Mangan, Riley | Scholars@Duke

Riley Mangan
Student

Doctor of Philosophy (Ph.D.) Student. Molecular Genetics and Microbiology.
Program in Cell and Molecular Biology (CMB), 2018-Present

I am a graduate student in the lab of Craig B. Lowe, where I study the genetic control of human brain evolution. My work combines tools from evolutionary developmental biology, cell and molecular neuroscience, and comparative genomics to investigate how changes in gene regulation have led to human-unique disease susceptibility and the emergence of human-specific neurological traits of language, consciousness, and cognition.

Prior to joining Duke CMB, I worked for two years as a research technician in the laboratory of Dr. Sallie Permar at the Duke Human Vaccine Institute investigating a variety of topics related to mother to child transmission of HIV-1. In particular, I investigated the mechanism of interaction between the HIV-1 envelope and the extracellular matrix protein Tenascin-C, which has been previously identified as an innate, broadly HIV-neutralizing factor present in mucosal fluids.

Bachelor of Science, 2016
Davidson College (Davidson, NC, USA)
Biology, Magna Cum Laude

Current Appointments & Affiliations

Student, Basic Science Departments, School of Medicine

Contact Information

riley.mangan@duke.edu

Expertise
Subject Headings
Research
Selected Grants
- From a Long List to Causal Variants: High-Throughput Gene Regulatory Assays in Developing Tissues awarded by National Institutes of Health 2020 - 2025
- The Genetic Basis of Macroevolutionary Trends awarded by University of Minnesota 2021 - 2024
- Transmission-blocking potential of novel HIV Env-specific mucosal antibodies awarded by National Institutes of Health 2013 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mangan, Riley J., Fernando C. Alsina, Federica Mosti, Jesús Emiliano Sotelo-Fonseca, Daniel A. Snellings, Eric H. Au, Juliana Carvalho, et al. “Adaptive sequence divergence forged new neurodevelopmental enhancers in humans.” Cell 185, no. 24 (November 23, 2022): 4587-4603.e23. https://doi.org/10.1016/j.cell.2022.10.016.
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  - Itell, Hannah L., Andrew Berenz, Riley J. Mangan, Sallie R. Permar, and David A. Kaufman. “Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin.” Biochem Cell Biol 99, no. 1 (February 2021): 25–34. https://doi.org/10.1139/bcb-2020-0238.
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  - Berendam, Stella J., Papa K. Morgan-Asiedu, Riley J. Mangan, Shuk Hang Li, Holly Heimsath, Kan Luo, Alan D. Curtis, et al. “Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.” Plos One 16, no. 12 (2021): e0256885. https://doi.org/10.1371/journal.pone.0256885.
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  - Martinez, David R., Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, et al. “Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.” Mbio 11, no. 2 (March 10, 2020). https://doi.org/10.1128/mBio.00176-20.
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  - Goswami, Ria, Ashley N. Nelson, Joshua J. Tu, Maria Dennis, Liqi Feng, Amit Kumar, Jesse Mangold, et al. “Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model.” Mbio 10, no. 5 (September 5, 2019). https://doi.org/10.1128/mBio.01971-19.
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  - Nelson, Ashley N., Ria Goswami, Maria Dennis, Joshua Tu, Riley J. Mangan, Pooja T. Saha, Derek W. Cain, et al. “Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.” J Virol 93, no. 15 (August 1, 2019). https://doi.org/10.1128/JVI.00168-19.
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  - Mangan, Riley J., Lisa Stamper, Tomoo Ohashi, Joshua A. Eudailey, Eden P. Go, Frederick H. Jaeger, Hannah L. Itell, et al. “Determinants of Tenascin-C and HIV-1 envelope binding and neutralization.” Mucosal Immunol 12, no. 4 (July 2019): 1004–12. https://doi.org/10.1038/s41385-019-0164-2.
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  - Kim, Jonathan D., Andy Y. Chun, Riley J. Mangan, George Brown, Bruno Mourao Pacheco, Hannah Doyle, Austin Leonard, and Rachid El Bejjani. “A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity.” Journal of Cell Science 132, no. 5 (February 2019): jcs223586. https://doi.org/10.1242/jcs.223586.
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  - Himes, Jonathon E., Ria Goswami, Riley J. Mangan, Amit Kumar, Thomas L. Jeffries, Joshua A. Eudailey, Holly Heimsath, et al. “Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.” Mucosal Immunol 11, no. 6 (November 2018): 1716–26. https://doi.org/10.1038/s41385-018-0067-7.
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  - Nguyen, Quang N., David R. Martinez, Jonathon E. Himes, R. Whitney Edwards, Qifeng Han, Amit Kumar, Riley Mangan, et al. “Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys.” Retrovirology 15, no. 1 (March 9, 2018): 24. https://doi.org/10.1186/s12977-018-0406-5.
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  - Principe, D. R., A. M. Diaz, C. Torres, R. J. Mangan, B. DeCant, R. McKinney, M. -. S. Tsao, et al. “TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.” Oncogene 36, no. 30 (July 2017): 4336–48. https://doi.org/10.1038/onc.2016.500.
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  - Principe, Daniel R., Brian DeCant, Jonas Staudacher, Dominic Vitello, Riley J. Mangan, Elizabeth A. Wayne, Emman Mascariñas, et al. “Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation.” Oncotarget 8, no. 3 (January 17, 2017): 3826–39. https://doi.org/10.18632/oncotarget.9830.
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  - Principe, Daniel R., Brian DeCant, Andrew M. Diaz, Riley J. Mangan, Rosa Hwang, Andrew Lowy, Brandon B. Shetuni, et al. “PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.” Oncotarget 7, no. 19 (May 10, 2016): 28218–34. https://doi.org/10.18632/oncotarget.8587.
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- Book Sections
  - Principe, Daniel, Riley Mangan, and Paul Grippo. “Transforming Growth Factor β.” In Cancer Therapeutic Targets. Springer, 2017.

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Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections