Scholars@Duke

• Recognition
• 

  In the News

  • MAR 30, 2020

    Postdoctoral Associate Awarded Prestigious Grant

  • OCT 29, 2019

    Dr. Velagapudi Receives DIBS Germinator Award
• Research
• 

  Selected Grants

  • Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2022
  • TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc 2020 - 2021
  • Profiling postoperative neuroinflammation in a mouse model of delirium superimposed on Parkinson's disease. awarded by  Harvard University 2020 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yang, Ting, Ravikanth Velagapudi, and Niccolò Terrando. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.” Nat Immunol 21, no. 11 (November 2020): 1319–26. https://doi.org/10.1038/s41590-020-00812-1.
       Full Text  Link to Item
    • Wang, Ping, Ravikanth Velagapudi, Cuicui Kong, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Miles Berger, Harris A. Gelbard, Carol A. Colton, and Niccolò Terrando. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement 16, no. 5 (May 2020): 734–49. https://doi.org/10.1002/alz.12064.
       Full Text  Link to Item
    • Velagapudi, Ravikanth, Faisal Jamshaid, Izabela Lepiarz, Folashade O. Katola, Karl Hemming, and Olumayokun A. Olajide. “The tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but-3-en-1-yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways in BV-2 microglia.” International Immunopharmacology 77 (December 2019): 105951. https://doi.org/10.1016/j.intimp.2019.105951.
       Full Text
    • Velagapudi, Ravikanth, Ayokulehin M. Kosoko, and Olumayokun A. Olajide. “Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin.” Cellular and Molecular Neurobiology 39, no. 8 (November 2019): 1187–1200. https://doi.org/10.1007/s10571-019-00713-4.
       Full Text
    • Velagapudi, Ravikanth, Izabela Lepiarz, Abdelmeneim El-Bakoush, Folashade O. Katola, Harsharan Bhatia, Bernd L. Fiebich, and Olumayokun A. Olajide. “Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells.” Molecular Nutrition & Food Research 63, no. 10 (May 2019): e1801237. https://doi.org/10.1002/mnfr.201801237.
       Full Text
    • Liu, Jie, Feng Zhang, Velagapudi Ravikanth, Olumayokun A. Olajide, Cen Li, and Li-Xin Wei. “Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity.” Evidence Based Complementary and Alternative Medicine : Ecam 2019 (January 10, 2019): 1697804. https://doi.org/10.1155/2019/1697804.
       Full Text
    • Velagapudi, Ravikanth, Saraswathi Subramaniyan, Chao Xiong, Fiona Porkka, Ramona M. Rodriguiz, William C. Wetsel, and Niccolò Terrando. “Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.” Front Immunol 10 (2019): 2675. https://doi.org/10.3389/fimmu.2019.02675.
       Full Text  Link to Item
    • Velagapudi, Ravikanth, Abdelmeneim El-Bakoush, and Olumayokun A. Olajide. “Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.” Molecular Neurobiology 55, no. 10 (October 2018): 8103–23. https://doi.org/10.1007/s12035-018-0975-2.
       Full Text
    • Velagapudi, Ravikanth, Olusiji O. Ajileye, Uchechukwu Okorji, Priya Jain, Mutalib A. Aderogba, and Olumayokun A. Olajide. “Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells.” Phytotherapy Research : Ptr 32, no. 10 (October 2018): 1957–66. https://doi.org/10.1002/ptr.6122.
       Full Text
    • Velagapudi, Ravikanth, Abdelmeneim El-Bakoush, Izabela Lepiarz, Folashade Ogunrinade, and Olumayokun A. Olajide. “AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.” Molecular and Cellular Biochemistry 435, no. 1–2 (November 2017): 149–62. https://doi.org/10.1007/s11010-017-3064-3.
       Full Text
    • Velagapudi, Ravikanth, Asit Kumar, Harsharan S. Bhatia, Abdelmeneim El-Bakoush, Izabela Lepiarz, Bernd L. Fiebich, and Olumayokun A. Olajide. “Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.” International Immunopharmacology 48 (July 2017): 17–29. https://doi.org/10.1016/j.intimp.2017.04.018.
       Full Text
    • Okorji, Uchechukwu P., Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Bernd L. Fiebich, and Olumayokun A. Olajide. “Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.” Molecular Neurobiology 53, no. 9 (November 2016): 6426–43. https://doi.org/10.1007/s12035-015-9543-1.
       Full Text
    • Velagapudi, Ravikanth, Gina Baco, Sunjeet Khela, Uchechukwu Okorji, and Olumayokun Olajide. “Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.” European Journal of Nutrition 55, no. 4 (June 2016): 1653–60. https://doi.org/10.1007/s00394-015-0984-0.
       Full Text
    • Onasanwo, Samuel A., Ravikanth Velagapudi, Abdelmeneim El-Bakoush, and Olumayokun A. Olajide. “Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism.” Molecular and Cellular Biochemistry 414, no. 1–2 (March 2016): 23–36. https://doi.org/10.1007/s11010-016-2655-8.
       Full Text
    • Velagapudi, Ravikanth, Mutallib Aderogba, and Olumayokun A. Olajide. “Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia.” Biochimica Et Biophysica Acta 1840, no. 12 (December 2014): 3311–19. https://doi.org/10.1016/j.bbagen.2014.08.008.
       Full Text
    • Olajide, Olumayokun A., Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji, and Bernd L. Fiebich. “Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.” Molecular Nutrition & Food Research 58, no. 9 (September 2014): 1843–51. https://doi.org/10.1002/mnfr.201400163.
       Full Text
    • Olajide, Olumayokun A., Ravikanth Velagapudi, Uchechukwu P. Okorji, Satyajit D. Sarker, and Bernd L. Fiebich. “Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells.” Journal of Ethnopharmacology 152, no. 2 (March 2014): 377–83. https://doi.org/10.1016/j.jep.2014.01.027.
       Full Text

  • Conference Papers

    • Velagapudi, Ravikanth, and Olumayokun Olajide. “Neuroprotective Effects of Thymoquinone in A beta(1-42)-induced Toxicity in SK-N-SH Neuronal Cells.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.