Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • residency, Psychiatry And Behavioral Sciences, Duke University School of Medicine 2008 - 2012
  • M.D., University of Wisconsin at Madison 2008
  • Ph.D., University of Wisconsin at Madison 2006
• 

  Duke Appointment History

  • Consulting Associate in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2015 - 2016
  • Consulting Associate in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, General Psychiatry, Psychiatry & Behavioral Sciences 2013 - 2015
  • Consulting Associate in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2012 - 2013
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Burton, NC, Johnson, DA, Lee, JM, Kraft, AD, Calkins, MJ, Jakel, RJ, and Johnson, JA. "Neurotoxicant-Induced Oxidative Events and Antioxidative Interventions in the Central Nervous System." In Comprehensive Toxicology, Second Edition, 59-69. August 12, 2010.  Full Text

  • Journal Articles

    • Muzyk, AJ, Jakel, RJ, and Preud'homme, X. "Serotonin syndrome after a massive overdose of controlled-release paroxetine." Psychosomatics 51, no. 5 (September 2010): 437-442.  Full Text  Link to Item
    • Johnson, JA, Johnson, DA, Kraft, AD, Calkins, MJ, Jakel, RJ, Vargas, MR, and Chen, P-C. "The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration." Ann N Y Acad Sci 1147 (December 2008): 61-69. (Review)  Full Text  Link to Item
    • Johnson, JA, Johnson, DA, Lee, JM, Li, J, Kraft, AD, Calkins, MJ, and Jakel, RJ. "The Nrf2-ARE pathway: A potential therapeutic target for neurodegenerative diseases." International Congress Series 1302 (June 1, 2007): 143-153.  Full Text
    • Jakel, RJ, Townsend, JA, Kraft, AD, and Johnson, JA. "Nrf2-mediated protection against 6-hydroxydopamine." Brain Res 1144 (May 4, 2007): 192-201.  Full Text  Link to Item
    • Jakel, RJ, Kern, JT, Johnson, DA, and Johnson, JA. "Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro." Toxicol Sci 87, no. 1 (September 2005): 176-186.  Full Text  Link to Item
    • Lee, J-M, Li, J, Johnson, DA, Stein, TD, Kraft, AD, Calkins, MJ, Jakel, RJ, and Johnson, JA. "Nrf2, a multi-organ protector?." FASEB J 19, no. 9 (July 2005): 1061-1066.  Full Text  Link to Item
    • Calkins, MJ, Jakel, RJ, Johnson, DA, Chan, K, Kan, YW, and Johnson, JA. "Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription." Proc Natl Acad Sci U S A 102, no. 1 (January 4, 2005): 244-249.  Full Text  Link to Item
    • McBride, JL, Behrstock, SP, Chen, E-Y, Jakel, RJ, Siegel, I, Svendsen, CN, and Kordower, JH. "Human neural stem cell transplants improve motor function in a rat model of Huntington's disease." J Comp Neurol 475, no. 2 (July 19, 2004): 211-219.  Full Text  Link to Item
    • Jakel, RJ, Schneider, BL, and Svendsen, CN. "Using human neural stem cells to model neurological disease." Nat Rev Genet 5, no. 2 (February 2004): 136-144. (Review)  Full Text  Link to Item
    • Maragos, WF, Jakel, R, Chesnut, D, Pocernich, CB, Butterfield, DA, St Clair, D, and Cass, WA. "Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase." Brain Res 878, no. 1-2 (September 29, 2000): 218-222.  Link to Item
    • Jakel, RJ, and Maragos, WF. "Neuronal cell death in Huntington's disease: a potential role for dopamine." Trends Neurosci 23, no. 6 (June 2000): 239-245. (Review)  Link to Item
    • Maragos, WF, Tillman, PA, Chesnut, MD, and Jakel, RJ. "Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions." Brain Res 834, no. 1-2 (July 10, 1999): 168-172.  Link to Item
    • Kruman, II, Nath, A, Maragos, WF, Chan, SL, Jones, M, Rangnekar, VM, Jakel, RJ, and Mattson, MP. "Evidence that Par-4 participates in the pathogenesis of HIV encephalitis." Am J Pathol 155, no. 1 (July 1999): 39-46.  Full Text  Link to Item
    • Maragos, WF, Jakel, RJ, Chesnut, MD, Geddes, JW, and Dwoskin, LP. "Does dopamine contribute to striatal damage caused by impaired mitochondrial function?." Ann N Y Acad Sci 893 (1999): 345-349.  Link to Item
    • Maragos, WF, Jakel, RJ, Pang, Z, and Geddes, JW. "6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions." Exp Neurol 154, no. 2 (December 1998): 637-644.  Full Text  Link to Item

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