Current Appointments & Affiliations
Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics
·
2025 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency.
Journal Article Nucleic Acids Res · February 8, 2025 Lung cancer sequencing efforts have uncovered mutational signatures that are attributed to exposure to the cigarette smoke carcinogen benzo[a]pyrene. Benzo[a]pyrene metabolizes in cells to benzo[a]pyrene diol epoxide (BPDE) and reacts with guanine nucleoti ... Full text Link to item CiteHigh UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma.
Journal Article Proc Natl Acad Sci U S A · January 23, 2024 Noncoding mutation hotspots have been identified in melanoma and many of them occur at the binding sites of E26 transformation-specific (ETS) proteins; however, their formation mechanism and functional impacts are not fully understood. Here, we used UV (Ul ... Full text Link to item CiteHigh-throughput data and modeling reveal insights into the mechanisms of cooperative DNA-binding by transcription factor proteins.
Journal Article Nucleic Acids Res · November 27, 2023 Cooperative DNA-binding by transcription factor (TF) proteins is critical for eukaryotic gene regulation. In the human genome, many regulatory regions contain TF-binding sites in close proximity to each other, which can facilitate cooperative interactions. ... Full text Link to item CiteRecent Grants
ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028Collaborative Research: NSF/MCB-BSF: The effect of transcription factor binding on UV lesion accumulation
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2023 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027View All Grants
Education, Training & Certifications
Duke University ·
2009
Ph.D.