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RAJESHKUMAR MANNE

Medical Instructor in the Department of Pathology
Pathology
210 Research Drive, GSRB-II, Room 4009, Durham, NC 27710
210 Research Drive, GSRB-II, Room 4035, Durham, NC 27710

Current Duke Appointments & Affiliations


Medical Instructor in the Department of Pathology · 2026 - Present Pathology, Clinical Science Departments
Medical Instructor in the Department of Pathology Pathology, Clinical Science Departments

Recent Scholarly Works


CD36-mediated endocytosis of proteolysis-targeting chimeras.

Journal article Cell · June 12, 2025 Passive diffusion does not explain why many drugs are too large and/or too polar for rule-breaking membrane penetration, such as proteolysis-targeting chimeras (PROTACs, generally of a molecular weight > 800 Da). Here, using biotinylated chemical-probe-bas ... Full text Open Access Link to item Cite

ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression.

Journal article Nat Cell Biol · May 2025 MPC1 and MPC2 are two well-known components of the mitochondrial pyruvate carrier (MPC) complex maintaining MPC activity to transport pyruvate into mitochondria for tricarboxylic acid (TCA) cycle entry in mammalian cells. It is currently unknown whether th ... Full text Open Access Link to item Cite
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Recent Grants


Identification and inhibition of the novel downstream effectors of mutant Ras for mutant Ras-driven cancer targeting

ResearchResearch Associate · Awarded by National Institutes of Health · 2026 - 2031

Regulation of oncogenic Akt ubiquitination and activation by diverse mechanisms in cancer

ResearchPostdoctoral Associate · Awarded by National Cancer Institute · 2023 - 2026

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Education


National Centre for Cell Science (India) · 2017 Ph.D.