Raul Salinas

Preprint · May 12, 2026 DNA is not merely a linear code of bases, but a mechanically constrained polymer whose backbone continuity restricts the conformations accessible during protein recognition. Yet, although base-sequence preferences have been extensively mapped across human ... Full text Link to item Cite

A phage encoded GapR nucleoid-associated protein binds a bacterial GapR to deactivate it via an inhibitory hetero-oligomer mechanism

Preprint · March 12, 2026 AbstractNucleoid associated proteins (NAPs) play key roles in bacterial chromosome organization and cellular processes. Recent work identified GapR as an essential NAP that is ubiquitous in α-proteobacteria. GapR structur ... Full text Cite

Systematic DNA nicking reveals the structural logic of protein recognition.

Preprint · July 4, 2025 Transcription factors (TFs) bind to specific genomic sites to regulate gene expression1,2. These interactions almost universally require DNA deformation and the accumulation of local mechanical strain within the double helix. As a result, TF-DNA recognitio ... Full text Link to item Cite