Scholars@Duke
Rebecca Beerman

Rebecca Beerman

Dir, Quality
Duke University
rebecca.beerman@duke.edu
MSRB II Building, Rm 1089, 2 Genome Court, Box 102800, Durham, NC 27710
2 Genome Court, MSRB II Building. Rm 1089, Durham, NC 27710

Scholarly Works - Journal articles

Implementation of a responsible conduct of research education program at Duke University School of Medicine.

Journal article Account Res · July 2019 Academic medical centers rarely require all of their research faculty and staff to participate in educational programs on the responsible conduct of research (RCR). There is also little published evidence of RCR programs addressing high-profile, internal c ... Full text Link to item Cite

Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.

Journal article Elife · January 29, 2019 Mycobacterium tuberculosis is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by multi-drug-resistant strains. Host-directed therapies have been proposed ... Full text Link to item Cite

Infection-Induced Vascular Permeability Aids Mycobacterial Growth.

Journal article J Infect Dis · March 1, 2017 Pathogenic mycobacteria trigger formation of organized granulomas. As granulomas mature, they induce angiogenesis and vascular permeability. Here, in a striking parallel to tumor pro-angiogenic signaling, we identify angiopoietin-2 (ANG-2) induction as an ... Full text Link to item Cite

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.

Journal article Immunity · October 18, 2016 Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flat ... Full text Link to item Cite

Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.

Journal article Cell Rep · December 15, 2015 Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remain challenging. Using light-sheet micro ... Full text Open Access Link to item Cite

Epigenetic control of intestinal barrier function and inflammation in zebrafish.

Journal article Proc Natl Acad Sci U S A · March 3, 2015 The intestinal epithelium forms a barrier protecting the organism from microbes and other proinflammatory stimuli. The integrity of this barrier and the proper response to infection requires precise regulation of powerful immune homing signals such as tumo ... Full text Link to item Cite

Interception of host angiogenic signalling limits mycobacterial growth.

Journal article Nature · January 29, 2015 Pathogenic mycobacteria induce the formation of complex cellular aggregates called granulomas that are the hallmark of tuberculosis. Here we examine the development and consequences of vascularization of the tuberculous granuloma in the zebrafish-Mycobacte ... Full text Open Access Link to item Cite

Interception of host angiogenic signalling limits mycobacterial growth

Journal article Nature · January 29, 2015 Pathogenic mycobacteria induce the formation of complex cellular aggregates called granulomas that are the hallmark of tuberculosis. Here we examine the development and consequences of vascularization of the tuberculous granuloma in the zebrafish-Mycobacte ... Full text Cite

The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish.

Journal article PLoS One · 2015 Transgenic labeling of innate immune cell lineages within the larval zebrafish allows for real-time, in vivo analyses of microbial pathogenesis within a vertebrate host. To date, labeling of zebrafish macrophages has been relatively limited, with the most ... Full text Open Access Link to item Cite

A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms.

Journal article Neuroscience · May 2011 Fragile X syndrome is caused by the loss of expression of the fragile X mental retardation protein (FMRP). As a RNA binding protein, FMRP functions in translational regulation, localization, and stability of its neuronal target transcripts. The Drosophila ... Full text Cite

Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects.

Journal article PloS one · October 2009 Fragile X Syndrome is caused by the silencing of the Fragile X Mental Retardation gene (FMR1). Regulating dosage of FMR1 levels is critical for proper development and function of the nervous system and germ line, but the pathways responsible for maintainin ... Full text Cite

Cell-type specific regulation of gene expression by simian virus 40 T antigens.

Journal article Virology · March 2009 SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumo ... Full text Cite