Scholars@Duke

• Recognition
• 

  In the News

  • MAR 30, 2020

    Postdoctoral Associate Awarded Prestigious Grant

  • OCT 29, 2019

    Dr. Velagapudi Receives DIBS Germinator Award
• Research
• 

  Selected Grants

  • Understanding the role of senescence on post-operative neuroinflammation awarded by National Institutes of Health 2022 - 2025
  • Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2023
  • TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc 2020 - 2021
  • Profiling postoperative neuroinflammation in a mouse model of delirium superimposed on Parkinson's disease. awarded by  Harvard University 2020 - 2021
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Miller-Rhodes, Patrick, Herman Li, Ravikanth Velagapudi, Wesley Chiang, Niccolò Terrando, and Harris A. Gelbard. “URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.” Faseb J 36, no. 6 (June 2022): e22343. https://doi.org/10.1096/fj.202200184RR.
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    • Zhang, Zhiquan, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, and Niccolò Terrando. “Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.” Front Immunol 13 (2022): 856254. https://doi.org/10.3389/fimmu.2022.856254.
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    • Velagapudi, R., W. J. Huffman, X. Zhang, C. A. Colton, and N. Terrando. “Percutaneous vagus nerve stimulation modulates glia activity and rescues acute Aβ deposition in a mouse model of delirium superimposed on dementia.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association 17 (December 1, 2021): e056571. https://doi.org/10.1002/alz.056571.
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    • Yang, Ting, Ravikanth Velagapudi, and Niccolò Terrando. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.” Nat Immunol 21, no. 11 (November 2020): 1319–26. https://doi.org/10.1038/s41590-020-00812-1.
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    • Wang, Ping, Ravikanth Velagapudi, Cuicui Kong, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Miles Berger, Harris A. Gelbard, Carol A. Colton, and Niccolò Terrando. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement 16, no. 5 (May 2020): 734–49. https://doi.org/10.1002/alz.12064.
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    • Velagapudi, Ravikanth, Faisal Jamshaid, Izabela Lepiarz, Folashade O. Katola, Karl Hemming, and Olumayokun A. Olajide. “The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but-3-en-1-yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia.” Int Immunopharmacol 77 (December 2019): 105951. https://doi.org/10.1016/j.intimp.2019.105951.
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    • Velagapudi, Ravikanth, Ayokulehin M. Kosoko, and Olumayokun A. Olajide. “Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin.” Cell Mol Neurobiol 39, no. 8 (November 2019): 1187–1200. https://doi.org/10.1007/s10571-019-00713-4.
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    • Velagapudi, Ravikanth, Izabela Lepiarz, Abdelmeneim El-Bakoush, Folashade O. Katola, Harsharan Bhatia, Bernd L. Fiebich, and Olumayokun A. Olajide. “Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells.” Mol Nutr Food Res 63, no. 10 (May 2019): e1801237. https://doi.org/10.1002/mnfr.201801237.
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    • Liu, Jie, Feng Zhang, Velagapudi Ravikanth, Olumayokun A. Olajide, Cen Li, and Li-Xin Wei. “Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity.” Evid Based Complement Alternat Med 2019 (2019): 1697804. https://doi.org/10.1155/2019/1697804.
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    • Velagapudi, Ravikanth, Saraswathi Subramaniyan, Chao Xiong, Fiona Porkka, Ramona M. Rodriguiz, William C. Wetsel, and Niccolò Terrando. “Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.” Front Immunol 10 (2019): 2675. https://doi.org/10.3389/fimmu.2019.02675.
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    • Velagapudi, Ravikanth, Abdelmeneim El-Bakoush, and Olumayokun A. Olajide. “Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.” Mol Neurobiol 55, no. 10 (October 2018): 8103–23. https://doi.org/10.1007/s12035-018-0975-2.
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    • Velagapudi, Ravikanth, Olusiji O. Ajileye, Uchechukwu Okorji, Priya Jain, Mutalib A. Aderogba, and Olumayokun A. Olajide. “Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells.” Phytother Res 32, no. 10 (October 2018): 1957–66. https://doi.org/10.1002/ptr.6122.
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    • Velagapudi, Ravikanth, Abdelmeneim El-Bakoush, Izabela Lepiarz, Folashade Ogunrinade, and Olumayokun A. Olajide. “AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.” Mol Cell Biochem 435, no. 1–2 (November 2017): 149–62. https://doi.org/10.1007/s11010-017-3064-3.
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    • Velagapudi, Ravikanth, Asit Kumar, Harsharan S. Bhatia, Abdelmeneim El-Bakoush, Izabela Lepiarz, Bernd L. Fiebich, and Olumayokun A. Olajide. “Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.” Int Immunopharmacol 48 (July 2017): 17–29. https://doi.org/10.1016/j.intimp.2017.04.018.
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    • Okorji, Uchechukwu P., Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Bernd L. Fiebich, and Olumayokun A. Olajide. “Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.” Mol Neurobiol 53, no. 9 (November 2016): 6426–43. https://doi.org/10.1007/s12035-015-9543-1.
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    • Velagapudi, Ravikanth, Gina Baco, Sunjeet Khela, Uchechukwu Okorji, and Olumayokun Olajide. “Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.” Eur J Nutr 55, no. 4 (June 2016): 1653–60. https://doi.org/10.1007/s00394-015-0984-0.
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    • Onasanwo, Samuel A., Ravikanth Velagapudi, Abdelmeneim El-Bakoush, and Olumayokun A. Olajide. “Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism.” Mol Cell Biochem 414, no. 1–2 (March 2016): 23–36. https://doi.org/10.1007/s11010-016-2655-8.
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    • Velagapudi, Ravikanth, Mutallib Aderogba, and Olumayokun A. Olajide. “Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia.” Biochim Biophys Acta 1840, no. 12 (December 2014): 3311–19. https://doi.org/10.1016/j.bbagen.2014.08.008.
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    • Olajide, Olumayokun A., Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji, and Bernd L. Fiebich. “Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.” Mol Nutr Food Res 58, no. 9 (September 2014): 1843–51. https://doi.org/10.1002/mnfr.201400163.
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    • Olajide, Olumayokun A., Ravikanth Velagapudi, Uchechukwu P. Okorji, Satyajit D. Sarker, and Bernd L. Fiebich. “Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells.” J Ethnopharmacol 152, no. 2 (March 14, 2014): 377–83. https://doi.org/10.1016/j.jep.2014.01.027.
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  • Conference Papers

    • Velagapudi, Ravikanth, and Olumayokun Olajide. “Neuroprotective Effects of Thymoquinone in A beta(1-42)-induced Toxicity in SK-N-SH Neuronal Cells.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.
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