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Raul Zavaliev

Affiliate
Biology

Selected Publications


NPR1, a key immune regulator for plant survival under biotic and abiotic stresses.

Journal Article Molecular cell · January 2024 Nonexpressor of pathogenesis-related genes 1 (NPR1) was discovered in Arabidopsis as an activator of salicylic acid (SA)-mediated immune responses nearly 30 years ago. How NPR1 confers resistance against a variety of pathogens and stresses has been extensi ... Full text Cite

Seeing is believing: Understanding functions of NPR1 and its paralogs in plant immunity through cellular and structural analyses.

Journal Article Curr Opin Plant Biol · June 2023 In the past 30 years, our knowledge of how nonexpressor of pathogenesis-related genes 1 (NPR1) serves as a master regulator of salicylic acid (SA)-mediated immune responses in plants has been informed largely by molecular genetic studies. Despite extensive ... Full text Link to item Cite

Structural basis of NPR1 in activating plant immunity.

Journal Article Nature · May 2022 NPR1 is a master regulator of the defence transcriptome induced by the plant immune signal salicylic acid1-4. Despite the important role of NPR1 in plant immunity5-7, understanding of its regulatory mechanisms has been hindered by a lack of structural info ... Full text Link to item Cite

Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response.

Journal Article Cell · September 2020 In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, which is restricted by NPR1, an activator of systemic acquired resistance. However, the biochemical activities of NPR1 enabling it to promote defense and restrict c ... Full text Cite

Membrane Trafficking in Plant Immunity.

Journal Article Molecular plant · August 2017 Plants employ sophisticated mechanisms to interact with pathogenic as well as beneficial microbes. Of those, membrane trafficking is key in establishing a rapid and precise response. Upon interaction with pathogenic microbes, surface-localized immune recep ... Full text Open Access Cite

Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal.

Journal Article Plant physiology · October 2016 Plasmodesmata (Pd) are membranous channels that serve as a major conduit for cell-to-cell communication in plants. The Pd-associated β-1,3-glucanase (BG_pap) and CALLOSE BINDING PROTEIN1 (PDCB1) were identified as key regulators of Pd conductivity. Both ar ... Full text Cite

Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses.

Journal Article Cell host & microbe · August 2015 NPR1, a master regulator of basal and systemic acquired resistance in plants, confers immunity through a transcriptional cascade, which includes transcription activators (e.g., TGA3) and repressors (e.g., WRKY70), leading to the massive induction of antimi ... Full text Cite

Imaging callose at plasmodesmata using aniline blue: quantitative confocal microscopy.

Chapter · January 2015 Callose (β-1,3-glucan) is both structural and functional component of plasmodesmata (Pd). The turnover of callose at Pd controls the cell-to-cell diffusion rate of molecules through Pd. An accurate assessment of changes in levels of Pd-associated callose h ... Full text Cite

Subcellular dynamics and role of Arabidopsis β-1,3-glucanases in cell-to-cell movement of tobamoviruses.

Journal Article Molecular plant-microbe interactions : MPMI · September 2013 β-1,3-Glucanases (BG) have been implicated in enhancing virus spread by degrading callose at plasmodesmata (Pd). Here, we investigate the role of Arabidopsis BG in tobamovirus spread. During Turnip vein clearing virus infection, the transcription of two pa ... Full text Cite

Biology of callose (β-1,3-glucan) turnover at plasmodesmata.

Journal Article Protoplasma · January 2011 The turnover of callose (β-1,3-glucan) within cell walls is an essential process affecting many developmental, physiological and stress related processes in plants. The deposition and degradation of callose at the neck region of plasmodesmata (Pd) is one o ... Full text Cite

The constitutive expression of Arabidopsis plasmodesmal-associated class 1 reversibly glycosylated polypeptide impairs plant development and virus spread.

Journal Article Journal of experimental botany · January 2010 Arabidopsis class 1 reversibly glycosylated polypeptides (C1RGPs) were shown to be plasmodesmal-associated proteins. Transgenic tobacco (Nicotiana tabacum) plants constitutively expressing GFP tagged AtRGP2 under the control of the CaMV 35S promoter are st ... Full text Cite