Scholars@Duke
Rachel Ann Miller

Rachel Ann Miller

Professor of Medicine
Medicine, Infectious Diseases

Scholarly Works

Kaposi Sarcoma–Associated Herpesvirus Infection and Complications Among Solid Organ Transplant Recipients — United States, January 2021–September 2025

Journal article MMWR Surveillance Summaries · March 5, 2026 Kaposi sarcoma–associated herpesvirus (KSHV) infection is the cause of Kaposi sarcoma (KS), certain lymphoproliferative disorders, and the inflammatory condition Kaposi sarcoma–associated herpesvirus inflammatory cytokine syndrome (KICS). In solid organ tr ... Full text Cite

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People.

Journal article Clin Infect Dis · January 16, 2026 This article is part of a larger clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this article, the panel provides recommendations for trea ... Full text Link to item Cite

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People.

Journal article Clin Infect Dis · January 16, 2026 This paper is part of a larger clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this paper, the panel provides a recommendation for treatme ... Full text Link to item Cite

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People.

Journal article Clin Infect Dis · January 16, 2026 As the first part of an update to the clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, we present 4 updated recommendations. These recommendat ... Full text Link to item Cite

Invasive surgical site infections after lung transplantation: contemporary risk factors and associated clinical outcomes.

Journal article JHLT Open · August 2025 BACKGROUND: Invasive primary surgical site infections (IP-SSI) complicate lung transplant (LT) surgery. Identification of IP-SSI risk factors is critical to IP-SSI prevention. METHODS: This single-center retrospective cohort study of adult patients who und ... Full text Open Access Link to item Cite

A change of heart: Limitations of National Healthcare Safety Network (NHSN) and Society of Thoracic Surgeons (STS) surveillance strategies in identifying surgical site infections after heart transplant surgery.

Journal article Am J Infect Control · July 2025 Surgical site infections (SSI) surveillance after heart transplantation is critical for preventing SSI. We analyzed the accuracy of 3 SSI surveillance systems: National-Healthcare-Safety-Network (NHSN), Society-of-Thoracic-Surgeons (STS), and detailed manu ... Full text Link to item Cite

The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients.

Journal article Med Mycol Case Rep · June 2025 Donor-derived invasive fungal infections among solid organ transplant recipients are rare but sometimes devastating events associated with notable morbidity and mortality. Here we describe two donor-derived fungal infections - one Candida parapsilosis comp ... Full text Link to item Cite

Coccidioidomycosis Transmission Through Solid Organ Transplantation (2013-2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee.

Journal article Transpl Infect Dis · 2025 BACKGROUND: Coccidioidomycosis is a fungal infection that poses a serious risk when transmitted through organ transplantation. We analyzed cases reported to the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee fr ... Full text Link to item Cite

Contemporary Cytomegalovirus (CMV) Infections in Low-Risk CMV Seronegative Recipients of Solid Organ Transplants From CMV Seronegative Donors (D-/R-): Time to Reexamine Donor CMV Serostatus.

Journal article Clin Transplant · January 2025 BACKGROUND: Early posttransplant cytomegalovirus (CMV) infections in CMV seronegative solid organ transplant recipients (SOTR) with CMV seronegative donors (D-/R-) are often attributed transfusion-transmitted CMV. The prevalence of false-negative donor CMV ... Full text Link to item Cite

Risk Factors for Invasive Surgical Site Infections Among Adult Single Liver Transplant Recipients at Duke University Hospital in the Period 2015-2020.

Journal article Transplant Direct · December 2024 BACKGROUND: Invasive primary surgical site infections (IP-SSI) are a severe complication of liver transplant surgery. Identification of risk factors for IP-SSI is critical to IP-SSI prevention. METHODS: All adult single liver transplants performed at Duke ... Full text Open Access Link to item Cite

Hepatitis B transmission/reactivation associated with Hepatitis B core antibody and Hepatitis C nucleic acid testing positive organs: A report from the Organ Procurement and Transplantation Network Disease Transmission Advisory Committee.

Journal article Transpl Infect Dis · November 2024 BACKGROUND: Better access to direct-acting antiviral (DAA) therapy has broadened the utilization of hepatitis C virus (HCV) nucleic acid testing (NAT) positive organs with excellent outcomes. However, DAA therapy has been associated with hepatitis B virus ... Full text Link to item Cite

Late surgical site infections among solid organ transplant recipients: an unrecognized clinical entity.

Journal article Infect Control Hosp Epidemiol · October 2024 This study identified 26 late invasive primary surgical site infection (IP-SSI) within 4-12 months of transplantation among 2073 SOT recipients at Duke University Hospital over the period 2015-2019. Thoracic organ transplants accounted for 25 late IP-SSI. ... Full text Link to item Cite

Minimizing risk while maximizing opportunity: The infectious disease organ offer process survey.

Journal article Transpl Infect Dis · October 2024 BACKGROUND: The purpose of this study was to understand how transplant infectious disease (TID) physicians assess a potential donor with known or suspected infection and describe posttransplant management. METHODS: We designed a survey of 10 organ offer sc ... Full text Link to item Cite

Real-World Experience With Maribavir for Treatment of Cytomegalovirus Infection in High-Risk Solid Organ Transplant Recipients.

Journal article Open Forum Infect Dis · July 2024 We evaluated use of maribavir (MBV) for treatment of 15 episodes of refractory/resistant cytomegalovirus infection in 13 solid organ transplant recipients. Treatment failure due to treatment-emergent MBV resistance or early virological recurrence after MBV ... Full text Link to item Cite

Risk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation.

Journal article Am J Transplant · April 2024 Mollicute infections, caused by Mycoplasma and Ureaplasma species, are serious complications after lung transplantation; however, understanding of the epidemiology and outcomes of these infections remains limited. We conducted a single-center retrospective ... Full text Open Access Link to item Cite

Limitations of antifungal prophylaxis in preventing invasive Candida surgical site infections after liver transplant surgery.

Journal article Antimicrob Agents Chemother · March 6, 2024 Invasive primary Candida surgical site infections (IP-SSIs) are a common complication of liver transplantation, and targeted antifungal prophylaxis is an efficient strategy to limit their occurrence. We performed a retrospective single-center cohort study ... Full text Link to item Cite

Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report.

Journal article Ann Am Thorac Soc · March 2023 Pneumonia imposes a significant clinical burden on people with immunocompromising conditions. Millions of individuals live with compromised immunity because of cytotoxic cancer treatments, biological therapies, organ transplants, inherited and acquired imm ... Full text Link to item Cite

Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients.

Journal article Annu Rev Med · January 27, 2023 Cytomegalovirus (CMV) is a common viral pathogen in the transplant population and is associated with significant morbidity and mortality. CMV prevention is paramount; however, selecting the best preventive strategy depends on many factors including donor-r ... Full text Link to item Cite

Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Journal article Am J Transplant · December 2022 Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult ... Full text Open Access Link to item Cite

Clinical characteristics of COVID-19 in solid organ transplant recipients following COVID-19 vaccination: A multicenter case series.

Journal article Transpl Infect Dis · April 2022 BACKGROUND: Solid organ transplant recipients (SOTR) have diminished humoral immune responses to COVID-19 vaccination and higher rates of COVID-19 vaccine breakthrough infection than the general population. Little is known about COVID-19 disease severity i ... Full text Link to item Cite

Updates on Histoplasmosis in Solid Organ Transplantation.

Journal article Curr Fungal Infect Rep · 2022 PURPOSE OF REVIEW: Histoplasmosis remains a challenging infection in solid organ transplantation. This review provides a topic update with emphasis on the changing Histoplasma epidemiology, along with new diagnostic and treatment innovations. RECENT FINDIN ... Full text Link to item Cite

Transplant Infectious Disease Evaluation of Cytopenias

Book section · January 1, 2021 Cytopenias are a common occurrence in both hematopoietic stem cell and solid organ transplant recipients, particularly in the early post-transplant time period. The etiology is frequently multifactorial, reflecting the simultaneous interplay of infection, ... Full text Cite

Surgical infection prophylaxis prior to left ventricular assist device implantation: A survey of clinical practice.

Journal article J Card Surg · October 2020 BACKGROUND: Short duration, antimicrobial prophylaxis that includes antistaphylococcal activity is recommended at the time of left ventricular assist device (LVAD) implantation to reduce infection-related complications. There continues to be wide variabili ... Full text Link to item Cite

Update on Nocardia infections in solid-organ transplantation.

Journal article Curr Opin Organ Transplant · August 2020 PURPOSE OF REVIEW: Nocardia is a ubiquitous pathogen associated with life-threatening opportunistic infections. Organ transplant recipients are uniquely predisposed to Nocardia infections due to their iatrogenic cell-mediated immune deficit necessary to ma ... Full text Link to item Cite

Oral and Inhaled Ribavirin Treatment for Respiratory Syncytial Virus Infection in Lung Transplant Recipients.

Journal article Transplantation · June 2020 BACKGROUND: Respiratory syncytial virus (RSV) infection in lung transplant recipients (LTRs) causes mortality rates of 10%-20% despite antiviral therapy. Ribavirin (RBV) has been used to treat RSV-infected LTRs with limited data. METHODS: A retrospective s ... Full text Link to item Cite

Cytomegalovirus in Allogeneic Hematopoietic Transplantation: Impact on Costs and Clinical Outcomes Using a Preemptive Strategy.

Journal article Biol Blood Marrow Transplant · March 2020 Cytomegalovirus (CMV) results in significant morbidity and mortality following hematopoietic cell transplantation (HCT). Establishing the cost and clinical impact is imperative to the selection of appropriate CMV preventative strategies. This is a retrospe ... Full text Link to item Cite

Endemic fungal infections in solid organ transplant recipients-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Journal article Clin Transplant · September 2019 These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of blastomycosis, histoplasmosis, and coccidioidomycosis in the pre- and post-transplant ... Full text Link to item Cite

Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document.

Journal article Allergy · March 2019 Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus ... Full text Link to item Cite

Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension.

Journal article Transpl Infect Dis · February 2019 The unexpected transmission of donor-derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor-derived transmission of Herpes Simplex Virus (HSV)-2 via deceased ... Full text Link to item Cite

Dementia Reported Missing: Use of an Online Search Engine to Track Outcomes in Persons With Dementia Reported Missing.

Journal article Alzheimer Dis Assoc Disord · 2019 BACKGROUND: Persons with dementia (PWD) reported missing are known to be at high risk for mortality. Analysis of online search engines' reports of missing PWD may show patterns in the data of this relatively common event and the broad patterns relevant to ... Full text Link to item Cite

A randomized, placebo-controlled phase I trial of live, attenuated herpes zoster vaccine in subjects with end-stage renal disease immunized prior to renal transplantation.

Journal article Transpl Infect Dis · June 2018 BACKGROUND: Solid organ transplant recipients are at increased risk for reactivation of herpes zoster, or shingles, and have a higher frequency of serious complications including post-herpetic neuralgia. A live, attenuated shingles vaccine is effective and ... Full text Link to item Cite

A Case for Antifungal Stewardship

Journal article Current Fungal Infection Reports · March 1, 2018 Purpose of Review: The expanding utilization of limited available antifungal agents has led to a pressing need to implement interventions to ensure appropriate usage. The global emergence of resistant, difficult-to-treat invasive fungal infections among th ... Full text Cite

High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus.

Journal article Transpl Infect Dis · August 2017 Despite careful donor screening, unexpected donor-derived infections continue to occur in organ transplant recipients (OTRs). Lymphocytic choriomeningitis virus (LCMV) is one such transplant-transmitted infection that in previous reports has resulted in a ... Full text Link to item Cite

Unique characteristics of cryptococcosis identified after death in patients with liver cirrhosis: comparison with concurrent cohort diagnosed antemortem.

Journal article Med Mycol · April 1, 2017 Characteristics of cirrhosis-associated cryptococcosis first diagnosed after death are not fully known. In a multicenter study, data generated as standard of care was systematically collected in 113 consecutive patients with cirrhosis and cryptococcosis fo ... Full text Link to item Cite

Current practices for treatment of respiratory syncytial virus and other non-influenza respiratory viruses in high-risk patient populations: a survey of institutions in the Midwestern Respiratory Virus Collaborative.

Journal article Transpl Infect Dis · April 2016 BACKGROUND: The optimal treatment for respiratory syncytial virus (RSV) infection in adult immunocompromised patients is unknown. We assessed the management of RSV and other non-influenza respiratory viruses in Midwestern transplant centers. METHODS: A sur ... Full text Link to item Cite

Cryptococcosis in Patients With Cirrhosis of the Liver and Posttransplant Outcomes.

Journal article Transplantation · October 2015 BACKGROUND: The outcomes and optimal management of cirrhotic patients who develop cryptococcosis before transplantation are not fully known. METHODS: We conducted a multicenter study involving consecutive patients with cirrhosis and cryptococcosis between ... Full text Link to item Cite

Histoplasmosis complicating tumor necrosis factor-α blocker therapy: a retrospective analysis of 98 cases.

Journal article Clin Infect Dis · August 1, 2015 BACKGROUND: Histoplasmosis may complicate tumor necrosis factor (TNF)-α blocker therapy. Published case series provide limited guidance on disease management. We sought to determine the need for long-term antifungal therapy and the safety of resuming TNF-α ... Full text Link to item Cite

Communication gaps associated with donor-derived infections.

Journal article Am J Transplant · January 2015 The detection and management of potential donor-derived infections is challenging, in part due to the complexity of communications between diverse labs, organ procurement organizations (OPOs), and recipient transplant centers. We sought to determine if com ... Full text Link to item Cite

Solid organ transplant donors with central nervous system infection.

Journal article Transplantation · September 27, 2014 BACKGROUND: While donor-derived infections (DDI) remain uncommon, multiple reports describe DDI with pathogens that cause central nervous system (CNS) infection resulting in significant recipient disease. The Ad Hoc Disease Transmission Advisory Committee ... Full text Link to item Cite

Management practices and major infections after cardiac surgery.

Journal article J Am Coll Cardiol · July 29, 2014 BACKGROUND: Infections are the most common noncardiac complication after cardiac surgery, but their incidence across a broad range of operations, as well as the management factors that shape infection risk, remain unknown. OBJECTIVES: This study sought to ... Full text Link to item Cite

Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation - Iowa, 2013.

Journal article MMWR Morb Mortal Wkly Rep · March 21, 2014 On April 26, 2013, the United Network for Organ Sharing reported to CDC a cluster of ill organ transplant recipients in Iowa with a common organ donor. Infection with lymphocytic choriomeningitis virus (LCMV) was suspected. LCMV is a rodent-borne virus tha ... Link to item Cite

At the boundary of the self: the insular cortex in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers.

Journal article Int J Dev Neurosci · February 2014 The insular cortex (insula), whose normal function involves delineating the boundary between self and non-self stimuli, has been implicated in the pathophysiology of the positive symptoms of schizophrenia, including hallucinations and delusions. Childhood- ... Full text Link to item Cite

Histoplasmosis after solid organ transplant.

Journal article Clin Infect Dis · December 2013 BACKGROUND: To improve our understanding of risk factors, management, diagnosis, and outcomes associated with histoplasmosis after solid organ transplant (SOT), we report a large series of histoplasmosis occurring after SOT. METHODS: All cases of histoplas ... Full text Link to item Cite

Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings.

Journal article J Am Acad Child Adolesc Psychiatry · May 2013 OBJECTIVE: The hippocampus has been implicated in the pathogenesis of schizophrenia, and hippocampal volume deficits have been a consistently reported abnormality, but the subregional specificity of the deficits remains unknown. The authors explored the na ... Full text Link to item Cite

Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia.

Journal article J Child Adolesc Psychopharmacol · March 2013 OBJECTIVE: The purpose of this study was to retrospectively analyze rates of neutropenia and risk factors for neutropenia in hospitalized children and adolescents treated with clozapine. METHODS: A retrospective chart review was conducted for all patients ... Full text Link to item Cite

Communication gaps for solid organ transplant-transmitted infections among infectious disease physicians: an Emerging Infections Network survey.

Journal article Transpl Infect Dis · February 2013 Infectious disease (ID) physicians were surveyed concerning knowledge and management of potential transplant-transmitted infections (TTIs). On the basis of cumulative responses to 4 questions that assessed solid organ transplant-related clinical exposures ... Full text Link to item Cite

Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings.

Journal article Psychiatry Res · January 30, 2013 The corpus callosum (CC) has been implicated in the pathogenesis of schizophrenia, and CC deficits have been reported in adults with schizophrenia. We explored the developmental trajectory of the corpus callosum in childhood-onset schizophrenia (COS) patie ... Full text Link to item Cite

Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia.

Journal article Schizophr Bull · January 2013 BACKGROUND: Progressive cortical gray matter (GM) abnormalities are an established feature of schizophrenia and are more pronounced in rare, severe, and treatment refractory childhood-onset schizophrenia (COS) cases. The effect of sex on brain development ... Full text Link to item Cite

Psychotic symptoms and gray matter deficits in clinical pediatric populations.

Journal article Schizophr Res · September 2012 BACKGROUND: Neuroanatomic studies have not yet addressed how subtle phenotypic distinctions in psychosis alter the underlying brain changes, and whether there is evidence for psychosis as a dimensional construct. We explored the relationship of cortical GM ... Full text Link to item Cite

Are we managing acute knee effusion well?

Journal article British Journal of Medical Practitioners · March 1, 2012 Background: Non-traumatic knee effusion is a common referral to the on-call Orthopaedic team. The two most common causes of this presentation are septic and crystal arthritis. Crystal-induced arthritis can easily be overlooked or misdiagnosed as septic art ... Cite

A multicenter study of histoplasmosis and blastomycosis after solid organ transplantation.

Journal article Transpl Infect Dis · February 2012 AIM: A review of the clinical presentation, diagnosis, treatment and outcomes of 30 solid organ transplant recipients (SOTRs) with histoplasmosis or blastomycosis from 3 Midwestern academic medical centers. BACKGROUND: The endemic fungal pathogens, Histopl ... Full text Link to item Cite

A pilot study of the use of biocide-impregnated gauze as an adjunct to wound care in a burn population.

Journal article J Burn Care Res · 2012 The aim of this study was to evaluate the use of a polyhexamethylene biguanide biocide-impregnated gauze (Kerlix™ AMD gauze dressing, Covidien d/b/a Tyco Healthcare Group LP) as an adjuvant to routine burn care and its impact on the incidence of hospital-a ... Full text Link to item Cite

Open-Ended and Open-Door Treatment Groups for Young People with Mental Illness

Journal article Social Work with Groups · January 1, 2012 The concept of open-ended groups is expanded to include an open-door model (OEOD) wherein members with severe mental illnesses, including schizophrenia disorders and bipolar, can join, leave, and reenter groups as their life circumstances dictate their ava ... Full text Cite

Childhood-onset schizophrenia: the challenge of diagnosis.

Journal article Curr Psychiatry Rep · October 2011 During the past two decades, the Child Psychiatry Branch at the National Institute of Mental Health has conducted a longitudinal study (including long-term prospective follow-up) of childhood-onset schizophrenia, a rare form of the disorder. Critical to th ... Full text Link to item Cite

Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia.

Journal article Brain Stimul · October 2011 BACKGROUND: In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking. OBJECTIVE: This study aim ... Full text Link to item Cite

Olanzapine vs. risperidone in patients with first-episode schizophrenia and a lifetime history of cannabis use disorders: 16-week clinical and substance use outcomes.

Journal article Psychiatry Res · August 15, 2011 The purpose of this study is to compare the efficacy of olanzapine and risperidone for the acute treatment of first-episode schizophrenia patients with cannabis use disorders. This secondary analysis of a previously published study included 49 first-episod ... Full text Link to item Cite

Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia.

Journal article J Am Acad Child Adolesc Psychiatry · July 2011 OBJECTIVE: Cortical gray matter (GM) abnormalities in patients with childhood-onset schizophrenia (COS) progress during adolescence ultimately localizing to prefrontal and temporal cortices by early adult age. A previous study of 52 nonpsychotic siblings o ... Full text Link to item Cite

Childhood onset schizophrenia: High rate of visual hallucinations

Journal article Journal of the American Academy of Child and Adolescent Psychiatry · January 1, 2011 Objective: To document high rates and clinical correlates of nonauditory hallucinations in childhood onset schizophrenia (COS). Method: Within a sample of 117 pediatric patients (mean age 13.6 years), diagnosed with COS, the presence of auditory, visual, s ... Full text Cite

Are cannabis use disorders associated with an earlier age at onset of psychosis? A study in first episode schizophrenia.

Journal article Schizophr Res · July 2010 INTRODUCTION: The purpose of this study is to determine if an earlier age at onset of positive symptoms in schizophrenia is associated with cannabis use disorders (CUD). METHODS: 49 first-episode schizophrenia subjects with CUD were compared to 51 first-ep ... Full text Link to item Cite

American Journal of Transplantation: Foreword

Journal article American Journal of Transplantation · December 1, 2009 Full text Cite

General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study.

Journal article Schizophr Res · November 2009 BACKGROUND: Childhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset illness, with more salient neurobiological causes. Previous cross-sectional structural neuroimaging research has suggested that normal cortical asymmetry patterns [(R ... Full text Link to item Cite

Adjunctive use of lithium carbonate for the management of neutropenia in clozapine-treated children.

Journal article Hum Psychopharmacol · October 2009 OBJECTIVE: Clozapine, a dibenzodiazepine antipsychotic, is the most effective medication for treatment-resistant schizophrenia. However, its use has been limited by the high risk of neutropenia. In children, the rate of neutropenia is higher when compared ... Full text Link to item Cite

A prospective study of cannabis use as a risk factor for non-adherence and treatment dropout in first-episode schizophrenia.

Journal article Schizophr Res · September 2009 INTRODUCTION: Although several studies have reported on cannabis use and adherence for first episode of psychosis patients, the findings remain unclear as to whether cannabis use is a risk factor for poor adherence in young people with first-episode schizo ... Full text Link to item Cite

Patterns of stress in schizophrenia.

Journal article Psychiatry Res · July 15, 2008 Although it is widely recognized that stress plays a key role in the pathophysiology of schizophrenia, little is known regarding the particular types of stress patients experience. Less is known about the interplay among stressful events, personality media ... Full text Link to item Cite

Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia.

Journal article Neuropsychopharmacology · April 2008 The objective of this study was to investigate the clinical and neuropsychological correlates of white matter abnormalities in patients with schizophrenia studied early in the course of illness. A total of 33 (21 male/12 female) patients with recent onset ... Full text Link to item Cite

Older donor livers show early severe histological activity, fibrosis, and graft failure after liver transplantation for hepatitis C.

Journal article Transplantation · August 15, 2007 BACKGROUND: In hepatitis C virus (HCV)-positive liver transplant recipients, infection of the allograft and recurrent liver disease are important problems. Increased donor age has emerged as an important variable affecting patient and graft survival; howev ... Full text Link to item Cite

A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C.

Journal article Transplant Proc · December 2006 UNLABELLED: Rapid recurrence of severe hepatitis C (HCV) after liver transplantation is a major barrier to survival of the transplanted liver. While cyclosporine (CsA) in vitro has been shown to suppress HCV replication, an effect is not seen with tacrolim ... Full text Link to item Cite

Faith and religious delusions in first-episode schizophrenia

Journal article Social Work in Mental Health · November 15, 2006 This article reports on faith and religious delusions at initial intake and 12 months later in work with a group of 77 patients experiencing the first-episode of schizophrenia. Both religious delusions and faith are frequent for first-episode patients in t ... Full text Cite

Stigma and schizophrenia: Directions in student training

Journal article Journal of Teaching in Social Work · October 12, 2006 The persistence of stigma related to schizophrenia is addressed as a continuing challenge for social work students working in mental health. Student education is best grounded in direct clinical work with clients in conjunction with field supervision and c ... Full text Cite

Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: a prospective, multicenter, observational study.

Journal article Transplantation · February 15, 2006 BACKGROUND: : The efficacy of the combination of voriconazole and caspofungin when used as primary therapy for invasive aspergillosis in organ transplant recipients has not been defined. METHODS: : Transplant recipients who received voriconazole and caspof ... Full text Link to item Cite

Positive serum cryoglobulin is associated with worse outcome after liver transplantation for chronic hepatitis C.

Journal article Transplantation · August 27, 2005 BACKGROUND: Recurrent hepatitis C virus (HCV) infection in patients after liver transplantation is an important clinical problem. Because serum cryoglobulins (CG) are known to be associated with an increased incidence of cirrhosis in nontransplant patients ... Full text Link to item Cite

The Insight-Adherence-Abstinence triad: an integrated treatment focus for cannabis-using first-episode schizophrenia patients.

Journal article Bull Menninger Clin · 2005 Insight-Adherence-Abstinence focused treatment for first episode of schizophrenia and schizoaffective patients is described using examples from clinical practice with 68 patients, 30 of whom have recent or active cannabis misuse. The treatment model is bas ... Full text Link to item Cite

Cognitive enhancement therapy: a therapeutic treatment strategy for first-episode schizophrenia patients.

Journal article Bull Menninger Clin · 2004 Cognitive enhancement therapy (CET) for first-episode schizophrenia combines supportive therapy with social skills and cognitive remediation training. It includes exercises aimed at ameliorating cognitive and negative symptoms in a purposefully motivationa ... Full text Link to item Cite

Using group therapy to enhance treatment compliance in first episode schizophrenia

Journal article Social Work with Groups · February 19, 2002 Group therapy for first episode of schizophrenia patients is examined for its effect on treatment compliance and dropout rates. Results from data collected over a two-year period on 77 patients in the first episode of schizophrenia show that there is a sta ... Full text Cite

Antioxidant enzyme expression in clinical isolates of Pseudomonas aeruginosa: identification of an atypical form of manganese superoxide dismutase.

Journal article Infect Immun · December 2001 Expression of superoxide dismutases (FeSOD and MnSOD) and catalases by laboratory strains of Pseudomonas aeruginosa is modulated by exogenous factors. Whether clinical isolates behave similarly and whether antioxidant enzyme expression influences P. aerugi ... Full text Link to item Cite

Suprahepatic venacavaplasty (cavaplasty) with retrohepatic cava extension in liver transplantation: experience with first 115 cases.

Journal article Transplantation · October 27, 2001 BACKGROUND: We first introduced the orthotopic liver transplantation utilizing cavaplasty technique in 1994. This paper describes the surgical technique and assesses the outcome of the cavaplasty OLT. METHODS: The cavaplasty procedure was used in 115 conse ... Full text Link to item Cite

Safe sex and first-episode schizophrenia.

Journal article Bull Menninger Clin · 2001 The need for educating patients about the dangers of unprotected sexual activity is well documented in the literature. Using clinical examples, the authors describe safe-sex strategies for patients experiencing their first episode of schizophrenia. Interve ... Full text Link to item Cite

Group work with first episode schizophrenia clients

Journal article Social Work with Groups · February 18, 1999 Group work with first episode schizophrenia clients is an effective way of improving ego functioning, building adaptive coping skills, and addressing the painful feelings associated with learning of this diagnosis. First episode schizophrenia clients are t ... Full text Cite

Phase-specific psychosocial interventions for first-episode schizophrenia.

Journal article Bull Menninger Clin · 1999 Phase-specific psychosocial interventions for first-episode schizophrenia are outlined and described using examples from clinical practice with 68 patients. These interventions are based on the unique aspects of the first episode and patients' clinical sta ... Link to item Cite

Role of oxidants in microbial pathophysiology.

Journal article Clin Microbiol Rev · January 1997 Reactive oxidant species (superoxide, hydrogen peroxide, hydroxyl radical, hypohalous acid, and nitric oxide) are involved in many of the complex interactions between the invading microorganism and its host. Regardless of the source of these compounds or w ... Full text Link to item Cite

Protease cleavage of iron-transferrin augments pyocyanin-mediated endothelial cell injury via promotion of hydroxyl radical formation.

Journal article Infect Immun · January 1996 Although a number of bacterium- and host-derived factors have been suggested to contribute to the pathogenesis of Pseudomonas aeruginosa-associated tissue injury, the mechanism remains unclear. We have previously shown that protease modification of iron (F ... Full text Link to item Cite

Characterization of antioxidant enzymes among pseudomonas aeruginosa clinical isolates

Journal article Journal of Investigative Medicine · January 1, 1996 Pseudomonas aeruginosa (PA) is subjected to endogenous oxidative stress from aerobic metabolism and exogenous oxidative stress as a result of exposure to oxidantproducing neutrophils. Like other bacteria, laboratory strains of PA contain anrtoxidant enzyme ... Cite

Mycobacterium tuberculosis in lung transplant recipients.

Journal article Am J Respir Crit Care Med · July 1995 The diagnosis and treatment of Mycobacterium tuberculosis, although difficult in normal hosts, are even more complex in transplant recipients. As a result of the use of immunosuppressive agents, transplant recipients are not only predisposed to primary tub ... Full text Link to item Cite

Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation.

Journal article J Clin Invest · June 1995 Previous work has shown that the Pseudomonas-derived protease, pseudomonas elastase (PAE), can modify transferrin to form iron complexes capable of catalyzing the formation of hydroxyl radical (.OH) from neutrophil (PMN)-derived superoxide (.O2-) and hydro ... Full text Link to item Cite