Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., New York University 1990
• 

  Medical Licensure

  • 2178. North Carolina. 1996
• 

  Previous Appointments & Affiliations

  • Professor of Psychology and Neuroscience, Psychology & Neuroscience, Trinity College of Arts & Sciences 2011 - 2022
  • Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2021 - 2022
  • Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2007 - 2020
  • Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2016 - 2020
  • Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2005 - 2007
  • Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1997 - 2005
  • Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1995 - 1997
• Recognition
• 

  In the News

  • NOV 19, 2019

    Global List of Highly Cited Puts Duke in Top Ten

  • NOV 27, 2018

    Duke Faculty Plentiful On ‘Highly Cited’ List

  • APR 24, 2014

    The News & Observer

    Richard Keefe: Bruce Springsteen offers chance to recall impulsiveness of teen brains

  • APR 24, 2014

    The News & Observer

    Richard Keefe: Bruce Springsteen offers chance to recall impulsiveness of teen brains
• Expertise
• 

  Global Scholarship

  • Expertise

    • Singapore (Country) 

  • Research

    • Singapore (Country) 
• Research
• 

  Selected Grants

  • A phase II randomised, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered BI 409306 during a 52-week treatment period as an early intervention in patients with attenuated psychosis syndrom awarded by Boehringer Ingelheim Pharmaceuticals, Inc. 2017 - 2021
  • Auditory Perception and Emotion Recognition in Young People at Risk for Psychosis awarded by National Institutes of Health 2016 - 2019
  • Study to Evaulate the Kappa Opioid Receptor as a Target for the Treatment of Mood and Anxiety Spectrum Disorders by Evaluating Whether LY2456302 Engages Reward-related Neural Circuitry. awarded by National Institutes of Health 2013 - 2017
  • Specific Auditory Perception Impairment and Emotion Recognition in Schizophrenia awarded by National Institutes of Health 2014 - 2017
  • FAST- MAS Administrative Task Year 3 awarded by National Institutes of Health 2014 - 2015
  • IPA - Richard Keefe awarded by Durham Veterans Affairs Medical Center 2013 - 2014
  • IPA - Richard Keefe awarded by Veterans Administration Medical Center 2012 - 2013
  • IPA - Richard Keefe awarded by Veterans Administration Medical Center 2010 - 2011
  • Neural Circuitry And Cognitive Function In Schizophrenia awarded by National Institutes of Health 1995 - 2001
  • Neural Circuitry & Cognitive Function In Schizophrenia awarded by National Institutes of Health 1995 - 1999
  • Neural Circuitry & Function In Schizophrenia awarded by National Institutes of Health 1995 - 1999
  • Neural Corcuitry And Cognitive Function In Schizophrenia awarded by National Institutes of Health 1995 - 1999
• 

  External Relationships

  • Boehringer Ingleheim
  • Karuna
  • WCG VeraSci
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Williamson, David J., Keith H. Nuechterlein, Todd Tishler, Joseph Ventura, Benjamin M. Ellingson, Ibrahim Turkoz, Richard S. E. Keefe, and Larry Alphs. “Dispersion of cognitive performance test scores on the MATRICS Consensus Cognitive Battery: A different perspective.” Schizophr Res Cogn 30 (December 2022): 100270. https://doi.org/10.1016/j.scog.2022.100270.
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    • Seccomandi, Benedetta, Deborah Agbedjro, Richard S. E. Keefe, Silvana Galderisi, Joanna Fiszdon, Armida Mucci, Til Wykes, and Matteo Cella. “Evaluating how treatment adherence influences cognitive remediation outcomes.” Behav Res Ther 158 (November 2022): 104186. https://doi.org/10.1016/j.brat.2022.104186.
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    • Keefe, Richard S. E., Elena Cañadas, Deborah Farlow, and Amit Etkin. “Digital Intervention for Cognitive Deficits in Major Depression: A Randomized Controlled Trial to Assess Efficacy and Safety in Adults.” Am J Psychiatry 179, no. 7 (July 2022): 482–89. https://doi.org/10.1176/appi.ajp.21020125.
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    • Zhang, Lusi, Scot Kristian Hill, Bin Guo, Baolin Wu, Ney Alliey-Rodriguez, Seenae Eum, Paulo Lizano, et al. “Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.” Prog Neuropsychopharmacol Biol Psychiatry 113 (March 8, 2022): 110464. https://doi.org/10.1016/j.pnpbp.2021.110464.
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    • Kraus, Michael S., Trina M. Walker, Diana Perkins, and Richard S. E. Keefe. “Basic auditory processing and emotion recognition in individuals at clinical high risk for psychosis.” Schizophr Res Cogn 27 (March 2022): 100225. https://doi.org/10.1016/j.scog.2021.100225.
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    • Lim, Keane, Attilio Rapisarda, Richard S. E. Keefe, and Jimmy Lee. “Social skills, negative symptoms and real-world functioning in individuals at ultra-high risk of psychosis.” Asian J Psychiatr 69 (March 2022): 102996. https://doi.org/10.1016/j.ajp.2021.102996.
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    • Atkins, Alexandra S., Michael S. Kraus, Matthew Welch, Zhenhua Yuan, Heather Stevens, Kathleen A. Welsh-Bohmer, and Richard S. E. Keefe. “Remote self-administration of digital cognitive tests using the Brief Assessment of Cognition: Feasibility, reliability, and sensitivity to subjective cognitive decline.” Front Psychiatry 13 (2022): 910896. https://doi.org/10.3389/fpsyt.2022.910896.
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    • Eskridge, Courtney L. M., William C. Hochberger, Erin T. Kaseda, Rebekka Lencer, James L. Reilly, Sarah K. Keedy, Richard S. E. Keefe, et al. “Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders.” Schizophr Res 236 (October 2021): 54–60. https://doi.org/10.1016/j.schres.2021.07.036.
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    • Keefe, Richard S. E., Scott W. Woods, Tyrone D. Cannon, Stephan Ruhrmann, Daniel H. Mathalon, Philip McGuire, Holger Rosenbrock, et al. “A randomized Phase II trial evaluating efficacy, safety, and tolerability of oral BI 409306 in attenuated psychosis syndrome: Design and rationale.” Early Interv Psychiatry 15, no. 5 (October 2021): 1315–25. https://doi.org/10.1111/eip.13083.
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    • Eum, Seenae, S Kristian Hill, Ney Alliey-Rodriguez, James M. Stevenson, Leah H. Rubin, Adam M. Lee, Lauren J. Mills, et al. “Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders.” Neuropsychopharmacology 46, no. 10 (September 2021): 1802–10. https://doi.org/10.1038/s41386-021-01057-8.
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    • Lim, Keane, Jason Smucny, Deanna M. Barch, Max Lam, Richard S. E. Keefe, and Jimmy Lee. “Cognitive Subtyping in Schizophrenia: A Latent Profile Analysis.” Schizophr Bull 47, no. 3 (April 29, 2021): 712–21. https://doi.org/10.1093/schbul/sbaa157.
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    • Cohen, Elan A., Howard H. Hassman, Larry Ereshefsky, David P. Walling, Vera M. Grindell, Richard S. E. Keefe, Katarzyna Wyka, and William P. Horan. “Placebo response mitigation with a participant-focused psychoeducational procedure: a randomized, single-blind, all placebo study in major depressive and psychotic disorders.” Neuropsychopharmacology 46, no. 4 (March 2021): 844–50. https://doi.org/10.1038/s41386-020-00911-5.
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    • Fleischhacker, W Wolfgang, Jana Podhorna, Martina Gröschl, Sanjay Hake, Yihua Zhao, Songqiao Huang, Richard S. E. Keefe, et al. “Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study.” Lancet Psychiatry 8, no. 3 (March 2021): 191–201. https://doi.org/10.1016/S2215-0366(20)30513-7.
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    • Keefe, Richard S. E. “Where do we cut the bell-shaped curve of CIAS?” Schizophr Res 228 (February 2021): 633–34. https://doi.org/10.1016/j.schres.2021.01.013.
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    • Seccomandi, Benedetta, Deborah Agbedjro, Morris Bell, Richard S. E. Keefe, Matcheri Keshavan, Silvana Galderisi, Joanna Fiszdon, et al. “Exploring the role of age as a moderator of cognitive remediation for people with schizophrenia.” Schizophr Res 228 (February 2021): 29–35. https://doi.org/10.1016/j.schres.2020.11.060.
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    • Seccomandi, Benedetta, Deborah Agbedjro, Morris Bell, Richard S. E. Keefe, Matcheri Keshavan, Silvana Galderisi, Joanna Fiszdon, et al. “Can IQ moderate the response to cognitive remediation in people with schizophrenia?” J Psychiatr Res 133 (January 2021): 38–45. https://doi.org/10.1016/j.jpsychires.2020.12.013.
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    • Turner, Travis H., Alexandra Atkins, and Richard S. E. Keefe. “Virtual Reality Functional Capacity Assessment Tool (VRFCAT-SL) in Parkinson's Disease.” J Parkinsons Dis 11, no. 4 (2021): 1917–25. https://doi.org/10.3233/JPD-212688.
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    • Keefe, Richard S. E., Michael F. Green, and Philip D. Harvey. “Requisite Skills and the Meaningful Measurement of Cognition.” Jama Psychiatry 77, no. 11 (November 1, 2020): 1103–4. https://doi.org/10.1001/jamapsychiatry.2020.1618.
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    • Kilciksiz, C. M., R. Keefe, J. Benoit, D. Öngür, and J. Torous. “Verbal memory measurement towards digital perspectives in first-episode psychosis: A review.” Schizophrenia Research: Cognition 21 (September 1, 2020). https://doi.org/10.1016/j.scog.2020.100177.
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    • Lindenmayer, Jean-Pierre, Abraham Goldring, Sophia Borne, Anzalee Khan, Richard S. E. Keefe, Beverly J. Insel, Amod Thanju, Isidora Ljuri, and Bronwen Foreman. “Assessing instrumental activities of daily living (iADL) with a game-based assessment for individuals with schizophrenia.” Schizophr Res 223 (September 2020): 166–72. https://doi.org/10.1016/j.schres.2020.07.001.
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    • Harvey, Philip D., William P. Horan, Alexandra S. Atkins, Heather Stevens, Matthew Welch, Joshua Yuan, Thomas L. Patterson, Meera Narasimhan, and Richard S. E. Keefe. “Factor structure of cognitive performance and functional capacity in schizophrenia: Evidence for differences across functional capacity measures.” Schizophr Res 223 (September 2020): 297–304. https://doi.org/10.1016/j.schres.2020.08.010.
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    • Chaturvedi, Rahul, Michael Kraus, and Richard S. E. Keefe. “A new measure of authentic auditory emotion recognition: Application to patients with schizophrenia.” Schizophr Res 222 (August 2020): 450–54. https://doi.org/10.1016/j.schres.2019.11.043.
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    • Krystal, Andrew D., Diego A. Pizzagalli, Moria Smoski, Sanjay J. Mathew, John Nurnberger, Sarah H. Lisanby, Dan Iosifescu, et al. “A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.” Nat Med 26, no. 5 (May 2020): 760–68. https://doi.org/10.1038/s41591-020-0806-7.
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    • Ho, New Fei, Benjamin J. H. Lee, Jordon X. J. Tng, Max Z. Y. Lam, Guoyang Chen, Mingyuan Wang, Juan Zhou, Richard S. E. Keefe, and Kang Sim. “Corticolimbic brain anomalies are associated with cognitive subtypes in psychosis: A longitudinal study.” Eur Psychiatry 63, no. 1 (April 27, 2020): e40. https://doi.org/10.1192/j.eurpsy.2020.36.
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    • Kollins, Scott H., Denton J. DeLoss, Elena Cañadas, Jacqueline Lutz, Robert L. Findling, Richard S. E. Keefe, Jeffery N. Epstein, Andrew J. Cutler, and Stephen V. Faraone. “A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial.” Lancet Digit Health 2, no. 4 (April 2020): e168–78. https://doi.org/10.1016/S2589-7500(20)30017-0.
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    • Kraus, Michael S., James M. Gold, Deanna M. Barch, Trina M. Walker, Charlotte A. Chun, Robert W. Buchanan, John G. Csernansky, et al. “The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures.” Schizophr Res Cogn 19 (March 2020): 100161. https://doi.org/10.1016/j.scog.2019.100161.
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    • Rakesh, Gopalkumar, Nicholas A. Mischel, Bruce Luber, Richard S. E. Keefe, Sara Emory, Sarah H. Lisanby, and Steven T. Szabo. “Theta Burst for Cognitive Remediation in Schizophrenia: A Case Series and Feasibility Study.” J Ect 36, no. 1 (March 2020): 72–74. https://doi.org/10.1097/YCT.0000000000000625.
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    • Ventura, Joseph, Tamara Welikson, Arielle Ered, Kenneth L. Subotnik, Richard S. E. Keefe, Gerhard S. Hellemann, and Keith H. Nuechterlein. “Virtual reality assessment of functional capacity in the early course of schizophrenia: Associations with cognitive performance and daily functioning.” Early Interv Psychiatry 14, no. 1 (February 2020): 106–14. https://doi.org/10.1111/eip.12831.
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    • Goldberg, T. E., P. D. Harvey, D. P. Devanand, R. S. E. Keefe, and J. J. Gomar. “Development of an UPSA Short Form for Use in Longitudinal Studies in the Early Alzheimer's Disease Spectrum.” J Prev Alzheimers Dis 7, no. 3 (2020): 179–83. https://doi.org/10.14283/jpad.2019.51.
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    • Pani, Luca, and Richard S. E. Keefe. “Approaches to attenuated psychosis syndrome treatments: A perspective on the regulatory issues.” Schizophr Res Cogn 18 (December 2019): 100155. https://doi.org/10.1016/j.scog.2019.100155.
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    • Harvey, Philip D., Anzalee Khan, Alexandra Atkins, Trina M. Walker, and Richard S. E. Keefe. “Comprehensive review of the research employing the schizophrenia cognition rating scale (SCoRS).” Schizophr Res 210 (August 2019): 30–38. https://doi.org/10.1016/j.schres.2019.05.040.
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    • Harvey, Philip D., Anzalee Khan, Alexandra Atkins, and Richard Se Keefe. “Virtual reality assessment of functional capacity in people with Schizophrenia: Associations with reduced emotional experience and prediction of functional outcomes.” Psychiatry Res 277 (July 2019): 58–63. https://doi.org/10.1016/j.psychres.2019.01.045.
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    • Keefe, Richard S. E. “Why are there no approved treatments for cognitive impairment in schizophrenia?” World Psychiatry 18, no. 2 (June 2019): 167–68. https://doi.org/10.1002/wps.20648.
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    • Mahncke, Henry W., Sarah-Jane Kim, Annika Rose, Catherine Stasio, Peter Buckley, Stanley Caroff, Erica Duncan, et al. “Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial.” Schizophr Res 208 (June 2019): 182–89. https://doi.org/10.1016/j.schres.2019.03.006.
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    • Kraus, Michael S., Trina M. Walker, L Fredrik Jarskog, Robert A. Millet, and Richard S. E. Keefe. “Basic auditory processing deficits and their association with auditory emotion recognition in schizophrenia.” Schizophr Res 204 (February 2019): 155–61. https://doi.org/10.1016/j.schres.2018.08.031.
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    • Krystal, Andrew D., Diego A. Pizzagalli, Sanjay J. Mathew, Gerard Sanacora, Richard Keefe, Allen Song, Joseph Calabrese, et al. “The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.” Nat Rev Drug Discov 18, no. 1 (December 28, 2018): 82–84. https://doi.org/10.1038/nrd.2018.222.
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    • Wang, Chenhao, Jimmy Lee, New Fei Ho, Joseph K. W. Lim, Joann S. Poh, Gurpreet Rekhi, Ranga Krishnan, et al. “Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study.” Cereb Cortex 28, no. 12 (December 1, 2018): 4234–43. https://doi.org/10.1093/cercor/bhx278.
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    • Keefe, Richard S. E., and Luca Pani. “Take This Cognitive Training Efficacy Bar Fight Outside (to a Regulatory Agency).” Biol Psychiatry Cogn Neurosci Neuroimaging 3, no. 11 (November 2018): 900–902. https://doi.org/10.1016/j.bpsc.2018.09.002.
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    • Yang, Zixu, Keane Lim, Max Lam, Richard Keefe, and Jimmy Lee. “Factor structure of the positive and negative syndrome scale (PANSS) in people at ultra high risk (UHR) for psychosis.” Schizophr Res 201 (November 2018): 85–90. https://doi.org/10.1016/j.schres.2018.05.024.
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    • Lam, Max, Jimmy Lee, Attilio Rapisarda, Yuen Mei See, Zixu Yang, Sara-Ann Lee, Nur Amirah Abdul-Rashid, et al. “Longitudinal Cognitive Changes in Young Individuals at Ultrahigh Risk for Psychosis.” Jama Psychiatry 75, no. 9 (September 1, 2018): 929–39. https://doi.org/10.1001/jamapsychiatry.2018.1668.
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    • Fava, Maurizio, Atul R. Mahableshwarkar, William Jacobson, Wei Zhong, Richard Se Keefe, Christina Kurre Olsen, and Judith Jaeger. “What is the overlap between subjective and objective cognitive impairments in MDD?” Ann Clin Psychiatry 30, no. 3 (August 2018): 176–84.
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    • Xavier, Rose Mary, Jennifer R. Dungan, Richard S. E. Keefe, and Allison Vorderstrasse. “Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.” Schizophr Res Cogn 12 (June 2018): 11–19. https://doi.org/10.1016/j.scog.2018.01.001.
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    • Blokland, Gabriëlla A. M., Elisabetta C. Del Re, Raquelle I. Mesholam-Gately, Jorge Jovicich, Joey W. Trampush, Matcheri S. Keshavan, Lynn E. DeLisi, et al. “The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project.” Schizophr Res 195 (May 2018): 306–17. https://doi.org/10.1016/j.schres.2017.09.024.
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    • Keefe, Richard S. E., George Nomikos, Wei Zhong, Michael Cronquist Christensen, and William Jacobson. “A Subgroup Analysis of the Impact of Vortioxetine on Functional Capacity, as Measured by UPSA, in Patients with Major Depressive Disorder and Subjective Cognitive Dysfunction.” Int J Neuropsychopharmacol 21, no. 5 (May 1, 2018): 442–47. https://doi.org/10.1093/ijnp/pyy020.
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    • Xavier, Rose Mary, Allison Vorderstrasse, Richard S. E. Keefe, and Jennifer R. Dungan. “Genetic correlates of insight in schizophrenia.” Schizophr Res 195 (May 2018): 290–97. https://doi.org/10.1016/j.schres.2017.10.021.
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    • Shafee, Rebecca, Pranav Nanda, Jaya L. Padmanabhan, Neeraj Tandon, Ney Alliey-Rodriguez, Sreeja Kalapurakkel, Daniel J. Weiner, et al. “Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls.” Transl Psychiatry 8, no. 1 (April 12, 2018): 78. https://doi.org/10.1038/s41398-018-0124-8.
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    • Kendler, K. S., H. Ohlsson, R. S. E. Keefe, K. Sundquist, and J. Sundquist. “The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders: a delineation of four potential pathways to illness.” Mol Psychiatry 23, no. 4 (April 2018): 1076–83. https://doi.org/10.1038/mp.2017.78.
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    • Xavier, Rose Mary, Wei Pan, Jennifer R. Dungan, Richard S. E. Keefe, and Allison Vorderstrasse. “Unraveling interrelationships among psychopathology symptoms, cognitive domains and insight dimensions in chronic schizophrenia.” Schizophr Res 193 (March 2018): 83–90. https://doi.org/10.1016/j.schres.2017.07.002.
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    • Healey, Kristin M., David L. Penn, Diana Perkins, Scott W. Woods, Richard S. E. Keefe, and Jean Addington. “Latent Profile Analysis and Conversion to Psychosis: Characterizing Subgroups to Enhance Risk Prediction.” Schizophr Bull 44, no. 2 (February 15, 2018): 286–96. https://doi.org/10.1093/schbul/sbx080.
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    • Hochberger, W. C., T. Combs, J. L. Reilly, J. R. Bishop, R. S. E. Keefe, B. A. Clementz, M. S. Keshavan, et al. “Deviation from expected cognitive ability across psychotic disorders.” Schizophr Res 192 (February 2018): 300–307. https://doi.org/10.1016/j.schres.2017.05.019.
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    • Atkins, A. S., A. Khan, D. Ulshen, A. Vaughan, D. Balentin, H. Dickerson, L. E. Liharska, B. Plassman, K. Welsh-Bohmer, and R. S. E. Keefe. “Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).” J Prev Alzheimers Dis 5, no. 4 (2018): 216–34. https://doi.org/10.14283/jpad.2018.28.
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    • Keefe, Richard S. E., Philip D. Harvey, Anzalee Khan, Jay B. Saoud, Corinne Staner, Michael Davidson, and Remy Luthringer. “Cognitive Effects of MIN-101 in Patients With Schizophrenia and Negative Symptoms: Results From a Randomized Controlled Trial.” J Clin Psychiatry 79, no. 3 (2018). https://doi.org/10.4088/JCP.17m11753.
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    • Romero, Heather R., Andreas U. Monsch, Kathleen M. Hayden, Brenda L. Plassman, Alexandra S. Atkins, Richard S. E. Keefe, Shyama Brewster, et al. “TOMMORROW neuropsychological battery: German language validation and normative study.” Alzheimers Dement (N Y) 4 (2018): 314–23. https://doi.org/10.1016/j.trci.2018.06.009.
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    • Harvey, Philip D., Anzalee Khan, and Richard S. E. Keefe. “Using the Positive and Negative Syndrome Scale (PANSS) to Define Different Domains of Negative Symptoms: Prediction of Everyday Functioning by Impairments in Emotional Expression and Emotional Experience.” Innov Clin Neurosci 14, no. 11–12 (December 1, 2017): 18–22.
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    • Khan, Anzalee, Lora Liharska, Philip D. Harvey, Alexandra Atkins, Daniel Ulshen, and Richard S. E. Keefe. “Negative Symptom Dimensions of the Positive and Negative Syndrome Scale Across Geographical Regions: Implications for Social, Linguistic, and Cultural Consistency.” Innov Clin Neurosci 14, no. 11–12 (December 1, 2017): 30–40.
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    • Ang, Mei San, Nur Amirah Abdul Rashid, Max Lam, Attilio Rapisarda, Michael Kraus, Richard S. E. Keefe, and Jimmy Lee. “The Impact of Medication Anticholinergic Burden on Cognitive Performance in People With Schizophrenia.” J Clin Psychopharmacol 37, no. 6 (December 2017): 651–56. https://doi.org/10.1097/JCP.0000000000000790.
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    • Georgiades, Anastasia, Vicki G. Davis, Alexandra S. Atkins, Anzalee Khan, Trina W. Walker, Antony Loebel, George Haig, et al. “Psychometric characteristics of the MATRICS Consensus Cognitive Battery in a large pooled cohort of stable schizophrenia patients.” Schizophr Res 190 (December 2017): 172–79. https://doi.org/10.1016/j.schres.2017.03.040.
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    • Cella, M., D. Stahl, S. Morris, R. S. E. Keefe, M. D. Bell, and T. Wykes. “Effects of cognitive remediation on negative symptoms dimensions: exploring the role of working memory.” Psychol Med 47, no. 15 (November 2017): 2593–2601. https://doi.org/10.1017/S0033291717000757.
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    • Lam, Max, Mingyuan Wang, Wanping Huang, Goi Khia Eng, Attilio Rapisarda, Michael Kraus, Sim Kang, R. S. E. Keefe, and Jimmy Lee. “Establishing the Brief Assessment of Cognition - Short form.” J Psychiatr Res 93 (October 2017): 1–11. https://doi.org/10.1016/j.jpsychires.2017.05.006.
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    • Keefe, Richard S. E., Vicki G. Davis, Philip D. Harvey, Alexandra S. Atkins, George M. Haig, Owen Hagino, Stephen Marder, Dana C. Hilt, and Daniel Umbricht. “Placebo Response and Practice Effects in Schizophrenia Cognition Trials.” Jama Psychiatry 74, no. 8 (August 1, 2017): 807–14. https://doi.org/10.1001/jamapsychiatry.2017.1574.
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    • Mazhari, Shahrzad, Ali R. Ghafaree-Nejad, Somayeh Soleymani-Zade, and Richard S. E. Keefe. “Validation of the Persian version of the Schizophrenia Cognition Rating Scale (SCoRS) in patients with schizophrenia.” Asian J Psychiatr 27 (June 2017): 12–15. https://doi.org/10.1016/j.ajp.2017.02.007.
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    • Keefe, Richard S. E., and René S. Kahn. “Cognitive Decline and Disrupted Cognitive Trajectory in Schizophrenia.” Jama Psychiatry 74, no. 5 (May 1, 2017): 535–36. https://doi.org/10.1001/jamapsychiatry.2017.0312.
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    • Atkins, Alexandra S., Tina Tseng, Adam Vaughan, Elizabeth W. Twamley, Philip Harvey, Thomas Patterson, Meera Narasimhan, and Richard S. E. Keefe. “Validation of the tablet-administered Brief Assessment of Cognition (BAC App).” Schizophr Res 181 (March 2017): 100–106. https://doi.org/10.1016/j.schres.2016.10.010.
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    • Reilly, James L., S Kristian Hill, James M. Gold, Richard S. E. Keefe, Brett A. Clementz, Elliot Gershon, Matcheri S. Keshavan, Godfrey Pearlson, Carol A. Tamminga, and John A. Sweeney. “Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder.” Schizophr Bull 43, no. 2 (March 1, 2017): 397–406. https://doi.org/10.1093/schbul/sbw081.
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    • Nutt, David, Christine C. Gispen-de Wied, Celso Arango, Richard S. E. Keefe, Rafael Penadés, Declan G. Murphy, Trevor W. Robbins, and Barbara J. Sahakian. “Cognition in schizophrenia: summary Nice Consultation Meeting 2012.” Eur Neuropsychopharmacol 23, no. 8 (August 2013): 769–78. https://doi.org/10.1016/j.euroneuro.2013.03.005.
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    • Jarskog, L Fredrik, Zhengchao Dong, Alayar Kangarlu, Tiziano Colibazzi, Ragy R. Girgis, Lawrence S. Kegeles, Deanna M. Barch, et al. “Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia.” Neuropsychopharmacology 38, no. 7 (June 2013): 1245–52. https://doi.org/10.1038/npp.2013.23.
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    • Cruz, Breno Fiúza, Camilo Brandão de Resende, Mery Natali Abreu, Fábio Lopes Rocha, Antonio Lúcio Teixeira, Richard S. E. Keefe, and João Vinícius Salgado. “How specific are negative symptoms and cognitive impairment in schizophrenia? An analysis of PANSS and SCoRS.” Cogn Neuropsychiatry 18, no. 3 (May 2013): 243–51. https://doi.org/10.1080/13546805.2012.730995.
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    • Keefe, R. S. E., H. C. Kraemer, R. S. Epstein, E. Frank, G. Haynes, T. P. Laughren, J. McNulty, S. D. Reed, J. Sanchez, and A. C. Leon. “Defining a clinically meaningful effect for the design and interpretation of randomized controlled trials.” Innovations in Clinical Neuroscience 10, no. 5–6 (May 1, 2013).
    • Keefe, Richard S. E., Helena C. Kraemer, Robert S. Epstein, Ellen Frank, Ginger Haynes, Thomas P. Laughren, James McNulty, Shelby D. Reed, Juan Sanchez, and Andrew C. Leon. “Defining a clinically meaningful effect for the design and interpretation of randomized controlled trials.” Innov Clin Neurosci 10, no. 5-6 Suppl A (May 2013): 4S-19S.
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    • Vita, Antonio, Giacomo Deste, Stefano Barlati, Luca De Peri, Agnese Giambra, Roberto Poli, Richard S. E. Keefe, and Emilio Sacchetti. “Interview-based assessment of cognition in schizophrenia: applicability of the Schizophrenia Cognition Rating Scale (SCoRS) in different phases of illness and settings of care.” Schizophr Res 146, no. 1–3 (May 2013): 217–23. https://doi.org/10.1016/j.schres.2013.02.035.
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    • Sakurai, Hitoshi, Robert R. Bies, Scott T. Stroup, Richard S. E. Keefe, Tarek K. Rajji, Takefumi Suzuki, David C. Mamo, et al. “Dopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data.” Schizophr Bull 39, no. 3 (May 2013): 564–74. https://doi.org/10.1093/schbul/sbr189.
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    • Ventura, Joseph, Steven P. Reise, Richard S. E. Keefe, Irene M. Hurford, Rachel C. Wood, and Robert M. Bilder. “The Cognitive Assessment Interview (CAI): reliability and validity of a brief interview-based measure of cognition.” Schizophr Bull 39, no. 3 (May 2013): 583–91. https://doi.org/10.1093/schbul/sbs001.
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    • Barbato, Mariapaola, Mark A. Colijn, Richard S. E. Keefe, Diana O. Perkins, Scott W. Woods, Keith A. Hawkins, Bruce K. Christensen, and Jean Addington. “The course of cognitive functioning over six months in individuals at clinical high risk for psychosis.” Psychiatry Res 206, no. 2–3 (April 30, 2013): 195–99. https://doi.org/10.1016/j.psychres.2012.10.013.
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    • Lam, Max, Goi Khia Eng, Attilio Rapisarda, Mythily Subramaniam, Michael Kraus, Richard S. E. Keefe, and Simon Lowes Collinson. “Formulation of the age-education index: measuring age and education effects in neuropsychological performance.” Psychol Assess 25, no. 1 (March 2013): 61–70. https://doi.org/10.1037/a0030548.
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    • Keefe, Richard S. E., Robert W. Buchanan, Stephen R. Marder, Nina R. Schooler, Ashish Dugar, Milana Zivkov, and Michelle Stewart. “Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far?” Schizophr Bull 39, no. 2 (March 2013): 417–35. https://doi.org/10.1093/schbul/sbr153.
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    • Kim, Jeong Lan, Shilpa Rele, David M. Marks, Prakash S. Masand, Pallavi Yerramsetty, Robert A. Millet, Richard S. Keefe, and Ashwin A. Patkar. “Effects of milnacipran on neurocognition, pain, and fatigue in fibromyalgia: a 13-week, randomized, placebo-controlled, crossover trial.” Prim Care Companion Cns Disord 15, no. 6 (2013). https://doi.org/10.4088/PCC.13m01555.
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    • Lee, Tih-Shih, Siau Juinn Alexa Goh, Shin Yi Quek, Rachel Phillips, Cuntai Guan, Yin Bun Cheung, Lei Feng, et al. “A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.” Plos One 8, no. 11 (2013): e79419. https://doi.org/10.1371/journal.pone.0079419.
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    • Rapisarda, Attilio, Thomas F. Lim, Matthew Lim, Simon L. Collinson, Michael S. Kraus, and Richard S. E. Keefe. “Applicability of the MATRICS Consensus Cognitive Battery in Singapore.” Clin Neuropsychol 27, no. 3 (2013): 455–69. https://doi.org/10.1080/13854046.2012.762120.
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    • Matza, Louis S., Glenn A. Phillips, Dennis A. Revicki, Haya Ascher-Svanum, Karen G. Malley, Andrew C. Palsgrove, Douglas E. Faries, et al. “Validation of a clinician questionnaire to assess reasons for antipsychotic discontinuation and continuation among patients with schizophrenia.” Psychiatry Res 200, no. 2–3 (December 30, 2012): 835–42. https://doi.org/10.1016/j.psychres.2012.05.005.
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    • Harvey, P. D., and R. S. Keefe. “Technology, society, and mental illness: Challenges and opportunities for assessment and treatment.” Innovations in Clinical Neuroscience 9, no. 11–12 (December 1, 2012): 47–50.
    • Kahn, Phoebe V., Trina M. Walker, Teresa S. Williams, Barbara A. Cornblatt, Richard C. Mohs, and Richard S. E. Keefe. “Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study.” Schizophr Res 142, no. 1–3 (December 2012): 153–58. https://doi.org/10.1016/j.schres.2012.09.009.
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    • Meier, Madeline H., Avshalom Caspi, Antony Ambler, HonaLee Harrington, Renate Houts, Richard S. E. Keefe, Kay McDonald, Aimee Ward, Richie Poulton, and Terrie E. Moffitt. “Persistent cannabis users show neuropsychological decline from childhood to midlife.” Proc Natl Acad Sci U S A 109, no. 40 (October 2, 2012): E2657–64. https://doi.org/10.1073/pnas.1206820109.
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    • Geffen, Yona, Richard Keefe, Jonathan Rabinowitz, Ravi Anand, and Michael Davidson. “Bl-1020, a new γ-aminobutyric acid-enhanced antipsychotic: results of 6-week, randomized, double-blind, controlled, efficacy and safety study.” J Clin Psychiatry 73, no. 9 (September 2012): e1168–74. https://doi.org/10.4088/JCP.12m07642.
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    • Keefe, Richard S. E., Sophia Vinogradov, Alice Medalia, Peter F. Buckley, Stanley N. Caroff, Deepak C. D’Souza, Phillip D. Harvey, et al. “Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial.” J Clin Psychiatry 73, no. 7 (July 2012): 1016–22. https://doi.org/10.4088/JCP.11m07100.
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    • Weiser, Mark, Ari A. Gershon, Katya Rubinstein, Camelia Petcu, Maria Ladea, Dorina Sima, Delia Podea, Richard S. E. Keefe, and John M. Davis. “A randomized controlled trial of allopurinol vs. placebo added on to antipsychotics in patients with schizophrenia or schizoaffective disorder.” Schizophr Res 138, no. 1 (June 2012): 35–38. https://doi.org/10.1016/j.schres.2012.02.014.
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    • Keefe, Richard S. E., and Michael S. Kraus. “Clues to the cognitive and perceptual origins of social isolation and psychosis in schizophrenia.” Am J Psychiatry 169, no. 4 (April 2012): 354–57. https://doi.org/10.1176/appi.ajp.2012.12010042.
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    • Javitt, Daniel C., Robert W. Buchanan, Richard S. E. Keefe, Robert Kern, Robert P. McMahon, Michael F. Green, Jeffrey Lieberman, et al. “Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia.” Schizophr Res 136, no. 1–3 (April 2012): 25–31. https://doi.org/10.1016/j.schres.2011.11.001.
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    • Krishnan, R. R., M. Fivaz, M. S. Kraus, and R. S. E. Keefe. “Erratum: Hierarchical temporal processing deficit model of reality distortion and psychoses (Molecular Psychiatry (2011) 16, (129-144) DOI: 10.1038/mp.2010.63).” Molecular Psychiatry 17, no. 4 (January 1, 2012): 470. https://doi.org/10.1038/mp.2011.54.
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    • Matza, Louis S., Glenn A. Phillips, Dennis A. Revicki, Haya Ascher-Svanum, Karen G. Malley, Andrew C. Palsgrove, Douglas E. Faries, et al. “Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation.” Patient Prefer Adherence 6 (2012): 521–32. https://doi.org/10.2147/PPA.S25635.
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    • Keefe, Richard S. E., and Philip D. Harvey. “Cognitive impairment in schizophrenia.” Handb Exp Pharmacol, no. 213 (2012): 11–37. https://doi.org/10.1007/978-3-642-25758-2_2.
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    • Greenberg, Greg, Robert A. Rosenheck, Steven K. Erickson, Rani A. Desai, Elina A. Stefanovics, Marvin Swartz, Richard S. E. Keefe, Joe McEvoy, T Scott Stroup, and T Scott CATIE Investigators. “Criminal justice system involvement among people with schizophrenia.” Community Ment Health J 47, no. 6 (December 2011): 727–36. https://doi.org/10.1007/s10597-010-9362-9.
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    • Buchanan, Robert W., Richard S. E. Keefe, Daniel Umbricht, Michael F. Green, Thomas Laughren, and Stephen R. Marder. “The FDA-NIMH-MATRICS guidelines for clinical trial design of cognitive-enhancing drugs: what do we know 5 years later?” Schizophr Bull 37, no. 6 (November 2011): 1209–17. https://doi.org/10.1093/schbul/sbq038.
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    • Kerfoot, Karin E., Robert A. Rosenheck, Ismene L. Petrakis, Marvin S. Swartz, Richard S. E. Keefe, Joseph P. McEvoy, T Scott Stroup, and T Scott CATIE Investigators. “Substance use and schizophrenia: adverse correlates in the CATIE study sample.” Schizophr Res 132, no. 2–3 (November 2011): 177–82. https://doi.org/10.1016/j.schres.2011.07.032.
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    • Chong, Siow-Ann, Alastair Campbell, Michael Chee, Jianjun Liu, Christine Marx, Patrick McGorry, Mythily Subramaniam, Alison Yung, and Richard S. E. Keefe. “The Singapore flagship programme in translational and clinical research in psychosis.” Early Interv Psychiatry 5, no. 4 (November 2011): 290–300. https://doi.org/10.1111/j.1751-7893.2011.00304.x.
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    • Keefe, Richard S. E., Sophia Vinogradov, Alice Medalia, Steven M. Silverstein, Morris D. Bell, Dwight Dickinson, Joseph Ventura, Stephen R. Marder, and T Scott Stroup. “Report from the working group conference on multisite trial design for cognitive remediation in schizophrenia.” Schizophr Bull 37, no. 5 (September 2011): 1057–65. https://doi.org/10.1093/schbul/sbq010.
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    • Stroup, T Scott, Paul S. Appelbaum, Hongbin Gu, Spencer Hays, Marvin S. Swartz, Richard S. E. Keefe, Scott Y. Kim, et al. “Longitudinal consent-related abilities among research participants with schizophrenia: results from the CATIE study.” Schizophr Res 130, no. 1–3 (August 2011): 47–52. https://doi.org/10.1016/j.schres.2011.04.012.
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    • Vigen, Cheryl L. P., Wendy J. Mack, Richard S. E. Keefe, Mary Sano, David L. Sultzer, T Scott Stroup, Karen S. Dagerman, et al. “Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: outcomes from CATIE-AD.” Am J Psychiatry 168, no. 8 (August 2011): 831–39. https://doi.org/10.1176/appi.ajp.2011.08121844.
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    • Burdick, Katherine E., Terry E. Goldberg, Barbara A. Cornblatt, Richard S. Keefe, Chaya B. Gopin, Pamela Derosse, Raphael J. Braga, and Anil K. Malhotra. “The MATRICS consensus cognitive battery in patients with bipolar I disorder.” Neuropsychopharmacology 36, no. 8 (July 2011): 1587–92. https://doi.org/10.1038/npp.2011.36.
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    • Krishnan, Ranga R., Michael S. Kraus, and Richard S. E. Keefe. “Comprehensive model of how reality distortion and symptoms occur in schizophrenia: could impairment in learning-dependent predictive perception account for the manifestations of schizophrenia?” Psychiatry Clin Neurosci 65, no. 4 (June 2011): 305–17. https://doi.org/10.1111/j.1440-1819.2011.02203.x.
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    • Hurford, Irene M., Stephen R. Marder, Richard S. E. Keefe, Steven P. Reise, and Robert M. Bilder. “A brief cognitive assessment tool for schizophrenia: construction of a tool for clinicians.” Schizophr Bull 37, no. 3 (May 2011): 538–45. https://doi.org/10.1093/schbul/sbp095.
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    • Sim, Kang, Jimmy Lee, Mythily Subramaniam, Jian Jun Liu, Richard Keefe, Xiao Dong Zhang, Tih Shih Lee, and Siow Ann Chong. “Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview.” Early Interv Psychiatry 5, no. 2 (May 2011): 91–99. https://doi.org/10.1111/j.1751-7893.2011.00272.x.
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    • Harvey, Philip D., Masaaki Ogasa, Josephine Cucchiaro, Antony Loebel, and Richard S. E. Keefe. “Performance and interview-based assessments of cognitive change in a randomized, double-blind comparison of lurasidone vs. ziprasidone.” Schizophr Res 127, no. 1–3 (April 2011): 188–94. https://doi.org/10.1016/j.schres.2011.01.004.
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    • Caroff, Stanley N., Vicki G. Davis, Del D. Miller, Sonia M. Davis, Robert A. Rosenheck, Joseph P. McEvoy, E Cabrina Campbell, et al. “Treatment outcomes of patients with tardive dyskinesia and chronic schizophrenia.” J Clin Psychiatry 72, no. 3 (March 2011): 295–303. https://doi.org/10.4088/JCP.09m05793yel.
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    • Kern, Robert S., James M. Gold, Dwight Dickinson, Michael F. Green, Keith H. Nuechterlein, Lyle E. Baade, Richard S. E. Keefe, et al. “The MCCB impairment profile for schizophrenia outpatients: results from the MATRICS psychometric and standardization study.” Schizophr Res 126, no. 1–3 (March 2011): 124–31. https://doi.org/10.1016/j.schres.2010.11.008.
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    • Marder, Stephen R., David G. Daniel, Larry Alphs, A George Awad, and Richard S. E. Keefe. “Methodological issues in negative symptom trials.” Schizophr Bull 37, no. 2 (March 2011): 250–54. https://doi.org/10.1093/schbul/sbq161.
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    • Reise, Steven P., Joseph Ventura, Richard S. E. Keefe, Lyle E. Baade, James M. Gold, Michael F. Green, Robert S. Kern, et al. “Bifactor and item response theory analyses of interviewer report scales of cognitive impairment in schizophrenia.” Psychol Assess 23, no. 1 (March 2011): 245–61. https://doi.org/10.1037/a0021501.
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    • Sachs, G., B. Winklbaur, R. Jagsch, and R. S. E. Keefe. “Validation of the German version of the brief assessment of cognition in Schizophrenia (BACS) - preliminary results.” Eur Psychiatry 26, no. 2 (March 2011): 74–77. https://doi.org/10.1016/j.eurpsy.2009.10.006.
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    • Buchanan, Robert W., Richard S. E. Keefe, Jeffrey A. Lieberman, Deanna M. Barch, John G. Csernansky, Donald C. Goff, James M. Gold, et al. “A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia.” Biol Psychiatry 69, no. 5 (March 1, 2011): 442–49. https://doi.org/10.1016/j.biopsych.2010.09.052.
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    • Segarra, N., M. Bernardo, F. Gutierrez, A. Justicia, E. Fernadez-Egea, M. Allas, G. Safont, et al. “Spanish validation of the Brief Assessment in Cognition in Schizophrenia (BACS) in patients with schizophrenia and healthy controls.” Eur Psychiatry 26, no. 2 (March 2011): 69–73. https://doi.org/10.1016/j.eurpsy.2009.11.001.
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    • Keefe, Richard S. E., Kolleen Hurley Fox, Philip D. Harvey, Josephine Cucchiaro, Cynthia Siu, and Antony Loebel. “Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial.” Schizophr Res 125, no. 2–3 (February 2011): 161–68. https://doi.org/10.1016/j.schres.2010.09.015.
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    • Krishnan, R. R., M. Fivaz, M. S. Kraus, and R. S. E. Keefe. “Hierarchical temporal processing deficit model of reality distortion and psychoses.” Mol Psychiatry 16, no. 2 (February 2011): 129–44. https://doi.org/10.1038/mp.2010.63.
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    • McClay, Joseph L., Daniel E. Adkins, Karolina Aberg, Jozsef Bukszár, Amit N. Khachane, Richard S. E. Keefe, Diana O. Perkins, et al. “Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.” Neuropsychopharmacology 36, no. 3 (February 2011): 616–26. https://doi.org/10.1038/npp.2010.193.
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    • Keefe, Richard S. E., Michael S. Kraus, and Ranga R. Krishnan. “Failures in learning-dependent predictive perception as the key cognitive vulnerability to psychosis in schizophrenia.” Neuropsychopharmacology 36, no. 1 (January 2011): 367–68. https://doi.org/10.1038/npp.2010.153.
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    • Kane, John M., Deepak C. D’Souza, Ashwin A. Patkar, James M. Youakim, Jane M. Tiller, Ronghua Yang, and Richard S. E. Keefe. “Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study.” J Clin Psychiatry 71, no. 11 (November 2010): 1475–81. https://doi.org/10.4088/JCP.09m05950gry.
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    • Ascher-Svanum, Haya, Allen W. Nyhuis, Virginia Stauffer, Bruce J. Kinon, Douglas E. Faries, Glenn A. Phillips, Kory Schuh, A George Awad, Richard Keefe, and Dieter Naber. “Reasons for discontinuation and continuation of antipsychotics in the treatment of schizophrenia from patient and clinician perspectives.” Curr Med Res Opin 26, no. 10 (October 2010): 2403–10. https://doi.org/10.1185/03007995.2010.515900.
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    • Ventura, Joseph, Steven P. Reise, Richard S. E. Keefe, Lyle E. Baade, James M. Gold, Michael F. Green, Robert S. Kern, et al. “The Cognitive Assessment Interview (CAI): development and validation of an empirically derived, brief interview-based measure of cognition.” Schizophr Res 121, no. 1–3 (August 2010): 24–31. https://doi.org/10.1016/j.schres.2010.04.016.
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    • Konneker, Thomas I., James J. Crowley, Corey R. Quackenbush, Richard S. E. Keefe, Diana O. Perkins, T Scott Stroup, Jeffrey A. Lieberman, Edwin van den Oord, and Patrick F. Sullivan. “No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition.” Am J Med Genet B Neuropsychiatr Genet 153B, no. 5 (July 2010): 1115–17. https://doi.org/10.1002/ajmg.b.31077.
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    • Chia, Ming Ying, Wai Yen Chan, Kok Yeow Chua, Helen Lee, Jimmy Lee, Rebecca Lee, Caroline Lim, et al. “The Schizophrenia Cognition Rating Scale: validation of an interview-based assessment of cognitive functioning in Asian patients with schizophrenia.” Psychiatry Res 178, no. 1 (June 30, 2010): 33–38. https://doi.org/10.1016/j.psychres.2010.03.020.
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    • Chan, Wai-Yen, Guo-Liang Yang, Ming-Ying Chia, Puay-San Woon, Jimmy Lee, Richard Keefe, Yih-Yian Sitoh, Wieslaw Lucjan Nowinski, and Kang Sim. “Cortical and subcortical white matter abnormalities in adults with remitted first-episode mania revealed by Tract-Based Spatial Statistics.” Bipolar Disord 12, no. 4 (June 2010): 383–89. https://doi.org/10.1111/j.1399-5618.2010.00829.x.
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    • Seidman, Larry J., Anthony J. Giuliano, Eric C. Meyer, Jean Addington, Kristin S. Cadenhead, Tyrone D. Cannon, Thomas H. McGlashan, et al. “Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis.” Arch Gen Psychiatry 67, no. 6 (June 2010): 578–88. https://doi.org/10.1001/archgenpsychiatry.2010.66.
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    • Goldberg, Terry E., Richard S. E. Keefe, Robert S. Goldman, Delbert G. Robinson, and Philip D. Harvey. “Circumstances under which practice does not make perfect: a review of the practice effect literature in schizophrenia and its relevance to clinical treatment studies.” Neuropsychopharmacology 35, no. 5 (April 2010): 1053–62. https://doi.org/10.1038/npp.2009.211.
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    • Polanczyk, Guilherme, Terrie E. Moffitt, Louise Arseneault, Mary Cannon, Antony Ambler, Richard S. E. Keefe, Renate Houts, Candice L. Odgers, and Avshalom Caspi. “Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.” Arch Gen Psychiatry 67, no. 4 (April 2010): 328–38. https://doi.org/10.1001/archgenpsychiatry.2010.14.
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    • Reichenberg, Abraham, Avshalom Caspi, Honalee Harrington, Renate Houts, Richard S. E. Keefe, Robin M. Murray, Richie Poulton, and Terrie E. Moffitt. “Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study.” Am J Psychiatry 167, no. 2 (February 2010): 160–69. https://doi.org/10.1176/appi.ajp.2009.09040574.
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    • Barch, Deanna M., and Richard S. E. Keefe. “Anticipating DSM-V: opportunities and challenges for cognition and psychosis.” Schizophr Bull 36, no. 1 (January 2010): 43–47. https://doi.org/10.1093/schbul/sbp139.
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    • Keefe, R. S. E. “Neurocognition,” January 1, 2010, 97–119. https://doi.org/10.1017/CBO9780511712265.007.
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    • Lamonica, Haley M., Richard S. E. Keefe, Philip D. Harvey, James M. Gold, and Terry E. Goldberg. “Differential effects of emotional information on interference task performance across the life span.” Front Aging Neurosci 2 (2010). https://doi.org/10.3389/fnagi.2010.00141.
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    • Pinheiro, A. P., R. S. E. Keefe, T. Skelly, M. Olarte, K. Leviel, L. A. Lange, E. M. Lange, T. S. Stroup, J. Lieberman, and P. F. Sullivan. “Erratum: AKT1 and neurocognition in schizophrenia (Australian and New Zealand Journal of Psychiatry (2007) 41 (169-177)).” Australian and New Zealand Journal of Psychiatry 43, no. 10 (December 8, 2009): 983. https://doi.org/10.1080/00048670903228991.
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    • Fox, K. H., K. E. Burdick, I. Lombardo, and R. S. E. Keefe. “Cognitive impairment in patients with bipolar disorder.” Psychiatric Times 26, no. 12 (December 1, 2009): 66–68.
    • Penn, David L., Richard S. E. Keefe, Sonia M. Davis, Piper S. Meyer, Diana O. Perkins, Diane Losardo, and Jeffrey A. Lieberman. “The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trial.” Schizophr Res 115, no. 1 (November 2009): 17–23. https://doi.org/10.1016/j.schres.2009.08.016.
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    • Pinheiro, A. P., R. S. E. Keefe, T. Skelly, M. Olarte, K. Leviel, L. A. Lange, E. M. Lange, T. S. Stroup, J. Lieberman, and P. F. Sullivan. “Erratum: Rates of depressive and anxiety disorders in a residential mother-infant unit for unsettled infants (Australian and New Zealand Journal of Psychiatry (2007) 41 (836-842)).” Australian and New Zealand Journal of Psychiatry 43, no. 11 (November 1, 2009): 1087. https://doi.org/10.1080/00048670903270266.
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    • Keefe, R. S. E., L. J. Seidman, B. K. Christensen, R. M. Hamer, T. Sharma, M. M. Sitskoorn, R. R. J. Lewine, et al. “Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: A randomized, double-blind trial of olanzapine versus low doses of haloperidol (American Journal of Psychiatry (2004) 161, (985-995)).” American Journal of Psychiatry 166, no. 8 (September 21, 2009): 942.
    • Kraus, Michael S., Richard S. E. Keefe, and Ranga K. R. Krishnan. “Memory-prediction errors and their consequences in schizophrenia.” Neuropsychol Rev 19, no. 3 (September 2009): 336–52. https://doi.org/10.1007/s11065-009-9106-1.
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    • Lipkovich, Ilya A., Walter Deberdt, John G. Csernansky, Bernard Sabbe, Richard Se Keefe, and Sara Kollack-Walker. “Relationships among neurocognition, symptoms and functioning in patients with schizophrenia: a path-analytic approach for associations at baseline and following 24 weeks of antipsychotic drug therapy.” Bmc Psychiatry 9 (July 14, 2009): 44. https://doi.org/10.1186/1471-244X-9-44.
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    • Crowley, James J., Richard S. E. Keefe, Diana O. Perkins, T Scott Stroup, Jeffrey A. Lieberman, and Patrick F. Sullivan. “The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition.” Am J Med Genet B Neuropsychiatr Genet 147B, no. 7 (October 5, 2008): 1298–1300. https://doi.org/10.1002/ajmg.b.30727.
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    • Miller, Del D., Stanley N. Caroff, Sonia M. Davis, Robert A. Rosenheck, Joseph P. McEvoy, Bruce L. Saltz, Silvana Riggio, et al. “Extrapyramidal side-effects of antipsychotics in a randomised trial.” Br J Psychiatry 193, no. 4 (October 2008): 279–88. https://doi.org/10.1192/bjp.bp.108.050088.
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    • Mohamed, Somaia, Robert Rosenheck, Marvin Swartz, Scott Stroup, Jeffrey A. Lieberman, and Richard S. E. Keefe. “Relationship of cognition and psychopathology to functional impairment in schizophrenia.” Am J Psychiatry 165, no. 8 (August 2008): 978–87. https://doi.org/10.1176/appi.ajp.2008.07111713.
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    • Keefe, Richard S. E., Philip D. Harvey, Terry E. Goldberg, James M. Gold, Trina M. Walker, Courtney Kennel, and Kirsten Hawkins. “Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS).” Schizophr Res 102, no. 1–3 (July 2008): 108–15. https://doi.org/10.1016/j.schres.2008.03.024.
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    • Keefe, Richard S. E., Anil K. Malhotra, Herbert Y. Meltzer, John M. Kane, Robert W. Buchanan, Anita Murthy, Mindy Sovel, Chunming Li, and Robert Goldman. “Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial.” Neuropsychopharmacology 33, no. 6 (May 2008): 1217–28. https://doi.org/10.1038/sj.npp.1301499.
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    • Lieberman, Jeffrey A., Robert E. Drake, Lloyd I. Sederer, Aysenil Belger, Richard Keefe, Diana Perkins, and Scott Stroup. “Science and recovery in schizophrenia.” Psychiatr Serv 59, no. 5 (May 2008): 487–96. https://doi.org/10.1176/ps.2008.59.5.487.
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    • Resnick, Sandra G., Robert A. Rosenheck, Jose M. Canive, Cyril De Souza, T Scott Stroup, Joseph McEvoy, Sonia Davis, Richard S. E. Keefe, Marvin Swartz, and Jeffrey Lieberman. “Employment outcomes in a randomized trial of second-generation antipsychotics and perphenazine in the treatment of individuals with schizophrenia.” J Behav Health Serv Res 35, no. 2 (April 2008): 215–25. https://doi.org/10.1007/s11414-007-9101-3.
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    • Kern, Robert S., Keith H. Nuechterlein, Michael F. Green, Lyle E. Baade, Wayne S. Fenton, James M. Gold, Richard S. E. Keefe, et al. “The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization.” Am J Psychiatry 165, no. 2 (February 2008): 214–20. https://doi.org/10.1176/appi.ajp.2007.07010043.
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    • Keefe, Richard S. E. “Should cognitive impairment be included in the diagnostic criteria for schizophrenia?” World Psychiatry 7, no. 1 (February 2008): 22–28. https://doi.org/10.1002/j.2051-5545.2008.tb00142.x.
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    • Kaneda, Yasuhiro, Tomiki Sumiyoshi, Richard Keefe, Yasuhito Ishimoto, Shusuke Numata, and Tetsuro Ohmori. “Brief assessment of cognition in schizophrenia: validation of the Japanese version.” Psychiatry Clin Neurosci 61, no. 6 (December 2007): 602–9. https://doi.org/10.1111/j.1440-1819.2007.01725.x.
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    • Keefe, R. S. E., J. A. Sweeney, H. Gu, R. M. Hamer, D. O. Perkins, J. P. McEvoy, and J. A. Lieberman. “Dr. Keefe and colleagues reply.” American Journal of Psychiatry 164, no. 12 (December 1, 2007): 1911–12. https://doi.org/10.1176/appi.ajp.2007.07071086r.
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    • Goff, Donald C., Richard Keefe, Leslie Citrome, Katherine Davy, John H. Krystal, Charles Large, Thomas R. Thompson, Jan Volavka, and Elizabeth L. Webster. “Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials.” J Clin Psychopharmacol 27, no. 6 (December 2007): 582–89. https://doi.org/10.1097/jcp.0b013e31815abf34.
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    • Bralet, Marie-Cécile, Bruno Falissard, Xavier Neveu, Margaret Lucas-Ross, Anne-Marie Eskenazi, and Richard S. E. Keefe. “Validation of the French version of the BACS (the brief assessment of cognition in schizophrenia) among 50 French schizophrenic patients.” Eur Psychiatry 22, no. 6 (September 2007): 365–70. https://doi.org/10.1016/j.eurpsy.2007.02.001.
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    • Pandina, Gahan J., Robert Bilder, Philip D. Harvey, Richard S. E. Keefe, Michael G. Aman, and Georges Gharabawi. “Risperidone and cognitive function in children with disruptive behavior disorders.” Biol Psychiatry 62, no. 3 (August 1, 2007): 226–34. https://doi.org/10.1016/j.biopsych.2006.09.036.
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    • Keefe, Richard S. E., John A. Sweeney, Hongbin Gu, Robert M. Hamer, Diana O. Perkins, Joseph P. McEvoy, and Jeffrey A. Lieberman. “Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison.” Am J Psychiatry 164, no. 7 (July 2007): 1061–71. https://doi.org/10.1176/ajp.2007.164.7.1061.
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    • Keefe, Richard S. E., and Wayne S. Fenton. “How should DSM-V criteria for schizophrenia include cognitive impairment?” Schizophr Bull 33, no. 4 (July 2007): 912–20. https://doi.org/10.1093/schbul/sbm046.
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    • Keefe, Richard S. E., Robert M. Bilder, Sonia M. Davis, Philip D. Harvey, Barton W. Palmer, James M. Gold, Herbert Y. Meltzer, et al. “Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial.” Arch Gen Psychiatry 64, no. 6 (June 2007): 633–47. https://doi.org/10.1001/archpsyc.64.6.633.
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    • ROSENHECK, R., T. S. STROUP, M. SWARTZ, J. McEVOY, S. M. DAVIS, R. S. E. KEEFE, J. K. HSIAO, and J. LIEBERMAN. “Dr. Rosenheck and Colleagues Reply.” American Journal of Psychiatry 164, no. 4 (April 1, 2007): 678–80. https://doi.org/10.1176/appi.ajp.164.4.678-a.
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    • Rosenheck, Robert, Marvin Swartz, Joseph McEvoy, T Scott Stroup, Sonia Davis, Richard Se Keefe, John Hsiao, and Jeffrey Lieberman. “Second-generation antipsychotics: reviewing the cost-effectiveness component of the CATIE trial.” Expert Rev Pharmacoecon Outcomes Res 7, no. 2 (April 2007): 103–11. https://doi.org/10.1586/14737167.7.2.103.
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    • Sullivan, Patrick F., Richard S. E. Keefe, Leslie A. Lange, Ethan M. Lange, T Scott Stroup, Jeffrey Lieberman, and Patricia F. Maness. “NCAM1 and neurocognition in schizophrenia.” Biol Psychiatry 61, no. 7 (April 1, 2007): 902–10. https://doi.org/10.1016/j.biopsych.2006.07.036.
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    • McEvoy, Joseph P., Jackie Johnson, Diana Perkins, Jeffrey A. Lieberman, Robert M. Hamer, Richard S. E. Keefe, Mauricio Tohen, Ira D. Glick, and Tonmoy Sharma. “Insight in first-episode psychosis.” Psychol Med 36, no. 10 (October 2006): 1385–93. https://doi.org/10.1017/S0033291706007793.
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    • Chakos, Miranda H., Ira D. Glick, Alexander L. Miller, Mark B. Hamner, Del D. Miller, Jayendra K. Patel, Andre Tapp, Richard S. E. Keefe, and Robert A. Rosenheck. “Baseline use of concomitant psychotropic medications to treat schizophrenia in the CATIE trial.” Psychiatr Serv 57, no. 8 (August 2006): 1094–1101. https://doi.org/10.1176/ps.2006.57.8.1094.
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    • Keefe, Richard S. E., Margaret Poe, Trina M. Walker, Joseph W. Kang, and Philip D. Harvey. “The Schizophrenia Cognition Rating Scale: an interview-based assessment and its relationship to cognition, real-world functioning, and functional capacity.” Am J Psychiatry 163, no. 3 (March 2006): 426–32. https://doi.org/10.1176/appi.ajp.163.3.426.
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    • LIEBERMAN, JEFFREY A., T S. C. O. T. T. STROUP, JOSEPH P. McEVOY, MARVIN S. SWARTZ, ROBERT A. ROSENHECK, DIANA O. PERKINS, RICHARD S. E. KEEFE, et al. “Dr. Lieberman and Colleagues Reply.” American Journal of Psychiatry 163, no. 3 (March 2006). https://doi.org/10.1176/appi.ajp.163.3.555-a.
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    • Narendran, Rajesh, W Gordon Frankle, Richard Keefe, Roberto Gil, Diana Martinez, Mark Slifstein, Lawrence S. Kegeles, et al. “Altered prefrontal dopaminergic function in chronic recreational ketamine users.” Am J Psychiatry 162, no. 12 (December 2005): 2352–59. https://doi.org/10.1176/appi.ajp.162.12.2352.
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    • Rosenheck, Robert, Scott Stroup, Richard S. E. Keefe, Joseph McEvoy, Marvin Swartz, Diana Perkins, John Hsiao, Martha Shumway, and Jeffrey Lieberman. “Measuring outcome priorities and preferences in people with schizophrenia.” Br J Psychiatry 187 (December 2005): 529–36. https://doi.org/10.1192/bjp.187.6.529.
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    • Stroup, Scott, Paul Appelbaum, Marvin Swartz, Mukesh Patel, Sonia Davis, Dilip Jeste, Scott Kim, et al. “Decision-making capacity for research participation among individuals in the CATIE schizophrenia trial.” Schizophr Res 80, no. 1 (December 1, 2005): 1–8. https://doi.org/10.1016/j.schres.2005.08.007.
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    • Strakowski, Stephen M., Jacqueline L. Johnson, Melissa P. Delbello, Robert M. Hamer, Alan I. Green, Mauricio Tohen, Jeffrey A. Lieberman, Ira Glick, Jayendra K. Patel, and Jayendra K. HGDH Research Group. “Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode.” Schizophr Res 78, no. 2–3 (October 15, 2005): 161–69. https://doi.org/10.1016/j.schres.2005.04.017.
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    • Lieberman, Jeffrey A., T Scott Stroup, Joseph P. McEvoy, Marvin S. Swartz, Robert A. Rosenheck, Diana O. Perkins, Richard S. E. Keefe, et al. “Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.” N Engl J Med 353, no. 12 (September 22, 2005): 1209–23. https://doi.org/10.1056/NEJMoa051688.
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    • Artiola I Fortuny, Lidia, Maite Garolera, David Hermosillo Romo, Esther Feldman, Héctor Fernández Barillas, Richard Keefe, Monique J. Lemaître, et al. “Research with spanish-speaking populations in the United States: lost in the translation. A commentary and a plea.” J Clin Exp Neuropsychol 27, no. 5 (July 2005): 555–64. https://doi.org/10.1080/13803390490918282.
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    • Lieberman, Jeffrey A., Gary D. Tollefson, Cecil Charles, Robert Zipursky, Tonmoy Sharma, Rene S. Kahn, Richard S. E. Keefe, et al. “Antipsychotic drug effects on brain morphology in first-episode psychosis.” Arch Gen Psychiatry 62, no. 4 (April 2005): 361–70. https://doi.org/10.1001/archpsyc.62.4.361.
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    • Keefe, Richard S. E., Charles E. Eesley, and Margaret P. Poe. “Defining a cognitive function decrement in schizophrenia.” Biol Psychiatry 57, no. 6 (March 15, 2005): 688–91. https://doi.org/10.1016/j.biopsych.2005.01.003.
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    • Buchanan, Robert W., Miriam Davis, Donald Goff, Michael F. Green, Richard S. E. Keefe, Andrew C. Leon, Keith H. Nuechterlein, et al. “A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia.” Schizophr Bull 31, no. 1 (January 2005): 5–19. https://doi.org/10.1093/schbul/sbi020.
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    • Green, Michael F., Keith H. Nuechterlein, James M. Gold, Deanna M. Barch, Jonathan Cohen, Susan Essock, Wayne S. Fenton, et al. “Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria.” Biol Psychiatry 56, no. 5 (September 1, 2004): 301–7. https://doi.org/10.1016/j.biopsych.2004.06.023.
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    • Keefe, Richard S. E., Larry J. Seidman, Bruce K. Christensen, Robert M. Hamer, Tonmoy Sharma, Margriet M. Sitskoorn, Richard R. J. Lewine, et al. “Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol.” Am J Psychiatry 161, no. 6 (June 2004): 985–95. https://doi.org/10.1176/appi.ajp.161.6.985.
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    • Keefe, Richard S. E., Terry E. Goldberg, Philip D. Harvey, James M. Gold, Margaret P. Poe, and Leigh Coughenour. “The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery.” Schizophr Res 68, no. 2–3 (June 1, 2004): 283–97. https://doi.org/10.1016/j.schres.2003.09.011.
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    • Hawkins, K. A., J. Addington, R. S. E. Keefe, B. Christensen, D. O. Perkins, R. Zipurksy, S. W. Woods, et al. “Neuropsychological status of subjects at high risk for a first episode of psychosis.” Schizophr Res 67, no. 2–3 (April 1, 2004): 115–22. https://doi.org/10.1016/j.schres.2003.08.007.
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    • Harvey, Philip D., Michael F. Green, Richard S. E. Keefe, and Dawn I. Velligan. “Cognitive functioning in schizophrenia: a consensus statement on its role in the definition and evaluation of effective treatments for the illness.” J Clin Psychiatry 65, no. 3 (March 2004): 361–72.
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    • Keefe, Richard S. E., Margaret P. Poe, Joseph P. McEvoy, and Adam Vaughan. “Source monitoring improvement in patients with schizophrenia receiving antipsychotic medications.” Psychopharmacology (Berl) 169, no. 3–4 (September 2003): 383–89. https://doi.org/10.1007/s00213-003-1476-0.
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    • Keefe, Richard S. E., Richard C. Mohs, Robert M. Bilder, Philip D. Harvey, Michael F. Green, Herbert Y. Meltzer, James M. Gold, and Mary Sano. “Neurocognitive assessment in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project schizophrenia trial: development, methodology, and rationale.” Schizophr Bull 29, no. 1 (2003): 45–55. https://doi.org/10.1093/oxfordjournals.schbul.a006990.
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    • Keefe, Richard S. E., Miriam C. Arnold, Ute J. Bayen, Joseph P. McEvoy, and William H. Wilson. “Source-monitoring deficits for self-generated stimuli in schizophrenia: multinomial modeling of data from three sources.” Schizophr Res 57, no. 1 (September 1, 2002): 51–67. https://doi.org/10.1016/s0920-9964(01)00306-1.
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    • Conway, Charles R., Anna M. Bollini, Brevick G. Graham, Richard S. E. Keefe, Susan S. Schiffman, and Joseph P. McEvoy. “Sensory acuity and reasoning in delusional disorder.” Compr Psychiatry 43, no. 3 (2002): 175–78. https://doi.org/10.1053/comp.2002.32358.
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    • Keefe, R. S. E. “[The evaluation of cognitive dysfunctions in schizophrenia].” Encephale 28 Spec No 2 Pt 2 (2002): S11–13.
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    • Harvey, P. D., and R. S. Keefe. “Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment.” Am J Psychiatry 158, no. 2 (February 2001): 176–84. https://doi.org/10.1176/appi.ajp.158.2.176.
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    • Bollini, A. M., M. C. Arnold, and R. S. Keefe. “Test-retest reliability of the dot test of visuospatial working memory in patients with schizophrenia and controls.” Schizophr Res 45, no. 1–2 (September 29, 2000): 169–73. https://doi.org/10.1016/s0920-9964(99)00216-9.
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    • Roitman, S. E., V. Mitropoulou, R. S. Keefe, J. M. Silverman, M. Serby, P. D. Harvey, D. A. Reynolds, R. C. Mohs, and L. J. Siever. “Visuospatial working memory in schizotypal personality disorder patients.” Schizophr Res 41, no. 3 (February 14, 2000): 447–55. https://doi.org/10.1016/s0920-9964(99)00085-7.
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    • Keefe, R. S., M. C. Arnold, U. J. Bayen, and P. D. Harvey. “Source monitoring deficits in patients with schizophrenia; a multinomial modelling analysis.” Psychol Med 29, no. 4 (July 1999): 903–14. https://doi.org/10.1017/s0033291799008673.
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    • Keefe, R. S. E., A. M. Bollini, and S. G. Silva. “Do novel antipsychotics improve cognition? A report of a meta-analysis.” Psychiatric Annals 29, no. 11 (January 1, 1999): 623–29. https://doi.org/10.3928/0048-5713-19991101-08.
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    • Keefe, R. S., S. G. Silva, D. O. Perkins, and J. A. Lieberman. “The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis.” Schizophr Bull 25, no. 2 (1999): 201–22. https://doi.org/10.1093/oxfordjournals.schbul.a033374.
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    • Davis, K. L., M. S. Buchsbaum, L. Shihabuddin, J. Spiegel-Cohen, M. Metzger, E. Frecska, R. S. Keefe, and P. Powchik. “Ventricular enlargement in poor-outcome schizophrenia.” Biol Psychiatry 43, no. 11 (June 1, 1998): 783–93. https://doi.org/10.1016/s0006-3223(97)00553-2.
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    • Keefe, R. S. E., M. Courtney, U. J. Bayan, P. D. Harvey, and J. M. McEvoy. “Does autonoetic agnosia underlie specific psychotic symptoms in schizophrenia?” Schizophrenia Research 29, no. 1–2 (January 1998): 36–36. https://doi.org/10.1016/s0920-9964(97)88379-x.
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    • Vocisano, C., D. N. Klein, and R. S. Keefe. “Lifetime comorbidity, lifetime history of psychosis and suicide attempts, and current symptoms of patients with deteriorated affective disorder.” Psychiatry Res 73, no. 1–2 (November 14, 1997): 33–45. https://doi.org/10.1016/s0165-1781(97)00114-5.
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    • Roitman, S. E., R. S. Keefe, P. D. Harvey, L. J. Siever, and R. C. Mohs. “Attentional and eye tracking deficits correlate with negative symptoms in schizophrenia.” Schizophr Res 26, no. 2–3 (August 29, 1997): 139–46. https://doi.org/10.1016/s0920-9964(97)00044-3.
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    • Keefe, R. S., S. E. Lees-Roitman, and R. L. Dupre. “Performance of patients with schizophrenia on a pen and paper visuospatial working memory task with short delay.” Schizophr Res 26, no. 1 (July 25, 1997): 9–14. https://doi.org/10.1016/S0920-9964(97)00037-6.
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    • Roitman, S. E., B. A. Cornblatt, A. Bergman, M. Obuchowski, V. Mitropoulou, R. S. Keefe, J. M. Silverman, and L. J. Siever. “Attentional functioning in schizotypal personality disorder.” Am J Psychiatry 154, no. 5 (May 1997): 655–60. https://doi.org/10.1176/ajp.154.5.655.
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    • Keefe, R. S., J. M. Silverman, R. C. Mohs, L. J. Siever, P. D. Harvey, L. Friedman, S. E. Roitman, et al. “Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia.” Arch Gen Psychiatry 54, no. 2 (February 1997): 169–76. https://doi.org/10.1001/archpsyc.1997.01830140081014.
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    • Harvey, P. D., and R. S. E. Keefe. “Cognitive impairment in schizophrenia and implications of atypical neuroleptic treatment.” Cns Spectrums 2, no. 8 (January 1, 1997): 41–55. https://doi.org/10.1017/S1092852900005034.
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    • Harvey, P. D., and R. S. E. Keefe. “Cognitive impairment in schizophrenia and implications of atypical neuroleptic treatment.” Cns Spectrums 2, no. 8 (1997): 41–55.
    • Keefe, Richard S. E., Miriam Courtney, and Joseph M. McEvoy. “Self-monitoring deficits in schizophrenia: Autonoetic agnosia.” Schizophrenia Research 24, no. 1–2 (January 1997): 110–110. https://doi.org/10.1016/s0920-9964(97)82306-7.
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    • Harvey, P. D., M. Davidson, L. White, R. S. Keefe, J. Hirschowitz, R. C. Mohs, and K. L. Davis. “Empirical evaluation of the factorial structure of clinical symptoms in schizophrenia: effects of typical neuroleptics on the brief psychiatric rating scale.” Biol Psychiatry 40, no. 8 (October 15, 1996): 755–60. https://doi.org/10.1016/0006-3223(95)00486-6.
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    • Keefe, R. S. E., and B. A. Cornblatt. “The neuropsychology of schizophrenia - David,AS, Cutting,JC.” Contemporary Psychology 41, no. 9 (September 1, 1996): 900–902.
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    • Keefe, R. S., E. Frescka, S. H. Apter, M. Davidson, J. M. Macaluso, J. Hirschowitz, and K. L. Davis. “Clinical characteristics of Kraepelinian schizophrenia: replication and extension of previous findings.” Am J Psychiatry 153, no. 6 (June 1996): 806–11. https://doi.org/10.1176/ajp.153.6.806.
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    • Epstein, J. I., R. S. Keefe, S. L. Roitman, P. D. Harvey, and R. C. Mohs. “Impact of neuroleptic medications on continuous performance test measures in schizophrenia.” Biol Psychiatry 39, no. 10 (May 15, 1996): 902–5. https://doi.org/10.1016/0006-3223(95)00588-9.
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    • Siegel, B. V., R. L. Trestman, S. O’Flaithbheartaigh, V. Mitropoulou, F. Amin, R. Kirrane, J. Silverman, J. Schmeidler, R. S. Keefe, and L. J. Siever. “D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.” Schizophr Res 20, no. 1–2 (May 1996): 29–32. https://doi.org/10.1016/0920-9964(95)00002-x.
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    • Harvey, P. D., R. S. E. Keefe, V. Mitroupolou, R. DuPre, S. L. Roitman, R. C. Mohs, and L. J. Siever. “Information-processing markers of vulnerability to schizophrenia: Performance of patients with schizotypal and nonschizotypal personality disorders.” Psychiatry Research 60, no. 1 (February 28, 1996): 49–56. https://doi.org/10.1016/0165-1781(95)02764-5.
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    • Vocisano, C., D. N. Klein, R. S. Keefe, E. R. Dienst, and M. M. Kincaid. “Demographics, family history, premorbid functioning, developmental characteristics, and course of patients with deteriorated affective disorder.” Am J Psychiatry 153, no. 2 (February 1996): 248–55. https://doi.org/10.1176/ajp.153.2.248.
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    • Trestman, R. L., R. S. Keefe, V. Mitropoulou, P. D. Harvey, M. L. deVegvar, S. Lees-Roitman, M. Davidson, A. Aronson, J. Silverman, and L. J. Siever. “Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder.” Psychiatry Res 59, no. 1–2 (November 29, 1995): 127–36. https://doi.org/10.1016/0165-1781(95)02709-2.
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    • Davidson, M., and R. S. Keefe. “Cognitive impairment as a target for pharmacological treatment in schizophrenia.” Schizophr Res 17, no. 1 (September 1995): 123–29. https://doi.org/10.1016/0920-9964(95)00037-m.
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    • Keefe, R. S., S. E. Roitman, P. D. Harvey, C. S. Blum, R. L. DuPre, D. M. Prieto, M. Davidson, and K. L. Davis. “A pen-and-paper human analogue of a monkey prefrontal cortex activation task: spatial working memory in patients with schizophrenia.” Schizophr Res 17, no. 1 (September 1995): 25–33. https://doi.org/10.1016/0920-9964(95)00027-j.
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    • Keefe, Richard S. E., Sonia Lees Roitman, Rachel L. Dupre, Philip D. Harvey, Kenneth L. Davis, and Richard C. Mohs. “The relationship between working memory deficits and other measures sensitive to prefrontal dysfunction.” Schizophrenia Research 15, no. 1–2 (April 1995): 123–123. https://doi.org/10.1016/0920-9964(95)95378-m.
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    • Davidson, M., P. D. Harvey, P. Powchik, M. Parrella, L. White, H. Y. Knobler, M. F. Losonczy, R. S. Keefe, S. Katz, and E. Frecska. “Severity of symptoms in chronically institutionalized geriatric schizophrenic patients.” Am J Psychiatry 152, no. 2 (February 1995): 197–207. https://doi.org/10.1176/ajp.152.2.197.
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    • Keefe, R. S. “The contribution of neuropsychology to psychiatry.” Am J Psychiatry 152, no. 1 (January 1995): 6–15. https://doi.org/10.1176/ajp.152.1.6.
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    • Yehuda, R., R. S. Keefe, P. D. Harvey, R. A. Levengood, D. K. Gerber, J. Geni, and L. J. Siever. “Learning and memory in combat veterans with posttraumatic stress disorder.” Am J Psychiatry 152, no. 1 (January 1995): 137–39. https://doi.org/10.1176/ajp.152.1.137.
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    • Siever, L. J., L. Friedman, J. Moskowitz, V. Mitropoulou, R. Keefe, S. L. Roitman, D. Merhige, R. Trestman, J. Silverman, and R. Mohs. “Eye movement impairment and schizotypal psychopathology.” Am J Psychiatry 151, no. 8 (August 1994): 1209–15. https://doi.org/10.1176/ajp.151.8.1209.
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    • Keefe, R. S., J. M. Silverman, S. E. Roitman, P. D. Harvey, M. A. Duncan, D. Alroy, L. J. Siever, K. L. Davis, and R. C. Mohs. “Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests.” Psychiatry Res 53, no. 1 (July 1994): 1–12. https://doi.org/10.1016/0165-1781(94)90091-4.
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    • Apter, S. H., R. S. E. Keefe, J. Hirschowitz, M. Davidson, J. M. Macaluso, R. Amato, and K. L. Davis. “Longitudinal classification in schizophrenia: The relationship between kraepelinian and deficit syndrome subtypologies.” Biological Psychiatry 35, no. 9 (May 1994): 695–695. https://doi.org/10.1016/0006-3223(94)90944-x.
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    • Epstein, J. I., R. S. E. Keefe, S. E. Lees Roitman, P. D. Harvey, M. Davidson, L. J. Siever, and R. C. Mohs. “Neuroleptic effects on CPT and eye tracking in schizophrenia.” Biological Psychiatry 35, no. 9 (May 1994): 674–674. https://doi.org/10.1016/0006-3223(94)90872-9.
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    • Frecska, E., M. F. Losonczy, R. S. E. Keefe, S. Apter, M. Davidson, R. C. Mohs, and K. L. Davis. “Age dependent change of ventricular measures in schizophrenia: Cross-sectional analysis.” Biological Psychiatry 35, no. 9 (May 1994): 704–5. https://doi.org/10.1016/0006-3223(94)90980-6.
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    • Keefe, R. S. E., C. Blum, S. L. Roitman, P. D. Harvey, M. Davidson, R. C. Mohs, and K. L. Davis. “Working memory dysfunction in Kraepelinian schizophrenics.” Biological Psychiatry 35, no. 9 (May 1994): 660–660. https://doi.org/10.1016/0006-3223(94)90820-6.
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    • Kahn, R. S., P. D. Harvey, M. Davidson, R. S. Keefe, S. Apter, J. M. Neale, R. C. Mohs, and K. L. Davis. “Neuropsychological correlates of central monoamine function in chronic schizophrenia: relationship between CSF metabolites and cognitive function.” Schizophr Res 11, no. 3 (February 1994): 217–24. https://doi.org/10.1016/0920-9964(94)90015-9.
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    • Siever, L. J., O. F. Kalus, and R. S. Keefe. “The boundaries of schizophrenia.” Psychiatr Clin North Am 16, no. 2 (June 1993): 217–44.
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    • Frecska, E., M. F. Losonczy, R. S. E. Keefe, J. M. Silverman, M. Davidson, and K. L. Davis. “The characteristics of poor outcome, 'Kraepelinian' schizophrenia.” European Neuropsychopharmacology 3, no. 3 (January 1, 1993): 400. https://doi.org/10.1016/0924-977X(93)90193-P.
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    • Harvey, P. D., M. F. Lenzenweger, R. S. Keefe, D. L. Pogge, M. R. Serper, and R. C. Mohs. “Empirical assessment of the factorial structure of clinical symptoms in schizophrenic patients: formal thought disorder.” Psychiatry Res 44, no. 2 (November 1992): 141–51. https://doi.org/10.1016/0165-1781(92)90048-8.
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    • Keefe, R. S., P. D. Harvey, M. F. Lenzenweger, M. Davidson, S. H. Apter, J. Schmeidler, R. C. Mohs, and K. L. Davis. “Empirical assessment of the factorial structure of clinical symptoms in schizophrenia: negative symptoms.” Psychiatry Res 44, no. 2 (November 1992): 153–65. https://doi.org/10.1016/0165-1781(92)90049-9.
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    • Davidson, M., R. S. Kahn, R. G. Stern, P. D. Harvey, R. Keefe, P. Knott, S. Apter, L. Webster, and K. L. Davis. “Measurements of plasma homovanillic acid in schizophrenic patients.” Clin Neuropharmacol 15 Suppl 1 Pt A (1992): 521A-522A. https://doi.org/10.1097/00002826-199201001-00271.
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    • Harvey, P. D., R. S. Kahn, M. Davidson, R. C. Mohs, R. S. E. Keefe, and K. L. Davis. “Dopaminergic correlates of attentional performance in unmedicated schizophrenic patients.” Schizophrenia Research 6, no. 2 (January 1992): 136–136. https://doi.org/10.1016/0920-9964(92)90194-a.
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    • Keefe, R. S. E., J. M. Silverman, F. Amin, S. E. Lees, A. Duncan, P. D. Harvey, M. Davidson, L. J. Siever, R. C. Mohs, and K. L. Davis. “Frontal functioning and plasma HVA in the relatives of schizophrenic patients.” Schizophrenia Research 6, no. 2 (January 1992): 158–158. https://doi.org/10.1016/0920-9964(92)90244-y.
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    • CORNBLATT, B. A., and R. S. E. KEEFE. “THE GENETICS OF MENTAL-ILLNESS - AN OVERVIEW.” Social Biology 38, no. 3–4 (September 1, 1991): R1–5.
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    • Harvey, P. D., K. M. Putnam, M. Davidson, R. S. Kahn, P. Powchik, R. McQueeney, R. S. Keefe, and K. L. Davis. “Brief neuroleptic discontinuation and clinical symptoms in Kraepelinian and non-Kraepelinian chronic schizophrenic patients.” Psychiatry Res 38, no. 3 (September 1991): 285–92. https://doi.org/10.1016/0165-1781(91)90018-k.
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    • Thaker, G., M. Moran, S. Cassady, H. Adami, and C. Tamminga. “Normal smooth pursuit eye movements in volunteer subjects meeting schizotypal personality disorder criteria.” Am J Psychiatry 148, no. 8 (August 1991): 1096–97.
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    • Frecska, E., M. Losonczy, R. S. E. Keefe, J. M. Silverman, M. Davidson, P. Harvey, R. T. McQueeney, D. Lobel, S. Apter, and K. L. Davis. “Kraepelinian schizophrenia: A replication in an independent sample.” Schizophrenia Research 4, no. 3 (May 1991): 257–257. https://doi.org/10.1016/0920-9964(91)90108-4.
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    • Harvey, P. D., M. Davidson, R. C. Mohs, R. S. E. Keefe, J. Moskowitz, P. Knott, and M. Duffelmeyer. “Plasma HVA correlates of attentional performance in unmedicated schizophrenics.” Schizophrenia Research 4, no. 3 (May 1991): 345–46. https://doi.org/10.1016/0920-9964(91)90258-s.
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    • Keefe, R. S., D. S. Lobel, R. C. Mohs, J. M. Silverman, P. D. Harvey, M. Davidson, M. F. Losonczy, and K. L. Davis. “Diagnostic issues in chronic schizophrenia: kraepelinian schizophrenia, undifferentiated schizophrenia, and state-independent negative symptoms.” Schizophr Res 4, no. 2 (1991): 71–79. https://doi.org/10.1016/0920-9964(91)90026-n.
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    • Keefe, R. S., J. M. Silverman, L. J. Siever, and B. A. Cornblatt. “Refining phenotype characterization in genetic linkage studies of schizophrenia.” Soc Biol 38, no. 3–4 (1991): 197–218. https://doi.org/10.1080/19485565.1991.9988788.
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    • Harvey, P. D., R. S. Keefe, J. Moskowitz, K. M. Putnam, R. C. Mohs, and K. L. Davis. “Attentional markers of vulnerability to schizophrenia: performance of medicated and unmedicated patients and normals.” Psychiatry Res 33, no. 2 (August 1990): 179–88. https://doi.org/10.1016/0165-1781(90)90072-d.
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    • Siever, L. J., J. M. Silverman, T. B. Horvath, H. Klar, E. Coccaro, R. S. Keefe, L. Pinkham, P. Rinaldi, R. C. Mohs, and K. L. Davis. “Increased morbid risk for schizophrenia-related disorders in relatives of schizotypal personality disordered patients.” Arch Gen Psychiatry 47, no. 7 (July 1990): 634–40. https://doi.org/10.1001/archpsyc.1990.01810190034005.
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    • Siever, L. J., R. Keefe, D. P. Bernstein, E. F. Coccaro, H. M. Klar, Z. Zemishlany, A. E. Peterson, M. Davidson, T. Mahon, and T. Horvath. “Eye tracking impairment in clinically identified patients with schizotypal personality disorder.” Am J Psychiatry 147, no. 6 (June 1990): 740–45. https://doi.org/10.1176/ajp.147.6.740.
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    • Keefe, R. S., R. C. Mohs, M. F. Losonczy, M. Davidson, J. M. Silverman, T. B. Horvath, and K. L. Davis. “Premorbid sociosexual functioning and long-term outcome in schizophrenia.” Am J Psychiatry 146, no. 2 (February 1989): 206–11. https://doi.org/10.1176/ajp.146.2.206.
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    • Silverman, J. M., R. S. Keefe, R. C. Mohs, and K. L. Davis. “A study of the reliability of the family history method in genetic studies of Alzheimer disease.” Alzheimer Dis Assoc Disord 3, no. 4 (1989): 218–23.
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    • Keefe, R. S., L. J. Siever, R. C. Mohs, A. E. Peterson, T. R. Mahon, R. L. Bergman, and K. L. Davis. “Eye tracking, schizophrenic symptoms, and schizotypal personality disorder.” Eur Arch Psychiatry Neurol Sci 239, no. 1 (1989): 39–42. https://doi.org/10.1007/BF01739742.
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    • Keefe, R. S., R. C. Mohs, M. Davidson, M. F. Losonczy, J. M. Silverman, J. C. Lesser, T. B. Horvath, and K. L. Davis. “Kraepelinian schizophrenia: a subgroup of schizophrenia?” Psychopharmacol Bull 24, no. 1 (1988): 56–61.
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    • Silverman, J. M., R. C. Mohs, M. Davidson, M. F. Losonczy, R. S. Keefe, J. C. Breitner, J. E. Sorokin, and K. L. Davis. “Familial schizophrenia and treatment response.” Am J Psychiatry 144, no. 10 (October 1987): 1271–76. https://doi.org/10.1176/ajp.144.10.1271.
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    • Davidson, M., R. S. Keefe, R. C. Mohs, L. J. Siever, M. F. Losonczy, T. B. Horvath, and K. L. Davis. “L-dopa challenge and relapse in schizophrenia.” Am J Psychiatry 144, no. 7 (July 1987): 934–38. https://doi.org/10.1176/ajp.144.7.934.
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    • Keefe, R. S., R. C. Mohs, M. F. Losonczy, M. Davidson, J. M. Silverman, K. S. Kendler, T. B. Horvath, R. Nora, and K. L. Davis. “Characteristics of very poor outcome schizophrenia.” Am J Psychiatry 144, no. 7 (July 1987): 889–95. https://doi.org/10.1176/ajp.144.7.889.
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  • Book Sections

    • Vance, M., E. Pappadopulos, R. Keefe, and A. Kalali. “Conceptual issues in cultural adaptation and the role of culture in assessment of health-related quality of life in schizophrenia.” In Beyond Assessment of Quality of Life in Schizophrenia, 53–62, 2016. https://doi.org/10.1007/978-3-319-30061-0_4.
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    • Harvey, Philip D., and Richard S. E. Keefe. “The importance of treating cognition in schizophrenia and other severe mental illnesses: background, strategies, and findings to date.” In ESSENTIAL CNS DRUG DEVELOPMENT, 177–91, 2012.
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  • Conference Papers

    • Brown, David, Kazuyuki Nakagome, Joachim Cordes, Ronald Brenner, Gerhard Gründer, Richard S. E. Keefe, Robert Riesenberg, et al. “Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.” In Schizophr Bull, 45:350–59, 2019. https://doi.org/10.1093/schbul/sby049.
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    • Eum, Seenae, S Kristian Hill, Leah H. Rubin, Ryan M. Carnahan, James L. Reilly, Elena I. Ivleva, Sarah K. Keedy, et al. “Cognitive burden of anticholinergic medications in psychotic disorders.” In Schizophr Res, 190:129–35, 2017. https://doi.org/10.1016/j.schres.2017.03.034.
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    • Graham, K. A., R. S. Keefe, J. A. Lieberman, A. S. Calikoglu, K. M. Lansing, and D. O. Perkins. “Relationship of low vitamin D status with positive, negative and cognitive symptom domains in people with first-episode schizophrenia.” In Early Interv Psychiatry, 9:397–405, 2015. https://doi.org/10.1111/eip.12122.
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    • Cella, Matteo, Daniel Stahl, Sarah Morris, Richard Keefe, Morris David Bell, Robea Heinssen, and Til Wykes. “EFFECTS OF COGNITIVE REMEDIATION ON NEGATIVE SYMPTOMS DIMENSIONS: EXPLORING THE ROLE OF WORKING MEMORY.” In Schizophrenia Bulletin, 41:S40–41. OXFORD UNIV PRESS, 2015.
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    • Keefe, R. S. E., A. R. Mahableshwarkar, and C. K. Olsen. “P.2.f.013 Clinical evidence for improvement in cognitive dysfunction in patients with major depressive disorder (MDD) after treatment with vortioxetine.” In European Neuropsychopharmacology, 23:S402–3. Elsevier BV, 2013. https://doi.org/10.1016/s0924-977x(13)70636-9.
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    • Madhoo, M., R. M. Roth, R. S. E. Keefe, A. Sambunaris, B. Scheckner, J. Nielsen, B. Adeyi, J. Wu, and R. Lasser. “P.2.a.017 Lisdexamfetamine dimesylate augmentation effects on executive function in major depressive disorder based on depressive symptom levels.” In European Neuropsychopharmacology, 22:S233–34. Elsevier BV, 2012. https://doi.org/10.1016/s0924-977x(12)70346-2.
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    • Madhoo, M., R. S. E. Keefe, R. M. Roth, A. Sambunaris, J. Wu, M. H. Trivedi, C. S. Anderson, and R. Lasser. “Efficacy and safety of lisdexamfetamine dimesylate in adults with executive dysfunction and partial or full remission of major depressive disorder.” In International Journal of Neuropsychopharmacology, 15:189–189. OXFORD UNIV PRESS, 2012.
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    • Supina, D., J. Endicott, M. Madhoo, R. S. E. Keefe, M. Trivedi, J. Wu, B. Scheckner, and R. Lasser. “PMH61 Effects of Lisdexamfetamine Dimesylate Augmentation on Functional Outcomes in Adults with Partially or Fully Remitted Major Depressive Disorder.” In Value in Health, 15:A93–A93. Elsevier BV, 2012. https://doi.org/10.1016/j.jval.2012.03.506.
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    • Jarskog, F Fredrik, Richard A. Grove, Joseph P. McEvoy, Richard S. E. Keefe, Martin T. Lowy, Joseph P. Horrigan, and Margaret A. Peykamian. “Randomized, Double-Blind, Placebo Controlled, Parallel Group Exploratory Study of GSK239512 for Cognitive Impairment in Stable Schizophrenia Subjects on Background Antipsychotic Therapy.” In Biological Psychiatry, 71:63S-64S. ELSEVIER SCIENCE INC, 2012.
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    • Uchida, Hiroyuki, Hitoshi Sakurai, Robert R. Bies, Scott Stroup, Richard S. E. Keefe, Takefumi Suzuki, Takashi Tsuboi, Masaru Mimura, Bruce G. Pollock, and David C. Mamo. “DOPAMINE D2 RECEPTOR OCCUPANCY AND COGNITION IN SCHIZOPHRENIA: ANALYSIS OF THE CATIE DATA.” In Schizophrenia Research, 136:S359–S359. ELSEVIER SCIENCE BV, 2012.
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    • Colijn, Mark A., Mariapaola Barbato, Richard S. E. Keefe, Diana O. Perkins, Scott W. Woods, and Jean Addington. “Poster #143 AT RISK FOR PSYCHOSIS: THE ROLE OF COGNITION.” In Schizophrenia Research, 136:S237–S237. Elsevier BV, 2012. https://doi.org/10.1016/s0920-9964(12)70715-6.
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    • Keefe, Richard S. E., Robert W. Buchanan, Stephen R. Marder, Nina R. Schooler, Ashish Dugar, Milana Zivkov, and Michelle Stewart. “Poster #199 CLINICAL TRIALS OF POTENTIAL COGNITIVE-ENHANCING DRUGS IN SCHIZOPHRENIA: WHAT HAVE WE LEARNED SO FAR?” In Schizophrenia Research, 136:S352–S352. Elsevier BV, 2012. https://doi.org/10.1016/s0920-9964(12)71031-9.
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    • Sarkisyan, G., I. Gurovich, and R. S. E. Keefe. “NORMATIVE DATA FOR RUSSIAN POPULATION AND STANDARDIZATION OF THE SCALE "BRIEF ASSESSMENT OF COGNITION IN SCHIZOPHRENIA".” In European Psychiatry, Vol. 26. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2011.
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    • Reichenberg, Abraham, Avshalom Caspi, HonaLee Harrington, Renate Houts, Richard S. Keefe, Robin M. Murray, Richie Poulton, and Terrie E. Moffitt. “Static and Dynamic Cognitive Deficits in Childhood Precede Adult Schizophrenia: A 30-Year Study.” In Biological Psychiatry, 67:12S-12S. ELSEVIER SCIENCE INC, 2010.
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    • Kern, Robert S., James M. Gold, Dwight Dickinson, Michael F. Green, Keith H. Nuechterlein, Richard S. E. Keefe, Stephen R. Marder, and Catherine A. Sugar. “COGNITIVE DYSFUNCTION AND COMMUNITY FUNCTIONING IN SCHIZOPHRENIA: RESULTS FROM THE MATRICS PSYCHOMETRIC AND STANDARDIZATION STUDY (PASS).” In Schizophrenia Research, 117:323–24. Elsevier BV, 2010. https://doi.org/10.1016/j.schres.2010.02.551.
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    • Reichenberg, Abraham, Avshalom Caspi, HonaLee Harrington, Renate Houts, Richard Keefe, Robin Murray, Richie Poulton, and Terrie Moffitt. “STATIC AND DYNAMIC COGNITIVE DEFICITS IN CHILDHOOD PRECEDE ADULT SCHIZOPHRENIA: A 30-YEAR STUDY.” In Schizophrenia Research, 117:175–175. Elsevier BV, 2010. https://doi.org/10.1016/j.schres.2010.02.207.
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    • Keefe, Richard S. E., and Wayne S. Fenton. “HOW SHOULD DSM-V CRITERIA FOR SCHIZOPHRENIA INCLUDE COGNITIVE IMPAIRMENT?” In Deconstructing Psychosis: Refining the Research Agenda for Dsm V, edited by C. A. Tamminga, P. J. Sirovatka, D. A. Regier, and J. VanOs, 83–98. AMER PSYCHIATRIC PRESS, INC, 2010.
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    • Keefe, Richard S. E. “Increasing sensitivity of early detection of psychosis with cognitive measures.” In International Journal of Psychiatry in Clinical Practice, 13:7–7. TAYLOR & FRANCIS AS, 2009.
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    • Javitt, Daniel C., R. W. Buchanan, J. A. Lieberman, R. S. Keefe, and S. R. Marder. “EVALUATION OF THE EFFECTS OF AL-108 ON NEUROCOGNITION IN SCHIZOPHRENIA: INITIAL TURNS STUDY RESULTS.” In Schizophrenia Bulletin, 35:365–66, 2009.
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    • Ventura, Joseph, R. M. Bilder, S. R. Reise, and R. S. Keefe. “DEVELOPMENT OF AN INTERVIEW-BASED "CO-PRIMARY'' MEASURE OF COGNITION.” In Schizophrenia Bulletin, 35:21–22, 2009.
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    • Keefe, R. S. E., P. D. Harvey, T. E. Goldberg, J. M. Gold, and T. M. Walker. “General and specific cognitive deficits in bipolar depression: the Brief Assessment of Cognition in Affective Disorders (BAC-A).” In Bipolar Disorders, 9:9–9. BLACKWELL PUBLISHING, 2007.
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    • Marx, Christine E., Richard S. Keefe, Linda A. Leimone, Robert M. Hamer, Daniel W. Bradford, Lawrence Dunn, Victoria M. Payne, et al. “Proof-of-concept trial with the neurosterold pregnenolone targeting neurocognitive and negative symptoms in schizophrenia.” In Biological Psychiatry, 61:13S-13S. ELSEVIER SCIENCE INC, 2007.
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    • Nasrallah, Henry A., Richard S. E. Keefe, Sonia Davis, Joseph Mcevoy, Don Goff, Jonathan Meyer, T Scott Stroup, and Jeffrey A. Lieberman. “Cognitive improvement correlates with weight gain in schizophrenia subjects receiving quetiapine but not other antipsychotics: Data from the CATIE trial.” In Biological Psychiatry, 61:247S-248S. ELSEVIER SCIENCE INC, 2007.
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    • Bratti, I., S. R. Marder, R. S. Keefe, and R. M. Bilder. “A brief cognitive assessment tool for schizophrenia (B-CATS): Scale construction.” In Schizophrenia Bulletin, 33:584–584, 2007.
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    • Hill, S. K., J. A. Sweeney, R. M. Hamer, R. S. Keefe, D. O. Perkins, H. Gu, G. Koch, J. P. McEvoy, and J. A. Lieberman. “Efficiency of the BACS and CATIE neuropsychological batteries in assessing cognition and antipsychotic treatment related change in cognition during the CAFE clinical trial.” In Schizophrenia Bulletin, 33:561–561, 2007.
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    • Keefe, Richard, Robert M. Bilder, Sonia M. Davis, Philip D. Harvey, Barton W. Palmer, James M. Gold, Herbert Y. Meltzer, et al. “Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial.” In Neuropsychopharmacology, 31:S244–45. NATURE PUBLISHING GROUP, 2006.
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    • Keefe, R. S. E. “Measures of cognitive change in schizophrenia clinical trials.” In International Journal of Neuropsychopharmacology, 9:S48–S48. CAMBRIDGE UNIV PRESS, 2006.
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    • Keefe, R. S. E., G. U. Hongbin, J. A. Sweeney, D. O. Perkins, J. P. McEvoy, R. M. Hamer, and J. A. Lieberman. “The effects of olanzapine, quetiapine, and risperidone on neurocognitive function in first-episode psychosis: A double-blind, 52-week comparison.” In Biological Psychiatry, 59:231S-232S. ELSEVIER SCIENCE INC, 2006.
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    • Keefe, R. S. E., H. Gu, D. Perkins, R. M. Hamer, and J. A. Lieberman. “The effects of olanzapine, quetiapine, and risperidone on neurocognitive function in first-episode psychosis: A double-blind, 52-week comparison.” In Schizophrenia Research, 81:54–54. ELSEVIER SCIENCE BV, 2006.
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    • Lieberman, J. A., T. S. Stroup, J. P. McEvoy, M. S. Swartz, R. A. Rosenheck, D. O. Perkins, R. S. Keefe, et al. “Effectiveness of antipsychotic drugs in patients with chronic schizophrenia: Primary efficacy and safety outcomes of the clinical antipsychotic trials of intervention effectiveness (CATIE) schizophrenia trial.” In Neuropsychopharmacology, 30:S32–S32, 2005.
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    • Sethuraman, G., S. Ahmed, S. L. Rock, C. A. Young, E. M. Marquez, S. E. Purdon, and R. S. E. Keefe. “P.2.137 Can the PANSS cognitive factor be a validsurrogate for neurocognon in schizophrenia?” In European Neuropsychopharmacology, 14:S292–93. Elsevier BV, 2004. https://doi.org/10.1016/s0924-977x(04)80357-2.
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    • Keefe, R. S. E. “Treatment of cognitive deficits in first episode schizophrenia.” In International Journal of Neuropsychopharmacology, 7:S87–S87. CAMBRIDGE UNIV PRESS, 2004.
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    • Keefe, R. S. E. “Cognition as a key to alliance, adherence, and functional outcomes.” In International Journal of Neuropsychopharmacology, 7:S106–S106. CAMBRIDGE UNIV PRESS, 2004.
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    • Marquez, E. M., R. S. Keefe, S. E. Purdon, S. L. Rock, K. Alaka, S. Ahmed, and R. C. Mohs. “Is cognitive improvement with antipsychotic treatment pseudospecific?” In International Journal of Neuropsychopharmacology, 7:S394–S394. CAMBRIDGE UNIV PRESS, 2004.
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    • Sethuraman, G., S. Ahmed, S. L. Rock, C. A. Young, E. M. Marquez, S. E. Purdon, and R. S. Keefe. “Can the panss cognitive factor be a valid surrogate for neurocognition in schizophrenia?” In International Journal of Neuropsychopharmacology, 7:S226–S226. CAMBRIDGE UNIV PRESS, 2004.
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    • Hawkins, K. A., J. Addington, R. S. E. Keefe, B. K. Christensen, S. W. Woods, T. J. Miller, Q. N. Trzaskoma, et al. “Effect of olanzapine versus placebo on the neuropsychological status of prodromal subjects.” In Biological Psychiatry, 55:27S-27S. ELSEVIER SCIENCE INC, 2004.
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    • Marquez, E., R. S. E. Keefe, S. E. Purdon, S. L. Rock, K. J. Alaka, S. Ahmed, and R. C. Mohs. “The relationship of cognition changes and other symptoms following antipsychotic treatment.” In Biological Psychiatry, 55:175S-175S. ELSEVIER SCIENCE INC, 2004.
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    • Narendran, R., W. G. Frankle, R. S. E. Keefe, R. B. Gil, D. Martinez, L. S. Kegeles, P. S. Talbot, et al. “PET imaging of prefrontal dopamine D1 receptors in chronic ketamine human abusers: A model for schizophrenia.” In Biological Psychiatry, 55:19S-20S. ELSEVIER SCIENCE INC, 2004.
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    • Sharma, T., P. D. Harvey, V. Kumari, and R. S. E. Keefe. “Cognitive enhancement in schizophrenia: Ending the therapeutic nihilism.” In Biological Psychiatry, 55:151S-151S. ELSEVIER SCIENCE INC, 2004.
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    • Keefe, R. S. E. “Cognition and the concept of schizotaxia.” In European Psychiatry, 19:114S-114S. EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2004.
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    • Keefe, R. S. E. “The functional hurdle: Connecting through cognition.” In Schizophrenia Research, 67:277–277. ELSEVIER SCIENCE BV, 2004.
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    • Keefe, R. S. E., L. J. Seidman, B. Christensen, R. M. Hamer, and D. Yurgelun-Todd. “Neurocognitive effects of olanzapine and low-dose haloperidol: A two-year treatment study in first episode psychosis.” In Schizophrenia Research, 67:206–206. ELSEVIER SCIENCE BV, 2004.
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    • Keefe, R. S. E., T. E. Goldberg, P. D. Harvey, J. M. Gold, M. Poe, and L. Coughenour. “The brief assessment of cognition in schizophrenia: Reliability, sensitivity, and comparison with a standard neurocognitive battery.” In Schizophrenia Research, 67:263–263. ELSEVIER SCIENCE BV, 2004.
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    • Marquez, E. M., R. S. E. Keefe, S. E. Purdon, S. L. Rock, K. J. Alaka, S. Ahmed, and R. C. Mohs. “Is cognitive improvement with antipsychotic treatment pseudospecific?” In Schizophrenia Research, 67:207–207. ELSEVIER SCIENCE BV, 2004.
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    • Mohs, R. C., K. J. Alaka, R. S. E. Keefe, S. E. Purdon, S. L. Rock, H. Wei, E. M. Marquez, and S. Ahmed. “Functional outcomes and characteristics of olanzapine cognitive super-responders.” In Schizophrenia Research, 67:207–8. ELSEVIER SCIENCE BV, 2004.
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    • Hawkins, K. A., J. Addington, R. S. Keefe, B. Christensen, S. W. Woods, T. J. Miller, Q. N. Trzaskoma, A. Breier, R. B. Zipursky, and D. O. Perkins. “Effect of olanzapine versus placebo on the neuropsychological status of prodromal subjects.” In Schizophrenia Research, 67:205–205, 2004.
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    • Keefe, R. S., C. E. Eesley, and M. P. Poe. “Defining a cognitive function decrement in schizophrenia.” In Biological Psychiatry, 55:41S-41S, 2004.
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    • Perkins, D., H. B. Gu, R. B. Zipursky, B. K. Christensen, V. Dixon, and R. S. Keefe. “Neurocognitive function in individuals "at-risk" for psychosis.” In Neuropsychopharmacology, 29:S220–S220, 2004.
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    • Keefe, R. S. E., L. J. Seidman, B. K. Christensen, R. M. Hamer, D. A. Yurgelun-Todd, R. R. J. Lewine, M. M. Sitskoorn, T. Sharma, M. Tohen, and J. A. Lieberman. “Neurocognitive effects of olanzapine and low-dose haloperidol: A two-year treatment study in first episode psychosis.” In Biological Psychiatry, 53:26S-26S. ELSEVIER SCIENCE INC, 2003.
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    • Yurgelun-Todd, D. A., P. F. Renshaw, H. Wei, R. S. E. Keefe, H. C. Charles, M. Tohen, L. J. Seidman, et al. “Improved attention is associated with reductions in frontal lobe lactate levels in first episode psychosis.” In Biological Psychiatry, 53:156S-156S. ELSEVIER SCIENCE INC, 2003.
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    • Breier, A., R. S. Keefe, C. A. Young, S. E. Purdon, J. M. Gold, and K. L. Davis. “A one-year double-blind comparison of the neurocognitive efficacy of olanzapine, risperidone, and haloperidol in patients with schizophrenia.” In Schizophrenia Research, 60:274–75. Elsevier BV, 2003. https://doi.org/10.1016/s0920-9964(03)80434-6.
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    • Keefe, R., L. J. Seidman, B. Christensen, R. M. Hamer, D. Yurgelun-Todd, R. Lewine, M. Sitskoorn, T. Sharma, M. Tohen, and J. A. Lieberman. “Neurocognitive effects of olanzapine and low-dose haloperidol: A two-year treatment study in first episode psychosis.” In Schizophrenia Research, 60:289–289. Elsevier BV, 2003. https://doi.org/10.1016/s0920-9964(03)80477-2.
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    • Yurgelun-Todd, D. A., P. F. Renshaw, H. Wei, R. S. Keefe, H. C. Charles, M. Tohen, and J. A. Liebermann. “Improved attention is associated with reductions in frontal lobe lactate levels in first episode psychosis.” In Schizophrenia Research, 60:318–318. Elsevier BV, 2003. https://doi.org/10.1016/s0920-9964(03)80271-2.
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    • Keefe, R. S., L. J. Seidman, B. K. Christensen, D. A. Yurgelun-Todd, R. R. Lewine, M. M. Sitskoorn, and J. A. Lieberman. “Treatment of neurocognitive deficits with olanzapine or low-dose haloperidol in first episode psychosis.” In Schizophrenia Research, 49:234–234, 2001.
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    • Keefe, R. S. E., A. M. Bollini, M. C. Courtney, W. H. Wilson, and J. P. McEvoy. “Successful treatment of self-monitoring deficits predicts psychotic symptom decrease.” In Schizophrenia Research, 36:172–172. ELSEVIER SCIENCE BV, 1999.
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    • Roitman, S. E. L., R. S. E. Keefe, V. Mitropoulou, R. L. Dupre, and L. J. Siever. “Visuospatial working memory in schizotypal personality disorder.” In Biological Psychiatry, 41:355–355. ELSEVIER SCIENCE INC, 1997.
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    • Roitman, S. E. L., R. S. E. Keefe, R. L. Dupre, and L. J. Siever. “Visuospatial working memory in schizotypal personality disorder.” In Biological Psychiatry, 39:266–266. ELSEVIER SCIENCE INC, 1996.
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    • Keefe, R. S. E., S. E. L. Roitman, R. L. Dupre, and P. D. Harvey. “Laboratory and clinical tests of spatial working memory.” In Schizophrenia Research, 18:XIII7–XIII7. ELSEVIER SCIENCE BV, 1996.
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    • EPSTEIN, J. I., R. S. E. KEEFE, P. D. HARVEY, R. C. MOHS, S. E. L. ROITMAN, M. DAVIDSON, and L. J. SIEVER. “THE EXTENT OF WORKING-MEMORY DEMANDS PREDICTS RESPONSE TO NEUROLEPTIC MEDICATION ON CONTINUOUS PERFORMANCE TESTS.” In Schizophrenia Research, 11:153–54. ELSEVIER SCIENCE BV, 1994.
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    • KEEFE, R. S. E., C. BLUM, P. D. HARVEY, M. DAVIDSON, S. E. ROITMAN, and K. L. DAVIS. “WORKING-MEMORY DEFICITS IN SCHIZOPHRENICS WITH SEVERE SELF-CARE DYSFUNCTION.” In Schizophrenia Research, 11:158–158. ELSEVIER SCIENCE BV, 1994.
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    • DAVIDSON, M., I. BERMAN, R. S. KEEFE, K. DUVVI, and M. PONTECORVO. “RISPERIDONE IN ELDERLY SCHIZOPHRENIC-PATIENTS.” In Schizophrenia Research, 11:197–197, 1994.
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    • DEVEGVAR, M. L., R. S. E. KEEFE, J. MOSKOWITZ, S. LEES, O. KALUS, P. KNOTT, R. L. TRESTMAN, and L. J. SIEVER. “PERFORMANCE ON TESTS SENSITIVE TO FRONTAL-LOBE DYSFUNCTION AND DEFICIT-LIKE SYMPTOMS IN SCHIZOTYPAL PERSONALITY-DISORDER.” In Biological Psychiatry, 33:A101–A101. ELSEVIER SCIENCE INC, 1993.
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    • KEEFE, R. S. E., C. BLUM, D. M. MERHIGE, S. E. LEES, D. M. ZOLOT, M. DAVIDSON, P. D. HARVEY, and K. L. DAVIS. “TASKS FROM MONKEY CORTEX STUDIES AND SPECIFIC PREFRONTAL DYSFUNCTION IN SCHIZOPHRENIA.” In Biological Psychiatry, 33:A92–A92. ELSEVIER SCIENCE INC, 1993.
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    • KEEFE, R. S. E., R. C. MOHS, J. M. SILVERMAN, M. F. LOSONCZY, M. DAVIDSON, T. B. HORVATH, and K. L. DAVIS. “CHARACTERISTICS OF KRAEPELINIAN SCHIZOPHRENIA AND THEIR RELATION TO PREMORBID SOCIOSEXUAL FUNCTIONING.” In Neuroleptic Nonresponsive Patient : Characterization and Treatment, edited by B. ANGRIST and S. C. SCHULZ, 27:1-+. AMER PSYCHIATRIC PRESS, 1990.
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  Outreach & Engaged Scholarship

  • Summer Neuroscience Program Mentor. Summer Neuroscience Program. 2019  2019

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