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Raluca Mihaela Gordan

Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Integrative Genomics
Duke Box 3382, Durham, NC 27710
101 Science Drive, 2179 CIEMAS, Durham, NC 27708

Current Appointments & Affiliations


Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics · 2025 - Present Biostatistics & Bioinformatics, Division of Integrative Genomics, Biostatistics & Bioinformatics
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published January 13, 2021
A Computer Scientist Investigating the Source Code of Life
Published October 21, 2020
Transcription Factors May Inadvertently Lock in DNA Mistakes
Published February 18, 2014
Five Science Faculty Win Sloan Fellowships

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Recent Publications


The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency.

Journal Article Nucleic Acids Res · February 8, 2025 Lung cancer sequencing efforts have uncovered mutational signatures that are attributed to exposure to the cigarette smoke carcinogen benzo[a]pyrene. Benzo[a]pyrene metabolizes in cells to benzo[a]pyrene diol epoxide (BPDE) and reacts with guanine nucleoti ... Full text Link to item Cite

High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma.

Journal Article Proc Natl Acad Sci U S A · January 23, 2024 Noncoding mutation hotspots have been identified in melanoma and many of them occur at the binding sites of E26 transformation-specific (ETS) proteins; however, their formation mechanism and functional impacts are not fully understood. Here, we used UV (Ul ... Full text Link to item Cite

High-throughput data and modeling reveal insights into the mechanisms of cooperative DNA-binding by transcription factor proteins.

Journal Article Nucleic Acids Res · November 27, 2023 Cooperative DNA-binding by transcription factor (TF) proteins is critical for eukaryotic gene regulation. In the human genome, many regulatory regions contain TF-binding sites in close proximity to each other, which can facilitate cooperative interactions. ... Full text Link to item Cite
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Recent Grants


ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses

ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028

Collaborative Research: NSF/MCB-BSF: The effect of transcription factor binding on UV lesion accumulation

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2023 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

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Education, Training & Certifications


Duke University · 2009 Ph.D.

External Links


Gordan Lab Website