Scholars@Duke
Priyatham S Mettu

Priyatham S Mettu

Assistant Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
DUMC 3802, Durham, NC 27710
Duke Eye Center, 2351 Erwin Road, Durham, NC 27705

Selected Publications

A Deep-Learning Algorithm to Predict Short-Term Progression to Geographic Atrophy on Spectral-Domain Optical Coherence Tomography.

Journal Article JAMA Ophthalmol · November 1, 2023 IMPORTANCE: The identification of patients at risk of progressing from intermediate age-related macular degeneration (iAMD) to geographic atrophy (GA) is essential for clinical trials aimed at preventing disease progression. DeepGAze is a fully automated a ... Full text Link to item Cite

Fluorescein CorneoGraphy (FCG): Use of a repurposed fluorescein imaging technique to objectively standardize corneal staining.

Journal Article Ocul Surf · January 2023 Punctate epithelial erosion (PEE) is a corneal sign of dry eye disease (DED), which is observable via staining with fluorescein on slit lamp as a standard of clinical practice and clinical research. There are currently many limitations for detecting PEE, s ... Full text Link to item Cite

Intravitreal Delivery of rAAV2tYF-CB-hRS1 Vector for Gene Augmentation Therapy in Patients with X-Linked Retinoschisis: 1-Year Clinical Results.

Journal Article Ophthalmol Retina · December 2022 PURPOSE: To evaluate the safety and efficacy of rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus vector expressing retinoschisin (RS1), in individuals with retinal disease caused by mutations in the RS1 gene. DESIGN: Open-label, phase I/II dose-escal ... Full text Link to item Cite

Multi-dimensional characterization of prediabetes in the Project Baseline Health Study.

Journal Article Cardiovasc Diabetol · July 18, 2022 BACKGROUND: We examined multi-dimensional clinical and laboratory data in participants with normoglycemia, prediabetes, and diabetes to identify characteristics of prediabetes and predictors of progression from prediabetes to diabetes or reversion to no di ... Full text Link to item Cite

Phase 1 Clinical Trial of Elamipretide in Dry Age-Related Macular Degeneration and Noncentral Geographic Atrophy: ReCLAIM NCGA Study.

Journal Article Ophthalmol Sci · March 2022 PURPOSE: Assess the safety, tolerability, and feasibility of subcutaneous administration of the mitochondrial-targeted drug elamipretide in patients with dry age-related macular degeneration (AMD) and noncentral geographic atrophy (NCGA) and to perform exp ... Full text Link to item Cite

Phase 1 Clinical Trial of Elamipretide in Intermediate Age-Related Macular Degeneration and High-Risk Drusen: ReCLAIM High-Risk Drusen Study.

Journal Article Ophthalmol Sci · March 2022 PURPOSE: To assess safety, tolerability, and feasibility of subcutaneous administration of the mitochondrial-targeted drug elamipretide in patients with intermediate age-related macular degeneration (AMD) and high-risk drusen (HRD) and to perform explorato ... Full text Link to item Cite

Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities.

Journal Article Prog Retin Eye Res · May 2021 Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the treatment of neovascular age-related macular degeneration (NVAMD). However, many patients suffer from incomplete response to anti-VEGF therapy (IRT), which is defined ... Full text Link to item Cite

Immunological Aspects of Age-Related Macular Degeneration.

Journal Article Adv Exp Med Biol · 2021 Increasing evidence over the past two decades points to a pivotal role for immune mechanisms in age-related macular degeneration (AMD) pathobiology. In this chapter, we will explore immunological aspects of AMD, with a specific focus on how immune mechanis ... Full text Link to item Cite

Mitochondrial dysfunction causes retraction of Muller cell lateral processes

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Deep learning-based single-shot prediction of differential effects of anti-VEGF treatment in patients with diabetic macular edema.

Journal Article Biomed Opt Express · February 1, 2020 Anti-vascular endothelial growth factor (VEGF) agents are widely regarded as the first line of therapy for diabetic macular edema (DME) but are not universally effective. An automatic method that can predict whether a patient is likely to respond to anti-V ... Full text Link to item Cite

Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.

Journal Article Exp Eye Res · November 2019 Diabetic retinopathy (DR) and retinal vein occlusion (RVO) are the two most common retinal vascular diseases and are major causes of vision loss and blindness worldwide. Recent and ongoing development of medical therapies including anti-vascular endothelia ... Full text Link to item Cite

Evaluation of a Remote Diagnosis Imaging Model vs Dilated Eye Examination in Referable Macular Degeneration.

Journal Article JAMA Ophthalmol · July 1, 2019 IMPORTANCE: In improving clinical outcomes, developing a sustainable, transformative care delivery model is important for accessible, efficient, low-cost, high-quality community-based imaging and diagnosis of retinal diseases. OBJECTIVE: To test the feasib ... Full text Link to item Cite

Remote diagnosis of referable macular pathology in high disease prevalence communities

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice.

Journal Article Invest Ophthalmol Vis Sci · July 2, 2018 PURPOSE: To determine the effects of aldosterone exposure on retinal edema and retinopathy in a mouse model of retinal vein occlusion (RVO). METHODS: RVO was induced immediately following intravenous injection of Rose bengal (66 mg/kg) using a 532-nm wavel ... Full text Link to item Cite

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: We assess the effect of intravitreal anti-VEGF injections on tonographic outflow facility. METHODS: Patients with age-related macular degeneration who had received unilateral intravitreal anti-VEGF injections were recruited into two groups, those ... Full text Link to item Cite

A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study.

Journal Article Transl Vis Sci Technol · March 2017 PURPOSE: We use semiautomated segmentation of fluorescein angiography (FA) to determine whether anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) differentially affects microaneurysm (MA)-associated leakage, termed f ... Full text Open Access Link to item Cite

Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.

Journal Article Opt Lett · January 1, 2017 Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, w ... Full text Link to item Cite

Feasibility and acceptance of retinal imaging in a medical clinic by non-expert imagers

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.

Journal Article JCI Insight · August 4, 2016 Fibrosis is a shared end-stage pathway to lung, liver, and heart failure. In the ocular mucosa (conjunctiva), fibrosis leads to blindness in trachoma, pemphigoid, and allergy. The indirect fibrogenic role of DCs via T cell activation and inflammatory cell ... Full text Link to item Cite

Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · April 1, 2016 PURPOSE: To develop image analysis software usable by nonexpert graders to segment geographic atrophy (GA) from dry AMD and to quantify rim area focal hyperautofluorescence (RAFH) surrounding GA on fundus autofluorescence (FAF) images. To compare the GA pr ... Full text Link to item Cite

Retinal Artery-Vein Classification via Topology Estimation.

Journal Article IEEE Trans Med Imaging · December 2015 We propose a novel, graph-theoretic framework for distinguishing arteries from veins in a fundus image. We make use of the underlying vessel topology to better classify small and midsized vessels. We extend our previously proposed tree topology estimation ... Full text Link to item Cite

Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema.

Journal Article Biomed Opt Express · April 1, 2015 We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers on spectral domain optical coherence tomography images of eyes with diabetic macular edema (DME). To achieve this, we developed a kernel regression (KR)-based ... Full text Link to item Cite

Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema.

Journal Article Invest Ophthalmol Vis Sci · January 29, 2015 PURPOSE: To create and validate software to automatically segment leakage area in real-world clinical fluorescein angiography (FA) images of subjects with diabetic macular edema (DME). METHODS: Fluorescein angiography images obtained from 24 eyes of 24 sub ... Full text Link to item Cite

Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization.

Journal Article Invest Ophthalmol Vis Sci · November 13, 2013 PURPOSE: Neovascular remodeling (NVR), the progression of small capillaries into large-caliber arterioles with perivascular fibrosis, represents a major therapeutic challenge in neovascular age-related macular degeneration (AMD). Neovascular remodeling occ ... Full text Link to item Cite

Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration.

Journal Article Mol Aspects Med · August 2012 Age-related macular degeneration (AMD) represents the leading cause of vision loss in the elderly. Accumulation of lipid- and protein-rich deposits under the retinal pigment epithelium (RPE) heralds the onset of early AMD, but the pathogenesis of subretina ... Full text Link to item Cite

Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast.

Journal Article Invest Ophthalmol Vis Sci · April 6, 2012 PURPOSE: This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical ... Full text Link to item Cite

Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration.

Journal Article Retina · September 2011 PURPOSE: To directly assess the recovery of the retina overlying choroidal neovascularization in neovascular age-related macular degeneration and to understand the relationship between macular sensitivity and visual functional measures and retinal structur ... Full text Link to item Cite

Retinal thickening in iridocyclitis.

Journal Article Am J Ophthalmol · September 2009 PURPOSE: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. DESIGN: Retrospective, observational case series. METHODS: Records we ... Full text Link to item Cite

Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.

Journal Article Invest Ophthalmol Vis Sci · July 2004 PURPOSE: To investigate the role of lysophospholipid growth factors in the regulation of aqueous humor outflow in the trabecular meshwork (TM). METHODS: The expression profile of the endothelial differentiation gene (Edg) family of G-protein coupled recept ... Full text Link to item Cite

Role of soluble guanylate cyclase in the modulation of aqueous humor outflow facility

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2004 Link to item Cite