Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Cincinnati, College of Medicine 2005
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2018 - 2020
  • Assistant Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2011 - 2018
• Research
• 

  Selected Grants

  • COTA Trauma Fellowship 2019-2020 awarded by Center for Orthopaedic Trauma Advancement 2019 - 2020
  • Supracondylar distal femur fractures awarded by St. Louis University 2016 - 2019
  • Hip Fracture Evaluation Alternatives of Total Hip vs Hemi-arthroplasty (HEALTH) awarded by NYU Langone Medical Center 2016 - 2019
  • Fresh Tissue Lab Agreement awarded by DePuy Synthes Companies 2016
  • Fresh Tissue Lab Agreement awarded by Smith & Nephew, Inc 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Patterson, Joseph T., Nathan N. O’Hara, Daniel O. Scharfstein, Renan C. Castillo, Robert V. O’Toole, Reza Firoozabadi, and Reza METRC. “Do superficial infections increase the risk of deep infections in tibial plateau and plafond fractures?” Eur J Orthop Surg Traumatol, November 23, 2022. https://doi.org/10.1007/s00590-022-03438-1.
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    • Carlini, Anthony R., Susan C. Collins, Elena D. Staguhn, Katherine P. Frey, Robert V. O’Toole, Kristin R. Archer, William T. Obremskey, et al. “Streamlining Trauma Research Evaluation With Advanced Measurement (STREAM) Study: Implementation of the PROMIS Toolbox Within an Orthopaedic Trauma Clinical Trials Consortium.” J Orthop Trauma 36, no. Suppl 1 (January 1, 2022): S33–39. https://doi.org/10.1097/BOT.0000000000002291.
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    • Sprague, S., P. Guyatt, S. Bzovsky, U. Nguyen, M. Bhandari, L. Thabane, B. Petrisor, et al. “Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study.” Pilot and Feasibility Studies 7, no. 1 (December 1, 2021). https://doi.org/10.1186/s40814-021-00800-8.
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    • Major Extremity Trauma Research Consortium (METRC), Beth H. “Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET).” The Journal of Bone and Joint Surgery. American Volume 103, no. 17 (September 2021): 1588–97. https://doi.org/10.2106/jbjs.20.01320.
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    • Pechero, G., B. Pfaff, M. Rao, D. Pogorzelski, P. McKay, E. Spicer, A. Howe, et al. “Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials.” Contemporary Clinical Trials Communications 22 (June 1, 2021). https://doi.org/10.1016/j.conctc.2021.100787.
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    • Major Extremity Trauma Research Consortium (METRC), Mary, Robert V. O’Toole, Manjari Joshi, Anthony R. Carlini, Clinton K. Murray, Lauren E. Allen, Yanjie Huang, et al. “Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.” Jama Surg 156, no. 5 (May 1, 2021): e207259. https://doi.org/10.1001/jamasurg.2020.7259.
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    • Pogorzelski, D., U. Nguyen, P. McKay, L. Thabane, M. Camara, L. Ramsey, R. Seymour, et al. “Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial.” Contemporary Clinical Trials Communications 21 (March 1, 2021). https://doi.org/10.1016/j.conctc.2021.100730.
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    • Tornetta, Paul, Gregory J. Della Rocca, Saam Morshed, Clifford Jones, Diane Heels-Ansdell, Sheila Sprague, Brad Petrisor, et al. “Risk Factors Associated With Infection in Open Fractures of the Upper and Lower Extremities.” J Am Acad Orthop Surg Glob Res Rev 4, no. 12 (December 8, 2020): e20.00188. https://doi.org/10.5435/JAAOSGlobal-D-20-00188.
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    • Sprague, Sheila, Taryn Scott, Shannon Dodds, David Pogorzelski, Paula McKay, Anthony D. Harris, Amber Wood, et al. “Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials.” Trials 21, no. 1 (September 30, 2020): 821. https://doi.org/10.1186/s13063-020-04767-4.
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    • Dagher, Michael, Felicia Ruffin, Steven Marshall, Magdalena Taracila, Robert A. Bonomo, Rachel Reilly, Vance G. Fowler, and Joshua T. Thaden. “Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol.” Open Forum Infect Dis 7, no. 5 (May 2020): ofaa150. https://doi.org/10.1093/ofid/ofaa150.
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    • Shea, Phelan, Nathan N. O’Hara, Sheila A. Sprague, Mohit Bhandari, Brad A. Petrisor, Kyle J. Jeray, Min Zhan, Gerard P. Slobogean, Raymond A. Pensy, and Raymond A. Fluid Lavage in Open Wounds Investigators. “Wound Surface Area as a Risk Factor for Flap Complications among Patients with Open Fractures.” Plast Reconstr Surg 142, no. 1 (July 2018): 228–36. https://doi.org/10.1097/PRS.0000000000004418.
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    • Sprague, Sheila, Paul Tornetta, Gerard P. Slobogean, Nathan N. O’Hara, Paula McKay, Brad Petrisor, Kyle J. Jeray, et al. “Are large clinical trials in orthopaedic trauma justified?” Bmc Musculoskelet Disord 19, no. 1 (April 20, 2018): 124. https://doi.org/10.1186/s12891-018-2029-3.
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    • Adams, Samuel B., Rachel M. Reilly, Janet L. Huebner, Virginia B. Kraus, and Dana L. Nettles. “Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.” Foot Ankle Int 38, no. 10 (October 2017): 1055–63. https://doi.org/10.1177/1071100717728234.
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    • Bosse, Michael J., David Teague, Lisa Reider, Joshua L. Gary, Saam Morshed, Rachel B. Seymour, James Toledano, et al. “Outcomes After Severe Distal Tibia, Ankle, and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation (OUTLET).” J Orthop Trauma 31 Suppl 1 (April 2017): S48–55. https://doi.org/10.1097/BOT.0000000000000799.
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    • OʼToole, Robert V., Manjari Joshi, Anthony R. Carlini, Clinton K. Murray, Lauren E. Allen, Daniel O. Scharfstein, Joshua L. Gary, Michael J. Bosse, Renan C. Castillo, and Renan C. METRC. “Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter, Randomized, Controlled Trial (VANCO Study).” J Orthop Trauma 31 Suppl 1 (April 2017): S18–24. https://doi.org/10.1097/BOT.0000000000000801.
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    • Reilly, Rachel M., Thomas Robertson, Robert V. O’Toole, and Theodore T. Manson. “Are antibiotic nails effective in the treatment of infected tibial fractures?” Injury 47, no. 12 (December 2016): 2809–15. https://doi.org/10.1016/j.injury.2016.10.010.
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    • Huebner, J. L., B. D. Furman, M. J. Manson, K. A. Kimmerling, S. A. Olson, F. Guilak, L. E. DeFrate, R. D. Zura, R. M. Reilly, and V. B. Kraus. “Acute inflammatory response after severe joint injury potentially involved in the development of post-traumatic arthritis.” Osteoarthritis and Cartilage 24 (April 2016): S79–80. https://doi.org/10.1016/j.joca.2016.01.169.
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    • Furman, Bridgette D., Kelly A. Kimmerling, Robert D. Zura, Rachel M. Reilly, Michal P. Zlowodzki, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines.” Arthritis Rheumatol 67, no. 5 (May 2015): 1234–39. https://doi.org/10.1002/art.39064.
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    • Reilly, Rachel M., Peter J. Stern, and Charles A. Goldfarb. “A retrospective review of the management of Dupuytren's nodules.” J Hand Surg Am 30, no. 5 (September 2005): 1014–18. https://doi.org/10.1016/j.jhsa.2005.03.005.
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    • Reilly, R. M., T. Robertson, R. V. O’Toole, and T. T. Manson. “Are antibiotic nails effective in the treatment of infected tibial fractures? Injury 2016;47:2809-2815.” Injury 2016, no. 47 (n.d.): 2809–15.

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