Roarke Horstmeyer

Journal article IEEE Journal of Selected Topics in Quantum Electronics · July 1, 2026 Diffuse correlation spectroscopy (DCS) is an emerging optical technique for non-invasive cerebral blood flow monitoring. Extraction of the DCS blood flow index typically involves calculating the temporal autocorrelation of the measured light intensity and ... Full text Cite

Chromatix: a differentiable, GPU-accelerated wave-optics library.

Journal article Nature methods · July 2026 Many current microscopy methods incorporate computational modeling as an integral part of the imaging process, either to solve inverse problems or optimize the optical system design itself. These methods often depend on differentiable optics simulations, y ... Full text Cite

Very Preterm Infant Retinal Microanatomy at 36 Weeks' Postmenstrual Age and 2-Year Neurodevelopment.

Journal article JAMA Ophthalmol · July 1, 2026 IMPORTANCE: If noninvasive optical coherence tomography (OCT) retinal imaging could predict 2-year neurodevelopment of very preterm (VPT; <32 weeks' gestational age) infants in neonatal intensive care, it might help to guide management. OBJECTIVE: To evalu ... Full text Link to item Cite

CortexCAM: A Camera Array Microscope for Cortex-Wide Cellular Imaging in Freely Locomoting Mice.

Journal article Res Sq · June 2, 2026 Understanding single-cell neuronal activity across multiple brain regions in the context of ethologically relevant behaviors is a major goal in systems neuroscience. Here we introduce the Cortex Camera Array Microscope (CortexCAM), integrating four miniatu ... Full text Link to item Cite

Cell-MICS: Detecting Immune Cells With Label-Free Two-Photon Autofluorescence and Deep Learning.

Journal article Journal of biophotonics · April 2026 Multiphoton imaging has been widely used for deep-tissue imaging. Although its label-free, metabolic contrast is ideal for investigating inflammation, the label-free two-photon induced autofluorescence is often regarded as less specific compared to convent ... Full text Cite

Towards a mobile quantitative phase imaging microscope with smartphone phase-detection sensors.

Journal article Biomedical optics express · April 2026 Quantitative phase imaging (QPI) enables the visualization and quantitative extraction of optical phase information from transparent samples. However, conventional QPI techniques typically rely on multi-frame acquisition or complex interferometric optical ... Full text Cite

Chromatix: a differentiable, GPU-accelerated wave-optics library.

Journal article bioRxiv · March 25, 2026 Modem microscopy methods incorporate computational modeling as an integral part of the imaging process, either to solve inverse problems or optimize the optical system design itself. These methods often depend on differentiable optics simulations, yet no s ... Full text Link to item Cite

Semi-supervised virtual staining using learned-illumination Fourier ptychography for high-speed label-free histopathology

Journal article Jphys Photonics · March 1, 2026 Virtual staining techniques enable the digital transformation of label-free images into clinically standardized stained images. However, the high costs and time involved in generating labeled datasets for training, combined with the absence of accelerated ... Full text Cite

Wide-field reflective imaging with an epi-illumination multi-camera array microscope.

Journal article Optics express · March 2026 We present an epi-illumination multi-camera array microscope (epi-MCAM) designed for wide-field reflective imaging of non-transparent samples. The epi-MCAM contains 24 tightly packed and synchronized epi-illumination microscope units, arranged in a 4 × 6 p ... Full text Cite

High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.

Journal article Communications biology · January 2026 Understanding the behavioral and morphological dynamics of moving model organisms like the zebrafish larvae requires accurate, high-throughput 3D analysis. However, traditional single-view 2D video tracking fails to capture the full scope of natural 3D mov ... Full text Cite

Large-scale compressive microscopy via diffractive multiplexing across a sensor array

Journal article Nature Photonics · January 1, 2026 Microscopes face a trade-off between spatial resolution, field of view and frame rate—improving one of these properties typically requires sacrificing others, owing to the limited spatiotemporal throughput of the sensor. To overcome this, we propose a new ... Full text Cite

A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.

Journal article J Biomech · November 2025 While knee osteoarthritis (OA) is a leading cause of disability in the United States, OA within the patellofemoral joint is understudied compared to the tibiofemoral joint. Mechanical alterations to cartilage may be among the first changes indicative of ea ... Full text Link to item Cite

Curvature-adaptive gigapixel microscopy at submicron resolution and centimeter scale.

Journal article Optics letters · October 2025 Large-area microscopy with submicron resolution is limited by tradeoffs between field of view (FOV), resolution, and imaging speed. Samples are rarely flat across centimeter-scale FOV, which often requires existing solutions to use mechanical scanning to e ... Full text Cite

Pan-cortical cellular imaging in freely behaving mice using a miniaturized micro-camera array microscope (mini-MCAM).

Journal article Science advances · October 2025 Understanding how circuits in the brain simultaneously coordinate their activity to mediate complex ethologically relevant behaviors requires recording neural activities from distributed populations of neurons in freely behaving animals. Current miniaturiz ... Full text Cite

Fourier Lightfield Multiview Stereoscope for Large Field-of-View 3D Imaging in Microsurgical Settings.

Journal article Advanced photonics nexus · June 2025 This work presents the Fourier Lightfield Multi-view Stereoscope (FiLM-Scope), a novel imaging device that combines concepts from Fourier Light Field Microscopy and Multi-view Stereo imaging to capture high-resolution 3D videos over large fields-of-view. T ... Full text Cite

High-speed 4D fluorescence light field tomography of whole freely moving organisms.

Journal article Optica · May 20, 2025 Volumetric fluorescence imaging techniques, such as confocal, multiphoton, light sheet, and light field microscopy, have become indispensable tools across a wide range of cellular, developmental, and neurobiological applications. However, it is difficult t ... Full text Link to item Cite

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy.

Journal article Neurophotonics · April 2025 SignificanceDiffuse correlation spectroscopy (DCS) allows label-free, non-invasive investigation of microvascular dynamics deep within tissue, such as cerebral blood flow (CBF). However, the signal-to-noise ratio (SNR) in DCS limits its effective ... Full text Open Access Cite

Recording dynamic facial micro-expressions with a multi-focus camera array.

Journal article Biomedical optics express · February 2025 We present a multi-camera array for capturing dynamic high-resolution videos of the human face. Compared to traditional single-camera configurations, our array of 54 individual cameras allows stitching of high-resolution composite video frames (709 megapix ... Full text Open Access Cite

Guest Editorial: Introduction to the Special Section on Computational Photography

Journal article IEEE Transactions on Pattern Analysis and Machine Intelligence · January 1, 2025 Full text Cite

Ptychography at all wavelengths.

Journal article Nature reviews. Methods primers · January 2025 Ptychography is a computational imaging technique that operates across multiple wavelength regimes, from electron (picometres) to X-ray (~0.1 nm), extreme ultraviolet (~10 nm), and visible light (micrometres). By reconstructing both amplitude and phase fro ... Full text Cite

Computational 3D topographic microscopy from terabytes of data per sample

Journal article Journal of Big Data · December 1, 2024 We present a large-scale computational 3D topographic microscope that enables 6-gigapixel profilometric 3D imaging at micron-scale resolution across >110 cm2 areas over multi-millimeter axial ranges. Our computational microscope, termed STARCAM ... Full text Cite

Rapid 3D imaging at cellular resolution for digital cytopathology with a multi-camera array scanner (MCAS).

Journal article Npj Imaging · October 1, 2024 Optical microscopy has long been the standard method for diagnosis in cytopathology. Whole slide scanners can image and digitize large sample areas automatically, but are slow, expensive and therefore not widely available. Clinical diagnosis of cytology sp ... Full text Link to item Cite

A comprehensive overview of diffuse correlation spectroscopy: Theoretical framework, recent advances in hardware, analysis, and applications.

Journal article NeuroImage · September 2024 Diffuse correlation spectroscopy (DCS) is a powerful tool for assessing microvascular hemodynamic in deep tissues. Recent advances in sensors, lasers, and deep learning have further boosted the development of new DCS methods. However, newcomers might feel ... Full text Cite

Pan-cortical cellular imaging in freely behaving mice using a miniaturized micro-camera array microscope (mini-MCAM).

Journal article bioRxiv · July 29, 2024 Understanding how circuits in the brain simultaneously coordinate their activity to mediate complex ethnologically relevant behaviors requires recording neural activities from distributed populations of neurons in freely behaving animals. Current miniaturi ... Full text Link to item Cite

Deep focusing with broadband light

Journal article Nature Photonics · July 1, 2024 Broadband energy can be delivered to extended targets deep inside a multiple-scattering system, paving ways for using broadband, partially incoherent light in a wide range of applications, such as deep-tissue imaging, laser therapy and optogenetics. ... Full text Cite

Anisotropic regularization for sparsely sampled and noise-robust Fourier ptychography.

Journal article Optics express · July 2024 Fourier ptychography (FP) is a powerful computational imaging technique that provides super-resolution and quantitative phase imaging capabilities by scanning samples in Fourier space with angle-varying illuminations. However, the image reconstruction in F ... Full text Cite

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

Journal article Advanced Photonics · March 1, 2024 We report tensorial tomographic Fourier ptychography (T2oFu), a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in 3D. Built upon Fourier ptychography, a qu ... Full text Cite

Message from the Chairs

Journal article 2024 IEEE International Conference on Computational Photography Iccp 2024 Proceedings · January 1, 2024 Full text Cite

Digital staining in optical microscopy using deep learning - a review

Journal article Photonix · December 1, 2023 Until recently, conventional biochemical staining had the undisputed status as well-established benchmark for most biomedical problems related to clinical diagnostics, fundamental research and biotechnology. Despite this role as gold-standard, staining pro ... Full text Cite

SEMPAI: a Self-Enhancing Multi-Photon Artificial Intelligence for Prior-Informed Assessment of Muscle Function and Pathology.

Journal article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · October 2023 Deep learning (DL) shows notable success in biomedical studies. However, most DL algorithms work as black boxes, exclude biomedical experts, and need extensive data. This is especially problematic for fundamental research in the laboratory, where often onl ... Full text Cite

scatterBrains: an open database of human head models and companion optode locations for realistic Monte Carlo photon simulations.

Journal article Journal of biomedical optics · October 2023 SignificanceMonte Carlo (MC) simulations are currently the gold standard in the near-infrared and diffuse correlation spectroscopy (NIRS/DCS) communities for generating light transport paths through tissue. However, realistic and diverse models th ... Full text Cite

High-resolution single-photon imaging with physics-informed deep learning.

Journal article Nature communications · September 2023 High-resolution single-photon imaging remains a big challenge due to the complex hardware manufacturing craft and noise disturbances. Here, we introduce deep learning into SPAD, enabling super-resolution single-photon imaging with enhancement of bit depth ... Full text Cite

Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second.

Journal article Nat Photonics · May 2023 Wide field of view microscopy that can resolve 3D information at high speed and spatial resolution is highly desirable for studying the behaviour of freely moving model organisms. However, it is challenging to design an optical instrument that optimises al ... Full text Open Access Link to item Cite

Multi-modal imaging using a cascaded microscope design.

Journal article Optics letters · April 2023 We present a multi-modal fiber array snapshot technique (M-FAST) based on an array of 96 compact cameras placed behind a primary objective lens and a fiber bundle array. Our technique is capable of large-area, high-resolution, multi-channel video acquisiti ... Full text Cite

Imaging across multiple spatial scales with the multi-camera array microscope

Journal article Optica · April 1, 2023 This paper experimentally examines different configurations of a multi-camera array microscope (MCAM) imaging technology. The MCAM is based upon a densely packed array of “micro-cameras” to jointly image across a large field-of-view (FOV) at high resolutio ... Full text Cite

Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second.

Journal article ArXiv · January 19, 2023 To study the behavior of freely moving model organisms such as zebrafish (Danio rerio) and fruit flies (Drosophila) across multiple spatial scales, it would be ideal to use a light microscope that can resolve 3D information over a wide field of view (FOV) ... Link to item Cite

Gigapixel imaging with a novel multi-camera array microscope.

Journal article Elife · December 14, 2022 The dynamics of living organisms are organized across many spatial scales. However, current cost-effective imaging systems can measure only a subset of these scales at once. We have created a scalable multi-camera array microscope (MCAM) that enables compr ... Full text Open Access Link to item Cite

Applications and Extensions of Fourier Ptychography

Journal article Microscopy Today · November 1, 2022 Abstract:This is the third article within a three-part series on Fourier ptychography, which is a computational microscopy technique for high-resolution, large field-of-view imaging. While the previous artic ... Full text Cite

Roadmap on wavefront shaping and deep imaging in complex media

Journal article Jphys Photonics · October 1, 2022 The last decade has seen the development of a wide set of tools, such as wavefront shaping, computational or fundamental methods, that allow us to understand and control light propagation in a complex medium, such as biological tissues or multimode fibers. ... Full text Cite

Fourier Ptychography Part II: Phase Retrieval and High-Resolution Image Formation

Journal article Microscopy Today · September 1, 2022 Abstract:This article is the second within a three-part series on Fourier ptychography, which is a computational microscopy technique for high-resolution, large field-of-view imaging. While the first article ... Full text Cite

Imaging Dynamics Beneath Turbid Media via Parallelized Single-Photon Detection.

Journal article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · August 2022 Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-est ... Full text Cite

A multiple instance learning approach for detecting COVID-19 in peripheral blood smears.

Journal article PLOS Digit Health · August 2022 A wide variety of diseases are commonly diagnosed via the visual examination of cell morphology within a peripheral blood smear. For certain diseases, such as COVID-19, morphological impact across the multitude of blood cell types is still poorly understoo ... Full text Open Access Link to item Cite

Optical imaging and spectroscopy for the study of the human brain: status report.

Journal article Neurophotonics · August 2022 This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly applicable to animal s ... Full text Cite

Introduction to Fourier Ptychography: Part I

Journal article Microscopy Today · May 2022 Abstract:Fourier ptychography is an emerging computational microscopy technique that can generate gigapixel-scale images of biological samples. With only the addition of a low-cost LED array to a standard digital microscope ... Full text Cite

Quantitative Jones matrix imaging using vectorial Fourier ptychography.

Journal article Biomed Opt Express · March 1, 2022 This paper presents a microscopic imaging technique that uses variable-angle illumination to recover the complex polarimetric properties of a specimen at high resolution and over a large field-of-view. The approach extends Fourier ptychography, which is a ... Full text Link to item Cite

The Role of Machine Learning in Cardiovascular Pathology.

Journal article Can J Cardiol · February 2022 Machine learning has seen slow but steady uptake in diagnostic pathology over the past decade to assess digital whole-slide images. Machine learning tools have incredible potential to standardise, and likely even improve, histopathologic diagnoses, but the ... Full text Link to item Cite

Increasing a microscope's effective field of view via overlapped imaging and machine learning.

Journal article Optics express · January 2022 This work demonstrates a multi-lens microscopic imaging system that overlaps multiple independent fields of view on a single sensor for high-efficiency automated specimen analysis. Automatic detection, classification and counting of various morphological f ... Full text Cite

Evaluation of U-Net Based Architectures for Automatic Aortic Dissection Segmentation

Journal article ACM Transactions on Computing for Healthcare · January 1, 2022 Segmentation and reconstruction of arteries is important for a variety of medical and engineering fields, such as surgical planning and physiological modeling. However, manual methods can be laborious and subject to a high degree of human variability. In t ... Full text Cite

Transient Motion Classification Through Turbid Volumes via Parallelized Single-Photon Detection and Deep Contrastive Embedding.

Journal article Frontiers in neuroscience · January 2022 Fast noninvasive probing of spatially varying decorrelating events, such as cerebral blood flow beneath the human skull, is an essential task in various scientific and clinical settings. One of the primary optical techniques used is diffuse correlation spe ... Full text Cite

Quantized Fourier ptychography with binary images from SPAD cameras

Journal article Photonics Research · October 1, 2021 Recently developed single-photon avalanche diode (SPAD) array cameras provide single-photon sensitivity and picosecond-scale time gating for time-of-flight measurements, with applications in LIDAR and fluorescence lifetime imaging. As compared to standard ... Full text Cite

Quantitative Jones matrix imaging using vectorial Fourier ptychography

Journal article · September 30, 2021 This paper presents a microscopic imaging technique that uses variable-angle illumination to recover the complex polarimetric properties of a specimen at high resolution and over a large field-of-view. The approach extends Fourier ptychography, which is a ... Open Access Link to item Cite

Imaging dynamics beneath turbid media via parallelized single-photon detection

Journal article · July 3, 2021 Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-est ... Open Access Link to item Cite

Deep image prior for undersampling high-speed photoacoustic microscopy.

Journal article Photoacoustics · June 2021 Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e., undersampling) for i ... Full text Open Access Cite

Deep image prior for undersampling high-speed photoacoustic microscopy

Journal article Photoacoustics · June 1, 2021 Photoacoustic microscopy (PAM) is an emerging imaging method combining light and sound. However, limited by the laser's repetition rate, state-of-the-art high-speed PAM technology often sacrifices spatial sampling density (i.e., undersampling) for increase ... Full text Cite

Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.

Journal article Sci Transl Med · April 7, 2021 Ebola virus (EBOV) hemorrhagic fever outbreaks have been challenging to deter due to the lack of health care infrastructure in disease-endemic countries and a corresponding inability to diagnose and contain the disease at an early stage. EBOV vaccines and ... Full text Open Access Link to item Cite

Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning.

Journal article IEEE transactions on medical imaging · February 2021 One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct undersampled PAM images and ... Full text Cite

Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection

Journal article APL Photonics · February 1, 2021 Diffuse correlation spectroscopy (DCS) is a well-established method that measures rapid changes in scattered coherent light to identify blood flow and functional dynamics within a tissue. While its sensitivity to minute scatterer displacements leads to a n ... Full text Cite

Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning.

Journal article IEEE Trans. Medical Imaging · 2021 Full text Cite

Increasing a microscope’s effective field of view via overlapped imaging and machine learning

Journal article Optics Infobase Conference Papers · January 1, 2021 We demonstrate a multi-lenses microscopic imaging system that records overlapping fields-of-view for high-efficiency automated specimen analysis. We show both in simulation and experiment how our system can achieve accurate target object detection on overl ... Cite

Mesoscopic photogrammetry with an unstabilized phone camera

Journal article CVPR 2021 · December 10, 2020 We present a feature-free photogrammetric technique that enables quantitative 3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy from sequences of images acquired by a smartphone at close range (several cm) under freehand motion ... Open Access Link to item Cite

Multi-element microscope optimization by a learned sensing network with composite physical layers.

Journal article Optics letters · October 2020 Standard microscopes offer a variety of settings to help improve the visibility of different specimens to the end microscope user. Increasingly, however, digital microscopes are used to capture images for automated interpretation by computer algorithms (e. ... Full text Cite

Towards an intelligent microscope: Adaptively learned illumination for optimal sample classification

Journal article ICASSP IEEE International Conference on Acoustics Speech and Signal Processing Proceedings · May 1, 2020 Recent machine learning techniques have dramatically changed how we process digital images. However, the way in which we capture images is still largely driven by human intuition and experience. This restriction is in part due to the many available degrees ... Full text Open Access Cite

Physics-enhanced machine learning for virtual fluorescence microscopy

Journal article · April 8, 2020 This paper introduces a new method of data-driven microscope design for virtual fluorescence microscopy. Our results show that by including a model of illumination within the first layers of a deep convolutional neural network, it is possible to learn task ... Open Access Link to item Cite

Diffraction tomography with a deep image prior.

Journal article Optics express · April 2020 We present a tomographic imaging technique, termed Deep Prior Diffraction Tomography (DP-DT), to reconstruct the 3D refractive index (RI) of thick biological samples at high resolution from a sequence of low-resolution images collected under angularly vary ... Full text Open Access Cite

Fourier ptychography: current applications and future promises.

Journal article Optics express · March 2020 Traditional imaging systems exhibit a well-known trade-off between the resolution and the field of view of their captured images. Typical cameras and microscopes can either "zoom in" and image at high-resolution, or they can "zoom out" to see a larger area ... Full text Cite

Learned Integrated Sensing Pipeline: Reconfigurable Metasurface Transceivers as Trainable Physical Layer in an Artificial Neural Network.

Journal article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · February 2020 The rapid proliferation of intelligent systems (e.g., fully autonomous vehicles) in today's society relies on sensors with low latency and computational effort. Yet current sensing systems ignore most available a priori knowledge, notably in the design of ... Full text Cite

Generation and characterization of focused helical x-ray beams.

Journal article Science advances · February 2020 The phenomenon of orbital angular momentum (OAM) affects a variety of important applications in visible optics, including optical tweezers, free-space communication, and 3D localization for fluorescence imaging. The lack of suitable wavefront shaping optic ... Full text Cite

Learned sensing: jointly optimized microscope hardware for accurate image classification.

Journal article Biomedical optics express · December 2019 Since its invention, the microscope has been optimized for interpretation by a human observer. With the recent development of deep learning algorithms for automated image analysis, there is now a clear need to re-design the microscope's hardware for specif ... Full text Open Access Cite

Scattering correlations of time-gated light

Journal article Optica · April 20, 2018 Manipulating the propagation of light through scattering media remains a major challenge for many applications, including astronomy, biomedical imaging, and colloidal optics. Light can be focused through inhomogeneous media into any desired point with wave ... Full text Open Access Cite

Convolutional neural networks that teach microscopes how to image

Journal article · September 21, 2017 Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to resolve with a standa ... Link to item Cite

Generalized optical memory effect

Journal article Optica · August 20, 2017 The optical memory effect is a well-known type of tilt/tilt wave correlation that is observed in coherent fields, allowing control over scattered light through thin and diffusive materials. Here we show that the optical memory effect is a special case of a ... Full text Open Access Cite

Subsampled phase retrieval for temporal resolution enhancement in lensless on-chip holographic video.

Journal article Biomedical optics express · March 2017 On-chip holographic video is a convenient way to monitor biological samples simultaneously at high spatial resolution and over a wide field-of-view. However, due to the limited readout rate of digital detector arrays, one often faces a tradeoff between the ... Full text Cite

Subsampled Phase Retrieval for On-chip Lensless Holographic Video

Journal article · December 7, 2016 On-chip holographic video is a convenient way to monitor biological samples simultaneously at high spatial resolution and over a wide field-of-view. However, due to the limited readout rate of digital detector arrays, one often faces a tradeoff between the ... Link to item Cite

Toward Long-Distance Subdiffraction Imaging Using Coherent Camera Arrays

Journal article IEEE Transactions on Computational Imaging · September 1, 2016 In this work, we propose using camera arrays coupled with coherent illumination as an effective method of improving spatial resolution in long distance images by a factor of ten and beyond. Recent advances in ptychography have demonstrated that one can ima ... Full text Cite

Diffraction tomography with Fourier ptychography.

Journal article Optica · August 2016 This paper presents a technique to image the complex index of refraction of a sample across three dimensions. The only required hardware is a standard microscope and an array of LEDs. The method, termed Fourier ptychographic tomography (FPT), first capture ... Full text Cite

Aperture scanning Fourier ptychographic microscopy.

Journal article Biomedical optics express · August 2016 Fourier ptychographic microscopy (FPM) is implemented through aperture scanning by an LCOS spatial light modulator at the back focal plane of the objective lens. This FPM configuration enables the capturing of the complex scattered field for a 3D sample bo ... Full text Cite

Standardizing the resolution claims for coherent microscopy

Journal article Nature Photonics · February 1, 2016 Full text Cite

Wide field-of-view fluorescence image deconvolution with aberration-estimation from Fourier ptychography.

Journal article Biomedical optics express · February 2016 This paper presents a method to simultaneously acquire an aberration-corrected, wide field-of-view fluorescence image and a high-resolution coherent bright-field image using a computational microscopy method. First, the procedure applies Fourier ptychograp ... Full text Cite

Erratum : Wide-field, high-resolution Fourier ptychographic microscopy (Nature Photonics (2013)7, (739-745))

Journal article Nature Photonics · September 28, 2015 Full text Cite

Translation correlations in anisotropically scattering media

Journal article Nature Physics · July 31, 2015 Controlling light propagation across scattering media by wavefront shaping holds great promise for a wide range of communications and imaging applications. But, finding the right shape for the wavefront is a challenge when the mapping between input and out ... Full text Cite

Digital pathology with Fourier ptychography.

Journal article Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · June 2015 Fourier ptychographic microscopy (FPM) is a recently introduced method of acquiring high-resolution, wide field of view (FOV) giga-pixel histology images. The FPM procedure first acquires a sequence of low-resolution images of a sample under variable-angle ... Full text Cite

Solving ptychography with a convex relaxation.

Journal article New journal of physics · May 2015 Ptychography is a powerful computational imaging technique that transforms a collection of low-resolution images into a high-resolution sample reconstruction. Unfortunately, algorithms that currently solve this reconstruction problem lack stability, robust ... Full text Cite

High numerical aperture Fourier ptychography: principle, implementation and characterization.

Journal article Optics express · February 2015 Fourier ptychography (FP) utilizes illumination control and computational post-processing to increase the resolution of bright-field microscopes. In effect, FP extends the fixed numerical aperture (NA) of an objective lens to form a larger synthetic system ... Full text Cite

Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue.

Journal article Nature photonics · January 2015 In the field of biomedical optics, optical scattering has traditionally limited the range of imaging within tissue to a depth of one millimetre. A recently developed class of wavefront-shaping techniques now aims to overcome this limit and achieve diffract ... Full text Cite

Toward Long Distance, Sub-diffraction Imaging Using Coherent Camera Arrays.

Journal article CoRR · 2015 Cite

Overlapped Fourier coding for optical aberration removal.

Journal article Optics express · October 2014 We present an imaging procedure that simultaneously optimizes a camera's resolution and retrieves a sample's phase over a sequence of snapshots. The technique, termed overlapped Fourier coding (OFC), first digitally pans a small aperture across a camera's ... Full text Cite

Aperture-scanning Fourier ptychography for 3D refocusing and super-resolution macroscopic imaging.

Journal article Optics express · June 2014 We report an imaging scheme, termed aperture-scanning Fourier ptychography, for 3D refocusing and super-resolution macroscopic imaging. The reported scheme scans an aperture at the Fourier plane of an optical system and acquires the corresponding intensity ... Full text Cite

Reconfigurable random bit storage using polymer-dispersed liquid crystal

Journal article · March 10, 2014 We present an optical method of storing random cryptographic keys, at high densities, within an electronically reconfigurable volume of polymer-dispersed liquid crystal (PDLC) film. We demonstrate how temporary application of a voltage above PDLC's saturat ... Link to item Cite

Diffusion model for ultrasound-modulated light.

Journal article Journal of biomedical optics · March 2014 Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US-optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion ap ... Full text Cite

Fourier pt ychographic microscopy

Journal article Optics and Photonics News · January 1, 2014 Full text Cite

A phase space model of Fourier ptychographic microscopy.

Journal article Optics express · January 2014 A new computational imaging technique, termed Fourier ptychographic microscopy (FPM), uses a sequence of low-resolution images captured under varied illumination to iteratively converge upon a high-resolution complex sample estimate. Here, we propose a mat ... Full text Cite

Physical key-protected one-time pad.

Journal article Scientific reports · December 2013 We describe an encrypted communication principle that forms a secure link between two parties without electronically saving either of their keys. Instead, random cryptographic bits are kept safe within the unique mesoscopic randomness of two volumetric sca ... Full text Cite

Quantitative phase imaging via Fourier ptychographic microscopy.

Journal article Optics letters · November 2013 Fourier ptychographic microscopy (FPM) is a recently developed imaging modality that uses angularly varying illumination to extend a system's performance beyond the limit defined by its optical components. The FPM technique applies a novel phase-retrieval ... Full text Cite

Wide-field, high-resolution Fourier ptychographic microscopy.

Journal article Nature photonics · September 2013 In this article, we report an imaging method, termed Fourier ptychographic microscopy (FPM), which iteratively stitches together a number of variably illuminated, low-resolution intensity images in Fourier space to produce a wide-field, high-resolution com ... Full text Cite

Characterization of spatially varying aberrations for wide field-of-view microscopy.

Journal article Optics express · July 2013 We describe a simple and robust approach for characterizing the spatially varying pupil aberrations of microscopy systems. In our demonstration with a standard microscope, we derive the location-dependent pupil transfer functions by first capturing multipl ... Full text Cite

Speckle-scale focusing in the diffusive regime with time-reversal of variance-encoded light (TROVE).

Journal article Nature photonics · April 2013 Focusing of light in the diffusive regime inside scattering media has long been considered impossible. Recently, this limitation has been overcome with time reversal of ultrasound-encoded light (TRUE), but the resolution of this approach is fundamentally l ... Full text Cite

Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium.

Journal article Journal of biomedical optics · February 2013 The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling throug ... Full text Cite

Re-designing the camera for computational photography

Journal article SPIE Newsroom · June 6, 2011 Full text Cite

Highlighted depth-of-field photography: Shining light on focus

Journal article ACM Transactions on Graphics · January 1, 2011 We present a photographic method to enhance intensity differences between objects at varying distances from the focal plane. By combining a unique capture procedure with simple image processing techniques, the detected brightness of an object is decreased ... Full text Cite

Iterative aperture mask design in phase space using a rank constraint.

Journal article Optics express · October 2010 We present an iterative camera aperture design procedure, which determines an optimal mask pattern based on a sparse set of desired intensity distributions at different focal depths. This iterative method uses the ambiguity function as a tool to shape the ... Full text Cite

View-Dependent Displays and the Space of Light Fields

Journal article · July 30, 2010 In this paper we explore how light propagates from thin elements into a volume for viewing. In particular, devices that are typically connected with geometric optics, like parallax barriers, differ in treatment with those that obey physical optics, like ho ... Link to item Cite

12C/13C ratio in planetary nebulae from the IUE archives

Journal article Astrophysical Journal · April 20, 2004 We investigated the abundance ratio of 12C/13C in planetary nebulae by examining emission lines arising from C III 2s2p 3P2,1,00 → 2s21S0. Spectra were retrieved from ... Full text Cite