Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Texas Southwestern Medical Center at Dallas Southwestern Medical School 1998
  • Ph.D., University of Texas Southwestern Medical Center at Dallas Southwestern Medical School 1998
• 

  Duke Appointment History

  • Associate Professor of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2015 - 2018
  • Instructor, Temporary in the Department of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2014 - 2015
• Research
• 

  Selected Grants

  • An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Noel, RJ. "Vomiting and Regurgitation." In Nelson Pediatric Symptom-Based Diagnosis, 204-234.e1. April 24, 2017.  Full Text
    • Noel, RJ. "Epidemiology, incidence, and prevalence of EoE in children." In Eosinophilic Esophagitis, 11-23. January 1, 2012.  Full Text

  • Journal Articles

    • Pollow, AS, Karls, CA, Witzlib, M, Noel, RJ, Goday, PS, and Silverman, AH. "Safety of Appetite Manipulation in Children with Feeding Disorders Admitted to an Inpatient Feeding Program." Journal of Pediatric Gastroenterology and Nutrition 66, no. 5 (May 2018): e127-e130.  Full Text
    • Pena, LDM, Jiang, Y-H, Schoch, K, Spillmann, RC, Walley, N, Stong, N, Rapisardo Horn, S, Sullivan, JA, McConkie-Rosell, A, Kansagra, S, Smith, EC, El-Dairi, M, Bellet, J, Keels, MA, Jasien, J, Kranz, PG, Noel, R, Nagaraj, SK, Lark, RK, Wechsler, DSG, Del Gaudio, D, Leung, ML, Hendon, LG, Parker, CC, Jones, KL, Undiagnosed Diseases Network Members, , Goldstein, DB, and Shashi, V. "Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases." Genetics in Medicine : Official Journal of the American College of Medical Genetics 20, no. 4 (April 2018): 464-469.  Full Text  Open Access Copy
    • Noel, RJ, and Silverman, AH. "A Problem That Is Difficult to Swallow." The Journal of Pediatrics 181 (February 2017): 7-8.  Full Text
    • Kelly, EA, Linn, D, Keppel, KL, Noel, RJ, and Chun, RH. "Otolaryngologic surgeries are frequent in children with eosinophilic esophagitis." The Annals of Otology, Rhinology, and Laryngology 124, no. 5 (May 2015): 355-360.  Full Text
    • Noel, RJ. "Another step towards celiac screening." Pediatrics 135, no. 4 (April 2015): 752-753.  Full Text
    • Alexander, ES, Martin, LJ, Collins, MH, Kottyan, LC, Sucharew, H, He, H, Mukkada, VA, Succop, PA, Abonia, JP, Foote, H, Eby, MD, Grotjan, TM, Greenler, AJ, Dellon, ES, Demain, JG, Furuta, GT, Gurian, LE, Harley, JB, Hopp, RJ, Kagalwalla, A, Kaul, A, Nadeau, KC, Noel, RJ, Putnam, PE, von Tiehl, KF, and Rothenberg, ME. "Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis." The Journal of Allergy and Clinical Immunology 134, no. 5 (November 2014): 1084-1092.e1.  Full Text
    • Hill, GD, Silverman, AH, Noel, RJ, Simpson, PM, Slicker, J, Scott, AE, and Bartz, PJ. "Feeding dysfunction in children with single ventricle following staged palliation." The Journal of pediatrics 164, no. 2 (February 2014): 243-6.e1.  Full Text
    • Hill, G, Silverman, A, Noel, R, and Bartz, PJ. "Feeding dysfunction in single ventricle patients with feeding disorder." Congenital Heart Disease 9, no. 1 (January 2014): 26-29.  Full Text
    • Silverman, AH, Kirby, M, Clifford, LM, Fischer, E, Berlin, KS, Rudolph, CD, and Noel, RJ. "Nutritional and psychosocial outcomes of gastrostomy tube-dependent children completing an intensive inpatient behavioral treatment program." Journal of pediatric gastroenterology and nutrition 57, no. 5 (November 2013): 668-672.  Full Text
    • Uzel, G, Sampaio, EP, Lawrence, MG, Hsu, AP, Hackett, M, Dorsey, MJ, Noel, RJ, Verbsky, JW, Freeman, AF, Janssen, E, Bonilla, FA, Pechacek, J, Chandrasekaran, P, Browne, SK, Agharahimi, A, Gharib, AM, Mannurita, SC, Yim, JJ, Gambineri, E, Torgerson, T, Tran, DQ, Milner, JD, and Holland, SM. "Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome." The Journal of Allergy and Clinical Immunology 131, no. 6 (June 2013): 1611-1623.  Full Text
    • Adamiak, T, Walkiewicz-Jedrzejczak, D, Fish, D, Brown, C, Tung, J, Khan, K, Faubion, W, Park, R, Heikenen, J, Yaffee, M, Rivera-Bennett, MT, Wiedkamp, M, Stephens, M, Noel, R, Nugent, M, Nebel, J, Simpson, P, Kappelman, MD, and Kugathasan, S. "Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study." Inflammatory Bowel Diseases 19, no. 6 (May 2013): 1218-1223.  Full Text
    • Noel, RJ, Duffy, KJ, Kelly, ME, Tondravi, N, North, PE, and Drolet, BA. "Endoscopic management of gastrointestinal bleeding from multifocal lymphangioendotheliomatosis with thrombocytopenia: limited efficacy and complications." Journal of pediatric gastroenterology and nutrition 54, no. 6 (June 2012): 822-824.  Full Text
    • Liacouras, CA, Furuta, GT, Hirano, I, Atkins, D, Attwood, SE, Bonis, PA, Burks, AW, Chehade, M, Collins, MH, Dellon, ES, Dohil, R, Falk, GW, Gonsalves, N, Gupta, SK, Katzka, DA, Lucendo, AJ, Markowitz, JE, Noel, RJ, Odze, RD, Putnam, PE, Richter, JE, Romero, Y, Ruchelli, E, Sampson, HA, Schoepfer, A, Shaheen, NJ, Sicherer, SH, Spechler, S, Spergel, JM, Straumann, A, Wershil, BK, Rothenberg, ME, and Aceves, SS. "Eosinophilic esophagitis: updated consensus recommendations for children and adults." The Journal of Allergy and Clinical Immunology 128, no. 1 (July 2011): 3-20.e6. (Review)  Full Text
    • Jensen, MK, Tipnis, NA, Bajorunaite, R, Sheth, MK, Sato, TT, and Noel, RJ. "Capsule endoscopy performed across the pediatric age range: indications, incomplete studies, and utility in management of inflammatory bowel disease." Gastrointestinal endoscopy 72, no. 1 (July 2010): 95-102.  Full Text
    • Feuling, MB, and Noel, RJ. "Medical and nutrition management of eosinophilic esophagitis in children." Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 25, no. 2 (April 2010): 166-174. (Review)  Full Text
    • Maronn, M, Catrine, K, North, P, Browning, MB, Kerschner, JE, Noel, R, Drolet, BA, and Kelly, M. "Expanding the phenotype of multifocal lymphangioendotheliomatosis with thrombocytopenia." Pediatric blood & cancer 52, no. 4 (April 2009): 531-534.  Full Text
    • Noel, RJ, and Werlin, SL. "Peutz-Jeghers syndrome: are "shaggy" villi part of the pathology?." Gastrointestinal endoscopy 68, no. 5 (November 2008): 1004-1005.  Full Text
    • Noel, RJ. "Disorders of Gastric Emptying." (December 1, 2007): 620-623. (Chapter)  Full Text
    • Kirby, M, and Noel, RJ. "Nutrition and gastrointestinal tract assessment and management of children with dysphagia." Seminars in speech and language 28, no. 3 (August 2007): 180-189. (Review)  Full Text
    • Assa'ad, AH, Putnam, PE, Collins, MH, Akers, RM, Jameson, SC, Kirby, CL, Buckmeier, BK, Bullock, JZ, Collier, AR, Konikoff, MR, Noel, RJ, Guajardo, JR, and Rothenberg, ME. "Pediatric patients with eosinophilic esophagitis: an 8-year follow-up." The Journal of Allergy and Clinical Immunology 119, no. 3 (March 2007): 731-738.  Full Text
    • Noel, RJ, and Cohen, MB. "Infectious Diarrhea." (December 1, 2006): 557-581. (Chapter)  Full Text
    • Konikoff, MR, Noel, RJ, Blanchard, C, Kirby, C, Jameson, SC, Buckmeier, BK, Akers, R, Cohen, MB, Collins, MH, Assa'ad, AH, Aceves, SS, Putnam, PE, and Rothenberg, ME. "A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis." Gastroenterology 131, no. 5 (November 2006): 1381-1391.  Full Text
    • Noel, RJ, and Tipnis, NA. "Eosinophilic esophagitis -- a mimic of GERD." International journal of pediatric otorhinolaryngology 70, no. 7 (July 2006): 1147-1153. (Review)  Full Text
    • Noel, RJ, and Rothenberg, ME. "Eosinophilic esophagitis." Current opinion in pediatrics 17, no. 6 (December 2005): 690-694. (Review)  Full Text
    • Kugathasan, S, Loizides, A, Babusukumar, U, McGuire, E, Wang, T, Hooper, P, Nebel, J, Kofman, G, Noel, R, Broeckel, U, and Tolia, V. "Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease." Inflammatory Bowel Diseases 11, no. 7 (July 2005): 631-638.  Full Text
    • Noel, RJ, Miles, L, Putnam, PE, and Farrell, MK. "Clinical quiz: rectal prolapse." Journal of pediatric gastroenterology and nutrition 39, no. 5 (November 2004): 567-575.  Full Text
    • Noel, RJ, Putnam, PE, and Rothenberg, ME. "Eosinophilic esophagitis." The New England Journal of Medicine 351, no. 9 (August 2004): 940-941. (Letter)  Full Text
    • Noel, RJ, Putnam, PE, Collins, MH, Assa'ad, AH, Guajardo, JR, Jameson, SC, and Rothenberg, ME. "Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2, no. 7 (July 2004): 568-575.  Full Text
    • Noel, RJ, and Balistreri, WF. "Pediatric liver disease." (April 23, 2004): 293-303. (Chapter)  Full Text
    • Noel, RJ, Glock, MS, Pranikoff, T, and Hill, ID. "Nonobstructive antral web: an unusual cause of excessive crying in an infant." Journal of pediatric gastroenterology and nutrition 31, no. 4 (October 2000): 439-441.  Full Text
    • Noel, RJ, Antinozzi, PA, McGarry, JD, and Newgard, CB. "Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling." J Biol Chem 272, no. 30 (July 25, 1997): 18621-18627.  Link to Item
    • Becker, TC, Noel, RJ, Johnson, JH, Lynch, RM, Hirose, H, Tokuyama, Y, Bell, GI, and Newgard, CB. "Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes." J Biol Chem 271, no. 1 (January 5, 1996): 390-394.  Link to Item
    • Becker, TC, BeltrandelRio, H, Noel, RJ, Johnson, JH, and Newgard, CB. "Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels." J Biol Chem 269, no. 33 (August 19, 1994): 21234-21238.  Link to Item
    • Ferber, S, BeltrandelRio, H, Johnson, JH, Noel, RJ, Cassidy, LE, Clark, S, Becker, TC, Hughes, SD, and Newgard, CB. "GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity." J Biol Chem 269, no. 15 (April 15, 1994): 11523-11529.  Link to Item
    • Becker, TC, Noel, RJ, Coats, WS, Gómez-Foix, AM, Alam, T, Gerard, RD, and Newgard, CB. "Use of recombinant adenovirus for metabolic engineering of mammalian cells." Methods in cell biology 43 Pt A (1994): 161-189.  Full Text

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