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Loretta Georgina Que

Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 2629, 203 Research Dr, Durham, NC 27710
279 MSRB1, Durham, NC 27710

Selected Publications


Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis.

Journal Article Am J Respir Cell Mol Biol · June 2024 Lung inflammation, caused by acute exposure to ozone (O3), one of the six criteria air pollutants, is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung, and their ... Full text Link to item Cite

Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation.

Journal Article Eur Respir J · February 8, 2024 BACKGROUND: Long COVID impacts ∼10% of people diagnosed with COVID-19, yet the pathophysiology driving ongoing symptoms is poorly understood. We hypothesised that 129Xe magnetic resonance imaging (MRI) could identify unique pulmonary phenotypic subgroups o ... Full text Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Link to item Cite

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

Journal Article BMJ Open Respir Res · December 20, 2023 INTRODUCTION: The genetic determinants of fractional exhalation of nitric oxide (FeNO), a marker of lung inflammation, are understudied in Black individuals. Alpha globin (HBA) restricts nitric oxide signalling in arterial endothelial cells via interaction ... Full text Link to item Cite

Considering Diversity in Pulmonary Function Testing

Journal Article American Journal of Respiratory and Critical Care Medicine · November 15, 2023 Full text Cite

Prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya: a single-centre, prospective cohort study.

Journal Article BMJ Open · September 18, 2023 OBJECTIVE: Global medical oxygen security is limited by knowledge gaps in hypoxaemia burden and oxygen access in low-income and middle-income countries. We examined the prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya ... Full text Open Access Link to item Cite

Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.

Journal Article ERJ Open Res · March 2023 BACKGROUND: Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway. We sought to assess the safety and effi ... Full text Link to item Cite

Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma.

Journal Article Am J Respir Crit Care Med · February 15, 2023 Full text Link to item Cite

Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.

Journal Article Ann Am Thorac Soc · February 2023 Rationale: People with obesity often have severe, difficult-to-control asthma. There is a need to develop better treatments for this population. One potential treatment is roflumilast, a phosphodiesterase 4 inhibitor, as it is reported to have efficacy for ... Full text Link to item Cite

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity.

Journal Article Front Endocrinol (Lausanne) · 2023 INTRODUCTION: Asthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticostero ... Full text Open Access Link to item Cite

Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.

Journal Article J Asthma Allergy · 2023 20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly pre ... Full text Open Access Link to item Cite

Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study.

Journal Article Int J Public Health · 2023 Objectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life. Methods: A three-stage, cluster-r ... Full text Open Access Link to item Cite

Effects of biological therapies on patients with Type-2 high asthma and comorbid obesity.

Journal Article Front Pharmacol · 2023 Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the US, is ... Full text Link to item Cite

Age and Comorbidities Predict COVID-19 Outcome, Regardless of Innate Immune Response Severity: A Single Institutional Cohort Study.

Journal Article Crit Care Explor · December 2022 UNLABELLED: The COVID-19 pandemic has claimed over eight hundred thousand lives in the United States alone, with older individuals and those with comorbidities being at higher risk of severe disease and death. Although severe acute respiratory syndrome cor ... Full text Link to item Cite

Electronic Cigarettes: A Pro-Con Review of the Current Literature.

Journal Article J Allergy Clin Immunol Pract · November 2022 Electronic cigarettes (e-cigarettes, e-cigs, or electronic nicotine delivery systems) are battery-operated devices typically containing glycerol and/or propylene glycol-based solutions with varying nicotine content, known as e-liquids. Although e-cigarette ... Full text Link to item Cite

Obesity and Asthma.

Journal Article Semin Respir Crit Care Med · October 2022 Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma-recent studies in the United States suggest that 60% of adults ... Full text Open Access Link to item Cite

Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative Losartan Effects on Emphysema Progression Clinical Trial.

Journal Article Am J Respir Crit Care Med · October 1, 2022 Rationale: There are no pharmacologic agents that modify emphysema progression in patients with chronic obstructive pulmonary disease (COPD). Objectives: To evaluate the efficacy of losartan, an angiotensin receptor blocker, to reduce emphysema progression ... Full text Open Access Link to item Cite

Advances in Asthma.

Journal Article Semin Respir Crit Care Med · October 2022 Full text Link to item Cite

Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study.

Journal Article Anesthesiology · July 1, 2022 BACKGROUND: COVID-19 causes hypercoagulability, but the association between coagulopathy and hypoxemia in critically ill patients has not been thoroughly explored. This study hypothesized that severity of coagulopathy would be associated with acute respira ... Full text Link to item Cite

Evaluation of the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma (SOURCE): a randomised, placebo-controlled, phase 3 study.

Journal Article Lancet Respir Med · July 2022 BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin. SOURCE evaluated the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma. METHODS: We conduct ... Full text Link to item Cite

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis.

Journal Article Am J Respir Cell Mol Biol · June 2024 Lung inflammation, caused by acute exposure to ozone (O3), one of the six criteria air pollutants, is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung, and their ... Full text Link to item Cite

Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation.

Journal Article Eur Respir J · February 8, 2024 BACKGROUND: Long COVID impacts ∼10% of people diagnosed with COVID-19, yet the pathophysiology driving ongoing symptoms is poorly understood. We hypothesised that 129Xe magnetic resonance imaging (MRI) could identify unique pulmonary phenotypic subgroups o ... Full text Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Link to item Cite

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

Journal Article BMJ Open Respir Res · December 20, 2023 INTRODUCTION: The genetic determinants of fractional exhalation of nitric oxide (FeNO), a marker of lung inflammation, are understudied in Black individuals. Alpha globin (HBA) restricts nitric oxide signalling in arterial endothelial cells via interaction ... Full text Link to item Cite

Considering Diversity in Pulmonary Function Testing

Journal Article American Journal of Respiratory and Critical Care Medicine · November 15, 2023 Full text Cite

Prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya: a single-centre, prospective cohort study.

Journal Article BMJ Open · September 18, 2023 OBJECTIVE: Global medical oxygen security is limited by knowledge gaps in hypoxaemia burden and oxygen access in low-income and middle-income countries. We examined the prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya ... Full text Open Access Link to item Cite

Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.

Journal Article ERJ Open Res · March 2023 BACKGROUND: Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway. We sought to assess the safety and effi ... Full text Link to item Cite

Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma.

Journal Article Am J Respir Crit Care Med · February 15, 2023 Full text Link to item Cite

Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.

Journal Article Ann Am Thorac Soc · February 2023 Rationale: People with obesity often have severe, difficult-to-control asthma. There is a need to develop better treatments for this population. One potential treatment is roflumilast, a phosphodiesterase 4 inhibitor, as it is reported to have efficacy for ... Full text Link to item Cite

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity.

Journal Article Front Endocrinol (Lausanne) · 2023 INTRODUCTION: Asthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticostero ... Full text Open Access Link to item Cite

Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.

Journal Article J Asthma Allergy · 2023 20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly pre ... Full text Open Access Link to item Cite

Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study.

Journal Article Int J Public Health · 2023 Objectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life. Methods: A three-stage, cluster-r ... Full text Open Access Link to item Cite

Effects of biological therapies on patients with Type-2 high asthma and comorbid obesity.

Journal Article Front Pharmacol · 2023 Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the US, is ... Full text Link to item Cite

Age and Comorbidities Predict COVID-19 Outcome, Regardless of Innate Immune Response Severity: A Single Institutional Cohort Study.

Journal Article Crit Care Explor · December 2022 UNLABELLED: The COVID-19 pandemic has claimed over eight hundred thousand lives in the United States alone, with older individuals and those with comorbidities being at higher risk of severe disease and death. Although severe acute respiratory syndrome cor ... Full text Link to item Cite

Electronic Cigarettes: A Pro-Con Review of the Current Literature.

Journal Article J Allergy Clin Immunol Pract · November 2022 Electronic cigarettes (e-cigarettes, e-cigs, or electronic nicotine delivery systems) are battery-operated devices typically containing glycerol and/or propylene glycol-based solutions with varying nicotine content, known as e-liquids. Although e-cigarette ... Full text Link to item Cite

Obesity and Asthma.

Journal Article Semin Respir Crit Care Med · October 2022 Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma-recent studies in the United States suggest that 60% of adults ... Full text Open Access Link to item Cite

Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative Losartan Effects on Emphysema Progression Clinical Trial.

Journal Article Am J Respir Crit Care Med · October 1, 2022 Rationale: There are no pharmacologic agents that modify emphysema progression in patients with chronic obstructive pulmonary disease (COPD). Objectives: To evaluate the efficacy of losartan, an angiotensin receptor blocker, to reduce emphysema progression ... Full text Open Access Link to item Cite

Advances in Asthma.

Journal Article Semin Respir Crit Care Med · October 2022 Full text Link to item Cite

Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study.

Journal Article Anesthesiology · July 1, 2022 BACKGROUND: COVID-19 causes hypercoagulability, but the association between coagulopathy and hypoxemia in critically ill patients has not been thoroughly explored. This study hypothesized that severity of coagulopathy would be associated with acute respira ... Full text Link to item Cite

Evaluation of the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma (SOURCE): a randomised, placebo-controlled, phase 3 study.

Journal Article Lancet Respir Med · July 2022 BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin. SOURCE evaluated the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma. METHODS: We conduct ... Full text Link to item Cite

Combining Heparin and a FX/Xa Aptamer to Reduce Thrombin Generation in Cardiopulmonary Bypass and COVID-19.

Journal Article Nucleic Acid Ther · June 2022 Known limitations of unfractionated heparin (UFH) have encouraged the evaluation of anticoagulant aptamers as alternatives to UFH in highly procoagulant settings such as cardiopulmonary bypass (CPB). Despite progress, these efforts have not been totally su ... Full text Open Access Link to item Cite

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.

Journal Article Respir Res · May 24, 2022 BACKGROUND: Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypot ... Full text Open Access Link to item Cite

DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists.

Journal Article Biomaterials · April 2022 Millions of COVID-19 patients have succumbed to respiratory and systemic inflammation. Hyperstimulation of toll-like receptor (TLR) signaling is a key driver of immunopathology following infection by viruses. We found that severely ill COVID-19 patients in ... Full text Link to item Cite

Racial Disparities in Pulmonary and Quality of Life Outcomes Among COVID-19 Survivors in the Southeast

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2022 Cite

Effect of Obesity on Long Term Outcomes After COVID-19 Infection

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2022 Cite

Subgroup Analysis of a Randomized Trial of the Effects of Positive Messaging on Patient-Reported Outcomes with Asthma - Effect of Obesity.

Journal Article J Asthma Allergy · 2022 OBJECTIVE: Asthma in obese patients represents a specific phenotype that is associated with increased symptoms, more frequent and severe exacerbations, reduced responsiveness to treatment, and decreased quality of life. Marketing and placebos have been sho ... Full text Link to item Cite

Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.

Journal Article Lancet Child Adolesc Health · December 2021 BACKGROUND: Pharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist in how individuals from diffe ... Full text Link to item Cite

Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline.

Journal Article Am J Respir Crit Care Med · November 15, 2021 Background: The fractional exhaled nitric oxide (FENO) test is a point-of-care test that is used in the assessment of asthma. Objective: To provide evidence-based clinical guidance on whether FENO testing is indicated to optimize asthma treatment in patien ... Full text Link to item Cite

Wood smoke particle exposure in mice reduces the severity of influenza infection.

Journal Article Toxicol Appl Pharmacol · September 1, 2021 Elevated ambient temperatures and extreme weather events have increased the incidence of wildfires world-wide resulting in increased wood smoke particle (WSP). Epidemiologic data suggests that WSP exposure associates with exacerbations of respiratory disea ... Full text Link to item Cite

Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.

Journal Article JCI insight · July 2021 BACKGROUNDIndividuals recovering from COVID-19 frequently experience persistent respiratory ailments, which are key elements of postacute sequelae of SARS-CoV-2 infection (PASC); however, little is known about the underlying biological factors that may dir ... Full text Open Access Cite

Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.

Journal Article Sci Adv · June 2021 Highly sensitive, specific, and point-of-care (POC) serological assays are an essential tool to manage coronavirus disease 2019 (COVID-19). Here, we report on a microfluidic POC test that can profile the antibody response against multiple severe acute resp ... Full text Link to item Cite

Oxygen delivery systems for adults in Sub-Saharan Africa: A scoping review.

Journal Article J Glob Health · May 8, 2021 BACKGROUND: Respiratory diseases are the leading cause of death and disability worldwide. Oxygen is an essential medicine used to treat hypoxemia from respiratory diseases. However, the availability and utilization of oxygen delivery systems for adults in ... Full text Open Access Link to item Cite

Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.

Journal Article J Appl Physiol (1985) · May 1, 2021 Hyperpolarized 129Xe MRI has emerged as a novel means to evaluate pulmonary function via 3D mapping of ventilation, interstitial barrier uptake, and RBC transfer. However, the physiological interpretation of these measurements has yet to be firmly establis ... Full text Link to item Cite

Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 infection (PASC).

Journal Article medRxiv · April 21, 2021 INTRODUCTION: Subjects recovering from COVID-19 frequently experience persistent respiratory ailments; however, little is known about the underlying biological factors that may direct lung recovery and the extent to which these are affected by COVID-19 sev ... Full text Open Access Link to item Cite

Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.

Journal Article A A Pract · March 30, 2021 The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown. Patients with leukemia may display altered thromboinflammatory responses. We report a 53-year-old man presenting with acute leukemia and COVID-19 who developed thrombotic com ... Full text Open Access Link to item Cite

Abstract P102: Elevated Von Willebrand Factor in Patients Presenting With Large-Vessel Occlusion Stroke as First Symptom of COVID-19 Mirrors Levels in Patients With COVID-19 Requiring ICU-Level Care

Conference Stroke · March 2021 Introduction: COVID-19 is a coagulopathic disease marked by elevated d-dimers, fibrinogen, and von Willebrand factor (vWF) levels accompanying arterial and venous thrombosis. While the majority of thr ... Full text Cite

A Scoping Review of International Barriers to Asthma Medication Adherence Mapped to the Theoretical Domains Framework.

Journal Article J Allergy Clin Immunol Pract · January 2021 BACKGROUND: Internationally, adult asthma medication adherence rates are low. Studies characterizing variations in barriers by country are lacking. OBJECTIVE: To conduct a scoping review to characterize international variations in barriers to asthma medica ... Full text Link to item Cite

Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.

Journal Article Expert Rev Respir Med · January 2021 Introduction: We evaluated risk factors and demographic characteristics of associated with mild cognitive impairment (MCI) in patients with COPD. Methods: 220 individuals with COPD enrolled in a cohort study designed to evaluate anxiety conducted at 16 cli ... Full text Link to item Cite

Genetic variation in surfactant protein-A2 alters responses to ozone.

Journal Article PLoS One · 2021 BACKGROUND: Increased exposure to Ozone (O3) is associated with adverse health effects in individuals afflicted with respiratory diseases. Surfactant protein-A (SP-A), encoded by SP-A1 and SP-A2, is the largest protein component in pulmonary surfactant and ... Full text Link to item Cite

Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.

Journal Article J Asthma Allergy · 2021 Asthma is an obstructive airway disease that is characterized by reversible airway obstruction and is classically associated with atopic, TH2 driven inflammation. Landmark studies in the second half of the twentieth century identified eosinophils as a key ... Full text Open Access Link to item Cite

Functional significance of 8-isoprostanes in sinonasal disease and asthma.

Journal Article Respir Med · 2021 BACKGROUND: The purpose of this study was to investigate how 8-isoprostanes, used as a marker of airway oxidative stress, were related to sinus disease and asthma. METHODS: We analyzed samples and data from two separate studies, one investigating sinonasal ... Full text Link to item Cite

Vertical Sleeve Gastrectomy in Chronically Allergen-Challenged Obese Mice Increases Airway Hyperresponsiveness

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

AdheRence to Inhaled Corticosteroids in Asthma (ARICA): A Randomized Controlled Pilot Study

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Vertical Sleeve Gastrectomy Increased PPAR. Expression in Obese Mice Challenged with House Dust Mite

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Woodsmoke Particle Exposure in Mice Confers Protective Benefit Against PR8 Influenza Virus

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Multiplexed, quantitative serological profiling of COVID-19 from a drop of blood by a point-of-care test.

Journal Article medRxiv · November 7, 2020 Highly sensitive, specific, and point-of-care (POC) serological assays are an essential tool to manage the COVID-19 pandemic. Here, we report on a microfluidic, multiplexed POC test that can profile the antibody response against multiple SARS-CoV-2 antigen ... Full text Link to item Cite

Evaluation of Hypoxemia Among Patients Admitted to a Tertiary Referral Hospital in Western Kenya

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Patient, Provider and Community Stakeholder Recommendations for Asthma Interventions in Adult High-Risk Populations

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Alpha Globin Copy Number and Exhaled Nitric Oxide in Black Individuals

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Deficiency in Paraoxonase 2 Increases Airway Hyper Responsiveness After Ozone Exposure in Mice

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Elevated Airway Oxidative Stress in Obese Asthma Is Correlated with Increased Airway Closure

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

L-Citrulline increases nitric oxide and improves control in obese asthmatics.

Journal Article JCI Insight · December 19, 2019 BACKGROUNDThe airways of obese asthmatics have been shown to be NO deficient, and this contributes to airway dysfunction and reduced response to inhaled corticosteroids. In cultured airway epithelial cells, L-citrulline, a precursor of L-arginine recycling ... Full text Link to item Cite

Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.

Conference J Allergy Clin Immunol · November 2019 Physiological responses to HDM extracts are variable. To increase the transparency and reproducibility of published work, lot numbers, concentration of extract components, and methods for dose normalization need to be thoroughly reported. ... Full text Link to item Cite

Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets.

Journal Article Antioxid Redox Signal · October 1, 2019 Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more severe and less responsive to treatment in obese subjects. While alterations in mitochondrial function and redox signaling have been implicated in asthma pathogenesis, it i ... Full text Link to item Cite

Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.

Journal Article N Engl J Med · September 26, 2019 BACKGROUND: Morbidity from asthma is disproportionately higher among black patients than among white patients, and black patients constitute the minority of participants in trials informing treatment. Data indicate that patients with inadequately controlle ... Full text Link to item Cite

Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis.

Journal Article J Immunol · September 1, 2019 The CD4Cre transgenic model has been widely used for T cell-specific gene manipulation. We report unexpected highly efficient Cre-mediated recombination in alveolar macrophages (AMFs), bronchial epithelial cells (BECs), and alveolar epithelial cells (AECs) ... Full text Link to item Cite

Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.

Journal Article J Immunol · September 1, 2019 Surfactant protein-A (SP-A) is an important mediator of pulmonary immunity. A specific genetic variation in SP-A2, corresponding to a glutamine (Q) to lysine (K) amino acid substitution at position 223 of the lectin domain, was shown to alter the ability o ... Full text Link to item Cite

Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.

Journal Article Toxicol Sci · June 1, 2019 Sex differences clearly exist in incidence, susceptibility, and severity of airway disease and in pulmonary responses to air pollutants such as ozone (O3). Prior rodent O3 exposure studies demonstrate sex-related differences in the expression of lung infla ... Full text Link to item Cite

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.

Journal Article N Engl J Med · May 23, 2019 BACKGROUND: In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these patients is unknown. METHODS: In this 42-week, double-blind, crossover trial, we ... Full text Link to item Cite

Control of antiviral innate immune response by protein geranylgeranylation.

Journal Article Sci Adv · May 2019 The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing self-destructive inflammation remains obscure. Her ... Full text Open Access Link to item Cite

A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans.

Journal Article J Allergy Clin Immunol Pract · April 2019 BACKGROUND: Inhaled corticosteroid (ICS) adherence rates are suboptimal among adult black/African Americans. Comprehensive studies characterizing the effectiveness and the methodological approaches to the development of interventions to improve ICS adheren ... Full text Link to item Cite

Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?

Journal Article J Allergy Clin Immunol Pract · March 2019 BACKGROUND: Because respiratory tract infections (RTIs) precede most exacerbations, a better understanding of the risk factors of RTIs and RTI-associated exacerbations in patients with asthma is a pressing public health need. Obesity in patients with asthm ... Full text Link to item Cite

Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells.

Journal Article Am J Respir Cell Mol Biol · January 2019 Human rhinovirus (RV), the major cause of the common cold, triggers the majority of acute airway exacerbations in patients with asthma and chronic obstructive pulmonary disease. Nitric oxide, and the related metabolite S-nitrosoglutathione, are produced in ... Full text Link to item Cite

AdheRence to Inhaled Corticosteroids in Asthma (ARICA): Intervention Development

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Up-Regulation of Paraoxonase 2 in Human Bronchial Epithelial Cells

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Test Performance Characteristics of the AIR, GAD-7, and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease.

Journal Article Ann Am Thorac Soc · August 2018 Rationale: Anxiety is a common comorbidity of chronic obstructive pulmonary disease (COPD) that is associated with higher morbidity and mortality. We evaluated three anxiety screening questionnaires: the Generalized Anxiety Disorder 7-Item Scale (GAD-7), t ... Full text Link to item Cite

Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.

Journal Article Immun Inflamm Dis · June 2018 RATIONALE: Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. OBJECTIVES: An exploratory proof of concept clinical study of N6022 in mild asthma to determine the potential bronchoprotective effects o ... Full text Link to item Cite

Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov.

Journal Article Clin Trials · February 2018 Background/aims The Food and Drug Administration Amendments Act mandates that applicable clinical trials report basic summary results to the ClinicalTrials.gov database within 1 year of trial completion or termination. We aimed to determine the proportion ... Full text Link to item Cite

Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.

Journal Article J Am Med Inform Assoc · February 1, 2018 BACKGROUND: Electronic medical record (EMR) computed algorithms allow investigators to screen thousands of patient records to identify specific disease cases. No computed algorithms have been developed to detect all cases of human immunodeficiency virus (H ... Full text Link to item Cite

Validation of spirometry prediction equations in western Kenya.

Journal Article Int J Tuberc Lung Dis · January 1, 2018 SETTING: Community of Eldoret, Kenya. OBJECTIVE: To test the performance of three commonly used spirometry prediction equations in a healthy Kenyan population. DESIGN: Cross-sectional assessment of healthy adults in Eldoret. RESULTS: Of the 331 subjects en ... Full text Link to item Cite

S-Nitrosoglutathione Reductase Inhibitor Blockade of Rhinovirus A16 Replication by Targeting ICAM-1

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Characterization of Paraoxonases in Mice with Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Upregulation of Paraxonase 1 (PON1) in Severe Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Chronic Obstructive Pulmonary Disease Related with Increased Risk of Mild Cognitive Impairment

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Platelet and Airway Epithelium Bioenergetics Are Different in Obese Versus Lean Asthmatics

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.

Journal Article J Immunol · September 1, 2017 The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and indu ... Full text Link to item Cite

Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.

Journal Article J Allergy Clin Immunol · July 2017 BACKGROUND: Compositional differences in the bronchial bacterial microbiota have been associated with asthma, but it remains unclear whether the findings are attributable to asthma, to aeroallergen sensitization, or to inhaled corticosteroid treatment. OBJ ... Full text Link to item Cite

l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells.

Journal Article Clin Exp Allergy · February 2017 BACKGROUND: Asthma is associated with reduced systemic levels of l-arginine and increased asymmetric dimethylarginine (ADMA). This imbalance leads to nitric oxide synthase (NOS) uncoupling with reduced nitric oxide (NO) formation and greater oxidative and ... Full text Link to item Cite

Use and Perceived Risk of Electronic Cigarettes Among North Carolina Middle and High School Students.

Conference N C Med J · 2017 PURPOSE: Electronic cigarette (e-cigarette) use continues to rise among adolescents, but little is known regarding their risk perceptions of e-cigarette use. We aimed to describe the lifetime use and perceived risk of e-cigarette use in the context of othe ... Full text Link to item Cite

Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution.

Journal Article Acad Radiol · December 2016 RATIONALE AND OBJECTIVES: Ventilation heterogeneity is impossible to detect with spirometry. Alternatively, pulmonary ventilation can be imaged three-dimensionally using inhaled 129Xe magnetic resonance imaging (MRI). To date, such images have been quantif ... Full text Link to item Cite

Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.

Journal Article Stem Cell Reports · November 8, 2016 Recent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial. We sought to det ... Full text Open Access Link to item Cite

Metabolic Syndrome and the Lung.

Journal Article Chest · June 2016 A link between metabolic syndrome (MetS) and lung diseases has been observed in several cross-sectional and longitudinal studies. This syndrome has been identified as an independent risk factor for worsening respiratory symptoms, greater lung function impa ... Full text Link to item Cite

Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.

Journal Article Am J Respir Cell Mol Biol · January 2016 Elastin synthesis and degradation in the airway and lung parenchyma contribute to airway mechanics, including airway patency and elastic recoil. IL-13 mediates many features of asthma pathobiology, including airway remodeling, but the effects of IL-13 on e ... Full text Open Access Link to item Cite

A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.

Journal Article PLoS One · 2016 Flow cytometry is used extensively to examine immune cells in non-lymphoid tissues. However, a method of flow cytometric analysis that is both comprehensive and widely applicable has not been described. We developed a protocol for the flow cytometric analy ... Full text Open Access Link to item Cite

A Gsnor Inhibitor Blocks Hrv Infection Of Primary Human Airway Epithelial Cells

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Clinical Significance Of Isolated Decrease In Single Breath Lung Volume-Total Lung Capacity Ratio (va/tlc)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Surfactant Protein A Inhibits Il-13-Induced Inflammatory Response And Mucin Production In Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

A Novel Therapeutic Target In Asthma: Translational Evidence For Inhibition Of S-Nitrosoglutathione Reductase

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Ask the Experts

Journal Article WalletHub · 2015 Cite

Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?

Journal Article Am J Respir Cell Mol Biol · November 2014 Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophi ... Full text Link to item Cite

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.

Journal Article JAMA · May 2014 IMPORTANCE: In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency. OBJE ... Full text Link to item Cite

Genetic Variation In Surfactant Protein A2 Alters Airway Epithelial Response To Mycoplasma Pneumoniae Infection In Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2014 Link to item Cite

Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.

Journal Article J Proteome Res · May 3, 2013 The analysis of airway fluid, as sampled by bronchoalveolar lavage (BAL), provides a minimally invasive route to interrogate lung biology in health and disease. Here, we used immunodepletion, coupled with gel- and label-free LC-MS/MS, for quantitation of t ... Full text Link to item Cite

Proteomic Analysis Of Human Bronchoalveolar Lavage Fluid After Subsegmental Challenge

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2013 Cite

Surfactant Protein A Inhibits Il-13-Induced Pro-Inflammatory Response In Asthmatic Airway Epithelial Cells

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Nos2 Is Essential For The Therapeutic Effects Of Gsnor Inhibition In Experimental Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.

Journal Article J Proteome Res · April 6, 2012 The S-nitrosoglutathione-metabolizing enzyme, GSNO reductase (GSNOR), has emerged as an important regulator of protein S-nitrosylation. GSNOR ablation is protective in models of asthma and heart failure, raising the idea that GSNOR inhibitors might hold th ... Full text Link to item Cite

SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.

Journal Article J Immunol · April 1, 2012 Asthma is a chronic inflammatory disease in which airway epithelial cells are the first line of defense against exposure of the airway to infectious agents. Src homology protein (SHP)-1, a protein tyrosine phosphatase, is a negative regulator of signaling ... Full text Open Access Link to item Cite

The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.

Journal Article Am J Respir Crit Care Med · March 15, 2012 RATIONALE: Gene expression profiling of airway epithelial and inflammatory cells can be used to identify genes involved in environmental asthma. METHODS: Airway epithelia and inflammatory cells were obtained via bronchial brush and bronchoalveolar lavage ( ... Full text Link to item Cite

Increased Nitric Oxide Production Prevents Airway Hyperresponsiveness in Caveolin-1 Deficient Mice Following Endotoxin Exposure.

Journal Article J Allergy Ther · January 25, 2012 BACKGROUND: Caveolin-1, the hallmark protein of caveolae, is highly expressed within the lung in the epithelium, endothelium, and in immune cells. In addition to its classical roles in cholesterol metabolism and endocytosis, caveolin-1 has also been shown ... Full text Link to item Cite

Biochemistry of asthma.

Journal Article Biochim Biophys Acta · November 2011 Full text Link to item Cite

Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans.

Journal Article J Appl Physiol (1985) · September 2011 Effect of laboratory exposure to O₃ (220 ppb) and filtered air (FA) on respiratory physiology were evaluated at two time points (acute and 1 day postexposure) in healthy cohort (n = 138, 18-35 yr, 40% women) comprised mainly of Caucasian (60%) and African ... Full text Link to item Cite

Aerosolized Nitrosothiol Therapy Ameliorates Biologic And Physiologic Phenotypes Associated With Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2011 Link to item Cite

A Proteomic Investigation Of GSNOR-Regulated Pathways In Cytokine-Stimulated Mouse Alveolar Macrophages

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2011 Link to item Cite

Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009.

Journal Article Crit Care Med · November 2010 OBJECTIVE: Severe respiratory failure is a well-recognized complication of pH1N1 influenza infection. Limited data regarding the efficacy of rescue therapies, including high-frequency oscillatory ventilation and extracorporeal membrane oxygenation, have be ... Full text Link to item Cite

Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.

Journal Article Inhal Toxicol · August 2010 CONTEXT: Exposure to particulate matter (PM) is associated with systemic health effects, but the cellular and molecular mechanisms are unclear. OBJECTIVE: We hypothesized that, if circulating mononuclear cells play an important role in mediating systemic e ... Full text Link to item Cite

GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.

Journal Article Pharmacogenet Genomics · June 2010 BACKGROUND: Short-acting inhaled beta2-agonists such as albuterol are used for bronchodilation and are the mainstay of asthma treatment worldwide. There is significant variation in bronchodilator responsiveness to albuterol not only between individuals but ... Full text Link to item Cite

A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows.

Journal Article Chest · May 2010 Featured Publication BACKGROUND: Learning medical procedures relies predominantly on the apprenticeship model, and competency is established based on the number of performed procedures. Our study aimed to establish bronchoscopy competency metrics based on performance and enhan ... Full text Link to item Cite

In A Model Of Innate Immunity The Interaction Between Inducible Nitric Oxide Synthase And Surfactant Protein-A Regulates Airway Responsiveness

Journal Article A108. ALVEOLAR STRESS, INFLAMMATION AND IMMUNITY: SURFACTANT, COLLECTINS, AND BEYOND · May 2010 Full text Cite

S-nitrosoglutathione reductase: an important regulator in human asthma.

Journal Article Am J Respir Crit Care Med · August 1, 2009 Featured Publication RATIONALE: Nitric oxide bioactivity, mediated through the formation of S-nitrosothiols (SNOs), has a significant effect on bronchomotor tone. S-Nitrosoglutathione is an endogenous bronchodilator that is decreased in children with asthmatic respiratory fail ... Full text Link to item Cite

Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?

Journal Article Crit Care Med · January 2009 Featured Publication OBJECTIVE: To determine the impact of the Accreditation Council for Graduate Medical Education mandates for duty hours and competencies on instruction, evaluation, and patient care in intensive care units in the United States. DESIGN: A Web-based survey wa ... Full text Link to item Cite

AHR Is Attenuated in Caveolin-1 Deficient Mice

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

GSNO Reductase Expression and Activity Are Increased in Asthmatic Airway Macrophages

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Gene Expression in Circulating Mononuclear Cells after Ultrafine Carbon Particle Exposure

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Genetic profiling and tailored therapy in asthma: are we there yet?

Journal Article Curr Opin Mol Ther · December 2007 Featured Publication Asthma is characterized by reversible bronchial hyper-responsiveness and airway inflammation, and encompasses a wide variety of patients with different clinical phenotypes that display variable responses to therapy. The definition of genomic variation pres ... Link to item Cite

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.

Journal Article Cell · May 4, 2007 Featured Publication beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target receptors for internalization. Nitric ... Full text Link to item Cite

Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching.

Journal Article Crit Care Med · March 2007 Featured Publication OBJECTIVE: To develop an assessment tool for bedside teaching in the intensive care unit (ICU) that provides feedback to residents about their performance compared with clinical best practices. METHOD: We reviewed the literature on the assessment of reside ... Full text Link to item Cite

Protection from experimental asthma by an endogenous bronchodilator.

Journal Article Science · June 10, 2005 Featured Publication Mechanisms that protect against asthma remain poorly understood. S-nitrosoglutathione (GSNO), an endogenous bronchodilator, is depleted from asthmatic airways, suggesting a protective role. We report that, following allergen challenge, wild-type mice exhib ... Full text Link to item Cite

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock

Conference NITRIC OXIDE-BIOLOGY AND CHEMISTRY · August 1, 2004 Link to item Cite

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.

Journal Article Cell · February 20, 2004 Featured Publication The current perspective of NO biology is formulated predominantly from studies of NO synthesis. The role of S-nitrosothiol (SNO) formation and turnover in governing NO-related bioactivity remains uncertain. We generated mice with a targeted gene deletion o ... Full text Link to item Cite

S-nitrosothiols in lung inflammation

Chapter · January 1, 2003 S-Nitrosothiols (SNOs) are complexes of nitric oxide (NO) bound to thiol groups, which are present in biological systems as proteins and low molecular weight peptides (1,2). SNOs have been regarded by some as markers of NO production [i.e., nitric oxide sy ... Cite

Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver.

Journal Article Am J Physiol Gastrointest Liver Physiol · March 2002 Featured Publication Adenovirus-mediated gene transfer has become an important tool with which to introduce genetic material into cells. Available data emphasize efficient adenoviral transduction of parenchymal liver cells (i.e., hepatocytes) in both in vitro and in vivo model ... Full text Link to item Cite

Effects of arginase isoforms on NO Production by nNOS.

Journal Article Nitric Oxide · February 2002 Featured Publication Both arginase isoforms (AI and AII) regulate high-level NO production by the inducible NOS, but whether the arginase isoforms also regulate low-level NO production by neuronal NOS (nNOS) is not known. In this study, 293 cells that stably overexpress nNOS g ... Full text Link to item Cite

A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.

Journal Article Nature · March 22, 2001 Featured Publication Considerable evidence indicates that NO biology involves a family of NO-related molecules and that S-nitrosothiols (SNOs) are central to signal transduction and host defence. It is unknown, however, how cells switch off the signals or protect themselves fr ... Full text Link to item Cite

Pharmacologic adjuncts during mechanical ventilation.

Journal Article Semin Respir Crit Care Med · 2000 Featured Publication Despite recent advances in technology, the mortality rate for patients suffering from adult respiratory distress syndrome remains in the range of 40-50%. This high mortality rate may be in part related to complications from ventilator management, such as v ... Full text Link to item Cite

Malignant melanoma presenting as a mediastinal mass.

Journal Article Ann Thorac Surg · March 1999 Featured Publication A case of malignant melanoma presenting as a mediastinal mass without an extrathoracic primary is reported. Microscopically the tumor appeared consistent with malignant melanoma, with the presence of focal melanin pigment in large epithelioid cells. Fontan ... Full text Link to item Cite

Induction of arginase isoforms in the lung during hyperoxia.

Journal Article Am J Physiol · July 1998 Featured Publication L-Arginine can be metabolized by nitric oxide (NO) synthase (NOS) to produce NO or by arginase to produce urea and L-ornithine. In the liver, arginase (the AI isoform) is a key enzyme in the urea cycle. In extrahepatic organs including the lung, the functi ... Full text Link to item Cite

Induction of arginase isoforms in the lung during hyperoxia

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY · July 1, 1998 Link to item Cite

Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis.

Journal Article Shock · April 1998 Featured Publication The intercellular adhesion molecule (ICAM)-1 is expressed constitutively in normal lungs and increased in pulmonary inflammation. Whether increased ICAM-1 expression in the lung contributes to neutrophil sequestration during lung inflammation in sepsis is ... Full text Link to item Cite

Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.

Journal Article Am J Respir Crit Care Med · March 1998 Featured Publication Recruitment of polymorphonuclear leukocytes (PMN) through upregulation of cellular adhesion molecules is a proposed mechanism of injury in sepsis and acute respiratory distress syndrome (ARDS). We hypothesized that pretreatment of baboons with a monoclonal ... Full text Link to item Cite