Current Duke Appointments & Affiliations
Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics
·
2025 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Recent Scholarly Works
UV irradiation alters TFAM binding specificity and compaction of DNA.
Journal article Elife · March 25, 2026 Mitochondria lack nucleotide excision repair; however, mitochondrial DNA (mtDNA) is resistant to mutation accumulation following DNA damage. These observations suggest additional damage sensing or protection mechanisms. Transcription Factor A, Mitochondria ... Full text Link to item CiteHigh-throughput characterization of transcription factors that modulate UV damage formation and repair at single-nucleotide resolution.
Journal article Res Sq · December 10, 2025 Genomic studies have revealed elevated damage and mutation rates in active transcription factor (TF) binding sites in UV-linked cancers. Previous investigations into the relationship between TF activity and UV DNA damage have primarily focused on select TF ... Full text Link to item CiteComputational design of sequence-specific DNA-binding proteins.
Journal article Nat Struct Mol Biol · November 2025 Sequence-specific DNA-binding proteins (DBPs) have critical roles in biology and biotechnology and there has been considerable interest in the engineering of DBPs with new or altered specificities for genome editing and other applications. While there has ... Full text Link to item CiteRecent Grants
Genetics and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031Collaborative Research: NSF/MCB-BSF: The effect of transcription factor binding on UV lesion accumulation
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2023 - 2027Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome
ResearchTraining Faculty · Awarded by National Cancer Institute · 2020 - 2026View All Grants
Education
Duke University ·
2009
Ph.D.