Scholars@Duke
Rex Colle Bentley

Rex Colle Bentley

Professor of Pathology
Pathology
rex.bentley@duke.edu
Duke Box 3712, Durham, NC 27710
216A Davison Bldg, Durham, NC

Scholarly Works - Preprints

RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma.

Preprint · July 24, 2025 Fusion-positive rhabdomyosarcoma is an aggressive pediatric cancer of skeletal muscle lineage, with a 5-year overall survival of <30% for high-risk disease, and <8% when metastatic. The PAX3::FOXO1 fusion gene, resulting from t(2:13), is a signature driver ... Full text Link to item Cite