Scholars@Duke
Rodger Alan Liddle

Rodger Alan Liddle

Professor of Medicine
Medicine, Gastroenterology
rodger.liddle@duke.edu
Duke Box 103859, 1033A GSRB-1, Durham, NC 27710
1033A GSRB-1 Bldg, Durham, NC 27710

Featured Works

ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.

Journal article Hum Mol Genet · February 1, 2015 Featured Publication In the mammalian inner ear, bicellular and tricellular tight junctions (tTJs) seal the paracellular space between epithelial cells. Tricellulin and immunoglobulin-like (Ig-like) domain containing receptor 1 (ILDR1, also referred to as angulin-2) localize t ... Full text Link to item Cite

Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats.

Journal article Am J Physiol Gastrointest Liver Physiol · October 2002 Featured Publication We hypothesized that neurogenic inflammation is a common final pathway for parenchymal inflammation in pancreatitis and evaluated the role of primary sensory neurons in secretagogue-induced and obstructive pancreatitis. Neonatal rats received either the pr ... Full text Link to item Cite

Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells.

Journal article Am J Physiol Gastrointest Liver Physiol · January 2002 Featured Publication CCK is secreted into the blood from intestinal endocrine cells following ingestion of a meal. Recently, it has been demonstrated that the ability of certain foods to stimulate CCK release is mediated by endogenously produced CCK-releasing factors. A newly ... Full text Link to item Cite

Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.

Journal article Am J Physiol Gastrointest Liver Physiol · November 2001 Featured Publication We examined whether the capsaicin vanilloid receptor-1 (VR1) mediates substance P (SP) release from primary sensory neurons in experimental pancreatitis. Pancreatitis was achieved by 12 hourly injections of caerulein (50 microg/kg ip) in mice. One group re ... Full text Link to item Cite

Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.

Journal article Am J Physiol · October 1998 Featured Publication It has been demonstrated that K+ channel regulation of membrane potential is critical for control of CCK secretion. Because certain K+ channels are pH sensitive, it was postulated that pH affects K+ channel activity in the CCK-secreting cell line STC-1 and ... Full text Link to item Cite

Cholecystokinin cells.

Journal article Annu Rev Physiol · 1997 Featured Publication Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimu ... Full text Link to item Cite

Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion.

Journal article Proc Natl Acad Sci U S A · April 30, 1996 Featured Publication Cholecystokinin (CCK) secretion in rats and humans is inhibited by pancreatic proteases and bile acids in the intestine. It has been hypothesized that the inhibition of CCK release caused by pancreatic proteases is due to proteolytic inactivation of a CCK- ... Full text Link to item Cite

Regulation of cholecystokinin secretion by intraluminal releasing factors.

Journal article Am J Physiol · September 1995 Featured Publication Ingested nutrients stimulate secretion of gastrointestinal hormones that are necessary for the coordinated processes of digestion and absorption of food. One of the most important hormonal regulators of the digestive process is cholecystokinin (CCK). This ... Full text Link to item Cite