 (January 2012): 54-62. (Review) Full Text Link to Item
  - Meadows, SK, Dressman, HK, Daher, P, Himburg, H, Russell, JL, Doan, P, Chao, NJ, Lucas, J, Nevins, JR, and Chute, JP. "Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. (Published online)" PLoS One 5, no. 7 (July 12, 2010): e11535-. Full Text Open Access Copy Link to Item
  - Himburg, HA, Muramoto, GG, Daher, P, Meadows, SK, Russell, JL, Doan, P, Chi, J-T, Salter, AB, Lento, WE, Reya, T, Chao, NJ, and Chute, JP. "Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells." Nature Medicine 16, no. 4 (April 2010): 475-482. Full Text
  - Muramoto, GG, Russell, JL, Safi, R, Salter, AB, Himburg, HA, Daher, P, Meadows, SK, Doan, P, Storms, RW, Chao, NJ, McDonnell, DP, and Chute, JP. "Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity." Stem Cells 28, no. 3 (March 31, 2010): 523-534. Full Text Link to Item
  - Doan, PL, and Chao, NJ. "Advances in cord blood transplants in adults." F1000 Medicine Reports 2 (February 11, 2010). Full Text
  - Doan, PL, and Chao, NJ. "The role of oral beclometasone dipropionate in the treatment of gastrointestinal Graft-versus-Host Disease." Drugs 69, no. 10 (July 9, 2009): 1339-1350. (Review) Full Text Link to Item
  - Doan, PL, and Chao, NJ. "Umbilical cord blood: biology and transplantation." Expert Rev Hematol 2, no. 2 (April 2009): 197-208. (Review) Full Text Link to Item
  - Salter, AB, Meadows, SK, Muramoto, GG, Himburg, H, Doan, P, Daher, P, Russell, L, Chen, B, Chao, NJ, and Chute, JP. "Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo." Blood 113, no. 9 (February 26, 2009): 2104-2107. Full Text Link to Item
  - Safi, R, Muramoto, GG, Salter, AB, Meadows, S, Himburg, H, Russell, L, Daher, P, Doan, P, Leibowitz, MD, Chao, NJ, McDonnell, DP, and Chute, JP. "Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture." Mol Endocrinol 23, no. 2 (February 2009): 188-201. Full Text Link to Item
  - Doan, PL, O'Neil, BH, Moore, DT, and Bernard, SA. "Predictors of survival in patients with hepatocellular carcinoma treated with transarterial chemoembolization." JOURNAL OF CLINICAL ONCOLOGY 26, no. 15 (May 20, 2008). Full Text Link to Item
  - Hanks, BA, Suhocki, PV, DeLong, DM, Doan, PL, Liu, E, Tsai, AL, Burke, CT, Bernard, SA, O’Neil, BH, and Morse, MA. "The efficacy and tolerability of transarterial chemo-embolization (TACE) compared with transarterial embolization (TAE) for patients with unresectable hepatocellular carcinoma (HCC)." Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 4595-4595. Full Text
  - Hanks, BA, Suhocki, PV, DeLong, DM, Doan, PL, Liu, E, Tsai, AL, Burke, CT, Bernard, SA, O'Neil, BH, and Morse, MA. "The efficacy and tolerability of transarterial chemo-embolization (TACE) compared with transarterial embolization (TAE) for patients with unresectable hepatocellular carcinoma (HCC)." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 26, no. 15_suppl (May 2008): 4595-null.
  - Dellon, ES, Doan, PL, and Batey, BM. "Abdominal varices caused by chronic Budd-Chiari syndrome." Clinical Gastroenterology and Hepatology 4, no. 3 (2006): xxiv-. Full Text
  - Doan, PL, Belanger, KG, and Kreuzer, KN. "Two types of recombination hotspots in bacteriophage T4: one requires DNA damage and a replication origin and the other does not." Genetics 157, no. 3 (March 2001): 1077-1087.
- Book Sections
  - Doan, PL, Vauthey, JN, Palavecino, M, and Morse, MA. "Colorectal Liver Metastases." In Malignant Liver Tumors: Current and Emerging Therapies: Third Edition, 342-346. December 9, 2009. Full Text
- Conference Papers
  - Piryani, SO, Kam, AYF, Kliassov, EG, Chen, BJ, Spector, NL, Chute, JP, Chao, NJ, and Doan, PL. "EGF Accelerates Hematopoietic Stem Cell Regeneration Following 5-FU Chemotherapy Via G-CSF Receptor Signaling." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016. Link to Item
  - Chute, JP, Yan, X, Himburg, HA, Doan, PL, Quarmyne, M, Tran, E, Chao, NJ, and Zhao, L. "Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell (HSC) Self-Renewal and Regeneration Via Control of mTOR Signaling." March 2016. Full Text
  - Himburg, HA, Doan, PL, Yan, X, Quarmyne, M, Zhao, L, Tran, E, Chao, NJ, Harris, J, and Chute, JP. "Dickkopf 1 (Dkk1) Regulates Hematopoietic Stem Cell Regeneration." December 3, 2015. Link to Item
  - Yan, X, Himburg, HA, Doan, PL, Quarmyne, M, Tran, E, Zhao, L, Chao, NJ, and Chute, JP. "Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell (HSC) Self-Renewal Via Control of mTOR Signaling." December 3, 2015. Link to Item
  - Lento, W, Huang, W, Doan, P, Chao, NJ, and Racioppi, L. "Calcium Calmodulin Dependent Kinase Kinase 2 Regulates Hematopoietic Stem Cell Regeneration and Quiescence." December 6, 2014. Link to Item
  - Quarmyne, M, Doan, PL, Himburg, HA, Yan, X, Zhao, L, Chao, NJ, and Chute, JP. "Protein Tyrosine Phosphatase-Sigma (PTP sigma) Regulates Hematopoietic Stem Cell Repopulating Capacity." December 6, 2014. Link to Item
  - Yan, X, Himburg, HA, Doan, PL, Quarmyne, M, Chao, NJ, and Chute, JP. "Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell Renewal." December 6, 2014. Link to Item
  - Doan, PL, Russell, JL, Himburg, HA, Helms, K, Sullivan, JM, Jeffords, LB, Chao, NJ, Kirsch, DG, and Chute, JP. "EGF SIGNALING REGULATES HEMATOPOIETIC REGENERATION FOLLOWING TOTAL BODY IRRADIATION." February 2012. Full Text Link to Item
  - Himburg, HA, Ito, T, Harris, JR, Quarmyne, M, Helms, KL, Doan, PL, Reya, T, Chao, NJ, and Chute, JP. "PLEIOTROPHIN REGULATES NORMAL AND LEUKEMIC HEMATOPOIETIC STEM CELL FATE." February 2012. Full Text Link to Item
  - Gasparetto, C, Bacon, WA, Doan, P, Rizzieri, DA, Horwitz, ME, Chute, JP, Sullivan, KM, Yopp, A, Li, Z, Chao, NJ, and Long, GD. "High Dose BCNU/Melphalan Preparative Regimen Doubles Event Free Survival of Myeloma Patients Undergoing Autologous Transplantation." November 18, 2011. Link to Item
  - Doan, PL, Russell, JL, Himburg, HA, Helms, K, Meadows, SK, Daher, P, Sullivan, JM, Jeffords, LB, Chao, NJ, Kirsch, DG, and Chute, JP. "TIE2(+) ENDOTHELIAL CELLS MEDIATE HEMATOPOIETIC STEM CELL REGENERATION VIA EGF SIGNALING." February 2011. Full Text Link to Item
  - Himburg, H, Daher, P, Russell, L, Doan, P, Quarmyne, M, Meadows, S, Herradon, G, Chao, N, and Chute, J. "Pleiotrophin Signaling Is Necessary for Hematopoietic Stem Cell Self Renewal and Is Regulated by the Bone Marrow Microenvironment." February 2011. Full Text
  - Doan, PL, Russell, JL, Himburg, HA, Meadows, SK, Daher, P, Helms, K, Quarmyne, M, Harris, JR, Reya, T, Chao, NJ, Kirsch, DG, and Chute, JP. "Facilitation of Hematopoietic Reconstitution Via Inhibition of Bone Marrow Endothelial Cell-Mediated SDF-1 Signaling." November 19, 2010. Link to Item
  - Himburg, HA, Daher, P, Russell, JL, Doan, P, Quarmyne, M, Meadows, SK, Helms, K, Herradon, G, Chao, NJ, and Chute, JP. "Pleiotrophin Signaling Is Necessary and Sufficient for Hematopoietic Stem Cell Self-Renewal In Vivo." November 19, 2010. Link to Item
  - Russell, JL, Doan, P, Himburg, HA, Meadows, SK, Daher, P, Helms, K, Quarmyne, M, Chao, NJ, Kirsch, D, and Chute, JP. "VE Cadherin Positive Endothelial Cells Regulate Hematopoietic Reconstitution In Vivo." November 19, 2010. Link to Item
  - Doan, PL, Chute, JP, Gasparetto, C, Horwitz, M, Rizzieri, D, Smith, C, Sullivan, K, Edwards, J, Jacobson, R, Corbett, K, Chao, N, and Long, G. "Long Term Survival Following High-dose Sequential Therapy with Autologous Hematopoietic Cell Rescue for Multiple Myeloma." American Society of Blood and Marrow Transplantation. 2010.
  - Doan, PL, Russell, JL, Meadows, SK, Himburg, HA, Daher, P, Chao, NJ, Kirsch, DG, and Chute, JP. "Deletion of Bak and Bax in Tie2+BM Hematopoietic Stem Cells Induces a B Cell Lymphoproliferative Disorder." November 20, 2009. Link to Item
  - Doan, PL, Russell, JL, Meadows, SK, Himburg, HA, Daher, P, Chao, NJ, Kirsch, DG, and Chute, JP. "Tie2+Bone Marrow Endothelial Cells Regulate Hematopoietic Reconstitution In Vivo." November 20, 2009. Link to Item
  - Himburg, HA, Daher, P, Meadows, SK, Russell, JL, Doan, P, Muramoto, G, Chao, NJ, and Chute, J. "Systemic Administration of Pleiotrophin Induces Hematopoietic Stem Cell Regeneration In Vivo." November 20, 2009. Link to Item
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses