Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Medicine, Stanford University School of Medicine 1990 - 1991
  • Intern, Medicine, Stanford University School of Medicine 1989 - 1990
  • M.D., Stanford University 1989
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2013 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Beck, B, Lopez, RD, Gillespie, GY, Kim, H, Cloud, G, Pereboeva, L, and Jr, LLS. "Peripheral Blood gamma delta T Cell Response to High-Grade Glioma: Implications for Localized Adoptive Immunotherapy." November 16, 2012.  Link to Item
    • Beck, B, Lopez, RD, Gillespie, GY, Kim, H, Cloud, G, Pereboeva, L, and Jr, LLS. "Peripheral Blood gamma delta T Cell Response to High-Grade Glioma: Implications for Localized Adoptive Immunotherapy." November 16, 2012.  Link to Item
    • Suarez, C, Bryant, NL, Gillespie, Y, Lopez, RD, Markert, JM, and Lamb, LS. "gamma delta T cells as immunotherapy for glioblastoma multiforme." February 2007.  Full Text  Link to Item
    • Suarez-Cuervo, C, Bryant, NL, Lopez, RD, Gillespie, GY, and Lamb, LS. "Ex vivo activation and expansion of gamma delta T cells for immunotherapy of glioblastorna." June 20, 2006.  Link to Item
    • Gehrs, BC, and Lopez, RD. "Ex vivo expansion of gamma delta-T lymphocytes from melanoma patients and healthy control donors." September 2005.  Link to Item

  • Journal Articles

    • Bonneville, M, Chen, ZW, Déchanet-Merville, J, Eberl, M, Fournié, JJ, Jameson, JM, Lopez, RD, Massaia, M, and Silva-Santos, B. "Chicago 2014 – 30years of γδ T cells." Cellular Immunology 296, no. 1 (July 2015): 3-9.  Full Text
    • Xu, H-G, Zhai, Y-X, Chen, J, Lu, Y, Wang, J-W, Quan, C-S, Zhao, R-X, Xiao, X, He, Q, Werle, KD, Kim, H-G, Lopez, R, Cui, R, Liang, J, Li, Y-L, and Xu, Z-X. "LKB1 reduces ROS-mediated cell damage via activation of p38." Oncogene 34, no. 29 (July 2015): 3848-3859.  Full Text
    • Beck, BH, Kim, H, O'Brien, R, Jadus, MR, Gillespie, GY, Cloud, GA, Hoa, NT, Langford, CP, Lopez, RD, Harkins, LE, and Lamb, LS. "Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma." PloS one 10, no. 5 (January 2015): e0122387-.  Full Text
    • Lopez, RD. "Inhibiting inhibitory pathways in human γδ T cells." Blood 122, no. 6 (August 8, 2013): 857-858.  Full Text  Link to Item
    • Lindhorst, SM, Lopez, RD, and Sanders, RD. "An Unusual Presentation of Chronic Myelogenous Leukemia: A Review of Isolated Central Nervous System Relapse." JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 11, no. 7 (July 2013): 745-750.  Full Text  Link to Item
    • Beck, B, Gillespie, GY, Lopez, RD, Cloud, GA, Langford, C, Kim, H, Harkins, L, and Lamb, LS. "Abstract 530: Circulating γδ T cells are activated and depleted during progression of high-grade gliomas: Implications for γδ T cells therapy of GBM." Cancer Research 72, no. 8 Supplement (April 15, 2012): 530-530.  Full Text
    • Kanda, J, Lopez, RD, and Rizzieri, DA. "Alemtuzumab for the prevention and treatment of graft-versus-host disease." Int J Hematol 93, no. 5 (May 2011): 586-593. (Review)  Full Text  Link to Item
    • Bryant, NL, Gillespie, GY, Lopez, RD, Markert, JM, Cloud, GA, Langford, CP, Arnouk, H, Su, Y, Haines, HL, Suarez-Cuervo, C, and Lamb, LS. "Preclinical evaluation of ex vivo expanded/activated γδ T cells for immunotherapy of glioblastoma multiforme." J Neurooncol 101, no. 2 (January 2011): 179-188.  Full Text  Link to Item
    • Kanda, J, Lopez, RD, and Rizzieri, DA. "Alemtuzumab for the prevention and treatment of graft-versus-host disease." International Journal of Hematology (2011): 1-8.  Full Text
    • Beck, BH, Kim, H-G, Kim, H, Samuel, S, Liu, Z, Shrestha, R, Haines, H, Zinn, K, and Lopez, RD. "Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer." Breast Cancer Res Treat 122, no. 1 (July 2010): 135-144.  Full Text  Link to Item
    • Bryant, NL, Suarez-Cuervo, C, Gillespie, GY, Markert, JM, Nabors, LB, Meleth, S, Lopez, RD, and Lamb, LS. "Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma." Neuro Oncol 11, no. 4 (August 2009): 357-367.  Full Text  Link to Item
    • Liu, Z, Guo, B, and Lopez, RD. "Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer." J Gastroenterol Hepatol 24, no. 5 (May 2009): 900-911.  Full Text  Link to Item
    • Liu, Z, Eltoum, I-EA, Guo, B, Beck, BH, Cloud, GA, and Lopez, RD. "Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer." J Immunol 180, no. 9 (May 1, 2008): 6044-6053.  Link to Item
    • Guo, BL, Liu, Z, Aldrich, WA, and Lopez, RD. "Innate anti-breast cancer immunity of apoptosis-resistant human gammadelta-T cells." Breast Cancer Res Treat 93, no. 2 (September 2005): 169-175.  Full Text  Link to Item
    • Liu, Z, Guo, BL, Gehrs, BC, Nan, L, and Lopez, RD. "Ex vivo expanded human Vgamma9Vdelta2+ gammadelta-T cells mediate innate antitumor activity against human prostate cancer cells in vitro." J Urol 173, no. 5 (May 2005): 1552-1556.  Link to Item
    • Lamb, LS, and Lopez, RD. "gammadelta T cells: a new frontier for immunotherapy?." Biol Blood Marrow Transplant 11, no. 3 (March 2005): 161-168. (Review)  Full Text  Link to Item
    • Lamb, LS, and Lopez, RD. "γδ T cells: A new frontier for immunotherapy?." Biology of Blood and Marrow Transplantation 11, no. 3 (March 1, 2005): 161-168. (Review)  Full Text
    • Guo, BL, Hollmig, KA, and Lopez, RD. "Down-regulation of IL-2 receptor alpha (CD25) characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12." Cancer Immunol Immunother 50, no. 11 (January 2002): 625-637.  Full Text  Link to Item
    • Lopez, RD. "Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases." Immunol Res 26, no. 1-3 (2002): 207-221. (Review)  Full Text  Link to Item
    • Vaughan, WP, Katz, RO, Salzman, DE, Tilden, AB, Lopez, RD, Garcia, A, Pena, O, Shackelford, M, and Carabasi, MH. "MRD allo transplantation using a large volume leukopheresis product mobilized with G-CSF and Decadron, pharmacokinetics directed modest dose intravenous busulfan plus fludarabine conditioning, and long MTX/CSA results in sustained engraftment, low 30 day mortality, and low incidence of severe GVHD." BLOOD 98, no. 11 (November 16, 2001): 200A-200A.  Link to Item
    • Lopez, RD, Waller, EK, Lu, PH, and Negrin, RS. "CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells." Cancer Immunol Immunother 49, no. 12 (February 2001): 629-640.  Link to Item
    • Lopez, RD, Waller, EK, Lu, PH, and Negrin, RS. "CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56⁺T cells." Cancer Immunology, Immunotherapy 49, no. 11 (December 1, 2000): 629-640.
    • Lopez, RD, Xu, S, Guo, B, Negrin, RS, and Waller, EK. "CD2-mediated IL-12-dependent signals render human γδ-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: Implications for the development of adoptive immunotherapy strategies." Blood 96, no. 12 (December 1, 2000): 3827-3837.
    • Sun, Q, Burton, RL, Ship, AM, Vaughan, WP, Salzman, DE, Lopez, R, Carabasi, MA, Pohlman, B, and Lucas, KG. "Adoptive immunotherapy with allogeneic EBV CTL for organ transplant patients with ebv induced lymphoproliferative disease." Blood 96, no. 11 PART II (December 1, 2000).
    • Sherman, MA, Secor, VH, Lee, SK, Lopez, RD, and Brown, MA. "STAT6-independent production of IL-4 by mast cells." European journal of immunology 29, no. 4 (April 1999): 1235-1242.  Full Text
    • Lopez, RD, Poloso, N, Negrin, RS, Xu, S, and Waller, EK. "Engagement of CD2/LFA-2 on activated human peripheral blood T cells results in an IL-12-dependent resistance to Activation-Induced Cell Death (AICD) in γδ T cells." FASEB Journal 12, no. 5 (March 20, 1998).
    • Margulies, DH, Lopez, R, Boyd, LF, and McCluskey, J. "Engineering soluble major histocompatibility molecules: why and how." Immunologic research 6, no. 1-2 (January 1987): 101-116. (Review)  Full Text

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