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Rebecca Eli Sadun

Assistant Professor of Medicine
Medicine, Rheumatology and Immunology

Selected Publications


What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience.

Journal Article Curr Allergy Asthma Rep · April 3, 2024 PURPOSE OF REVIEW: This review reflects on the impact of the COVID-19 pandemic on the field of rheumatology, emphasizing resulting insights related to the risks of viral infections in immunosuppressed patients, vaccine immunogenicity in immunocompromised p ... Full text Link to item Cite

Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity.

Journal Article Clin Rheumatol · April 2024 BACKGROUND: Type 2 systemic lupus erythematosus (SLE) symptoms, including fatigue, fibromyalgia, and brain fog, contribute to poor health-related quality of life (HRQoL) in patients with lupus. To test the hypothesis that Type 1 (classical inflammatory lup ... Full text Link to item Cite

Renal Response Outcomes of the EuroLupus and National Institutes of Health Cyclophosphamide Dosing Regimens in Childhood-Onset Proliferative Lupus Nephritis.

Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: We compared clinical characteristics and renal response in patients with childhood-onset proliferative lupus nephritis (LN) treated with the EuroLupus versus National Institutes of Health (NIH) cyclophosphamide (CYC) regimen. METHODS: A retrospe ... Full text Link to item Cite

The Type 1 & 2 systemic lupus erythematosus model: Perspectives of people living with systemic lupus erythematosus.

Journal Article Lupus · March 2024 OBJECTIVE: In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), Type 1 SLE represents classic inflammatory manifestations, such as arthritis, while Type 2 SLE encompasses symptoms such as pain and fatigue where the relationship to inflammati ... Full text Link to item Cite

A qualitative study of facilitators of medication adherence in systemic lupus erythematosus: Perspectives from rheumatology providers/staff and patients.

Journal Article Lupus · February 2024 OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcomes. We aimed to ... Full text Open Access Link to item Cite

Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study.

Journal Article J Patient Rep Outcomes · December 21, 2023 OBJECTIVE: To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE activity, we developed the Type 1 and 2 SLE model. We examined PROMIS-29 scores, a composite patient-reporte ... Full text Link to item Cite

Development and psychometric evaluation of a physician global assessment for type 2 systemic lupus erythematosus symptoms.

Journal Article Lupus Sci Med · December 17, 2023 OBJECTIVE: Manifestations of SLE can be categorised as type 1 (classic signs and symptoms of SLE) or type 2 (fatigue, widespread pain and brain fog with an unclear relationship to inflammation). While measures of type 1 SLE activity exist, most current phy ... Full text Link to item Cite

The impact of pregnancy planning and medical readiness on reproductive outcomes in women with systemic lupus erythematosus.

Journal Article Lupus · December 2023 Women with systemic lupus erythematosus (SLE) who get pregnant while SLE is active or while on teratogens have higher risk of poor pregnancy outcomes. The American College of Rheumatology (ACR) Reproductive Health Guidelines recommend women conceive when S ... Full text Link to item Cite

Real-world use and outcomes of belimumab in childhood-onset lupus: A single-center retrospective study.

Journal Article Lupus · August 2023 BACKGROUND: Studies of real-world effectiveness of belimumab in adults with systemic lupus erythematosus have shown improved disease control and decreased oral glucocorticoid use. However, belimumab use outside of clinical trial settings has not been well ... Full text Link to item Cite

Pilot Intervention to Improve Medication Adherence Among Patients With Systemic Lupus Erythematosus Using Pharmacy Refill Data.

Journal Article Arthritis Care Res (Hoboken) · March 2023 OBJECTIVE: Despite high rates of medication nonadherence among patients with systemic lupus erythematosus (SLE), effective interventions to improve adherence in SLE are limited. We aimed to assess the feasibility of a pilot intervention and explore its eff ... Full text Open Access Link to item Cite

Implementation of Rheumatology Health Care Transition Processes and Adaptations to Systems Under Stress: A Mixed-Methods Study.

Journal Article Arthritis Care Res (Hoboken) · March 2023 OBJECTIVES: Despite poor health care transition outcomes among young adults with pediatric rheumatic diseases, adoption of transition best practices is low. We sought to understand how structured transition processes were operationalized within pediatric r ... Full text Link to item Cite

2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases.

Journal Article Arthritis Care Res (Hoboken) · March 2023 OBJECTIVE: To provide evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs). METHODS: This guideline follows American College of Rheumatology (ACR) policy guiding management of c ... Full text Link to item Cite

2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases.

Journal Article Arthritis Rheumatol · March 2023 OBJECTIVE: To provide evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs). METHODS: This guideline follows American College of Rheumatology (ACR) policy guiding management of c ... Full text Link to item Cite

Association of Hurried Communication and Low Patient Self-Efficacy With Persistent Nonadherence to Lupus Medications.

Conference Arthritis Care Res (Hoboken) · January 2023 OBJECTIVE: Medication nonadherence is common among patients with systemic lupus erythematosus (SLE), and adherence often fluctuates with time. Underrepresented racial minorities have disproportionately lower rates of medication adherence and more severe SL ... Full text Link to item Cite

American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 5.

Journal Article Arthritis Rheumatol · January 2023 OBJECTIVE: To provide guidance to rheumatology providers on the use of COVID-19 vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunologists, 2 infectious diseas ... Full text Link to item Cite

Development and Initial Validation of a Systemic Lupus Erythematosus-Specific Measure of the Extent of and Reasons for Medication Nonadherence.

Journal Article J Rheumatol · December 2022 OBJECTIVE: Medication nonadherence is common in patients with systemic lupus erythematosus (SLE) and negatively affects outcomes. To better recognize and address nonadherence in this population, there is a need for an easily implementable tool with interpr ... Full text Link to item Cite

Pediatric to Adult Transition Literature: Scoping Review and Rheumatology Research Prioritization Survey Results.

Journal Article J Rheumatol · November 2022 The transition from pediatric to adult care is the focus of growing research. It is important to identify how to direct future research efforts for maximum effect. Our goals were to perform a scoping review of the transition literature, highlight gaps in t ... Full text Link to item Cite

Barriers to Taking Medications for Systemic Lupus Erythematosus: A Qualitative Study of Racial Minority Patients, Lupus Providers, and Clinic Staff.

Journal Article Arthritis Care Res (Hoboken) · September 2022 OBJECTIVE: Underrepresented racial and ethnic minorities are disproportionately affected by systemic lupus erythematosus (SLE). Racial and ethnic minorities also have more severe SLE manifestations that require use of immunosuppressive medications, and oft ... Full text Open Access Link to item Cite

Intermittent and Persistent Type 2 lupus: patient perspectives on two distinct patterns of Type 2 SLE symptoms.

Journal Article Lupus Sci Med · August 2022 OBJECTIVE: We have developed a new conceptual model to characterise the signs and symptoms of SLE: the Type 1 and 2 SLE Model. Within the original model, Type 1 SLE consists of inflammatory manifestations like arthritis, nephritis and rashes; Type 2 SLE in ... Full text Link to item Cite

What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience.

Journal Article Curr Allergy Asthma Rep · April 3, 2024 PURPOSE OF REVIEW: This review reflects on the impact of the COVID-19 pandemic on the field of rheumatology, emphasizing resulting insights related to the risks of viral infections in immunosuppressed patients, vaccine immunogenicity in immunocompromised p ... Full text Link to item Cite

Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity.

Journal Article Clin Rheumatol · April 2024 BACKGROUND: Type 2 systemic lupus erythematosus (SLE) symptoms, including fatigue, fibromyalgia, and brain fog, contribute to poor health-related quality of life (HRQoL) in patients with lupus. To test the hypothesis that Type 1 (classical inflammatory lup ... Full text Link to item Cite

Renal Response Outcomes of the EuroLupus and National Institutes of Health Cyclophosphamide Dosing Regimens in Childhood-Onset Proliferative Lupus Nephritis.

Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: We compared clinical characteristics and renal response in patients with childhood-onset proliferative lupus nephritis (LN) treated with the EuroLupus versus National Institutes of Health (NIH) cyclophosphamide (CYC) regimen. METHODS: A retrospe ... Full text Link to item Cite

The Type 1 & 2 systemic lupus erythematosus model: Perspectives of people living with systemic lupus erythematosus.

Journal Article Lupus · March 2024 OBJECTIVE: In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), Type 1 SLE represents classic inflammatory manifestations, such as arthritis, while Type 2 SLE encompasses symptoms such as pain and fatigue where the relationship to inflammati ... Full text Link to item Cite

A qualitative study of facilitators of medication adherence in systemic lupus erythematosus: Perspectives from rheumatology providers/staff and patients.

Journal Article Lupus · February 2024 OBJECTIVE: Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcomes. We aimed to ... Full text Open Access Link to item Cite

Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study.

Journal Article J Patient Rep Outcomes · December 21, 2023 OBJECTIVE: To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE activity, we developed the Type 1 and 2 SLE model. We examined PROMIS-29 scores, a composite patient-reporte ... Full text Link to item Cite

Development and psychometric evaluation of a physician global assessment for type 2 systemic lupus erythematosus symptoms.

Journal Article Lupus Sci Med · December 17, 2023 OBJECTIVE: Manifestations of SLE can be categorised as type 1 (classic signs and symptoms of SLE) or type 2 (fatigue, widespread pain and brain fog with an unclear relationship to inflammation). While measures of type 1 SLE activity exist, most current phy ... Full text Link to item Cite

The impact of pregnancy planning and medical readiness on reproductive outcomes in women with systemic lupus erythematosus.

Journal Article Lupus · December 2023 Women with systemic lupus erythematosus (SLE) who get pregnant while SLE is active or while on teratogens have higher risk of poor pregnancy outcomes. The American College of Rheumatology (ACR) Reproductive Health Guidelines recommend women conceive when S ... Full text Link to item Cite

Real-world use and outcomes of belimumab in childhood-onset lupus: A single-center retrospective study.

Journal Article Lupus · August 2023 BACKGROUND: Studies of real-world effectiveness of belimumab in adults with systemic lupus erythematosus have shown improved disease control and decreased oral glucocorticoid use. However, belimumab use outside of clinical trial settings has not been well ... Full text Link to item Cite

Pilot Intervention to Improve Medication Adherence Among Patients With Systemic Lupus Erythematosus Using Pharmacy Refill Data.

Journal Article Arthritis Care Res (Hoboken) · March 2023 OBJECTIVE: Despite high rates of medication nonadherence among patients with systemic lupus erythematosus (SLE), effective interventions to improve adherence in SLE are limited. We aimed to assess the feasibility of a pilot intervention and explore its eff ... Full text Open Access Link to item Cite

Implementation of Rheumatology Health Care Transition Processes and Adaptations to Systems Under Stress: A Mixed-Methods Study.

Journal Article Arthritis Care Res (Hoboken) · March 2023 OBJECTIVES: Despite poor health care transition outcomes among young adults with pediatric rheumatic diseases, adoption of transition best practices is low. We sought to understand how structured transition processes were operationalized within pediatric r ... Full text Link to item Cite

2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases.

Journal Article Arthritis Care Res (Hoboken) · March 2023 OBJECTIVE: To provide evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs). METHODS: This guideline follows American College of Rheumatology (ACR) policy guiding management of c ... Full text Link to item Cite

2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases.

Journal Article Arthritis Rheumatol · March 2023 OBJECTIVE: To provide evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs). METHODS: This guideline follows American College of Rheumatology (ACR) policy guiding management of c ... Full text Link to item Cite

Association of Hurried Communication and Low Patient Self-Efficacy With Persistent Nonadherence to Lupus Medications.

Conference Arthritis Care Res (Hoboken) · January 2023 OBJECTIVE: Medication nonadherence is common among patients with systemic lupus erythematosus (SLE), and adherence often fluctuates with time. Underrepresented racial minorities have disproportionately lower rates of medication adherence and more severe SL ... Full text Link to item Cite

American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 5.

Journal Article Arthritis Rheumatol · January 2023 OBJECTIVE: To provide guidance to rheumatology providers on the use of COVID-19 vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunologists, 2 infectious diseas ... Full text Link to item Cite

Development and Initial Validation of a Systemic Lupus Erythematosus-Specific Measure of the Extent of and Reasons for Medication Nonadherence.

Journal Article J Rheumatol · December 2022 OBJECTIVE: Medication nonadherence is common in patients with systemic lupus erythematosus (SLE) and negatively affects outcomes. To better recognize and address nonadherence in this population, there is a need for an easily implementable tool with interpr ... Full text Link to item Cite

Pediatric to Adult Transition Literature: Scoping Review and Rheumatology Research Prioritization Survey Results.

Journal Article J Rheumatol · November 2022 The transition from pediatric to adult care is the focus of growing research. It is important to identify how to direct future research efforts for maximum effect. Our goals were to perform a scoping review of the transition literature, highlight gaps in t ... Full text Link to item Cite

Barriers to Taking Medications for Systemic Lupus Erythematosus: A Qualitative Study of Racial Minority Patients, Lupus Providers, and Clinic Staff.

Journal Article Arthritis Care Res (Hoboken) · September 2022 OBJECTIVE: Underrepresented racial and ethnic minorities are disproportionately affected by systemic lupus erythematosus (SLE). Racial and ethnic minorities also have more severe SLE manifestations that require use of immunosuppressive medications, and oft ... Full text Open Access Link to item Cite

Intermittent and Persistent Type 2 lupus: patient perspectives on two distinct patterns of Type 2 SLE symptoms.

Journal Article Lupus Sci Med · August 2022 OBJECTIVE: We have developed a new conceptual model to characterise the signs and symptoms of SLE: the Type 1 and 2 SLE Model. Within the original model, Type 1 SLE consists of inflammatory manifestations like arthritis, nephritis and rashes; Type 2 SLE in ... Full text Link to item Cite

Association of Health Literacy and Numeracy With Lupus Knowledge and the Creation of the Lupus Knowledge Assessment Test.

Journal Article J Rheumatol · June 2022 OBJECTIVE: Limited health literacy and numeracy are associated with worse patient-reported outcomes and higher disease activity in systemic lupus erythematosus (SLE), but which factors may mediate this association is unknown. We sought to determine the ass ... Full text Link to item Cite

Use of EuroLupus Cyclophosphamide Dosing for the Treatment of Lupus Nephritis in Childhood-onset Systemic Lupus Erythematosus in North America.

Journal Article J Rheumatol · June 2022 OBJECTIVE: Childhood-onset systemic lupus erythematosus (cSLE) has higher rates of lupus nephritis (LN) than adult-onset SLE, often requiring intensive immunosuppression. This study examined North American practices and preferences for the low-dose EuroLup ... Full text Link to item Cite

The use of patient-reported outcome measures to classify type 1 and 2 systemic lupus erythematosus activity.

Journal Article Lupus · May 2022 OBJECTIVE: We developed a model that categorizes systemic lupus erythematosus (SLE) activity into two dimensions: Type 1 SLE consists of inflammatory activity, including arthritis, nephritis, and rashes; Type 2 SLE includes fatigue, myalgia, mood disturban ... Full text Link to item Cite

American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 4.

Journal Article Arthritis Rheumatol · May 2022 OBJECTIVE: To provide guidance to rheumatology providers on the use of COVID-19 vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunologists, 2 infectious diseas ... Full text Link to item Cite

Translating research into practice-implementation recommendations for pediatric rheumatology; Proceedings of the childhood arthritis and rheumatology research alliance 2020 implementation science retreat.

Journal Article Pediatr Rheumatol Online J · February 7, 2022 The translation of research findings into clinical practice is challenging, especially fields like in pediatric rheumatology, where the evidence base is limited, there are few clinical trials, and the conditions are rare and heterogeneous. Implementation s ... Full text Link to item Cite

Transitioning to Adulthood with a Rheumatic Disease: A Case-Based Approach for Rheumatology Care Teams.

Journal Article Rheum Dis Clin North Am · February 2022 Both pediatric and adult rheumatology care teams play a central role in health care transition, the shift from child- and family-centered to adult-oriented health care. Components of transition preparation include readiness assessment, setting self-managem ... Full text Link to item Cite

American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 3.

Journal Article Arthritis Rheumatol · October 2021 OBJECTIVE: To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunol ... Full text Link to item Cite

Differences in Healthcare Transition Views, Practices, and Barriers Among North American Pediatric Rheumatology Clinicians From 2010 to 2018.

Conference J Rheumatol · September 2021 OBJECTIVE: Since 2010, the rheumatology community has developed guidelines and tools to improve healthcare transition. In this study, we aimed to compare current transition practices and beliefs among Childhood Arthritis and Rheumatology Research Alliance ... Full text Link to item Cite

Reply.

Journal Article Arthritis Rheumatol · September 2021 Full text Link to item Cite

Principles of pediatric lupus nephritis in a prospective contemporary multi-center cohort.

Journal Article Lupus · September 2021 Lupus nephritis (LN) is a life-threatening manifestation of systemic lupus erythematosus (SLE) and is more common in children than adults. The epidemiology and management of childhood-onset SLE (cSLE) have changed over time, prompting the need to reassess ... Full text Link to item Cite

American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 2.

Journal Article Arthritis Rheumatol · August 2021 OBJECTIVE: To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunol ... Full text Link to item Cite

Racial Differences in Patient-provider Communication, Patient Self-efficacy, and Their Associations With Systemic Lupus Erythematosus-related Damage: A Cross-sectional Survey.

Journal Article J Rheumatol · July 2021 OBJECTIVE: Despite significant racial disparities in systemic lupus erythematosus (SLE) outcomes, few studies have examined how disparities may be perpetuated in clinical encounters. We aimed to explore associations between areas of clinical encounters - p ... Full text Open Access Link to item Cite

American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 1.

Journal Article Arthritis Rheumatol · July 2021 OBJECTIVE: To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs). METHODS: A task force was assembled that included 9 rheumatologists/immunol ... Full text Link to item Cite

Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned.

Journal Article Curr Allergy Asthma Rep · January 21, 2021 PURPOSE OF REVIEW: Told from the viewpoint of rheumatologists, this review tells the story of hydroxychloroquine and its swift ascent to become a household name as a therapeutic strategy against the novel SARS-CoV-2 virus. This review describes the history ... Full text Link to item Cite

Racial Disparities in Medication Adherence between African American and Caucasian Patients With Systemic Lupus Erythematosus and Their Associated Factors.

Journal Article ACR Open Rheumatol · July 2020 OBJECTIVE: Medication nonadherence is more common in African Americans compared with Caucasians. We examined the racial adherence gaps among patients with systemic lupus erythematosus (SLE) and explored factors associated with nonadherence. METHODS: Cross- ... Full text Open Access Link to item Cite

Tailored use of belatacept in adolescent kidney transplantation.

Journal Article Am J Transplant · March 2020 Adolescent transplant recipients are at risk for nonadherence, development of de novo donor-specific antibody (dnDSA), and allograft loss. Belatacept, a selective T cell costimulatory blocker, is associated with reduced dnDSA, improved renal function, and ... Full text Link to item Cite

Mind the Gap: Improving Care in Pediatric-to-Adult Rheumatology Transition Through Education.

Journal Article Rheum Dis Clin North Am · February 2020 Adolescence and young adulthood represents a vulnerable period in the life of patients with rheumatic diseases, many of whom struggle with self-management of their chronic disease and adjustment to care with adult rheumatologists. Many adult rheumatologist ... Full text Link to item Cite

Lost in transition: resident and fellow training and experience caring for young adults with chronic conditions in a large United States' academic medical center.

Journal Article Med Educ Online · December 2019 BACKGROUND: The transition from pediatric to adult healthcare is a vulnerable time for adolescents and young adults (AYA), especially those with chronic conditions. Successful transition requires communication and coordination amongst providers, patients, ... Full text Link to item Cite

Biologic Differences Between Type 1 and 2 Lupus

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2019 Link to item Cite

Longitudinal Changes in Manifestations of SLE

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2019 Link to item Cite

The PROMIS-29 as a Measure of Type 1 and 2 SLE Activity

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2019 Link to item Cite

Racial Disparities in Lupus Medication Adherence

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2019 Link to item Cite

Disability Among Subtypes of SLE

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2019 Link to item Cite

Pharmacotherapies Targeting Type 2 SLE Symptoms

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2019 Link to item Cite

Using social media to promote medication adherence.

Journal Article Nat Rev Rheumatol · August 2018 Full text Link to item Cite

Increasing contraception use among women receiving teratogenic medications in a rheumatology clinic.

Journal Article BMJ Open Qual · 2018 Teratogenic medications are often prescribed to women of childbearing age with autoimmune diseases. Literature suggests that appropriate use of contraception among these women is low, potentially resulting in high-risk unintended pregnancies. Preliminary r ... Full text Open Access Link to item Cite

Transition and transfer of the patient with paediatric-onset lupus: a practical approach for paediatric and adult rheumatology practices.

Journal Article Lupus Sci Med · 2018 The prevalence of paediatric-onset SLE (pSLE) is estimated at 1million people worldwide and accounts for a significant proportion of SLE morbidity, mortality and cost. Patients with pSLE are especially vulnerable during and immediately following transfer f ... Full text Link to item Cite

Character development pilot evaluation of two studies

Journal Article Journal of Youth Development · 2015 Link to item Cite

Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models.

Journal Article J Immunother · April 2008 OX40L is a member of the tumor necrosis factor superfamily that provides a costimulatory signal to CD4+ and CD8+ T cells while inhibiting the effects of suppressive CD4+ CD25+ regulatory T cells. Because of this dual activity, OX40L may provide significant ... Full text Link to item Cite

Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.

Journal Article Clin Cancer Res · January 15, 2008 PURPOSE: To provide proper costimulation required for effective cancer T-cell immunity, Fc-GITRL fusion proteins were generated for use in immunotherapy protocols. EXPERIMENTAL DESIGN: Soluble fusion proteins consisting of the Fc fragment of immunoglobulin ... Full text Link to item Cite

Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy.

Journal Article Clin Cancer Res · July 1, 2007 PURPOSE: Despite lymphocyte infiltration of tumors and the activation of tumor-draining lymph nodes, malignant tumors are able to "escape" from both innate and adaptive immune responses. For immunotherapy to be successful, it must reverse these escape mech ... Full text Link to item Cite

Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors.

Journal Article Clin Cancer Res · May 1, 2007 INTRODUCTION: CD137L is a member of the tumor necrosis factor superfamily that provides a costimulatory signal to T cells. In this study, two novel CD137L fusion proteins were produced and compared with the CD137 agonist antibody 2A. MATERIALS AND METHODS: ... Full text Link to item Cite