Richard Francis Riedel | Scholars@Duke

Richard Francis Riedel
Associate Professor of Medicine

Novel therapies for soft tissue and bone sarcomas

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2000

Contact Information

Dept of Medicine, 25179 Morris Bldg, Durham, NC 27710
Duke Box 3198, Durham, NC 27710
richard.riedel@duke.edu (919) 681-8031

Background
Education, Training, & Certifications
- Fellow in Hematology-Oncology, Medicine, Duke University 2005 - 2007
- Fellow in Hematology-Oncology, Medicine, Duke University 2003 - 2004
- Resident in Medicine, Medicine, Duke University 2000 - 2003
- M.D., Thomas Jefferson University 2000
Duke Appointment History
- Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2013 - 2017
- Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2007 - 2013
- Instructor, Temporary in the Department of Medicine, Medicine, Medical Oncology, Medicine 2007
- Associate in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2004 - 2005
Recognition
In the News
- MAR 4, 2015 Australian Broadcasting’s “Health Report”
  
  Dr. Richard Riedel: Early palliative care can cut hospital re-admissions for cancer patients
- NOV 7, 2014 Duke Chronicle
  
  Duke revolutionizes cancer care, garners national attention
- OCT 22, 2014
  
  Early Palliative Care Can Cut Hospital Readmissions for Cancer Patients
Research
Selected Grants
External Relationships
- AADI
- Blueprint Medicines
- Copernicus Group Inc.
- Daiichi Sankyo Co., Ltd
- Deciphera
- GlaxoSmithKline
- Immune Design
- Karyopharm Therapeutics Inc
- Limbguard, LLC
- NanoCarrier
- Oncternal
- Springworks
- Tracon Pharma
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Joseph, Cissimol P., Sarah N. Abaricia, Michelle A. Angelis, Kathleen Polson, Robin L. Jones, Yoon-Koo Kang, Richard F. Riedel, et al. “Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors.” Oncologist 26, no. 4 (April 2021): e622–31. https://doi.org/10.1002/onco.13632.
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  - Haddox, Candace L., and Richard F. Riedel. “Recent advances in the understanding and management of liposarcoma.” Fac Rev 10 (2021): 1. https://doi.org/10.12703/r/10-1.
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  - Mehren, Margaret von, John M. Kane, Marilyn M. Bui, Edwin Choy, Mary Connelly, Sarah Dry, Kristen N. Ganjoo, et al. “NCCN Guidelines Insights: Soft Tissue Sarcoma, Version 1.2021.” J Natl Compr Canc Netw 18, no. 12 (December 2, 2020): 1604–12. https://doi.org/10.6004/jnccn.2020.0058.
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  - Riedel, Richard F., Karla V. Ballman, Yao Lu, Steven Attia, Elizabeth T. Loggers, Kristen N. Ganjoo, Michael B. Livingston, et al. “A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study.” Oncologist 25, no. 11 (November 2020): e1655–62. https://doi.org/10.1634/theoncologist.2020-0679.
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  - Chawla, Sant P., Sanjay Goel, Warren Chow, Fadi Braiteh, Arun S. Singh, Juneko E Grilley Olson, Atsushi Osada, Iulian Bobe, and Richard F. Riedel. “A Phase 1b Dose Escalation Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft-tissue Sarcoma.” Clin Cancer Res 26, no. 16 (August 15, 2020): 4225–32. https://doi.org/10.1158/1078-0432.CCR-20-0591.
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  - Hendrix, Cristina C., Doreen Matters, Tamara Griffin, Heather Batchelder, Patricia Kramer, Judy R. Prewitt, Loretta Matters, et al. “Academic-Practice Partnership for Caregiver Training and Support: The Duke Elder Family/Caregiver Training (DEFT) Center.” N C Med J 81, no. 4 (July 2020): 221–27. https://doi.org/10.18043/ncm.81.4.221.
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  - Keung, Emily Z., Melissa Burgess, Ruth Salazar, Edwin R. Parra, Jaime Rodrigues-Canales, Vanessa Bolejack, Brian A. Van Tine, et al. “Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab.” Clin Cancer Res 26, no. 6 (March 15, 2020): 1258–66. https://doi.org/10.1158/1078-0432.CCR-19-1824.
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  - Haddox, Candace L., and Richard F. Riedel. “Individualizing systemic therapy for advanced soft tissue sarcomas based on tumor histology and biology.” Expert Rev Anticancer Ther 20, no. 1 (January 2020): 5–8. https://doi.org/10.1080/14737140.2020.1708198.
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  - Davis, Lara E., Vanessa Bolejack, Christopher W. Ryan, Kristen N. Ganjoo, Elizabeth T. Loggers, Sant Chawla, Mark Agulnik, et al. “Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.” J Clin Oncol 37, no. 16 (June 1, 2019): 1424–31. https://doi.org/10.1200/JCO.18.02374.
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  - Ray, Emily M., Richard F. Riedel, Thomas W. LeBlanc, Christel N. Rushing, and Anthony N. Galanos. “Assessing the Impact of a Novel Integrated Palliative Care and Medical Oncology Inpatient Service on Health Care Utilization before Hospice Enrollment.” J Palliat Med 22, no. 4 (April 2019): 420–23. https://doi.org/10.1089/jpm.2018.0235.
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  - Schwartz, Abby J., Richard F. Riedel, Thomas W. LeBlanc, Devi Desai, Carol Jenkins, Ellen Mahoney, Janice Humphreys, and Cristina C. Hendrix. “The experiences of older caregivers of cancer patients following hospital discharge.” Support Care Cancer 27, no. 2 (February 2019): 609–16. https://doi.org/10.1007/s00520-018-4355-2.
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  - Batich, Kristen A., Richard F. Riedel, John P. Kirkpatrick, Betty C. Tong, William C. Eward, Char Loo Tan, Patricia D. Pittman, Roger E. McLendon, and Katherine B. Peters. “Recurrent Extradural Myxopapillary Ependymoma With Oligometastatic Spread.” Front Oncol 9 (2019): 1322. https://doi.org/10.3389/fonc.2019.01322.
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  - Riedel, Richard F. “Anti-angiogenic therapy for malignant solitary fibrous tumour: validation through collaboration.” Lancet Oncol 20, no. 1 (January 2019): 14–15. https://doi.org/10.1016/S1470-2045(18)30745-9.
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  - Gounder, Mrinal M., Michelle R. Mahoney, Brian A. Van Tine, Vinod Ravi, Steven Attia, Hari A. Deshpande, Abha A. Gupta, et al. “Sorafenib for Advanced and Refractory Desmoid Tumors.” N Engl J Med 379, no. 25 (December 20, 2018): 2417–28. https://doi.org/10.1056/NEJMoa1805052.
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  - Riedel, Richard F., Robin L. Jones, Antoine Italiano, Chet Bohac, Juliette C. Thompson, Kerstin Mueller, Zaeem Khan, Seth M. Pollack, and Brian A. Van Tine. “Systemic Anti-Cancer Therapy in Synovial Sarcoma: A Systematic Review.” Cancers (Basel) 10, no. 11 (November 1, 2018). https://doi.org/10.3390/cancers10110417.
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  - Wisdom, Amy J., Yvonne M. Mowery, Richard F. Riedel, and David G. Kirsch. “Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.” Cancer 124, no. 19 (October 1, 2018): 3819–29. https://doi.org/10.1002/cncr.31517.
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  - Vlahovic, Gordana, Kellen L. Meadows, Ace J. Hatch, Jingquan Jia, Andrew B. Nixon, Hope E. Uronis, Michael A. Morse, et al. “A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer.” Oncologist 23, no. 7 (July 2018): 782–90. https://doi.org/10.1634/theoncologist.2016-0377.
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  - Mehren, Margaret von, R Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Kristen N. Ganjoo, Suzanne George, et al. “Soft Tissue Sarcoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 16, no. 5 (May 2018): 536–63. https://doi.org/10.6004/jnccn.2018.0025.
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  - Choe, Jennifer, and Richard Riedel. “Making progress in a rare disease: emerging therapeutics in soft tissue sarcomas.” F1000res 7 (2018). https://doi.org/10.12688/f1000research.15868.1.
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  - Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca, GERI-BD Study, and GERI-BD Study Cancer Genome Atlas Research Network. “Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.” Cell 171, no. 4 (November 2, 2017): 950-965.e28. https://doi.org/10.1016/j.cell.2017.10.014.
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  - Tawbi, Hussein A., Melissa Burgess, Vanessa Bolejack, Brian A. Van Tine, Scott M. Schuetze, James Hu, Sandra D’Angelo, et al. “Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.” Lancet Oncol 18, no. 11 (November 2017): 1493–1501. https://doi.org/10.1016/S1470-2045(17)30624-1.
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  - Riedel, Richard F., Kim Slusser, Steve Power, Christopher A. Jones, Thomas W. LeBlanc, Arif H. Kamal, Devi Desai, et al. “Improvements in Patient and Health System Outcomes Using an Integrated Oncology and Palliative Medicine Approach on a Solid Tumor Inpatient Service.” J Oncol Pract 13, no. 9 (September 2017): e738–48. https://doi.org/10.1200/JOP.2017.022749.
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  - Tap, William D., Zsuzsanna Papai, Brian A. Van Tine, Steven Attia, Kristen N. Ganjoo, Robin L. Jones, Scott Schuetze, et al. “Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial.” Lancet Oncol 18, no. 8 (August 2017): 1089–1103. https://doi.org/10.1016/S1470-2045(17)30381-9.
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  - Riedel, Richard F., Kellen L. Meadows, Paula H. Lee, Michael A. Morse, Hope E. Uronis, Gerard C. Blobe, Daniel J. George, et al. “Phase I study of pazopanib plus TH-302 in advanced solid tumors.” Cancer Chemother Pharmacol 79, no. 3 (March 2017): 611–19. https://doi.org/10.1007/s00280-017-3256-2.
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  - Tap, W., Z. Papai, B. van Tine, S. Attia, K. Ganjoo, R. L. Jones, S. Schuetze, et al. “Randomized phase 3, multicenter, open-label study comparing evofosfamide (Evo) in combination with doxorubicin (D) vs. D alone in patients (pts) with advanced soft tissue sarcoma (STS): Study TH-CR-406/SARC021.” Annals of Oncology 27 (October 1, 2016): vi483. https://doi.org/10.1093/annonc/mdw388.01.
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  - Wagner, Andrew J., Mark Agulnik, Michael C. Heinrich, Daruka Mahadevan, Richard F. Riedel, Margaret von Mehren, Jonathan Trent, et al. “Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour.” Eur J Cancer 61 (July 2016): 94–101. https://doi.org/10.1016/j.ejca.2016.03.076.
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  - Mehren, Margaret von, R Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ernest U. Conrad, Kristen N. Ganjoo, et al. “Soft Tissue Sarcoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 14, no. 6 (June 2016): 758–86. https://doi.org/10.6004/jnccn.2016.0078.
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  - Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.
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  - Hendrix, Cristina C., Donald E. Bailey, Karen E. Steinhauser, Maren K. Olsen, Karen M. Stechuchak, Sarah G. Lowman, Abby J. Schwartz, et al. “Effects of enhanced caregiver training program on cancer caregiver's self-efficacy, preparedness, and psychological well-being.” Support Care Cancer 24, no. 1 (January 2016): 327–36. https://doi.org/10.1007/s00520-015-2797-3.
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  - Gwin, W., and R. F. Riedel. “Chemotherapy in soft-tissue sarcoma: where do we go from here?” Oncology (Williston Park, N.Y.) 29, no. 1 (January 1, 2015).
  - Gwin, W., and R. F. Riedel. “Chemotherapy in soft-tissue sarcoma: where do we go from here?” Oncology (Williston Park, N.Y.) 29, no. 1 (January 1, 2015).
  - Gwin, William, and Richard F. Riedel. “Chemotherapy in soft-tissue sarcoma: where do we go from here?” Oncology (Williston Park) 29, no. 1 (January 2015): 50–53.
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  - Jiang, Xiaoyin, H Bryan Anderson, Cynthia D. Guy, Paul J. Mosca, Richard F. Riedel, and Diana M. Cardona. “Rhabdomyosarcomatous Transformation of a Gastrointestinal Stromal Tumor following Treatment with Imatinib.” Case Rep Oncol Med 2015 (2015): 317493. https://doi.org/10.1155/2015/317493.
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  - Slusser, K., S. Power, C. A. Jones, T. W. LeBlanc, A. Kamal, D. Desai, D. Allen, and A. N. Galanos. “Early palliative care on an inpatient oncology unit: Impact of a novel co-rounding partnership on patient and health system outcomes.” J Clin Oncol 32, no. 31_suppl (November 2014): 3. https://doi.org/10.1200/jco.2014.32.31_suppl.3.
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  - Mehren, Margaret von, R Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad, et al. “Gastrointestinal stromal tumors, version 2.2014.” J Natl Compr Canc Netw 12, no. 6 (June 2014): 853–62. https://doi.org/10.6004/jnccn.2014.0080.
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  - Mehren, Margaret von, R Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad, et al. “Soft tissue sarcoma, version 2.2014.” J Natl Compr Canc Netw 12, no. 4 (April 2014): 473–83. https://doi.org/10.6004/jnccn.2014.0053.
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  - Meadows, Kellen L., Paula H. Lee, Richard F. Riedel, Michael A. Morse, Hope E. Uronis, Gerard C. Blobe, Daniel J. George, Jeffrey Crawford, and Herbert I. Hurwitz. “Abstract C61: Phase I Study of pazopanib in combination with the investigational hypoxia-targeted drug TH-302.” Clinical Trials, November 2013. https://doi.org/10.1158/1535-7163.targ-13-c61.
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  - Demetri, George D., Sant P. Chawla, Isabelle Ray-Coquard, Axel Le Cesne, Arthur P. Staddon, Mohammed M. Milhem, Nicolas Penel, et al. “Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy.” J Clin Oncol 31, no. 19 (July 1, 2013): 2485–92. https://doi.org/10.1200/JCO.2012.45.5766.
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  - Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.
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  - Cuneo, Kyle C., Richard F. Riedel, Leslie G. Dodd, David H. Harpole, and David G. Kirsch. “Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy.” J Clin Oncol 30, no. 28 (October 1, 2012): e291–93. https://doi.org/10.1200/JCO.2012.42.8797.
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  - Mehren, Margaret von, Robert S. Benjamin, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad, Thomas F. DeLaney, Kristen N. Ganjoo, et al. “Soft tissue sarcoma, version 2.2012: featured updates to the NCCN guidelines.” J Natl Compr Canc Netw 10, no. 8 (August 2012): 951–60. https://doi.org/10.6004/jnccn.2012.0099.
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  - Vlahovic, Gordana, Kellen L. Meadows, Hope E. Uronis, Michael A. Morse, Gerard C. Blobe, Richard F. Riedel, S Yousuf Zafar, et al. “A phase I study of bevacizumab, everolimus and panitumumab in advanced solid tumors.” Cancer Chemother Pharmacol 70, no. 1 (July 2012): 95–102. https://doi.org/10.1007/s00280-012-1889-8.
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  - Riedel, Richard F., Alessandro Porrello, Emily Pontzer, Emily J. Chenette, David S. Hsu, Bala Balakumaran, Anil Potti, Joseph Nevins, and Phillip C. Febbo. “Retraction in part: A genomic approach to identify molecular pathways associated with chemotherapy resistance.” Mol Cancer Ther 11, no. 5 (May 2012): 1214–15. https://doi.org/10.1158/1535-7163.MCT-12-0210.
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  - Riedel, Richard F. “Systemic therapy for advanced soft tissue sarcomas: highlighting novel therapies and treatment approaches.” Cancer 118, no. 6 (March 15, 2012): 1474–85. https://doi.org/10.1002/cncr.26415.
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  - Kim, Suzy, Rebecca D. Dodd, Jeffrey K. Mito, Yan Ma, Yongbaek Kim, Richard F. Riedel, and David G. Kirsch. “Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma.” Sarcoma 2012 (2012): 680708. https://doi.org/10.1155/2012/680708.
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  - Riedel, Richard F., Robert G. Maki, and Andrew J. Wagner. “Targeted therapy in sarcoma: should we be lumpers or splitters?” Am Soc Clin Oncol Educ Book, 2012, 652–57. https://doi.org/10.14694/EdBook_AM.2012.32.204.
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  - Riedel, Richard F. “Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type?” Semin Oncol 38 Suppl 3 (October 2011): S30–42. https://doi.org/10.1053/j.seminoncol.2011.09.003.
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  - Smith, Jason L., and Richard F. Riedel. “Emerging therapeutic targets for soft tissue sarcoma.” Curr Oncol Rep 13, no. 4 (August 2011): 350–58. https://doi.org/10.1007/s11912-011-0175-y.
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  - Chawla, S. P., J. Blay, I. L. Ray-Coquard, A. Le Cesne, A. P. Staddon, M. M. Milhem, N. Penel, et al. “Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT).” Journal of Clinical Oncology 29, no. 15_suppl (May 20, 2011): 10005–10005. https://doi.org/10.1200/jco.2011.29.15_suppl.10005.
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  - Chawla, S. P., J. Blay, I. L. Ray-Coquard, A. Le Cesne, A. P. Staddon, M. M. Milhem, N. Penel, et al. “Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT).” J Clin Oncol 29, no. 15_suppl (May 20, 2011): 10005.
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  - Hsu, D. S., C. R. Acharya, B. S. Balakumaran, R. F. Riedel, M. K. Kim, M. Stevenson, S. Tuchman, et al. “Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 13 (5312-5317) DOI: 10.1073/pnas.0900827106).” Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (2011): 14705-. https://doi.org/10.1073/pnas.1111196108.
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  - Palta, Manisha, Richard F. Riedel, James J. Vredenburgh, Thomas J. Cummings, Scott Green, Zheng Chang, and John P. Kirkpatrick. “Primary meningeal rhabdomyosarcoma.” Sarcoma 2011 (2011): 312802. https://doi.org/10.1155/2011/312802.
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  - Demetri, George D., Scott Antonia, Robert S. Benjamin, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad, Thomas F. DeLaney, et al. “Soft tissue sarcoma.” J Natl Compr Canc Netw 8, no. 6 (June 2010): 630–74. https://doi.org/10.6004/jnccn.2010.0049.
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  - Demetri, George D., Margaret von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W. T. Pisters, et al. “NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.” J Natl Compr Canc Netw 8 Suppl 2 (April 2010): S1-41. https://doi.org/10.6004/jnccn.2010.0116.
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  - Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” Plos One 4, no. 11 (November 30, 2009): e8075. https://doi.org/10.1371/journal.pone.0008075.
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  - Howard, L. A., K. E. Bullock, J. C. Bendell, H. E. Uronis, G. Vlahovic, G. C. Blobe, R. F. Riedel, A. B. Nixon, J. P. Gockerman, and H. I. Hurwitz. “Bevacizumab (B) plus everolimus (E) and panitumumab (P) in refractory advanced solid tumors.” J Clin Oncol 27, no. 15_suppl (May 20, 2009): 3551.
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  - Riedel, Richard F., Nicole Larrier, Leslie Dodd, David Kirsch, Salutario Martinez, and Brian E. Brigman. “The clinical management of chondrosarcoma.” Curr Treat Options Oncol 10, no. 1–2 (April 2009): 94–106. https://doi.org/10.1007/s11864-009-0088-2.
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  - Hsu, David S., Chaitanya R. Acharya, Bala S. Balakumaran, Richard F. Riedel, Mickey K. Kim, Marvaretta Stevenson, Sascha Tuchman, et al. “Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.” Proc Natl Acad Sci U S A 106, no. 13 (March 31, 2009): 5312–17. https://doi.org/10.1073/pnas.0900827106.
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  - Riedel, Richard F., Alessandro Porrello, Emily Pontzer, Emily J. Chenette, David S. Hsu, Bala Balakumaran, Anil Potti, Joseph Nevins, and Phillip G. Febbo. “A genomic approach to identify molecular pathways associated with chemotherapy resistance.” Mol Cancer Ther 7, no. 10 (October 2008): 3141–49. https://doi.org/10.1158/1535-7163.MCT-08-0642.
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  - Hsu, S. D., C. R. Acharya, R. F. Riedel, R. C. Redman, K. S. Garman, H. K. Dressman, G. Ginsburg, S. Powers, D. Mu, and A. Potti. “Use of co-activation of lung cancer specific developmental pathway genes, TTF-1, NKX2-8, and PAX9, to predict prognosis and guide therapeutic strategies.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 7511.
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  - Hsu, S. D., C. R. Acharya, R. F. Riedel, R. C. Redman, K. S. Garman, H. K. Dressman, G. Ginsburg, S. Powers, D. Mu, and A. Potti. “Use of co-activation of lung cancer specific developmental pathway genes, TTF-1, NKX2–8, and PAX9, to predict prognosis and guide therapeutic strategies.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 7511–7511. https://doi.org/10.1200/jco.2008.26.15_suppl.7511.
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  - Riedel, R. F., D. Friedman, and P. G. Febbo. “A genomic approach to identify therapeutic targets in histologic subtypes of soft tissue sarcoma.” J Clin Oncol 26, no. 15_suppl (May 20, 2008): 10577.
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  - Riedel, R. F., D. Friedman, and P. G. Febbo. “A genomic approach to identify therapeutic targets in histologic subtypes of soft tissue sarcoma.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 10577–10577. https://doi.org/10.1200/jco.2008.26.15_suppl.10577.
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  - Hsu, David S., Bala S. Balakumaran, Chaitanya R. Acharya, Vanja Vlahovic, Kelli S. Walters, Katherine Garman, Carey Anders, et al. “Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer.” J Clin Oncol 25, no. 28 (October 1, 2007): 4350–57. https://doi.org/10.1200/JCO.2007.11.0593.
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  - Riedel, Richard F., Carolyn Andrews, Jennifer Garst, Frank Dunphy, James E. Herndon, Susan Blackwell, Sally Barbour, and Jeffrey Crawford. “A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer.” J Thorac Oncol 2, no. 6 (June 2007): 520–25. https://doi.org/10.1097/JTO.0b013e318060107c.
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  - Riedel, Richard F., Jeffrey Crawford, Frank Dunphy, James E. Herndon, Jennifer Garst, and Michael J. Kelley. “Phase II study of carboplatin, irinotecan, and thalidomide combination in patients with extensive stage small-cell lung cancer.” Lung Cancer 54, no. 3 (December 2006): 431–32. https://doi.org/10.1016/j.lungcan.2006.08.008.
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  - Riedel, Richard F., Xiaofei Wang, Meg McCormack, Eric Toloza, Gustavo S. Montana, Gilbert Schreiber, and Michael J. Kelley. “Impact of a multidisciplinary thoracic oncology clinic on the timeliness of care.” J Thorac Oncol 1, no. 7 (September 2006): 692–96.
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  - Riedel, Richard F., and William R. Burfeind. “Thymoma: benign appearance, malignant potential.” Oncologist 11, no. 8 (September 2006): 887–94. https://doi.org/10.1634/theoncologist.11-8-887.
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  - Riedel, Richard F., and Phillip G. Febbo. “Epidermal growth factor receptor mutations predict sensitivity to gefitinib in patients with non-small-cell lung cancer.” Future Oncol 1, no. 4 (August 2005): 461–66. https://doi.org/10.2217/14796694.1.4.461.
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  - Riedel, Richard F., and Jeffrey Crawford. “Small-cell lung cancer: a review of clinical trials.” Semin Thorac Cardiovasc Surg 15, no. 4 (October 2003): 448–56. https://doi.org/10.1053/s1043-0679(03)00098-4.
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  - Luetteke, N. C., T. H. Qiu, S. E. Fenton, K. L. Troyer, R. F. Riedel, A. Chang, and D. C. Lee. “Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.” Development 126, no. 12 (June 1999): 2739–50.
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  - Salomoni, P., M. A. Wasik, R. F. Riedel, K. Reiss, J. K. Choi, T. Skorski, and B. Calabretta. “Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.” J Exp Med 187, no. 12 (June 15, 1998): 1995–2007. https://doi.org/10.1084/jem.187.12.1995.
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  - Berkowitz, E. A., K. B. Seroogy, J. A. Schroeder, W. E. Russell, E. P. Evans, R. F. Riedel, H. K. Phillips, C. A. Harrison, D. C. Lee, and N. C. Luetteke. “Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.” Cell Growth Differ 7, no. 9 (September 1996): 1271–82.
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- Book Sections
  - Larrier, N., W. C. Eward, and R. F. Riedel. “Bone Sarcomas.” In Cancer Consult: Expertise for Clinical Practice, 687–95, 2014. https://doi.org/10.1002/9781118589199.ch105.
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- Other Articles
  - Potti, Anil, Holly K. Dressman, Andrea Bild, Richard F. Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, et al. “Retraction: Genomic signatures to guide the use of chemotherapeutics.” Nat Med, January 2011. https://doi.org/10.1038/nm0111-135.
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  - “Retraction. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. J Clin Oncol 25:4350–7, 2007.” J Clin Oncol, December 10, 2010. https://doi.org/10.1200/JCO.2010.33.7311.
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  - Potti, A., H. K. Dressman, A. Bild, R. F. Riedel, G. Chan, R. Sayer, J. Cragun, et al. “Corrigendum: Genomic signatures to guide the use of chemotherapeutics (Nature Medicine (2006) 12, (1294-1300)).” Nature Medicine, August 1, 2008. https://doi.org/10.1038/nm0808-889.
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  - Potti, A., H. K. Dressman, A. Bild, R. F. Riedel, G. Chan, R. Sayer, J. Cragun, et al. “Erratum: Genomic signatures to guide the use of chemotherapeutics (Nature (2006) 12, (1294-1300)).” Nature Medicine, November 1, 2007. https://doi.org/10.1038/nm1107-1388.
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  - Potti, Anil, Holly K. Dressman, Andrea Bild, Richard F. Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, et al. “Genomic signatures to guide the use of chemotherapeutics.” Nat Med, November 2006. https://doi.org/10.1038/nm1491.
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- Conference Papers
  - Ludwig, J. A., N. Federman, P. Anderson, M. E. Macy, L. E. Davis, R. F. Riedel, J. A. Muscal, et al. “1620O Phase I study of TK216, a novel anti-ETS agent for Ewing sarcoma.” In Annals of Oncology, 31:S972–S972. Elsevier BV, 2020. https://doi.org/10.1016/j.annonc.2020.08.1846.
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  - Ingham, Matthew, Michelle R. Mahoney, Fabrizio Remotti, Ardaman Shergill, Mark Andrew Dickson, Richard F. Riedel, Steven Attia, et al. “A randomized phase II study of MLN0128 (M) versus pazopanib (P) in patients (pt) with advanced sarcoma (Alliance A091304).” In Journal of Clinical Oncology, Vol. 38, 2020.
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  - Kopp, Lisa M., Damon R. Reed, Safia K. Ahmed, Wendy Allen-Rhoades, Viswatej Avutu, Yen-Lin Chen, Lara E. Davis, et al. “Enrollment barriers of adolescents and young adults (AYA) on the non-chemotherapy arm of ARST1321.” In Journal of Clinical Oncology, Vol. 38, 2020.
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  - Wagner, Andrew J., Vinod Ravi, Richard F. Riedel, Kristen N. Ganjoo, Brian Andrew Van Tine, Rashmi Chugh, Lee D. Cranmer, et al. “Long-term follow-up for duration of response (DoR) after weekly nab-sirolimus in patients with advanced malignant perivascular epithelioid cell tumors (PEComa): Results from a registrational open-label phase II trial, AMPECT.” In Journal of Clinical Oncology, Vol. 38, 2020.
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  - Burgess, Melissa Amber, Vanessa Bolejack, Scott Schuetze, Brian Andrew Van Tine, Steven Attia, Richard F. Riedel, James S. Hu, et al. “Clinical activity of pembrolizumab (P) in undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated/pleomorphic liposarcoma (LPS): Final results of SARC028 expansion cohorts.” In Journal of Clinical Oncology, Vol. 37. AMER SOC CLINICAL ONCOLOGY, 2019.
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  - Chawla, Sant P., Brian Andrew Van Tine, Seth Pollack, Kristen N. Ganjoo, Anthony D. Elias, Richard F. Riedel, Steven Attia, et al. “A phase II randomized study of CMB305 and atezolizumab versus atezolizumab in NY-ESO-1(+) soft tissue sarcoma: Analysis of immunogenicity, tumor control, and patient survival.” In Journal of Clinical Oncology, Vol. 37. AMER SOC CLINICAL ONCOLOGY, 2019.
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  - Wagner, Andrew J., Vinod Ravi, Kristen N. Ganjoo, Brian Andrew Van Tine, Richard F. Riedel, Rashmi Chugh, Lee D. Cranmer, et al. “ABI-009 (nab-sirolimus) in advanced malignant perivascular epithelioid cell tumors (PEComa): Preliminary efficacy, safety, and mutational status from AMPECT, an open label phase II registration trial.” In Journal of Clinical Oncology, Vol. 37. AMER SOC CLINICAL ONCOLOGY, 2019.
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  - Gounder, Mrinal M., Neeta Somaiah, Steven Attia, Sant P. Chawla, Victor Manuel Villalobos, Bartosz Chmielowski, Melissa Amber Burgess, et al. “Phase 2 results of selinexor in advanced de-differentiated (DDLS) liposarcoma (SEAL) study: A phase 2/3, randomized, double blind, placebo controlled cross-over study.” In Journal of Clinical Oncology, 36:11512–11512. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.11512.
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  - Mowery, Yvonne Marie, Karla V. Ballman, Richard F. Riedel, Brian E. Brigman, Steven Attia, Christian Frederick Meyer, Scott Schuetze, et al. “SU2C-SARC032: A phase II randomized controlled trial of neoadjuvant pembrolizumab with radiotherapy and adjuvant pembrolizumab for high-risk soft tissue sarcoma.” In Journal of Clinical Oncology, 36:TPS11588–TPS11588. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.tps11588.
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  - Ravi, Vinod, Andrew Scott Brohl, Sant P. Chawla, Steven Attia, Richard F. Riedel, David A. Liebner, Katherine Anne Thornton, et al. “Detection of endoglin-expressing CTCs in patients enrolled in an adaptive enrichment phase 3 trial of TRC105 and pazopanib versus pazopanib alone in patients with advanced angiosarcoma (TAPPAS).” In Journal of Clinical Oncology, 36:e23570–e23570. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e23570.
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  - Ravi, Vinod, Andrew Scott Brohl, Sant P. Chawla, Steven Attia, Richard F. Riedel, David A. Liebner, Katherine Anne Thornton, et al. “TAPPAS: An adaptive enrichment phase 3 trial of TRC105 and pazopanib versus pazopanib alone in patients with advanced angiosarcoma.” In Journal of Clinical Oncology, 36:TPS11590–TPS11590. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.tps11590.
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  - Riedel, Richard F., Karla V. Ballman, Yao Lu, Steven Attia, Elizabeth Trice Loggers, Kristen N. Ganjoo, Michael B. Livingston, et al. “A randomized, double-blind, placebo-controlled, phase II study of regorafenib vs placebo in advanced/metastatic, treatment-refractory liposarcoma: results from the SARC024 study.” In Journal of Clinical Oncology, 36:11505–11505. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.11505.
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  - Wagner, Andrew J., Richard F. Riedel, Brian Andrew Van Tine, Rashmi Chugh, Kristen N. Ganjoo, Lee D. Cranmer, Seth Pollack, et al. “Mutational analysis and safety/efficacy in a phase 2 multi-center investigation of ABI-009 (nab-rapamycin) in patients with advanced malignant perivascular epithelioid cell tumors (PEComa).” In Journal of Clinical Oncology, 36:TPS11589–TPS11589. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.tps11589.
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  - Chawla, S., B. A. Van Tine, S. Pollack, K. Ganjoo, A. Elias, R. F. Riedel, S. Attia, et al. “A phase 2 study of CMB305 and atezolizumab in NY-ESO-1+soft tissue sarcoma: Interim analysis of immunogenicity, tumor control and survival.” In Annals of Oncology, Vol. 28. OXFORD UNIV PRESS, 2017.
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  - Attia, Steven, Vanessa Bolejack, Kristen N. Ganjoo, Suzanne George, Mark Agulnik, Daniel A. Rushing, Elizabeth Trice Loggers, et al. “A phase II trial of regorafenib (REGO) in patients (pts) with advanced Ewing sarcoma and related tumors (EWS) of soft tissue and bone: SARC024 trial results.” In Journal of Clinical Oncology, 35:11005–11005. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.11005.
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  - Burgess, Melissa Amber, Vanessa Bolejack, Brian Andrew Van Tine, Scott Schuetze, James Hu, Sandra P. D’Angelo, Steven Attia, et al. “Multicenter phase II study of pembrolizumab (P) in advanced soft tissue (STS) and bone sarcomas (BS): Final results of SARC028 and biomarker analyses.” In Journal of Clinical Oncology, 35:11008–11008. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.11008.
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  - Burgess, Melissa Amber, Jason Roszik, Brian Andrew Van Tine, James Hu, Scott Schuetze, Sandra P. D’Angelo, Steven Attia, et al. “Correlation of circulating PD-L2 levels with outcomes of therapy with the anti-PD-1 antibody pembrolizumab (P) in patients (pts) with advanced soft tissue sarcomas (STS): Biomarker analysis of SARC028.” In Journal of Clinical Oncology, 35:60–60. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.7_suppl.60.
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  - Rav, Emily Miller, Richard F. Riedel, Christel N. Rushing, and Anthony N. Galanos. “Healthcare utilization among cancer patients prior to hospice.” In Journal of Clinical Oncology, Vol. 34. AMER SOC CLINICAL ONCOLOGY, 2016.
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  - Attia, Steven, Kamalesh Kumar Sankhala, Richard F. Riedel, Steven Ian Robinson, Robert Martin Conry, Patrick McKay Boland, Minal A. Barve, et al. “A phase 1B/ phase 2A study of TRC105 (Endoglin Antibody) in combination with pazopanib (P) in patients (pts) with advanced soft tissue sarcoma (STS).” In Journal of Clinical Oncology, 34:11016–11016. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.11016.
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  - Gounder, Mrinal M., Andrew J. Wagner, Neeta Somaiah, Richard F. Riedel, Gary K. Schwartz, Steven Attia, Albiruni R. A. Razak, et al. “The Selinexor in Advanced Liposarcoma (SEAL) study: A phase 2/3, multicenter, randomized, double blind study of selinexor versus placebo in patients with advanced, unresectable, dedifferentiated liposarcoma (DDLS).” In Journal of Clinical Oncology, 34:TPS11072–TPS11072. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.tps11072.
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  - Patel, Krish, Lowell T. Nicholson, and Richard F. Riedel. “Defining the characteristics of medical oncology patients requiring inpatient hospital admission.” In Journal of Clinical Oncology, 34:e18023–e18023. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.e18023.
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  - Tawbi, Hussein Abdul-Hassan, Melissa Amber Burgess, John Crowley, Brian Andrew Van Tine, James Hu, Scott Schuetze, Sandra P. D’Angelo, et al. “Safety and efficacy of PD-1 blockade using pembrolizumab in patients with advanced soft tissue (STS) and bone sarcomas (BS): Results of SARC028—A multicenter phase II study.” In Journal of Clinical Oncology, 34:11006–11006. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.11006.
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  - Whitley, Melodi J., Diana M. Cardona, Dan G. Blazer, Shelley Hwang, Rachel A. Greenup, Paul J. Mosca, Joan Cahill, et al. “Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents.” In Molecular and Cellular Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-sy36-03.
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  - Attia, Steven, Richard F. Riedel, Steven Ian Robinson, Robert Martin Conry, Kamalesh Kumar Sankhala, Ben K. Seon, Delia Alvarez, Bonne J. Adams, Charles P. Theuer, and Robert G. Maki. “A phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) in combination with pazopanib in patients with advanced soft tissue sarcoma (STS).” In Journal of Clinical Oncology, Vol. 33. AMER SOC CLINICAL ONCOLOGY, 2015.
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  - Burgess, Melissa Amber, John Crowley, Denise K. Reinke, Richard F. Riedel, Suzanne George, Sujana Movva, Brian Andrew Van Tine, et al. “SARC 028: A phase II study of the anti-PD1 antibody pembrolizumab (P) in patients (Pts) with advanced sarcomas.” In Journal of Clinical Oncology, Vol. 33. AMER SOC CLINICAL ONCOLOGY, 2015.
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  - Whitley, M. J., D. M. Cardona, D. G. Blazer, E. Hwang, R. A. Greenup, P. J. Mosca, J. Cahill, et al. “A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery.” In Annals of Surgical Oncology, 22:S11–12. SPRINGER, 2015.
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  - Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.
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  - LeBlanc, Thomas William, James A. Tulsky, Amy Pickar Abernethy, Christopher A. Jones, Anthony N. Galanos, and Richard F. Riedel. “Oncologists' perceptions of rounding alongside palliative care physicians: Results of a post-intervention survey study.” In Journal of Clinical Oncology, Vol. 31. AMER SOC CLINICAL ONCOLOGY, 2013.
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  - Blay, Jean-Yves, Sant P. Chawla, Isabelle Ray-Coquard, Axel Le Cesne, Arthur P. Staddon, Mohammed M. Milhem, Nicolas Penel, et al. “Phase III, placebo-controlled trial (SUCCEED) evaluating ridaforolimus as maintenance therapy in advanced sarcoma patients following clinical benefit from prior standard cytotoxic chemotherapy: Long-term (>= 24 months) overall survival results.” In Journal of Clinical Oncology, Vol. 30. AMER SOC CLINICAL ONCOLOGY, 2012.
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  - Howard, L. A., K. E. Bullock, J. C. Bendell, H. E. Uronis, G. Vlahovic, G. C. Blobe, R. F. Riedel, A. B. Nixon, J. P. Gockerman, and H. I. Hurwitz. “Bevacizumab (B) plus everolimus (E) and panitumumab (P) in refractory advanced solid tumors.” In Journal of Clinical Oncology, Vol. 27. AMER SOC CLINICAL ONCOLOGY, 2009.
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  - Riedel, R. F., A. Porrello, E. Chenette, A. Potti, J. R. Nevins, and P. G. Febbo. “A genomic approach to identify mechanisms associated with chemotherapy resistance.” In Journal of Clinical Oncology, Vol. 25. AMER SOC CLINICAL ONCOLOGY, 2007.
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  - Riedel, R. F., P. G. Febbo, and J. Crawford. “IDENTIFYING MECHANISMS OF RESISTANCE IN PATIENTS WITH LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER RECEIVING DOSE-DENSE NEOADJUVANT/INDUCTION CHEMOTHERAPY.” In Journal of Investigative Medicine, 55:S282–S282. BMJ, 2007. https://doi.org/10.1097/00042871-200701010-00730.
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