Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Texas Southwestern Medical Center at Dallas Southwestern Medical School 1998
  • Ph.D., University of Texas Southwestern Medical Center at Dallas Southwestern Medical School 1998
• 

  Duke Appointment History

  • Associate Professor of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2018 - 2019
  • Associate Professor of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2015 - 2018
  • Instructor, Temporary in the Department of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2014 - 2015
• Research
• 

  Selected Grants

  • An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Klein, Lauren J., Avani A. Pendse, Rhonda Mittenzwei, and Richard Noel. “Defying Occam's Razor: Colonic Luminal Endometriosis in an Adolescent With Crohn's Disease.” J Adolesc Health, November 23, 2019. https://doi.org/10.1016/j.jadohealth.2019.09.018.
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    • Goday, Praveen S., Susanna Y. Huh, Alan Silverman, Colleen T. Lukens, Pamela Dodrill, Sherri S. Cohen, Amy L. Delaney, et al. “Pediatric Feeding Disorder: Consensus Definition and Conceptual Framework.” J Pediatr Gastroenterol Nutr 68, no. 1 (January 2019): 124–29. https://doi.org/10.1097/MPG.0000000000002188.
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    • Pollow, Alyssa S., Catherine A. Karls, Mary Witzlib, Richard J. Noel, Praveen S. Goday, and Alan H. Silverman. “Safety of Appetite Manipulation in Children with Feeding Disorders Admitted to an Inpatient Feeding Program.” J Pediatr Gastroenterol Nutr 66, no. 5 (May 2018): e127–30. https://doi.org/10.1097/MPG.0000000000001849.
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    • Pena, Loren D. M., Yong-Hui Jiang, Kelly Schoch, Rebecca C. Spillmann, Nicole Walley, Nicholas Stong, Sarah Rapisardo Horn, et al. “Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases.” Genet Med 20, no. 4 (April 2018): 464–69. https://doi.org/10.1038/gim.2017.128.
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    • Noel, Richard J., and Alan H. Silverman. “A Problem That Is Difficult to Swallow.” J Pediatr 181 (February 2017): 7–8. https://doi.org/10.1016/j.jpeds.2016.11.052.
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    • Kelly, Elizabeth A., David Linn, Kristina L. Keppel, Richard J. Noel, and Robert H. Chun. “Otolaryngologic surgeries are frequent in children with eosinophilic esophagitis.” Ann Otol Rhinol Laryngol 124, no. 5 (May 2015): 355–60. https://doi.org/10.1177/0003489414558108.
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    • Noel, Richard J. “Another step towards celiac screening.” Pediatrics 135, no. 4 (April 2015): 752–53. https://doi.org/10.1542/peds.2015-0209.
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    • Alexander, Eileen S., Lisa J. Martin, Margaret H. Collins, Leah C. Kottyan, Heidi Sucharew, Hua He, Vincent A. Mukkada, et al. “Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.” J Allergy Clin Immunol 134, no. 5 (November 2014): 1084-1092.e1. https://doi.org/10.1016/j.jaci.2014.07.021.
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    • Hill, Garick D., Alan H. Silverman, Richard J. Noel, Pippa M. Simpson, Julie Slicker, Ann E. Scott, and Peter J. Bartz. “Feeding dysfunction in children with single ventricle following staged palliation.” J Pediatr 164, no. 2 (February 2014): 243-6.e1. https://doi.org/10.1016/j.jpeds.2013.09.030.
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    • Hill, Garick, Alan Silverman, Richard Noel, and Peter J. Bartz. “Feeding dysfunction in single ventricle patients with feeding disorder.” Congenit Heart Dis 9, no. 1 (January 2014): 26–29. https://doi.org/10.1111/chd.12071.
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    • Silverman, Alan H., Midge Kirby, Lisa M. Clifford, Elizabeth Fischer, Kristoffer S. Berlin, Colin D. Rudolph, and Richard J. Noel. “Nutritional and psychosocial outcomes of gastrostomy tube-dependent children completing an intensive inpatient behavioral treatment program.” J Pediatr Gastroenterol Nutr 57, no. 5 (November 2013): 668–72. https://doi.org/10.1097/MPG.0b013e3182a027a3.
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    • Uzel, Gulbu, Elizabeth P. Sampaio, Monica G. Lawrence, Amy P. Hsu, Mary Hackett, Morna J. Dorsey, Richard J. Noel, et al. “Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.” J Allergy Clin Immunol 131, no. 6 (June 2013): 1611–23. https://doi.org/10.1016/j.jaci.2012.11.054.
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    • Adamiak, Tonya, Dorota Walkiewicz-Jedrzejczak, Daryl Fish, Christopher Brown, Jeanne Tung, Khalid Khan, William Faubion, et al. “Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study.” Inflamm Bowel Dis 19, no. 6 (May 2013): 1218–23. https://doi.org/10.1097/MIB.0b013e318280b13e.
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    • Noel, Richard J., Kelly J. Duffy, Michael E. Kelly, Nader Tondravi, Paula E. North, and Beth A. Drolet. “Endoscopic management of gastrointestinal bleeding from multifocal lymphangioendotheliomatosis with thrombocytopenia: limited efficacy and complications.” J Pediatr Gastroenterol Nutr 54, no. 6 (June 2012): 822–24. https://doi.org/10.1097/MPG.0b013e31822aa2db.
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    • Liacouras, Chris A., Glenn T. Furuta, Ikuo Hirano, Dan Atkins, Stephen E. Attwood, Peter A. Bonis, A Wesley Burks, et al. “Eosinophilic esophagitis: updated consensus recommendations for children and adults.” J Allergy Clin Immunol 128, no. 1 (July 2011): 3-20.e6. https://doi.org/10.1016/j.jaci.2011.02.040.
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    • Jensen, M Kyle, Neelesh A. Tipnis, Ruta Bajorunaite, Mehul K. Sheth, Thomas T. Sato, and Richard J. Noel. “Capsule endoscopy performed across the pediatric age range: indications, incomplete studies, and utility in management of inflammatory bowel disease.” Gastrointest Endosc 72, no. 1 (July 2010): 95–102. https://doi.org/10.1016/j.gie.2010.01.016.
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    • Feuling, Mary Beth, and Richard J. Noel. “Medical and nutrition management of eosinophilic esophagitis in children.” Nutr Clin Pract 25, no. 2 (April 2010): 166–74. https://doi.org/10.1177/0884533610361608.
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    • Maronn, Mandi, Kristina Catrine, Paula North, Meghen B. Browning, Joseph E. Kerschner, Richard Noel, Beth A. Drolet, and Michael Kelly. “Expanding the phenotype of multifocal lymphangioendotheliomatosis with thrombocytopenia.” Pediatr Blood Cancer 52, no. 4 (April 2009): 531–34. https://doi.org/10.1002/pbc.21766.
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    • Noel, Richard J., and Steven L. Werlin. “Peutz-Jeghers syndrome: are "shaggy" villi part of the pathology?” Gastrointest Endosc 68, no. 5 (November 2008): 1004–5. https://doi.org/10.1016/j.gie.2008.04.021.
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    • Noel, R. J. “Disorders of Gastric Emptying,” December 1, 2007, 620–23. https://doi.org/10.1016/B978-032303004-5.50100-9.
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    • Kirby, Midge, and Richard J. Noel. “Nutrition and gastrointestinal tract assessment and management of children with dysphagia.” Semin Speech Lang 28, no. 3 (August 2007): 180–89. https://doi.org/10.1055/s-2007-984724.
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    • Assa’ad, Amal H., Philip E. Putnam, Margaret H. Collins, Rachel M. Akers, Sean C. Jameson, Cassie L. Kirby, Bridget K. Buckmeier, et al. “Pediatric patients with eosinophilic esophagitis: an 8-year follow-up.” J Allergy Clin Immunol 119, no. 3 (March 2007): 731–38. https://doi.org/10.1016/j.jaci.2006.10.044.
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    • Noel, R. J., and M. B. Cohen. “Infectious Diarrhea,” December 1, 2006, 557–81. https://doi.org/10.1016/B978-0-7216-3924-6.50040-8.
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    • Konikoff, Michael R., Richard J. Noel, Carine Blanchard, Cassie Kirby, Sean C. Jameson, Bridget K. Buckmeier, Rachel Akers, et al. “A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis.” Gastroenterology 131, no. 5 (November 2006): 1381–91. https://doi.org/10.1053/j.gastro.2006.08.033.
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    • Noel, Richard Joseph, and Neelesh Ajit Tipnis. “Eosinophilic esophagitis -- a mimic of GERD.” Int J Pediatr Otorhinolaryngol 70, no. 7 (July 2006): 1147–53. https://doi.org/10.1016/j.ijporl.2006.01.012.
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    • Noel, Richard J., and Marc E. Rothenberg. “Eosinophilic esophagitis.” Curr Opin Pediatr 17, no. 6 (December 2005): 690–94. https://doi.org/10.1097/01.mop.0000184291.34654.be.
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    • Kugathasan, Subra, Anthony Loizides, Umesh Babusukumar, Erin McGuire, Tao Wang, Pleasant Hooper, Justin Nebel, et al. “Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease.” Inflamm Bowel Dis 11, no. 7 (July 2005): 631–38. https://doi.org/10.1097/01.mib.0000171279.05471.21.
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    • Noel, Richard J., Lili Miles, Philip E. Putnam, and Michael K. Farrell. “Clinical quiz: rectal prolapse.” J Pediatr Gastroenterol Nutr 39, no. 5 (November 2004): 567–75. https://doi.org/10.1097/00005176-200411000-00024.
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    • Noel, Richard J., Philip E. Putnam, and Marc E. Rothenberg. “Eosinophilic esophagitis.” N Engl J Med 351, no. 9 (August 26, 2004): 940–41. https://doi.org/10.1056/NEJM200408263510924.
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    • Noel, Richard J., Philip E. Putnam, Margaret H. Collins, Amal H. Assa’ad, Jesus R. Guajardo, Sean C. Jameson, and Marc E. Rothenberg. “Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis.” Clin Gastroenterol Hepatol 2, no. 7 (July 2004): 568–75. https://doi.org/10.1016/s1542-3565(04)00240-x.
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    • Noel, R. J., and W. F. Balistreri. “Pediatric liver disease,” April 23, 2004, 293–303. https://doi.org/10.1016/B978-0-443-06633-7.50028-4.
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    • Noel, R. J., M. S. Glock, T. Pranikoff, and I. D. Hill. “Nonobstructive antral web: an unusual cause of excessive crying in an infant.” J Pediatr Gastroenterol Nutr 31, no. 4 (October 2000): 439–41. https://doi.org/10.1097/00005176-200010000-00020.
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    • Noel, R. J., P. A. Antinozzi, J. D. McGarry, and C. B. Newgard. “Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.” J Biol Chem 272, no. 30 (July 25, 1997): 18621–27. https://doi.org/10.1074/jbc.272.30.18621.
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    • Becker, T. C., R. J. Noel, J. H. Johnson, R. M. Lynch, H. Hirose, Y. Tokuyama, G. I. Bell, and C. B. Newgard. “Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.” J Biol Chem 271, no. 1 (January 5, 1996): 390–94. https://doi.org/10.1074/jbc.271.1.390.
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    • Becker, T. C., H. BeltrandelRio, R. J. Noel, J. H. Johnson, and C. B. Newgard. “Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.” J Biol Chem 269, no. 33 (August 19, 1994): 21234–38.
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    • Ferber, S., H. BeltrandelRio, J. H. Johnson, R. J. Noel, L. E. Cassidy, S. Clark, T. C. Becker, S. D. Hughes, and C. B. Newgard. “GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.” J Biol Chem 269, no. 15 (April 15, 1994): 11523–29.
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    • Becker, T. C., R. J. Noel, W. S. Coats, A. M. Gómez-Foix, T. Alam, R. D. Gerard, and C. B. Newgard. “Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells.” Methods in Cell Biology 43, no. C (January 1, 1994): 161–89. https://doi.org/10.1016/S0091-679X(08)60603-2.
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  • Book Sections

    • Noel, R. J. “Vomiting and Regurgitation.” In Nelson Pediatric Symptom-Based Diagnosis, 204-234.e1, 2018. https://doi.org/10.1016/B978-0-323-39956-2.00012-1.
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    • Noel, R. J. “Epidemiology, incidence, and prevalence of EoE in children.” In Eosinophilic Esophagitis, 11–23, 2012. https://doi.org/10.1007/978-1-60761-515-6_2.
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