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Alan David Proia

Professor of Pathology
Pathology
DUMC 3712, Durham, NC 27710
3078 Davison Bldg, Duke Hospital South (Duke Clinics), Durham, NC

Featured Works


Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration.

Journal article Invest Ophthalmol Vis Sci · August 2010 Featured Publication PURPOSE: To analyze serum cytokine levels in subjects with different stages of AMD and to study the expression of salient cytokines in postmortem eyes with AMD. METHODS: A suspension array system was used to analyze sera (n = 18 to 20/group) from control s ... Full text Link to item Cite

Mixed tumor of the choroid.

Journal article Arch Ophthalmol · March 2010 Featured Publication Full text Link to item Cite

Intraretinal neovascularization in diabetic retinopathy.

Journal article Arch Ophthalmol · January 2010 Featured Publication Full text Link to item Cite

The histology of graft adhesion in descemet stripping with endothelial keratoplasty.

Journal article Am J Ophthalmol · August 2009 Featured Publication PURPOSE: To describe the histologic findings of full-thickness corneas from penetrating keratoplasty (PK) in 10 patients with a prior history of Descemet stripping with endothelial keratoplasty. DESIGN: Retrospective review of the histopathology of 10 PK s ... Full text Link to item Cite

Comparison of sutures and dendritic polymer adhesives for corneal laceration repair in an in vivo chicken model.

Journal article Arch Ophthalmol · April 2009 Featured Publication OBJECTIVE: To compare clinical and histologic healing of corneal lacerations repaired by sutures or a new polymeric adhesive. METHODS: A central full-thickness 4.1-mm laceration was made in the right eyes of 60 white leghorn chickens. Half of the wounds we ... Full text Link to item Cite

A previously unreported complication of apicoaortic conduit for severe aortic stenosis.

Journal article Ann Thorac Surg · March 2009 Featured Publication Given the aging population, use of an apicoaortic conduit serves as an alternative method to treat severe aortic stenosis, especially in patients with a heavily calcified ascending aorta or prior cardiac surgery. Although an apicoaortic conduit fractionate ... Full text Link to item Cite

Candida glabrata endophthalmitis following penetrating keratoplasty.

Journal article J Cataract Refract Surg · March 2009 Featured Publication We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man. The infection was thought to be treated successfully with intravitreal amphotericin B but flared 7 months later following cataract extraction and ... Full text Link to item Cite

Acne agminata limited to the eyelids.

Journal article Ophthalmic Plast Reconstr Surg · 2009 Featured Publication A 45-year-old woman had a 1-year history of multiple small papules on both upper eyelids that waxed and waned in size and disappeared in the vicinity of a steroid injection site. Acne agminata (lupus miliaris disseminatus faciei, acnitis, papular tuberculi ... Full text Link to item Cite

Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?

Journal article Anesth Analg · January 2008 Featured Publication BACKGROUND: Perfluorocarbon (PFC) emulsions are artificial oxygen carriers that have been shown to attenuate the effects of air embolism. Cerebral air embolism, known to occur during cardiopulmonary bypass (CPB), may contribute to adverse cerebral outcomes ... Full text Link to item Cite

Striated muscle hamartoma of the eyelid in an adult woman.

Journal article Ophthalmic Plast Reconstr Surg · 2008 Featured Publication A 57-year-old woman presented with a recurrent lower eyelid growth that was found to be a striated muscle hamartoma on surgical biopsy. This is a rare entity in adults with no history of congenital abnormality. Several other rare, benign lesions may be cli ... Full text Link to item Cite

Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.

Journal article J Cutan Pathol · November 2007 Featured Publication AIM: Adnexal tumors with divergent lines of differentiation are uncommon. Herein, I report a hamartoma of the eyelid with follicular, sebaceous and apocrine differentiation that exhibited prominent melanin pigmentation. METHODS: A 63-year-old white woman h ... Full text Link to item Cite

Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.

Journal article J Clin Oncol · July 1, 2006 Featured Publication PURPOSE: To investigate the impact of human epidermal growth factor receptor (HER) 1 and HER2 gene amplification on endocrine therapy responsiveness, a fluorescence in situ hybridization (FISH) study was conducted on tumor samples from 305 postmenopausal p ... Full text Link to item Cite

Recombinant tissue plasminogen activator injected into the vitreous cavity may penetrate the retinal veins of a porcine model of vascular occlusion.

Journal article Br J Ophthalmol · July 2006 Featured Publication AIM: To determine if recombinant tissue plasminogen activator (rtPA) injected into the vitreous cavity can penetrate the retinal vessels of porcine eyes with or without vascular occlusion. METHODS: Eight eyes (group I) of four pigs underwent clamping of th ... Full text Link to item Cite

Basal cell-signet-ring squamous cell carcinoma of the eyelid.

Journal article Arch Pathol Lab Med · March 2006 Featured Publication A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fl ... Full text Link to item Cite

Fibrovascular ingrowth as a cause of Ahmed glaucoma valve failure in children.

Journal article Am J Ophthalmol · February 2006 Featured Publication PURPOSE: The purpose of this study is to document the presence of fibrovascular ingrowth into the Ahmed glaucoma valve (AGV) as a cause of AGV failure in the pediatric population. DESIGN: Retrospective case series. METHODS: Retrospective study of six child ... Full text Link to item Cite

Dermoid cyst of conjunctival origin.

Journal article Ophthalmic Plast Reconstr Surg · 2006 Featured Publication A 22-year-old man with a recurrent intraconal cystic mass of the orbit presented with proptosis, motility restriction, and optic disc edema. On initial surgery, the cyst wall showed nonkeratinized cuboidal epithelium with adnexal structures. After recurren ... Full text Link to item Cite

Basal-like cells constitute the proliferating cell population in cystic fibrosis airways.

Journal article Am J Respir Crit Care Med · October 15, 2005 Featured Publication RATIONALE: Cystic fibrosis airways are recurrently exposed to noxious stimuli, leading to epithelial injury. Previous reports suggest that cystic fibrosis airway epithelia may respond to injury by increasing proliferation. OBJECTIVES: We sought to determin ... Full text Link to item Cite

Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.

Journal article Leuk Lymphoma · October 2005 Featured Publication This study investigated stromal changes in expression of tenascin and vasculogenesis in lymphoma. Documenting the dynamic nature of the stromal changes in lymphoma in relation to response to therapy is helpful in planning new therapies directed at these ta ... Full text Link to item Cite

Collagen-rich crystalloids in a scarred vascularized cornea.

Journal article Arch Pathol Lab Med · September 2005 Featured Publication Collagen-rich crystalloids, also referred to as collagenous crystalloids, are uncommon findings in benign salivary gland tumors with myoepithelial differentiation and in cutaneous neoplasms. Herein, we report the presence of collagen-rich crystalloids in t ... Full text Link to item Cite