Phyllis Carolyn Leppert

Professor Emeritus of Obstetrics and Gynecology

Obstetrics and Gynecology

phyllis.leppert@duke.edu

Box 3084 Med Ctr, Durham, NC 27710

329 Baker House, Durham, NC 27710

More About This Person

At a Glance

Credentials
1. Education

Academic Experience

Global Scholarship

Keywords

Research
1. Research Interests
2. Selected Grants

Scholarly Works

Teaching & Mentoring

Recognition

Professional Activities
1. Service to the Profession
2. Leadership & Clinical Positions

Scholarly Works - Conferences

COLLAGENASE -TREATED UTERINE FIBROIDS SHOW REDUCTION OF TISSUE STIFFNESS AND CELL PROLIFERATION, AND INDUCTION OF CELL DEATH THROUGH AUTOPHAGY AND NECROPTOSIS, AND ALTERATION OF HIPPO SIGNALING

Conference Fertility and Sterility · September 2020 Full text Cite

Patient-reported outcomes of a phase 1 clinical trial of injectable collagenase clostridium histolyticum (EN3835) for treatment of uterine fibroids

Conference Fertility and Sterility · September 2019 Full text Cite

Injectable Collagenase Clostridium Histolyticum (EN3835) for Uterine Fibroids: Results of a Phase 1 Clinical Trial.

Conference REPRODUCTIVE SCIENCES · March 1, 2019 Link to item Cite

A Pilot Study of Collagenase Clostridium Histolyticum as Treatment for Uterine Leiomyoma: Initial Report.

Conference REPRODUCTIVE SCIENCES · March 1, 2018 Link to item Cite

Stiffness of Uterine Fibroids Is Reduced After Treatment With Purified Clostridial Collagenase Due To Collagen Degradation.

Conference REPRODUCTIVE SCIENCES · March 1, 2015 Link to item Cite

Collagen-binding α11 integrin expression in human myometrium and fibroids utilizing a novel RNA in situ probe

Conference Fertility and Sterility · September 2013 Full text Cite

Organotypic 3D-culture of uterine fibroid cells

Conference GLYCOBIOLOGY · November 1, 2012 Link to item Cite

Treatment of uterine fibroids with highly purified clostridial collagenase

Conference Fertility and Sterility · September 2012 Full text Cite

An Elevated Leptin Obese Mouse Model Demonstrates Uterine Fibrosis and Decreased Uterine Contractility in Response to Oxytocin

Conference REPRODUCTIVE SCIENCES · March 1, 2012 Link to item Cite

Smart Therapy for Uterine Fibroids Enabled by the Hyperbranched Polyglycerol Platform

Conference JOURNAL OF WOMENS HEALTH · October 1, 2011 Link to item Cite

Mitochondrial progesterone receptor (PR-M) distribution in uterine leiomyoma and myometrium and impact on mitochondrial membrane potential (MMP) in immortilized human myometrial cells (HTERT-HM)

Conference Fertility and Sterility · September 2011 Full text Cite

Update on the Hyperbranched Polyglycerol Nanocarrier: Smart Therapy for Uterine Fibroids

Conference JOURNAL OF WOMENS HEALTH · October 1, 2010 Link to item Cite

Vitamin D receptor (VDR) is over-expressed in the center of uterine fibroids

Conference Fertility and Sterility · September 2010 Full text Cite

Pattern of Collagen Types in Uterine Fibroids.

Conference REPRODUCTIVE SCIENCES · March 2010 Link to item Cite

Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells.

Conference REPRODUCTIVE SCIENCES · March 1, 2010 Link to item Cite

A New Look at Uterine Wound Healing: Myometrial Hyperplasia, Myofiber Disarray, and a Uterine Keloid: Their Relationship to Fibroid Formation.

Conference REPRODUCTIVE SCIENCES · March 1, 2010 Link to item Cite

Factors Involved in Early Uterine Fibroid Development: The Initiation of Early Wound Healing Responses in Myometrial Cells.

Conference BIOLOGY OF REPRODUCTION · January 1, 2010 Link to item Cite

Fibroid Therapy Enabled by the Hyperbranched Polyglycerol Platform

Conference JOURNAL OF WOMENS HEALTH · October 1, 2009 Link to item Cite

The Duke Uterine Fibroid Tissue Repository - A Stepping Stone for Translational Research

Conference REPRODUCTIVE SCIENCES · March 1, 2009 Link to item Cite

Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium

Conference REPRODUCTIVE SCIENCES · March 1, 2009 Link to item Cite

Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium

Conference REPRODUCTIVE SCIENCES · March 1, 2009 Link to item Cite

Uterine fibroids: Development of a cell model of early fibroid growth

Conference REPRODUCTIVE SCIENCES · February 1, 2008 Link to item Cite

Thrombospondin-1 expression is increased in serum-deprived differentiated myometrial cell model of uterine fibroids

Conference REPRODUCTIVE SCIENCES · February 2008 Link to item Cite

Novel approach to genome-wide expression profiling analysis

Conference REPRODUCTIVE SCIENCES · February 2008 Link to item Cite

687: NF- is activated by cytokines in chorion cell primary culture but may not be the mechanism of apoptotic cell death

Conference American Journal of Obstetrics and Gynecology · December 2007 Full text Cite

A survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients

Conference Fertility and Sterility · September 2007 Full text Cite

P-564

Conference Fertility and Sterility · September 2006 Full text Cite

P-561

Conference Fertility and Sterility · September 2006 Full text Cite

Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome: Results from subjects presenting for inclusion in the NICHD-reproductive medicine network 's "pregnancy in polycystic ovary syndrome " (PPCOS) trial.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 2006 Link to item Cite

Pregnancy in polycystic ovary syndrome (PPCOS) baseline characteristics: Effect of race and ethnicity on the PCOS phenotype.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2006 Link to item Cite

Pregnancy in polycystic ovary syndrome (PPCOS): Study design and baseline characteristics of the randomized cohort.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2006 Link to item Cite

Brx Expression and Mechanotransduction in Uterine Leiomyomas

Conference Fertility and Sterility · September 2005 Full text Cite

Transforming growth factor beta3 overexpression results in altered extracellular matrix gene transcription in uterine fibroids.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 2005 Link to item Cite

Fibroid phenotype is related to altered expression of collagen subtypes

Conference Fertility and Sterility · September 2004 Full text Cite

Under-expression of alcohol dehydrogenase in uterine fibroids: Impact on retinoic acid pathway

Conference Fertility and Sterility · September 2004 Full text Cite

Molecular dissection of hereditary leiomyomatosis.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 2004 Link to item Cite

Absence of secretory endometrium after false positive home urine luteinizing hormone testing.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 1, 2004 Link to item Cite

Promoters of leiomyoma: Dermatopontin expression in leiomyoma suggests an association between fibroids and keloids.

Conference FERTILITY AND STERILITY · September 2003 Link to item Cite

Initiators of leiomyoma: Differential proto-oncogene expression in small versus large fibroids identified by microarray analysis.

Conference FERTILITY AND STERILITY · September 2003 Link to item Cite

Uterine leiomyomas are characterized by abnormal expression of Wnt signaling proteins and disordered collagen deposition

Conference Fertility and Sterility · September 2002 Full text Cite

Postmenopausal hormone replacement therapy may affect ascorbic acid status.

Conference FASEB JOURNAL · March 15, 1999 Link to item Cite

Cervical ripening: Relaxin's role in the biochemical cascade of cervical matrix rearrangement

Conference PROGRESS IN RELAXIN RESEARCH · 1995 Link to item Cite

THE COLLAGENOUS TISSUES OF THE CERVIX DURING PREGNANCY AND DELIVERY

Conference EXTRACELLULAR MATRIX OF THE UTERUS, CERVIX AND FETAL MEMBRANES : SYNTHESIS, DEGRADATION AND HORMONAL REGULATION · 1991 Link to item Cite

ELASTIN AND COLLAGEN IN THE HUMAN UTERUS AND CERVIX - BIOCHEMICAL AND HISTOLOGICAL CORRELATION

Conference EXTRACELLULAR MATRIX OF THE UTERUS, CERVIX AND FETAL MEMBRANES : SYNTHESIS, DEGRADATION AND HORMONAL REGULATION · 1991 Link to item Cite

ACCEPTING LIFE TOTALLY

Conference GOSPEL IMPERATIVE IN THE MIDST OF AIDS · 1989 Link to item Cite

ESTRADIOL-17 BETA INCREASE ELASTASE-LIKE ACTIVITY INVITRO IN A CELL-LINE DERIVED FROM UTERINE CERVICAL TISSUE

Conference COLLAGEN AND RELATED RESEARCH · November 1988 Link to item Cite

PRETERM INFANT-TERM SGA INFANT SEQUENCE IN ADOLESCENT PREGNANCY

Conference JOURNAL OF ADOLESCENT HEALTH · 1983 Link to item Cite

PREGNANCY INDUCED HYPERTENSION IN AN ADOLESCENT PROGRAM UTILIZING STRICT DIAGNOSTIC-CRITERIA

Conference JOURNAL OF ADOLESCENT HEALTH · 1982 Link to item Cite

476 CHILDHOOD RENAL AND RESPIRATORY DISEASE AS A MATERNAL RISK FACTOR IN LOW BIRTH WEIGHT

Conference Pediatric Research · April 1981 Full text Cite