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Rebecca W Knackstedt

Assistant Professor of Surgery
Surgery, Plastic, Maxillofacial, and Oral Surgery
Baker House 103, DUMC 3974, Durham, NC 27710

Selected Publications


Optimizing Blood Loss and Management in Craniosynostosis Surgery: A Systematic Review of Outcomes Over the Last 40 Years.

Journal Article Cleft Palate Craniofac J · December 2023 Surgical correction of craniosynostosis can involve significant blood loss. Rates of allogenic blood transfusion have been reported to approach 100%. Multiple interventions have been described to reduce blood loss and transfusion requirements. The aim of t ... Full text Link to item Cite

The Influence of Age on Complications After Correction of Congenital Breast Deformities: A National Analysis of the Pediatric and Adult NSQIP Data Sets.

Journal Article Aesthet Surg J · October 13, 2023 BACKGROUND: Timing of surgical intervention is controversial among patients seeking correction of congenital breast deformities. OBJECTIVES: This study aimed to assess the influence of age on 30-day complications and unplanned healthcare utilization after ... Full text Link to item Cite

Development of a Risk Prediction Model for Complications Following Forehead Flaps for Nasal and Periorbital Reconstruction.

Journal Article J Craniofac Surg · January 2023 BACKGROUND: Forehead flaps are a workhorse for nasal reconstruction, but complications occur in up to 30% of patients and risk factors are not well characterized. This study aimed to identify risk factors for complications, and provide clinicians a method ... Full text Link to item Cite

Sensory Restoration in Abdominally Based Free Flaps for Breast Reconstruction Using Nerve Allograft.

Journal Article Plast Reconstr Surg · January 1, 2023 BACKGROUND: Neurotization in breast reconstruction can be performed with the aid of nerve grafts and conduits to decrease the tedious dissection and overcome size mismatch. However, there has yet to be a formal analysis of this approach. The goal of this s ... Full text Link to item Cite

Current Concepts in Surgical Management of Lymphedema.

Journal Article Phys Med Rehabil Clin N Am · November 2022 The decision on whom to offer surgical interventions for lymphedema requires collaboration and input from all involved specialists and should address patients' expectations, invasiveness of procedures, and disease severity. There is no consensus on what co ... Full text Link to item Cite

Youngest Composite Full-Face Transplant: A Model for Vascularized Composite Allograft in Younger Populations.

Journal Article Ann Plast Surg · November 1, 2022 BACKGROUND: The field of face transplantation continues to evolve, with more complex defects being addressed, and, at the same time, increased outcome expectations. Given our unique long-term experience in this field, we consented one of the youngest patie ... Full text Link to item Cite

Outcomes of stage IV melanoma in the era of immunotherapy: a National Cancer Database (NCDB) analysis from 2014 to 2016.

Journal Article J Immunother Cancer · August 2022 BACKGROUND: To evaluate factors affecting the utilization of immunotherapy and to stratify results based on the approval of ipilimumab in 2011 and programmed death-1 inhibitors in 2014, an analysis of available data from the National Cancer Database (NCDB) ... Full text Link to item Cite

The Use and Technique of Sentinel Node Biopsy for Skin Cancer.

Journal Article Plast Reconstr Surg · May 1, 2022 LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the indications for and prognostic value of sentinel lymph node biopsy in skin cancer. 2. Learn the advantages and disadvantages of various modalities used a ... Full text Link to item Cite

Non-Operative Options for Loco-regional Melanoma.

Journal Article Clin Plast Surg · October 2021 Malignant melanoma is the 5th most common cancer and stage IV melanoma accounts for approximately 4% of new melanoma diagnoses in the United States. The prognosis for regionally advanced disease is poor, but there have been numerous recent advances in the ... Full text Link to item Cite

Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy Improves the Accuracy of Sentinel Lymph Node Biopsy in Melanoma.

Journal Article Plast Reconstr Surg · July 1, 2021 BACKGROUND: Despite advances in melanoma management, there remains room for improvement in the accuracy of sentinel lymph node biopsy. The authors analyzed a prospective cohort of patients with primary cutaneous melanoma who underwent sentinel lymph node b ... Full text Link to item Cite

Systemic Therapy for Head and Neck Skin Cancers

Journal Article Face · June 1, 2021 The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to im ... Full text Cite

New Developments in the Management of Cutaneous Squamous Cell Carcinoma.

Journal Article Plast Reconstr Surg · March 1, 2021 LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. List important prognostic features that affect cutaneous squamous cell carcinoma risk. 2. Summarize the changes to the AJCC Cancer Staging Manual, Eighth Edition, stagi ... Full text Link to item Cite

Optimizing Blood Loss and Management in Craniosynostosis Surgery: A Systematic Review of Outcomes Over the Last 40 Years.

Journal Article Cleft Palate Craniofac J · December 2023 Surgical correction of craniosynostosis can involve significant blood loss. Rates of allogenic blood transfusion have been reported to approach 100%. Multiple interventions have been described to reduce blood loss and transfusion requirements. The aim of t ... Full text Link to item Cite

The Influence of Age on Complications After Correction of Congenital Breast Deformities: A National Analysis of the Pediatric and Adult NSQIP Data Sets.

Journal Article Aesthet Surg J · October 13, 2023 BACKGROUND: Timing of surgical intervention is controversial among patients seeking correction of congenital breast deformities. OBJECTIVES: This study aimed to assess the influence of age on 30-day complications and unplanned healthcare utilization after ... Full text Link to item Cite

Development of a Risk Prediction Model for Complications Following Forehead Flaps for Nasal and Periorbital Reconstruction.

Journal Article J Craniofac Surg · January 2023 BACKGROUND: Forehead flaps are a workhorse for nasal reconstruction, but complications occur in up to 30% of patients and risk factors are not well characterized. This study aimed to identify risk factors for complications, and provide clinicians a method ... Full text Link to item Cite

Sensory Restoration in Abdominally Based Free Flaps for Breast Reconstruction Using Nerve Allograft.

Journal Article Plast Reconstr Surg · January 1, 2023 BACKGROUND: Neurotization in breast reconstruction can be performed with the aid of nerve grafts and conduits to decrease the tedious dissection and overcome size mismatch. However, there has yet to be a formal analysis of this approach. The goal of this s ... Full text Link to item Cite

Current Concepts in Surgical Management of Lymphedema.

Journal Article Phys Med Rehabil Clin N Am · November 2022 The decision on whom to offer surgical interventions for lymphedema requires collaboration and input from all involved specialists and should address patients' expectations, invasiveness of procedures, and disease severity. There is no consensus on what co ... Full text Link to item Cite

Youngest Composite Full-Face Transplant: A Model for Vascularized Composite Allograft in Younger Populations.

Journal Article Ann Plast Surg · November 1, 2022 BACKGROUND: The field of face transplantation continues to evolve, with more complex defects being addressed, and, at the same time, increased outcome expectations. Given our unique long-term experience in this field, we consented one of the youngest patie ... Full text Link to item Cite

Outcomes of stage IV melanoma in the era of immunotherapy: a National Cancer Database (NCDB) analysis from 2014 to 2016.

Journal Article J Immunother Cancer · August 2022 BACKGROUND: To evaluate factors affecting the utilization of immunotherapy and to stratify results based on the approval of ipilimumab in 2011 and programmed death-1 inhibitors in 2014, an analysis of available data from the National Cancer Database (NCDB) ... Full text Link to item Cite

The Use and Technique of Sentinel Node Biopsy for Skin Cancer.

Journal Article Plast Reconstr Surg · May 1, 2022 LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the indications for and prognostic value of sentinel lymph node biopsy in skin cancer. 2. Learn the advantages and disadvantages of various modalities used a ... Full text Link to item Cite

Non-Operative Options for Loco-regional Melanoma.

Journal Article Clin Plast Surg · October 2021 Malignant melanoma is the 5th most common cancer and stage IV melanoma accounts for approximately 4% of new melanoma diagnoses in the United States. The prognosis for regionally advanced disease is poor, but there have been numerous recent advances in the ... Full text Link to item Cite

Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy Improves the Accuracy of Sentinel Lymph Node Biopsy in Melanoma.

Journal Article Plast Reconstr Surg · July 1, 2021 BACKGROUND: Despite advances in melanoma management, there remains room for improvement in the accuracy of sentinel lymph node biopsy. The authors analyzed a prospective cohort of patients with primary cutaneous melanoma who underwent sentinel lymph node b ... Full text Link to item Cite

Systemic Therapy for Head and Neck Skin Cancers

Journal Article Face · June 1, 2021 The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to im ... Full text Cite

New Developments in the Management of Cutaneous Squamous Cell Carcinoma.

Journal Article Plast Reconstr Surg · March 1, 2021 LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. List important prognostic features that affect cutaneous squamous cell carcinoma risk. 2. Summarize the changes to the AJCC Cancer Staging Manual, Eighth Edition, stagi ... Full text Link to item Cite

Internal Mammary Vessels: Inframammary and Standard Approach

Chapter · January 1, 2021 The internal mammary artery and vein (IMA and IMV) are commonly utilized as recipient vessels for microsurgical breast reconstruction. While their identification and preparation has been previously described, surgical modifications and technical tips can a ... Full text Cite

Deep Inferior Epigastric Vessels

Chapter · January 1, 2021 Selection and dissection of recipient site vessels is critical for a successful free tissue transfer. This chapter describes the applied anatomy and various surgical approaches to exposing the deep inferior epigastric vessels for use as recipient in micros ... Full text Cite

The role of topical probiotics on wound healing: A review of animal and human studies.

Journal Article Int Wound J · December 2020 Pathogenic, opportunistic, and commensal bacterial coexist in the intestinal tract, and imbalances among these strains have been linked to systemic inflammation and a variety of disease states. Similarly, human skin plays an important role as an interface ... Full text Link to item Cite

Optimizing non-opioid pain control after implant-based breast reconstruction: a review of the literature and proposed pain control algorithm.

Journal Article J Plast Surg Hand Surg · December 2020 Despite the intense focus on the opioid epidemic and its known association with surgical procedures, there is a paucity of evidence-based literature on pain management in implant-based breast reconstruction (IBR). Herein, we present an updated review of th ... Full text Link to item Cite

Flap plus sub-flap irrigation and negative pressure therapy for infected extremity wounds

Journal Article Orthoplastic Surgery · December 1, 2020 Background: Infected wound reconstruction risks persistent infection and potential flap loss. Taking advantage of negative pressure wound therapy with instillation's ability to decrease bioburden, we introduce a novel paradigm “flap plus sub-flap irrigatio ... Full text Cite

Characterization of Face Transplant Candidates Evaluated at Cleveland Clinic and Algorithm to Maximize Efficacy of Screening Process.

Journal Article Ann Plast Surg · November 2020 INTRODUCTION: As a high-volume referral center for facial transplantation, we have learned significantly from the screening, evaluation, and enrollment process. This report analyzes our algorithm for the assessment of potential face transplant candidates r ... Full text Link to item Cite

Enhanced Recovery Protocol after Fronto-orbital Advancement Reduces Transfusions, Narcotic Usage, and Length of Stay

Journal Article Plastic and Reconstructive Surgery - Global Open · October 28, 2020 Background: Enhanced recovery after surgery (ERAS) protocols utilize multi-modal approaches to decrease morbidity, narcotic usage, and length of stay. In 2013, we made several changes to our perioperative approach to children undergoing complex craniofacia ... Full text Cite

Optimizing Postoperative Pain Control in Autologous Breast Reconstruction: A Systematic Review.

Journal Article J Reconstr Microsurg · September 2020 BACKGROUND:  Pain management approaches in autologous breast reconstruction have become a topic of great interest in the era of enhanced recovery after surgery protocols, as well as the opioid epidemic. The management of postoperative pain is of critical i ... Full text Link to item Cite

Advances and current concepts in reconstructive surgery for breast cancer.

Journal Article Semin Oncol · August 2020 In this article, we report on recent advancements in reconstructive care of the breast cancer patient. New developments in sensate breast reconstruction to help address the problem of numbness after mastectomy have emerged and show promise. Methods to rest ... Full text Link to item Cite

Evidence-Based Perioperative Nutrition Recommendations: Optimizing Results and Minimizing Risks.

Journal Article Plast Reconstr Surg · August 2020 Plastic surgery patients span the nutritional spectrum from generally healthy, nutritionally competent patients to inherently catabolic, nutritionally deficient, and chronic wound patients. Therefore, plastic and reconstructive surgery affords the opportun ... Full text Link to item Cite

Neurotization of the Nipple-Areola Complex during Implant-Based Reconstruction: Evaluation of Early Sensation Recovery.

Journal Article Plast Reconstr Surg · August 2020 The concept of sensate autologous breast reconstruction is not novel, and prior literature has focused mainly on sensate abdominally based breast reconstruction. The goal of this article is to present the authors' results with a novel technique performing ... Full text Link to item Cite

Utilization and impact of immunotherapy in stage IV melanoma using the National Cancer Database.

Journal Article Melanoma Res · August 2020 To evaluate factors affecting the utilization of immunotherapy and to stratify results based on the approval of ipilimumab in 2011 and PD-1 inhibitors in 2014, an analysis of available data from the National Cancer Database (NCDB) was performed. Stage IV m ... Full text Link to item Cite

The role of thermal injury on intestinal bacterial translocation and the mitigating role of probiotics: A review of animal and human studies.

Journal Article Burns · August 2020 INTRODUCTION: Burn patients represent a combination of nutritionally deplete and calorically demanding individuals who are susceptible to morbidity and mortality. A source of sepsis in thermal injury patients is the gastrointestinal tract with its interact ... Full text Link to item Cite

Congenital breast deformities: Anatomical basis and surgical approaches for optimal aesthetic outcomes.

Journal Article Breast J · July 2020 Plastic surgeons routinely encounter patients desiring correction of breast asymmetry, hypoplastic growth, or other aesthetic concerns. An appropriate recognition of congenital breast conditions is critical for plastic surgeons. Without consideration of un ... Full text Link to item Cite

Technical considerations in nonreconstructive mastectomy patients.

Journal Article Breast J · April 2020 BACKGROUND: Not all women undergo post-mastectomy breast reconstruction due to medical comorbidities or personal preference. An aesthetically pleasing closure and contour of the chest wall is still desired, though may be technically difficult to achieve in ... Full text Link to item Cite

Perioperative Homeopathic Arnica and Bromelain: Current Results and Future Directions.

Journal Article Ann Plast Surg · March 2020 INTRODUCTION: Arnica and bromelain, two of the most widely recommended homeopathic medications to improve perioperative outcomes, have yet to be widely adopted by allopathic practitioners. A significant barrier to utilization of herbal medications by allop ... Full text Link to item Cite

Collaboration between breast and reconstructive surgery in optimizing outcomes for women with breast cancer.

Journal Article Breast J · January 2020 Performing successful breast reconstruction after mastectomy requires communication and collaboration between the breast and reconstruction surgery teams. This allows for oncologic safety while providing esthetic and functional reconstruction. In this arti ... Full text Link to item Cite

The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies.

Journal Article Exp Dermatol · January 2020 There is increasing evidence that the intestinal microbiome plays an important role in modulating systemic inflammation and disease. Oral probiotics can modulate the intestinal microbiome and have demonstrated to be efficacious in treating topical skin con ... Full text Link to item Cite

The impact of recreational cannabinoids on peri-operative outcomes.

Journal Article J Plast Reconstr Aesthet Surg · January 2020 Full text Link to item Cite

Revisiting the "July Effect" in Plastic Surgery: New Data to Support Resident Autonomy.

Journal Article Ann Plast Surg · January 2020 BACKGROUND: The "July Effect" represents a topic of considerable interest across residency programs. This study investigated the frequency of postoperative complications following procedures with plastic surgery resident participation (all postgraduate yea ... Full text Link to item Cite

Neck Dissection and Parotidectomy for Melanoma

Chapter · January 1, 2020 Head and neck melanomas are a surgical and medical challenge. Facial anatomy and its lymphatic drainage are complex and often unpredictable. To balance oncologic clearance with morbidity, surgeons must be familiar with the anatomy of the head and neck regi ... Full text Cite

Collaboration between the breast and plastic surgeon in restoring sensation after mastectomy.

Journal Article Breast J · November 2019 Breast cancer is the most commonly diagnosed invasive cancer in women worldwide. While hypoesthesia is a known sequela after mastectomy, patients are now inquiring with renewed interest about the degree and timing of sensation after mastectomy. This is a t ... Full text Link to item Cite

Targeted breast re-innervation (TBR) for post-mastectomy pain.

Journal Article J Plast Reconstr Aesthet Surg · October 2019 Full text Link to item Cite

Challenges in Microsurgical Reconstruction for Craniofacial Osteomyelitis With Resultant Osteonecrosis.

Journal Article J Craniofac Surg · October 2019 INTRODUCTION: Chronic osteomyelitis is characterized by compromised blood supply and eventual osteonecrosis. Definitive treatment requires aggressive resection of affected bone. The resultant defect poses a unique challenge to reconstructive surgeons. Much ... Full text Link to item Cite

Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy for Sentinel Node Biopsy in Melanoma: Increasing the Sentinel Lymph Node-Positive Rate.

Journal Article Ann Surg Oncol · October 2019 INTRODUCTION: The goal of this study was to analyze patients who underwent a sentinel lymph node biopsy (SLNB) in melanoma with the combination of radioisotope lymphoscintigraphy and indocyanine green (ICG) fluorescence imaging to compare our true positive ... Full text Link to item Cite

Thromboprophylaxis in breast microvascular reconstruction: a review of the literature

Journal Article European Journal of Plastic Surgery · August 1, 2019 Microsurgical breast reconstruction patients are at an increased risk for venous thromboembolism (VTE) due to numerous risk factors. A meta-analysis focusing on anti-thrombotics in breast microsurgery has yet to be completed. We aimed to perform a systemat ... Full text Cite

Fat Grafting and the Palpable Breast Mass in Implant-Based Breast Reconstruction: Incidence and Implications.

Journal Article Plast Reconstr Surg · August 2019 BACKGROUND: Fat grafting is a powerful and increasingly used technique in breast reconstruction. However, fat necrosis can lead to palpable postoperative changes that can induce anxiety and lead to unplanned diagnostic studies. The authors' aim in this stu ... Full text Link to item Cite

Axillary reverse mapping and lymphaticovenous bypass: Lymphedema prevention through enhanced lymphatic visualization and restoration of flow.

Journal Article J Surg Oncol · August 2019 BACKGROUND: A lymphedema (LE) prevention surgery (LPS) paradigm for patients undergoing axillary lymphadenectomy (ALND) was developed to protect against LE through enhanced lymphatic visualization during axillary reverse mapping (ARM) and refinement in dec ... Full text Link to item Cite

A literature review and meta-analysis of outcomes in microsurgical reconstruction using vasopressors.

Journal Article Microsurgery · March 2019 INTRODUCTION: There is a hesitancy to utilize vasopressors in microsurgical reconstruction due to fear of vessel spasm and subsequent flap compromise. Although there are large literature reviews analyzing vasopressor usage in head and neck reconstruction, ... Full text Link to item Cite

Gene expression profiling in melanoma: past results and future potential.

Journal Article Future Oncol · March 2019 The field of melanoma oncology is rapidly evolving with advances in detection, staging and treatment. There is heterogeneity in all stages of melanoma where some patients fare better than others for reasons currently unknown and it is sometimes unclear whi ... Full text Link to item Cite

Predictable Location of Breast Sensory Nerves for Breast Reinnervation.

Journal Article Plast Reconstr Surg · February 2019 The sensory innervation to the breast originates from the medial and lateral cutaneous branches of the third to fifth intercostal nerves, which are at risk for injury or loss during mastectomy. Providing reinnervation after mastectomy was introduced almost ... Full text Link to item Cite

Anatomic Targets for Breast Reconstruction Neurotization: Past Results and Future Possibilities.

Journal Article Ann Plast Surg · February 2019 The concept of providing neurotized autologous breast reconstruction is not novel, but the introduction of cadaveric nerve grafts has allowed for the development of new techniques and a resurgence in academic interest. There has been a surge in the number ... Full text Link to item Cite

Postoperative Ketorolac Administration Is Not Associated with Hemorrhage in Cranial Vault Remodeling for Craniosynostosis

Journal Article Plastic and Reconstructive Surgery - Global Open · January 1, 2019 Background: Nonsteroidal anti-inflammatory drugs have been used as part of multimodal postoperative analgesic regimens to reduce the necessity of opioids. However, due to its effect on platelet function, there is a hesitation to utilize ketorolac postopera ... Full text Cite

Utilization of Indocyanine Green to Aid in Identifying Sentinel Lymph Nodes in Merkel Cell Cancer.

Journal Article J Surg Res · December 2018 BACKGROUND: Merkel cell carcinoma (MCC) is a relatively rare skin cancer with high rates of regional lymph node involvement and metastatic spread. National Comprehensive Cancer Network guidelines recommend sentinel lymph node biopsy (SLNB) for staging purp ... Full text Link to item Cite

Variations in the origins and absence of the common digital arteries of the hand: a cadaveric study.

Journal Article J Hand Surg Eur Vol · December 2018 We studied anomalies of the common digital arteries by dissecting 33 fresh cadaver hands under magnification. In the majority of the dissected hands (25 hands), common digital arteries took off from the superficial palmar arch and ran superficial and paral ... Full text Link to item Cite

Single-stage versus two-stage arteriovenous loop microsurgical reconstruction: A meta-analysis of the literature.

Journal Article Microsurgery · September 2018 BACKGROUND: Arteriovenous (AV) loops can be utilized in a single- or two-stage approach in free flap reconstruction when proper vessels are not available. However, there exists no consensus on which method leads to superior microsurgical and patient outcom ... Full text Link to item Cite

Indocyanine green fluorescence imaging with lymphoscintigraphy for sentinel node biopsy in head and neck melanoma.

Journal Article J Surg Res · August 2018 BACKGROUND: Head and neck melanoma is associated with a high false negative (FN) sentinel lymph node biopsy (SLNB) rate. If techniques are developed that can decrease FN SLNBs, better prognostic information will be obtained, and it may be possible to impro ... Full text Link to item Cite

Malignant Melanoma: Diagnostic and Management Update.

Journal Article Plast Reconstr Surg · August 2018 LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Summarize the changes to the American Joint Committee on Cancer Eighth Edition Melanoma Staging System. 2. List advances in genetic, molecular, and histopathologic mela ... Full text Link to item Cite

Treatment of dopplerable nummular headache with minimally invasive arterectomy under local anesthesia.

Journal Article J Plast Reconstr Aesthet Surg · July 2018 OBJECTIVE: The objective of the current study is to elucidate the potential role of surgery in the treatment of nummular headache (NH). BACKGROUND: NH is a disorder in which pain is localized to a specific area. Treatment has traditionally been medical, wi ... Full text Link to item Cite

Prospective, Randomized, Controlled Comparison of Bupivacaine versus Liposomal Bupivacaine for Pain Management after Unilateral Delayed Deep Inferior Epigastric Perforator Free Flap Reconstruction.

Journal Article Plast Reconstr Surg · June 2018 Effective postsurgical analgesia is a critical aspect of patient recovery. The goal of this prospective, randomized, controlled, blinded study was to examine the effect that liposomal bupivacaine delivered by means of a transversus abdominis plane block ha ... Full text Link to item Cite

Direct-to-Implant Breast Reconstruction in Women Older than 65 Years: A Retrospective Analysis of Complication Rate and Overall Outcomes.

Journal Article Plast Reconstr Surg · February 2018 BACKGROUND: Half of all cancers occur in women older than 65 years, yet only 4 to 14 percent of these women undergo reconstruction. Most studies on reconstruction in the elderly have focused on tissue expander/implant or autologous reconstruction. A direct ... Full text Link to item Cite

Comparison of Complication Rate Between LeFort III and Monobloc Advancement With or Without Distraction Osteogenesis.

Journal Article J Craniofac Surg · January 2018 BACKGROUND: LeFort III osteotomies or monobloc advancements, with or without distraction, can be used to treat mid-facial hypoplasia causing exorbitism and obstructive sleep apnea in syndromic patients. This report is a meta-analysis of the complication ra ... Full text Link to item Cite

Determining the False-Negative Rate Using Fluorescence Image-Assisted Sentinel Lymph Node Biopsy in Cutaneous Melanoma.

Journal Article Ann Plast Surg · January 2018 INTRODUCTION: Despite the advances in cutaneous melanoma management, the false-negative rates (FNRs) of sentinel lymph node biopsy (SLNB) are still high. These rates are dependent not only on the technique but also on definitional terms and percentage of h ... Full text Link to item Cite

Aggressive digital papillary adenocarcinoma: treatment with Mohs micrographic surgery and an update of the literature.

Journal Article Int J Dermatol · October 2017 BACKGROUND: Aggressive digital papillary adenocarcinoma (ADPA) is a rare adenocarcinoma of the sweat glands. AIMS: We wish to report the treatment of two cases of ADPA with Mohs micrographic surgery and review the presentation, management, and prognosis of ... Full text Link to item Cite

Closed Continuous Irrigation With Lidocaine and Immediate Mobilization for Treatment of Pyogenic Tenosynovitis.

Journal Article Tech Hand Up Extrem Surg · September 2017 Pyogenic flexor tenosynovitis treatment consists of either closed continuous irrigation with sterile saline or antibiotic solution, or open debridement and irrigation. These treatment approaches serve to resolve the infection, but are extremely painful and ... Full text Link to item Cite

The Anterolateral Thigh Flap as the Flap of Choice for Scalp Reconstruction.

Journal Article J Craniofac Surg · March 2017 INTRODUCTION: Large scalp soft tissue defects can present difficulties with reconstruction. The ideal flap for scalp reconstruction has yet to be described although the latissimus dorsi flap is frequently referred to as the first choice in this setting. PA ... Full text Link to item Cite

A novel approach to training students in delivering evidence-based obesity treatment.

Journal Article Fam Med · May 2015 BACKGROUND AND OBJECTIVES: Obesity is a major public health concern because of its prevalence, serious health consequences, and costs. Many health care providers believe they have been inadequately trained to treat obesity and, as a result, often do not ad ... Link to item Cite

Characterization of a novel two-component system in Burkholderia cenocepacia.

Journal Article Curr Microbiol · April 2015 Two-component systems are important regulatory systems that allow bacteria to adjust to environmental conditions, and in some bacteria are used in pathogenesis. We identified a novel two-component system in Burkholderia cenocepacia, an opportunistic pathog ... Full text Link to item Cite

Rash with DERMABOND PRINEO skin closure system use in bilateral reduction mammoplasty: A case series

Journal Article Case Reports in Medicine · January 1, 2015 Background. Bilateral reduction mammoplasty is a common plastic surgery procedure that can be complicated by unfavorable scar formation along incision sites. Surgical adhesives can be utilized as an alternative or as an adjunct to conventional suture closu ... Full text Cite

The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis.

Journal Article Dig Dis Sci · April 2014 BACKGROUND: In order for vitamin D to signal and regulate inflammatory pathways, it must bind to its receptor (VDR) which must heterodimerize with the retinoid X receptor alpha (RXRα). Although the role that vitamin D signaling plays in the development and ... Full text Link to item Cite

Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells

Journal Article Anticancer Research · December 1, 2013 Background: Colon cancer is still the second leading cause of cancer deaths in the United States. Epigenetic gene silencing involving DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) plays an important role in the progression of colon cancer ... Cite

Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.

Journal Article Cancer Prev Res (Phila) · June 2013 The anti-inflammatory actions of vitamin D have long been recognized and its importance in modulating colon cancer and colitis development is becoming apparent. The vitamin D receptor (VDR) is downregulated in human ulcerative colitis and colitis-associate ... Full text Link to item Cite

Epigenetic mechanisms underlying diet-sourced compounds in the prevention and treatment of gastrointestinal cancer.

Journal Article Anticancer Agents Med Chem · December 2012 The development of colon cancer, the third most diagnosed cancer and third leading cause of cancer deaths in the United States, can be influenced by genetic predispositions and environmental exposures. As 80% of colon cancer cases are sporadic in nature, m ... Full text Link to item Cite