Rebekah Ryanne Wu | Scholars@Duke

Rebekah Ryanne Wu
Assistant Professor of Medicine

Dr. Wu is an internal medicine physician and health services researcher. Her main research interest is the use of precision medicine applications to improve clinical care. She is involved in projects currently looking at a patient-facing family history risk assessment tool, MeTree, which provides individualized risk stratification and clinical decision support recommendations to clinicians and patients. In addition she is also involved in a large scale sequencing project in Singapore looking at the intersection of family health history and genomics to better understand how these data elements can complement one another and create more precise risk predictions. Dr. Wu is also a program director at the Cooperative Studies Program Epidemiology Center at the Durham VA Medical Center where she leads a team coordinating the VA's research efforts in understanding Gulf War Illness.

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, General Internal Medicine, Medicine 2015
Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014

Contact Information

104427, Durham, NC 27710
411 West Chapel Hill St., Suite 600, Durham, NC 27701
ryanne.wu@duke.edu (919) 286-0411

Background
Education, Training, & Certifications
- Chief Resident, Internal Medicine, Georgetown University School of Medicine 2009 - 2010
- Resident, Internal Medicine, Georgetown University School of Medicine 2006 - 2009
- M.D., University of North Carolina at Chapel Hill School of Medicine 2006
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2013 - 2015
Academic Positions Outside Duke
- Clinical Research Scientist, VA Cooperative Studies Program Epidemiology Center. 2018 - 2019
Research
Selected Grants
- Building and Deploying a Genomic-Medicine Risk Assessment Model for Diverse Primary Care Populations. awarded by National Institutes of Health 2018 - 2023
- Building and Deploying a Genomic-Medicine Risk Assessment Model for Diverse Primary Care Populations. awarded by National Institutes of Health 2018 - 2023
- Implementation, Adoption, and Utility of Family History in Diverse Care Settings awarded by National Institutes of Health 2013 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bylstra, Y., S. Davila, W. K. Lim, R. Wu, J. X. Teo, S. Kam, T. Lysaght, et al. “Implementation of genomics in medical practice to deliver precision medicine for an Asian population.” Npj Genomic Medicine 4, no. 1 (December 1, 2019). https://doi.org/10.1038/s41525-019-0085-8.
    Full Text
  - Ginsburg, Geoffrey S., R Ryanne Wu, and Lori A. Orlando. “Family health history: underused for actionable risk assessment..” Lancet 394, no. 10198 (August 17, 2019): 596–603. https://doi.org/10.1016/S0140-6736(19)31275-9.
    Full Text Link to Item
  - Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network..” Genet Med 21, no. 7 (July 2019). https://doi.org/10.1038/s41436-018-0280-5.
    Full Text Link to Item
  - Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, et al. “Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network..” Genet Med 21, no. 3 (March 2019): 743–47. https://doi.org/10.1038/s41436-018-0080-y.
    Full Text Link to Item
  - Wu, R Ryanne, Rachel A. Myers, Adam H. Buchanan, David Dimmock, Kimberly G. Fulda, Irina V. Haller, Susanne B. Haga, et al. “Effect of Sociodemographic Factors on Uptake of a Patient-Facing Information Technology Family Health History Risk Assessment Platform..” Appl Clin Inform 10, no. 2 (March 2019): 180–88. https://doi.org/10.1055/s-0039-1679926.
    Full Text Link to Item
  - Wu, R Ryanne, Rachel A. Myers, Nina Sperber, Corrine I. Voils, Joan Neuner, Catherine A. McCarty, Irina V. Haller, et al. “Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework..” Genet Med 21, no. 2 (February 2019): 331–38. https://doi.org/10.1038/s41436-018-0049-x.
    Full Text Link to Item
  - Orlando, Lori A., Nina R. Sperber, Corrine Voils, Marshall Nichols, Rachel A. Myers, R Ryanne Wu, Tejinder Rakhra-Burris, et al. “Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group..” Genet Med 20, no. 6 (June 2018): 655–63. https://doi.org/10.1038/gim.2017.144.
    Full Text Link to Item
  - Sperber, Nina R., Janet S. Carpenter, Larisa H. Cavallari, Laura J Damschroder, Rhonda M. Cooper-DeHoff, Joshua C. Denny, Geoffrey S. Ginsburg, et al. “Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network..” Bmc Med Genomics 10, no. 1 (May 22, 2017). https://doi.org/10.1186/s12920-017-0273-2.
    Full Text Open Access Copy Link to Item
  - Kinsinger, Linda S., Charles Anderson, Jane Kim, Martha Larson, Stephanie H. Chan, Heather A. King, Kathryn L. Rice, et al. “Implementation of Lung Cancer Screening in the Veterans Health Administration..” Jama Intern Med 177, no. 3 (March 1, 2017): 399–406. https://doi.org/10.1001/jamainternmed.2016.9022.
    Full Text Link to Item
  - Wu, R Ryanne, Rachel A. Myers, Elizabeth R. Hauser, Allison Vorderstrasse, Alex Cho, Geoffrey S. Ginsburg, and Lori A. Orlando. “Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes..” J Genet Couns 26, no. 1 (February 2017): 133–40. https://doi.org/10.1007/s10897-016-9988-z.
    Full Text Open Access Copy Link to Item
  - Orlando, Lori A., R Ryanne Wu, Rachel A. Myers, Adam H. Buchanan, Vincent C. Henrich, Elizabeth R. Hauser, and Geoffrey S. Ginsburg. “Clinical utility of a Web-enabled risk-assessment and clinical decision support program..” Genet Med 18, no. 10 (October 2016): 1020–28. https://doi.org/10.1038/gim.2015.210.
    Full Text Open Access Copy Link to Item
  - Weitzel, Kristin Wiisanen, Madeline Alexander, Barbara A. Bernhardt, Neil Calman, David J. Carey, Larisa H. Cavallari, Julie R. Field, et al. “The IGNITE network: a model for genomic medicine implementation and research..” Bmc Med Genomics 9 (January 5, 2016). https://doi.org/10.1186/s12920-015-0162-5.
    Full Text Open Access Copy Link to Item
  - Wu, R Ryanne, Rachel A. Myers, Catherine A. McCarty, David Dimmock, Michael Farrell, Deanna Cross, Troy D. Chinevere, Geoffrey S. Ginsburg, Lori A. Orlando, and Lori A. Family Health History Network. “Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study..” Implement Sci 10 (November 24, 2015). https://doi.org/10.1186/s13012-015-0352-8.
    Full Text Open Access Copy Link to Item
  - Wu, R Ryanne, and Lori A. Orlando. “Implementation of health risk assessments with family health history: barriers and benefits..” Postgrad Med J 91, no. 1079 (September 2015): 508–13. https://doi.org/10.1136/postgradmedj-2014-133195.
    Full Text Link to Item
  - McVay, Megan A., Christopher Beadles, Ryanne Wu, Janet Grubber, Cynthia J. Coffman, William S. Yancy, Isaac Lipkus Reiner, and Corrine I. Voils. “Effects of provision of type 2 diabetes genetic risk feedback on patient perceptions of diabetes control and diet and physical activity self-efficacy..” Patient Educ Couns, June 30, 2015. https://doi.org/10.1016/j.pec.2015.06.016.
    Full Text Link to Item
  - Wu, R Ryanne, Linda S. Kinsinger, Dawn Provenzale, Heather A. King, Patricia Akerly, Lottie K. Barnes, Santanu K. Datta, et al. “Implementation of new clinical programs in the VHA healthcare system: the importance of early collaboration between clinical leadership and research..” J Gen Intern Med 29 Suppl 4 (December 2014): 825–30. https://doi.org/10.1007/s11606-014-3026-3.
    Full Text Link to Item
  - Beadles, Chris A., R. Ryanne Wu, Tiffany Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth Hauser, Vincent C. Henrich, Geoffrey S. Ginsburg, and Lori A. Orlando. “Providing patient education: impact on quantity and quality of family health history collection..” Fam Cancer 13, no. 2 (June 2014): 325–32. https://doi.org/10.1007/s10689-014-9701-z.
    Full Text Link to Item
  - Orlando, Lori A., R Ryanne Wu, Chris Beadles, Tiffany Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Vincent C. Henrich, and Geoffrey S. Ginsburg. “Implementing family health history risk stratification in primary care: impact of guideline criteria on populations and resource demand..” Am J Med Genet C Semin Med Genet 166C, no. 1 (March 2014): 24–33. https://doi.org/10.1002/ajmg.c.31388.
    Full Text Link to Item
  - Wu, R Ryanne, Tiffany L. Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Geoffrey S. Ginsburg, Vincent C. Henrich, and Lori A. Orlando. “Quality of family history collection with use of a patient facing family history assessment tool..” Bmc Fam Pract 15 (February 13, 2014). https://doi.org/10.1186/1471-2296-15-31.
    Full Text Link to Item
  - Wu, R. R., T. L. Himmel, A. H. Buchanan, K. P. Powell, E. R. Hauser, G. S. Ginsburg, V. C. Henrich, and L. A. Orlando. “Quality of family history collection with use of a patient facing family history assessment tool.” Bmc Family Practice 15, no. 1 (2014). https://doi.org/10.1186/1471-2296-15-31.
    Full Text
  - Wu, R Ryanne, Lori A. Orlando, Tiffany L. Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey S. Ginsburg. “Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial..” Bmc Fam Pract 14 (August 6, 2013). https://doi.org/10.1186/1471-2296-14-111.
    Full Text Link to Item
  - Sun, J. F., R. R. Wu, C. Norris, A. M. Noone, M. Amankwa-Sakyi, R. Slack, and J. L. Marshall. “Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers.” Gastrointestinal Cancer Research 3, no. 4 (July 1, 2010): 134–40.
  - Ryanne Wu, Rebekah, Peter A. Lindenberg, Rebecca Slack, Anne-Michelle Noone, John L. Marshall, and Aiwu R. He. “Evaluation of hypertension as a marker of bevacizumab efficacy..” J Gastrointest Cancer 40, no. 3–4 (2009): 101–8. https://doi.org/10.1007/s12029-009-9104-9.
    Full Text Link to Item
- Book Sections
  - Orlando, L. A., and R. R. Wu. “Family Health History and Health Risk Assessment For Cardiovascular Disease in Health Care.” In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition, 1–16, 2017. https://doi.org/10.1016/B978-0-12-801812-5.00016-0.
    Full Text
  - Orlando, L. A., and R. R. Wu. “Family Health History and Health Risk Assessment in Health Care.” In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition, 189–204, 2016. https://doi.org/10.1016/B978-0-12-800681-8.00013-X.
    Full Text
- Conference Papers
  - Orlando, Lori A., R. R. Wu, Adam Buchanan, Rachel A. Myers, and Geoffrey S. Ginsburg. “THE INTERSECTION OF POPULATION HEALTH AND PRECISION MEDICINE: EMPLOYING TECHNOLOGY TO OPTIMIZE RISK ASSESSMENT IN PRIMARY CARE.” In Journal of General Internal Medicine, 33:S362–S362. SPRINGER, 2018.
    Link to Item
  - Wu, R. R., Tiffany Himmel, Rachel A. Myers, Elizabeth Hauser, Allison Vorderstrasse, Geoffrey Ginsburg, and Lori A. Orlando. “EFFECT OF FAMILY HISTORY AND GENETIC RISK COUNSELLING FOR TYPE 2 DIABETES ON PERCEPTIONS OF RISK AND CONTROL: SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL.” In Journal of General Internal Medicine, 30:S55–S55. SPRINGER, 2015.
    Link to Item
  - Wu, Rebekah R., Tiffany Himmel, Adam Buchanan, Karen Powell, Elizabeth Hauser, Astrid B. Agbaje, Geoffrey S. Ginsburg, Vincent Henrich, and Lori A. Orlando. “IMPACT OF A FAMILY HISTORY COLLECTION TOOL, METREE (c), IN IDENTIFYING INDIVIDUALS AT HIGH-RISK FOR CANCER AND THROMBOSIS.” In Journal of General Internal Medicine, 28:S101–S101. SPRINGER, 2013.
    Link to Item
  - Wu, Rebekah R., Tiffany Himmel, Karen Powell, Elizabeth Hauser, Astrid B. Agbaje, Vincent Henrich, Geoffrey S. Ginsburg, and Lori A. Orlando. “USABILITY OF A FAMILY HEALTH HISTORY AND CLINICAL DECISION SUPPORT TOOL FOR PATIENTS AND PRIMARY CARE PROVIDERS.” In Journal of General Internal Medicine, 28:S233–S233. SPRINGER, 2013.
    Link to Item
  - Wu, R. R., T. Himmel, K. Powell, E. Hauser, A. Agbaje, G. Ginsburg, V. Henrich, and L. Orlando. “USABILITYOF A FAMILY HEALTH HISTORY AND CLINICAL DECISION SUPPORT TOOL FOR PATIENTS AND PRIMARY CARE PROVIDERS.” In Journal of Investigative Medicine, 61:523–523. LIPPINCOTT WILLIAMS & WILKINS, 2013.
    Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Academic Positions Outside Duke

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers