Scholars@Duke
Purnima Thyagarajan Valdez

Purnima Thyagarajan Valdez

Associate Professor of Pediatrics
Pediatrics, Neurology
purnima.valdez@duke.edu
Box 3936 Med Ctr, Durham, NC 27710
2301 Erwin Rd, CHC T-0913, Durham, NC 27710

Scholarly Works - Journal articles

Impact of Intersecting Identities on Student Well-being.

Journal article J Dev Behav Pediatr · November 2025 John is a 12-year-old African-American boy with a Specific Learning Disorder in Reading and Generalized Anxiety Disorder who you are seeing in follow-up at your clinic. Last fall, when John was having an escalation of his anxiety symptoms at school, he ena ... Full text Link to item Cite

Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy.

Journal article Genet Med · September 2023 PURPOSE: Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN binding protein 2 (RANBP2)-associated acute necrotizing encephalopathy subtype 1 (ANE1). We provide clinical, genetic, ... Full text Link to item Cite

Skipping the Line: Inequality in Access to Developmental-Behavioral Care.

Journal article J Dev Behav Pediatr · December 1, 2022 The mother of an 18-month-old boy contacted the developmental and behavioral pediatrics clinic to request an evaluation because of concerns that her son is not using any words and only recently began walking. The child's mother became upset when she was no ... Full text Open Access Link to item Cite

Let Me Spell It Out: The Impact of Microaggression on the Health Care Professional

Journal article Journal of Developmental & Behavioral Pediatrics · June 2022 CASE:Rachel is a 10-year-old White girl with attention-deficit/hyperactivity disorder and a history of trauma who presented for evaluation by Dr. Narayanaswamy, a developmental-behavioral ... Full text Open Access Cite

Epigenetics and autism spectrum disorder: A report of an autism case with mutation in H1 linker histone HIST1H1E and literature review.

Journal article Am J Med Genet B Neuropsychiatr Genet · June 2018 Genetic mutations in genes encoding proteins involved in epigenetic machinery have been reported in individuals with autism spectrum disorder (ASD), intellectual disability, congenital heart disease, and other disorders. H1 histone linker protein, the basi ... Full text Link to item Cite

Loss-of-function variants of SCN8A in intellectual disability without seizures.

Journal article Neurol Genet · August 2017 OBJECTIVE: To determine the functional effect of SCN8A missense mutations in 2 children with intellectual disability and developmental delay but no seizures. METHODS: Genomic DNA was analyzed by next-generation sequencing. SCN8A variants were introduced in ... Full text Link to item Cite

Use of videotaped interactions during pediatric well-child care: impact at 33 months on parenting and on child development.

Journal article J Dev Behav Pediatr · June 2007 Featured Publication OBJECTIVE: We performed a randomized, controlled trial to assess the impact of the Video Interaction Project (VIP), a program based in pediatric primary care in which videotaped interactions are used by child development specialists to promote early child ... Full text Link to item Cite

Is exposure to media intended for preschool children associated with less parent-child shared reading aloud and teaching activities?

Journal article Ambul Pediatr · 2007 Featured Publication OBJECTIVE: To determine whether electronic media exposure is associated with decreased parental reading and teaching activities in the homes of preschool children. METHODS: A convenience sample presenting for well-child care to an urban hospital pediatric ... Full text Link to item Cite

Media content and externalizing behaviors in Latino toddlers.

Journal article Ambul Pediatr · 2007 Featured Publication OBJECTIVE: There has been limited study of the association between media exposure and behavior in children younger than age 3 years. We sought to study this association in toddlers and determine whether the association varied depending on media content. ME ... Full text Link to item Cite

What influences medical students' choice of surgical careers.

Journal article Surgery · August 2000 BACKGROUND: Recent emphasis in medical education has been to encourage students to pursue primary care careers. This could have a negative impact on applications to surgical residencies. METHODS: To determine what factors are most influential for a student ... Full text Link to item Cite