Scholars@Duke
Cary Nobles Robertson

Cary Nobles Robertson

Associate Professor Emeritus of Urology
Urology
cary.robertson@duke.edu
DUMC 3707, Durham, NC 27710
Box 3707 DUMC Rm 1572E Duke South, 40 Medicine Circle, Durham, NC 27710

Featured Works

Complete high-intensity focused ultrasound in prostate cancer: outcome from the @-Registry.

Journal article Prostate Cancer Prostatic Dis · September 2012 Featured Publication BACKGROUND: To analyze data on patients with localized prostate cancer who were treated with complete high-intensity focused ultrasound (HIFU) prospectively captured within a voluntary HIFU user database (@-Registry). METHODS: The @-Registry includes data ... Full text Link to item Cite

The number of high-risk factors and the risk of prostate cancer-specific mortality after brachytherapy: implications for treatment selection.

Journal article Int J Radiat Oncol Biol Phys · April 1, 2012 Featured Publication PURPOSE: To determine whether an increasing number of high-risk factors is associated with higher prostate cancer-specific mortality (PCSM) among men treated with brachytherapy (BT)-based treatment, and whether supplemental therapy has an impact on this ri ... Full text Link to item Cite

Utilization trends at a multidisciplinary prostate cancer clinic: initial 5-year experience from the Duke Prostate Center.

Journal article J Urol · January 2012 Featured Publication PURPOSE: The multidisciplinary approach is becoming increasingly encouraged but little is known about the multidisciplinary experience compared to routine care. For patients with prostate cancer the goal is to provide evaluations by urologists, medical and ... Full text Link to item Cite

Factors predicting early and late phase decline of sexual health-related quality of life following radical prostatectomy.

Journal article J Sex Med · October 2011 Featured Publication INTRODUCTION: The association between early and late phase sexual health-related quality of life (HRQoL) following radical prostatectomy (RP) is unclear. Moreover, factors that predict either early or late sexual HRQoL decline have not been fully investiga ... Full text Link to item Cite

Correlation of prostate-specific antigen nadir and biochemical failure after high-intensity focused ultrasound of localized prostate cancer based on the Stuttgart failure criteria - analysis from the @-Registry.

Journal article BJU Int · October 2011 Featured Publication OBJECTIVE: •To determine if the prostate-specific antigen (PSA) nadir after high-intensity focused ultrasound (HIFU) can be used as a predictor of the biochemical disease-free survival rate (DFSR). PATIENTS AND METHODS: •Patient data were derived from the ... Full text Link to item Cite

Kidney cancer.

Journal article J Natl Compr Canc Netw · September 1, 2011 Featured Publication Full text Link to item Cite

Salvage radiation in men after prostate-specific antigen failure and the risk of death.

Journal article Cancer · September 1, 2011 Featured Publication BACKGROUND: A survival benefit has been observed with salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in men with rapid rises in PSA doubling time (DT, < 6 months). Whether such a benefit exits in ... Full text Link to item Cite

Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.

Journal article BJU Int · July 2011 Featured Publication OBJECTIVE: • To evaluate weather prostate-specific antigen (PSA) velocity could be used to stratify patients at risk of death from prostate cancer (PCa) and be useful in aiding decision making regarding PSA screening in elderly men, as previous studies hav ... Full text Link to item Cite

Clinical predictors of renal mass pathological features.

Journal article BJU Int · March 2011 Featured Publication OBJECTIVE: • To evaluate the influence of radiographic tumour size and other preoperative variables on the pathological characteristics of the lesion to determine the distribution of pathological features and assess preoperative risk factors for potentiall ... Full text Link to item Cite

Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death.

Journal article BJU Int · December 2010 Featured Publication OBJECTIVE: To investigate whether salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure can provide the same result as adjuvant RT, which decreases the risk of all-cause mortality (ACM) for men with positive margins (R1), or extra-caps ... Full text Link to item Cite

Prostate-specific antigen-based risk-adapted discontinuation of prostate cancer screening in elderly African American and Caucasian American men.

Journal article Urology · November 2010 Featured Publication OBJECTIVES: To evaluate the relationship between initial prostate-specific antigen (PSA) and prostate cancer (PCa) risk in elderly African American (AA) and Caucasian American (CA) men. METHODS: A total of 408 AA and 1720 CA men whose initial PSA measureme ... Full text Link to item Cite

Predicting non-organ-confined prostate cancer in men diagnosed after 2000.

Journal article Prostate Cancer Prostatic Dis · September 2010 Featured Publication The objective of this study was to preoperatively predict non-organ-confined disease in patients considering radical prostatectomy. To account for the stage migration seen in prostate cancer, we included only those patients who underwent prostatectomy afte ... Full text Link to item Cite

Predicting occult multifocality of renal cell carcinoma.

Journal article Eur Urol · July 2010 Featured Publication BACKGROUND: Multifocal renal cell carcinoma (RCC) has been reported in up to 25% of all radical nephrectomy specimens. Modern imaging tends to underestimate the rate of multifocality. Recognition of multifocality before treatment may guide physicians and p ... Full text Link to item Cite

Public survey and survival data do not support recommendations to discontinue prostate-specific antigen screening in men at age 75.

Journal article Urology · May 2010 Featured Publication OBJECTIVES: To evaluate the US Preventative Services Task Force (USPSTF) recommendation to discontinue prostate-specific antigen (PSA) screening at age 75. METHODS: Public survey: A cohort of 340 patients was surveyed at our PSA screening clinic and strati ... Full text Link to item Cite

Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death.

Journal article Cancer · April 15, 2010 Featured Publication BACKGROUND: This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or ho ... Full text Link to item Cite

Initial prostate specific antigen 1.5 ng/ml or greater in men 50 years old or younger predicts higher prostate cancer risk.

Journal article J Urol · March 2010 Featured Publication PURPOSE: Studies show that initial prostate specific antigen higher than the median in young men predicts a subsequent higher risk of prostate cancer. To our knowledge this relationship has not been studied in patients stratified by race. MATERIALS AND MET ... Full text Link to item Cite

Tumor percent involvement predicts prostate specific antigen recurrence after radical prostatectomy only in men with smaller prostate.

Journal article J Urol · March 2010 Featured Publication PURPOSE: We determined the predictive power of tumor percent involvement on prostate specific antigen recurrence in patients when stratified by prostate weight. MATERIALS AND METHODS: Data on 3,057 patients who underwent radical prostatectomy between 1988 ... Full text Link to item Cite

Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?

Journal article Urology · February 2010 Featured Publication OBJECTIVES: To compare the effects of tumor volume (TV), tumor percentage involvement (TPI), and prostate volume (PV) on prostate-specific antigen (PSA) recurrence (PSAR) after radical prostatectomy (RP). METHODS: A cohort of 3528 patients receiving RP bet ... Full text Link to item Cite

Men older than 70 years have higher risk prostate cancer and poorer survival in the early and late prostate specific antigen eras.

Journal article J Urol · November 2009 Featured Publication PURPOSE: We clarified whether men older than 70 years have a higher risk of prostate cancer and poorer survival in the early and late prostate specific antigen eras. MATERIALS AND METHODS: A cohort of 4,561 men who underwent radical prostatectomy were stra ... Full text Link to item Cite

High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure.

Journal article BJU Int · October 2009 Featured Publication OBJECTIVES: To compare the specificity and sensitivity of different definitions of biochemical failure in patients treated with high-intensity focused ultrasound (HIFU) for prostate cancer, to identify the most accurate predictor of clinical failure after ... Full text Link to item Cite

Delayed prostate-specific antigen recurrence after radical prostatectomy: how to identify and what are their clinical outcomes?

Journal article Urology · September 2009 Featured Publication OBJECTIVES: To identify factors that predict delayed (> 5 years) prostate-specific antigen recurrence (PSAR) after radical prostatectomy (RP) and to analyze the associated clinical outcomes. METHODS: A cohort of 4561 men who underwent RP between 1988 and 2 ... Full text Link to item Cite

Effect of age and pathologic Gleason score on PSA recurrence: analysis of 2911 patients undergoing radical prostatectomy.

Journal article Urology · September 2009 Featured Publication OBJECTIVES: To clarify the relationship between age and pathologic Gleason score and their effect on prostate-specific antigen recurrence (PSAR). METHODS: The data from a cohort of 2911 men who had undergone radical prostatectomy from 1988 to 2006 were ret ... Full text Link to item Cite

A retrospective comparison of anesthetic management of robot-assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy.

Journal article J Clin Anesth · August 2009 Featured Publication STUDY OBJECTIVE: To compare anesthetic management and postoperative outcomes in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP) and radical retropubic prostatectomy (RRP) with general anesthesia. DESIGN: Retrospective database ... Full text Link to item Cite

Factors predicting prostatic biopsy Gleason sum under grading.

Journal article J Urol · July 2009 Featured Publication PURPOSE: We determined clinical factors affecting the under grading of biopsy Gleason sum compared with prostatectomy pathology and developed a model predicting the probability of under grading. MATERIALS AND METHODS: We analyzed a cohort of 1,701 patients ... Full text Link to item Cite

Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Journal article Cancer Epidemiol Biomarkers Prev · December 2008 Featured Publication BACKGROUND: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies ... Full text Link to item Cite

Significant discrepancies between diagnostic and pathologic Gleason sums in prostate cancer: the predictive role of age and prostate-specific antigen.

Journal article Urology · October 2008 Featured Publication OBJECTIVES: To assess the discrepancies between diagnostic and pathologic Gleason sums and the predictive role of age and prostate-specific antigen (PSA) level on Gleason sum discrepancies. METHODS: A total of 2963 patients receiving radical prostatectomy ... Full text Link to item Cite

Body mass index, prostate-specific antigen, and digital rectal examination findings among participants in a prostate cancer screening clinic.

Journal article Urology · May 2008 Featured Publication OBJECTIVES: Prior studies suggested obese men have lower prostate-specific antigen (PSA) values. However, the association between body mass index (BMI) and digital rectal examination (DRE) findings and the association between weight at age 18 and adult PSA ... Full text Link to item Cite

Race and prostate weight as independent predictors for biochemical recurrence after radical prostatectomy.

Journal article Prostate Cancer Prostatic Dis · 2008 Featured Publication We hypothesized that factors beyond pathological stage, grade, PSA and margin status would be important predictors of biochemical recurrence (BCR) after radical prostatectomy (RP). A cohort of 3194 patients who underwent RP between 1988 and 2007 and who ha ... Full text Link to item Cite

Rectourethral fistula after combination radiotherapy for prostate cancer.

Journal article Urology · May 2007 Featured Publication OBJECTIVES: To describe 6 cases of rectourethral fistula in patients treated with brachytherapy plus external beam radiotherapy for localized prostate cancer and subsequent rectal biopsies or rectal surgery. METHODS: A retrospective chart review was undert ... Full text Link to item Cite

The role of early adopter bias for new technologies in robot assisted laparoscopic prostatectomy.

Journal article J Urol · April 2007 Featured Publication PURPOSE: We determined the potential influence of an early adopter bias in patients undergoing robot assisted laparoscopic prostatectomy. MATERIALS AND METHODS: We compared baseline demographic, clinical and health related quality of life characteristics o ... Full text Link to item Cite

Prostate-specific antigen (PSA) and PSA velocity for prostate cancer detection in men aged <50 years.

Journal article BJU Int · April 2007 Featured Publication OBJECTIVE: To identify threshold values of prostate-specific antigen (PSA) levels and PSA velocity (PSAV) to optimize the assessment of the risk of prostate cancer in young men, as prostate cancer is detected increasingly in men aged <50 years. PATIENTS AN ... Full text Link to item Cite

Comparative financial analysis of minimally invasive surgery to open surgery for small renal tumours < or =3.5 cm: a single institutional experience.

Journal article Eur Urol · March 2007 Featured Publication OBJECTIVE: We analysed total hospital costs by comparing minimally invasive surgery (MIS) procedures, such as laparoscopic cryoablation (LCA), laparoscopic partial nephrectomy (LPN), and hand-assisted laparoscopic nephrectomy (HALN), with conventional surg ... Full text Link to item Cite

Financial comparative analysis of minimally invasive surgery to open surgery for localized prostate cancer: a single-institution experience.

Journal article Urology · February 2007 Featured Publication OBJECTIVES: To evaluate the financial implications of how the costs of new minimally invasive surgery such as laparoscopic robotic prostatectomy (LRP) and cryosurgical ablation of the prostate (CAP) technologies compare with those of conventional surgery. ... Full text Link to item Cite

Age adjusted prostate specific antigen and prostate specific antigen velocity cut points in prostate cancer screening.

Journal article J Urol · February 2007 Featured Publication PURPOSE: We identified age adjusted prostate specific antigen and prostate specific antigen velocity cut points for prostate cancer biopsy. MATERIALS AND METHODS: A cohort of 33,643 men was retrieved from the Duke Prostate Center database. Of this group 11 ... Full text Link to item Cite

Testicular cancer. Clinical practice guidelines in oncology.

Journal article J Natl Compr Canc Netw · November 2006 Featured Publication Full text Link to item Cite

Kidney cancer. Clinical practice guidelines in oncology.

Journal article J Natl Compr Canc Netw · November 2006 Featured Publication Full text Link to item Cite

Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate.

Journal article Prostate Cancer Prostatic Dis · 2006 Featured Publication To determine the timing and patterns of late recurrence after radical prostatectomy (RP) alone or RP plus adjuvant radiotherapy (RT). Between 1970 and 1983, 159 patients underwent RP for newly diagnosed adenocarcinoma of the prostate and were found to have ... Full text Link to item Cite

Kidney cancer. Clinical practice guidelines.

Journal article J Natl Compr Canc Netw · January 2005 Featured Publication Link to item Cite

Testicular cancer. Clinical practice guidelines.

Journal article J Natl Compr Canc Netw · January 2005 Featured Publication Link to item Cite

Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer.

Journal article J Urol · July 2002 Featured Publication PURPOSE: Positron emission tomography (PET) imaging is used for the metabolic evaluation of cancer. [18F]fluorodeoxyglucose (FDG) is commonly used as a radiotracer but its low cellular uptake rate in prostate cancer limits its usefulness. We evaluated the ... Link to item Cite

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features.

Journal article Urology · July 2001 Featured Publication OBJECTIVES: Dietary fat and fiber affect hormonal levels and may influence cancer progression. Flaxseed is a rich source of lignan and omega-3 fatty acids and may thwart prostate cancer. The potential effects of flaxseed may be enhanced with concomitant fa ... Full text Link to item Cite

Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1.

Journal article Anticancer Res · 2001 Featured Publication BACKGROUND: Mitogen-activated protein kinase (MAPK) is one of the transforming growth factor-beta (TGF-beta signaling pathways while heat shock protein 70 (HSP70) prevents apoptosis by affecting MAPK signaling downstream. However, the interrelationship bet ... Link to item Cite

Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.

Journal article Cancer Res · January 1, 2001 Featured Publication The up-regulation of rates of choline uptake and phosphorylation in certain malignancies has motivated the development of positron-labeled choline analogues for noninvasive detection of cancer using positron emission tomography (PET). The choline analogue, ... Link to item Cite

Early onset baldness and prostate cancer risk.

Journal article Cancer Epidemiol Biomarkers Prev · March 2000 Featured Publication Prostatic carcinoma is the leading cancer among American men, yet few risk factors have been established. Although increased androgen levels have long been associated with both prostatic carcinoma and baldness, to date no studies have shown an association ... Link to item Cite

Transient lumbosacral polyradiculopathy after prostatectomy: association with spinal stenosis.

Journal article South Med J · August 1999 Featured Publication Mononeuropathies are common after pelvic surgery. They are usually the result of unnatural positioning during surgery or faulty restraining devices. Polyneuropathy in the postoperative setting is rare. We report two cases of polyradiculopathy after radical ... Full text Link to item Cite

QOL and outcomes research in prostate cancer patients with low socioeconomic status.

Journal article Oncology (Williston Park) · June 1999 Featured Publication The VA Cancer of the Prostate Outcomes Study (VA CaPOS) is collecting quality-of-life (QOL) information from prostate cancer patients, spouses, and physicians at six VA medical centers. Currently, 601 men with prostate cancer are included in the study, mos ... Link to item Cite

Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping.

Journal article Genes Chromosomes Cancer · May 1999 Featured Publication The bladder cancer cell line BK-10 was established from a grade III-IV transitional cell carcinoma (TCC). BK-10 is near-tetraploid (+/-4n) and consists of two subclones with 20-25 structural aberrations. Here we report the cytogenetic analysis of BK-10 by ... Full text Link to item Cite