Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Medicine, Stanford University, School of Medicine 1990 - 1991
  • Intern, Medicine, Stanford University, School of Medicine 1989 - 1990
  • M.D., Stanford University 1989
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2013 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Anand, Sarah, Samantha Thomas, Terry Hyslop, Janet Adcock, Kelly Corbet, Cristina Gasparetto, Richard Lopez, et al. “Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization.” Biol Blood Marrow Transplant 23, no. 7 (July 2017): 1151–57. https://doi.org/10.1016/j.bbmt.2017.04.001.
       Full Text  Link to Item
    • Sivaraj, Dharshan, Michael M. Green, Zhiguo Li, Anthony D. Sung, Stefanie Sarantopoulos, Yubin Kang, Gwynn D. Long, et al. “Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma.” Biol Blood Marrow Transplant 23, no. 2 (February 2017): 262–68. https://doi.org/10.1016/j.bbmt.2016.11.010.
       Full Text  Link to Item
    • Bonneville, Marc, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, and Bruno Silva-Santos. “Chicago 2014--30 years of γδ T cells.” Cell Immunol 296, no. 1 (July 2015): 3–9. https://doi.org/10.1016/j.cellimm.2014.11.001.
       Full Text  Link to Item
    • Xu, H. -. G., Y. -. X. Zhai, J. Chen, Y. Lu, J. -. W. Wang, C. -. S. Quan, R. -. X. Zhao, et al. “LKB1 reduces ROS-mediated cell damage via activation of p38.” Oncogene 34, no. 29 (July 2015): 3848–59. https://doi.org/10.1038/onc.2014.315.
       Full Text  Link to Item
    • Beck, Benjamin H., Hyunggoon Kim, Rebecca O’Brien, Martin R. Jadus, G Yancey Gillespie, Gretchen A. Cloud, Neil T. Hoa, et al. “Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.” Plos One 10, no. 5 (2015): e0122387. https://doi.org/10.1371/journal.pone.0122387.
       Full Text  Link to Item
    • Lopez, Richard D. “Inhibiting inhibitory pathways in human γδ T cells.” Blood 122, no. 6 (August 8, 2013): 857–58. https://doi.org/10.1182/blood-2013-06-506584.
       Full Text  Link to Item
    • Lindhorst, Scott M., Richard D. Lopez, and Ronald D. Sanders. “An unusual presentation of chronic myelogenous leukemia: a review of isolated central nervous system relapse.” J Natl Compr Canc Netw 11, no. 7 (July 2013): 745–49. https://doi.org/10.6004/jnccn.2013.0097.
       Full Text  Link to Item
    • Beck, Benjamin, G Yancey Gillespie, Richard D. Lopez, Gretchen A. Cloud, Cathy Langford, Hyung Kim, Lualhati Harkins, and Lawrence S. Lamb. “Abstract 530: Circulating γδ T cells are activated and depleted during progression of high-grade gliomas: Implications for γδ T cells therapy of GBM.” Immunology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-530.
       Full Text
    • Kanda, Junya, Richard D. Lopez, and David A. Rizzieri. “Alemtuzumab for the prevention and treatment of graft-versus-host disease.” Int J Hematol 93, no. 5 (May 2011): 586–93. https://doi.org/10.1007/s12185-011-0802-2.
       Full Text  Link to Item
    • Bryant, Nichole L., G Yancey Gillespie, Richard D. Lopez, James M. Markert, Gretchen A. Cloud, Catherine P. Langford, Hilal Arnouk, et al. “Preclinical evaluation of ex vivo expanded/activated γδ T cells for immunotherapy of glioblastoma multiforme.” J Neurooncol 101, no. 2 (January 2011): 179–88. https://doi.org/10.1007/s11060-010-0245-2.
       Full Text  Link to Item
    • Kanda, J., R. D. Lopez, and D. A. Rizzieri. “Alemtuzumab for the prevention and treatment of graft-versus-host disease.” International Journal of Hematology, 2011, 1–8.
    • Beck, Benjamin H., Hyung-Gyoon Kim, Hyunki Kim, Sharon Samuel, Zhiyong Liu, Robin Shrestha, Hilary Haines, Kurt Zinn, and Richard D. Lopez. “Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer.” Breast Cancer Res Treat 122, no. 1 (July 2010): 135–44. https://doi.org/10.1007/s10549-009-0527-6.
       Full Text  Link to Item
    • Bryant, Nichole L., Catalina Suarez-Cuervo, G Yancey Gillespie, James M. Markert, L Burt Nabors, Sreelatha Meleth, Richard D. Lopez, and Lawrence S. Lamb. “Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma.” Neuro Oncol 11, no. 4 (August 2009): 357–67. https://doi.org/10.1215/15228517-2008-111.
       Full Text  Link to Item
    • Liu, Zhiyong, Ben Guo, and Richard D. Lopez. “Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer.” J Gastroenterol Hepatol 24, no. 5 (May 2009): 900–911. https://doi.org/10.1111/j.1440-1746.2008.05668.x.
       Full Text  Link to Item
    • Liu, Zhiyong, Isam-Eldin A. Eltoum, Ben Guo, Benjamin H. Beck, Gretchen A. Cloud, and Richard D. Lopez. “Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer.” J Immunol 180, no. 9 (May 1, 2008): 6044–53. https://doi.org/10.4049/jimmunol.180.9.6044.
       Full Text  Link to Item
    • Suarez-Cuervo, C., N. L. Bryant, R. D. Lopez, G. Y. Gillespie, and L. S. Lamb. “Ex vivo activation and expansion of γδ T cells for immunotherapy of glioblastoma.” J Clin Oncol 24, no. 18_suppl (June 20, 2006): 2553.
       Link to Item
    • Qiu, Wei-Hua, Bing-Sen Zhou, Peiguo-G Chu, Wen-Gang Chen, Christopher Chung, Jennifer Shih, Paul Hwu, Christopher Yeh, Richard Lopez, and Yun Yen. “Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.” World J Gastroenterol 11, no. 34 (September 14, 2005): 5266–72. https://doi.org/10.3748/wjg.v11.i34.5266.
       Full Text  Link to Item
    • Guo, Ben L., Zhiyong Liu, Wayne A. Aldrich, and Richard D. Lopez. “Innate anti-breast cancer immunity of apoptosis-resistant human gammadelta-T cells.” Breast Cancer Res Treat 93, no. 2 (September 2005): 169–75. https://doi.org/10.1007/s10549-005-4792-8.
       Full Text  Link to Item
    • Liu, Zhiyong, Ben L. Guo, Bradley C. Gehrs, Li Nan, and Richard D. Lopez. “Ex vivo expanded human Vgamma9Vdelta2+ gammadelta-T cells mediate innate antitumor activity against human prostate cancer cells in vitro.” J Urol 173, no. 5 (May 2005): 1552–56. https://doi.org/10.1097/01.ju.0000154355.45816.0b.
       Full Text  Link to Item
    • Lamb, Lawrence S., and Richard D. Lopez. “gammadelta T cells: a new frontier for immunotherapy?” Biol Blood Marrow Transplant 11, no. 3 (March 2005): 161–68. https://doi.org/10.1016/j.bbmt.2004.11.015.
       Full Text  Link to Item
    • Qiu, Weihua, Bingsen Zhou, Hongzhi Zou, Xiyong Liu, Peiguo G. Chu, Richard Lopez, Jennifer Shih, Christopher Chung, and Yun Yen. “Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.” Am J Pathol 165, no. 5 (November 2004): 1689–99. https://doi.org/10.1016/s0002-9440(10)63425-6.
       Full Text  Link to Item
    • Qiu, Weihua, Donald David, Bingsen Zhou, Peiguo G. Chu, Bohe Zhang, Mengchao Wu, Jiacheng Xiao, et al. “Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma.” Am J Pathol 162, no. 6 (June 2003): 1961–74. https://doi.org/10.1016/s0002-9440(10)64329-5.
       Full Text  Link to Item
    • Guo, Ben L., Klaus A. Hollmig, and Richard D. Lopez. “Down-regulation of IL-2 receptor alpha (CD25) characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12.” Cancer Immunol Immunother 50, no. 11 (January 2002): 625–37. https://doi.org/10.1007/s00262-001-0244-4.
       Full Text  Link to Item
    • Lopez, Richard D. “Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases.” Immunol Res 26, no. 1–3 (2002): 207–21. https://doi.org/10.1385/IR:26:1-3:207.
       Full Text  Link to Item
    • Vaughan, W. P., R. O. Katz, D. E. Salzman, A. B. Tilden, R. D. Lopez, A. Garcia, O. Pena, M. Shackelford, and M. H. Carabasi. “MRD allo transplantation using a large volume leukopheresis product mobilized with G-CSF and Decadron, pharmacokinetics directed modest dose intravenous busulfan plus fludarabine conditioning, and long MTX/CSA results in sustained engraftment, low 30 day mortality, and low incidence of severe GVHD.” Blood 98, no. 11 (November 16, 2001): 200A-200A.
       Link to Item
    • Lopez, R. D., E. K. Waller, P. H. Lu, and R. S. Negrin. “CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells.” Cancer Immunol Immunother 49, no. 12 (February 2001): 629–40. https://doi.org/10.1007/s002620000148.
       Full Text  Link to Item
    • Lopez, R. D., S. Xu, B. Guo, R. S. Negrin, and E. K. Waller. “CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies.” Blood 96, no. 12 (December 1, 2000): 3827–37.
       Link to Item
    • Sun, Q., R. L. Burton, A. M. Ship, W. P. Vaughan, D. E. Salzman, R. Lopez, M. A. Carabasi, B. Pohlman, and K. G. Lucas. “Adoptive immunotherapy with allogeneic EBV CTL for organ transplant patients with ebv induced lymphoproliferative disease.” Blood 96, no. 11 PART II (December 1, 2000).
    • Sherman, M. A., V. H. Secor, S. K. Lee, R. D. Lopez, and M. A. Brown. “STAT6-independent production of IL-4 by mast cells.” Eur J Immunol 29, no. 4 (April 1999): 1235–42. https://doi.org/10.1002/(SICI)1521-4141(199904)29:04<1235::AID-IMMU1235>3.0.CO;2-0.
       Full Text  Link to Item
    • Lopez, R. D., N. Poloso, R. S. Negrin, S. Xu, and E. K. Waller. “Engagement of CD2/LFA-2 on activated human peripheral blood T cells results in an IL-12-dependent resistance to Activation-Induced Cell Death (AICD) in γδ T cells.” Faseb Journal 12, no. 5 (March 20, 1998).
    • Margulies, D. H., R. Lopez, L. F. Boyd, and J. McCluskey. “Engineering soluble major histocompatibility molecules: why and how.” Immunol Res 6, no. 1–2 (1987): 101–16. https://doi.org/10.1007/BF02918107.
       Full Text  Link to Item

  • Conference Papers

    • Anand, Sarah, Samantha Thomas, Kelly Corbet, Cristina Gasparetto, Gwynn D. Long, Richard Lopez, Ashley K. Morris, et al. “Adult Umbilical Cord Blood Transplantation Using Myeloablative Thiotepa, Total Body Irradiation, and Fludarabine Conditioning.” In Biol Blood Marrow Transplant, 23:1949–54, 2017. https://doi.org/10.1016/j.bbmt.2017.06.027.
       Full Text  Link to Item
    • Beck, Benjamin, Richard D. Lopez, G Yancey Gillespie, Hyung Kim, Gretchen Cloud, Larisa Pereboeva, and Lamb Lawrence S. Jr. “Peripheral Blood gamma delta T Cell Response to High-Grade Glioma: Implications for Localized Adoptive Immunotherapy.” In Blood, Vol. 120, 2012.
       Link to Item
    • Beck, Benjamin, Richard D. Lopez, G Yancey Gillespie, Hyung Kim, Gretchen Cloud, Larisa Pereboeva, and Lawrence S. Lamb. “Peripheral Blood γδ T Cell Response to High-Grade Glioma: Implications for Localized Adoptive Immunotherapy.” In Blood, 120:4114–4114. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.4114.4114.
       Full Text
    • Suarez, C., N. L. Bryant, Y. Gillespie, R. D. Lopez, J. M. Markert, and L. S. Lamb. “189: γδ T cells as immunotherapy for glioblastoma multiforme.” In Biology of Blood and Marrow Transplantation, 13:70–70. Elsevier BV, 2007. https://doi.org/10.1016/j.bbmt.2006.12.193.
       Full Text
    • Suarez-Cuervo, C., N. L. Bryant, R. D. Lopez, G. Y. Gillespie, and L. S. Lamb. “Ex vivo activation and expansion of gamma delta T cells for immunotherapy of glioblastorna.” In Journal of Clinical Oncology, 24:113S-113S. AMER SOC CLINICAL ONCOLOGY, 2006.
       Link to Item
    • Gehrs, B. C., and R. D. Lopez. “Ex vivo expansion of gamma delta-T lymphocytes from melanoma patients and healthy control donors.” In Transfusion, 45:8A-8A. BLACKWELL PUBLISHING, 2005.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.