Scholars@Duke
Pei Zhong

Pei Zhong

Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
Thomas Lord Department of Mechanical Engineering and Materials Science
pzhong@duke.edu
1103 Engineering Annex, Box 90300, Durham, NC 27708-0300
1103 Engineering Annex, Box 90300, Durham, NC 27708

Featured Works

Cavitation Plays a Vital Role in Stone Dusting During Short Pulse Holmium:YAG Laser Lithotripsy.

Journal article J Endourol · May 2022 Featured Publication Objective: To investigate the mechanism of stone dusting in Holmium (Ho): YAG laser lithotripsy (LL). Materials and Methods: Cylindrical BegoStone samples (6 × 6 mm, H × D) were treated in water using a clinical Ho:YAG laser lithotripter in dusting mode (0 ... Full text Link to item Cite

Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity.

Journal article J Immunother Cancer · January 2022 Featured Publication BACKGROUND: Despite multimodal adjuvant management with radiotherapy, chemotherapy and hormonal therapies, most surgically resected primary breast cancers relapse or metastasize. A potential solution to late and distant recurrence is to augment systemic an ... Full text Link to item Cite

Variations of stress field and stone fracture produced at different lateral locations in a shockwave lithotripter field.

Journal article The Journal of the Acoustical Society of America · August 2021 Featured Publication During clinical procedures, the lithotripter shock wave (LSW) that is incident on the stone and resultant stress field is often asymmetric due to the respiratory motion of the patient. The variations of the LSW-stone interaction and associated fracture pat ... Full text Cite

The Role of Cavitation in Energy Delivery and Stone Damage During Laser Lithotripsy.

Journal article J Endourol · June 2021 Featured Publication Purpose: Although cavitation during laser lithotripsy (LL) contributes to the Moses effect, the impact of cavitation on stone damage is less clear. Using different laser settings, we investigate the role of cavitation bubbles in energy delivery and stone d ... Full text Link to item Cite

Tri-modality cavitation mapping in shock wave lithotripsy.

Journal article The Journal of the Acoustical Society of America · February 2021 Featured Publication Shock wave lithotripsy (SWL) has been widely used for non-invasive treatment of kidney stones. Cavitation plays an important role in stone fragmentation, yet it may also contribute to renal injury during SWL. It is therefore crucial to determine the spatio ... Full text Cite

Optimal pulse length of insonification for Piezo1 activation and intracellular calcium response.

Journal article Scientific reports · January 2021 Featured Publication Ultrasound (US) neuromodulation, especially sonogenetics, has been demonstrated with potential applications in noninvasive and targeted treatment of various neurological disorders. Despite the growing interest, the mechanism for US neuromodulation remains ... Full text Cite

Nanosecond shock wave-induced surface acoustic waves and dynamic fracture at fluid-solid boundaries.

Journal article Physical review research · November 2019 Featured Publication We investigate the generation and propagation characteristics of leaky Rayleigh waves (LRWs) caused by a spherical shock wave incident on a water-glass boundary both experimentally and numerically. The maximum tensile stress produced on the solid boundary ... Full text Cite

Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow.

Journal article Proceedings of the National Academy of Sciences of the United States of America · January 2018 Featured Publication One of the earliest events in cellular mechanotransduction is often an increase in intracellular calcium concentration associated with intracellular calcium waves (ICWs) in various physiologic or pathophysiologic processes. Although cavitation-induced calc ... Full text Cite

Cell membrane deformation and bioeffects produced by tandem bubble-induced jetting flow.

Journal article Proceedings of the National Academy of Sciences of the United States of America · December 2015 Featured Publication Cavitation with bubble-bubble interaction is a fundamental feature in therapeutic ultrasound. However, the causal relationships between bubble dynamics, associated flow motion, cell deformation, and resultant bioeffects are not well elucidated. Here, we re ... Full text Cite

Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter.

Journal article Proc Natl Acad Sci U S A · April 1, 2014 Featured Publication The efficiency of shock wave lithotripsy (SWL), a noninvasive first-line therapy for millions of nephrolithiasis patients, has not improved substantially in the past two decades, especially in regard to stone clearance. Here, we report a new acoustic lens ... Full text Open Access Link to item Cite

Pulsating tandem microbubble for localized and directional single-cell membrane poration.

Journal article Physical review letters · August 2010 Featured Publication The interaction of laser-generated tandem microbubble (maximum diameter of about 50  μm) with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation o ... Full text Open Access Cite

Investigation of HIFU-induced anti-tumor immunity in a murine tumor model.

Journal article J Transl Med · July 11, 2007 Featured Publication BACKGROUND: High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment modality for localized treatment of cancers. While current clinical strategies employ HIFU exclusively for thermal ablation of the target sites, biological responses ... Full text Link to item Cite

Shock wave interaction with laser-generated single bubbles.

Journal article Physical review letters · July 2005 Featured Publication The interaction of a lithotripter shock wave (LSW) with laser-generated single vapor bubbles in water is investigated using high-speed photography and pressure measurement via a fiber-optic probe hydrophone. The interaction leads to nonspherical collapse o ... Full text Cite