Rebekah Ryanne Wu | Scholars@Duke

Rebekah Ryanne Wu
Associate Professor of Medicine

Dr. Wu is an internal medicine physician and health services researcher. Her main research interest is studying the implementation of precision medicine applications to improve clinical care. She is involved in projects currently looking at a patient-facing family history risk assessment tool, MeTree, which provides individualized risk stratification and clinical decision support recommendations to clinicians and patients. In addition she is also involved in a large scale sequencing program in Singapore looking at the intersection of family health history and genomics to better understand how these data elements can complement one another and create more precise risk predictions. She is a member of NHGRI's IGNITE network as a co-investigator on a multi-site pragmatic clinical trial of the impact of pharmacogenetic testing on management of depression and acute, and chronic pain. She is the implementation science advisor for the VA's Pharmacogenomic Testing for Veterans (PHASER) program, which is working to complete preemptive PGx testing on up to 250,000 Veterans by 2024.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, General Internal Medicine, Medicine 2021
Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014

Contact Information

304 Research Drive, Box 90141, Durham, NC 27708
90141, Durham, NC 27710
ryanne.wu@duke.edu (919) 684-5479

Background
Education, Training, & Certifications
- Chief Resident, Internal Medicine, Georgetown University School of Medicine 2009 - 2010
- Resident, Internal Medicine, Georgetown University School of Medicine 2006 - 2009
- M.D., University of North Carolina, Chapel Hill, School of Medicine 2006
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, General Internal Medicine, Medicine 2021
- Assistant Professor of Medicine, Medicine, General Internal Medicine, Medicine 2015 - 2020
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2013 - 2015
Leadership & Clinical Positions at Duke
- Genome Forum Director, Center for Applied Genomics and Precision Medicine, Department of Medicine, 2019 to present.
  
  Department of Medicine Genome Sequencing working group
Academic Positions Outside Duke
- Adjunct Associate Professor, Duke-NUS Medical School. 2018 - 2022
- Assistant Professor of Health Services and Systems Research, Duke-NUS Medical School. 2015 - 2018
Research
Selected Grants
- Building and Deploying a Genomic-Medicine Risk Assessment Model for Diverse Primary Care Populations. awarded by National Institutes of Health 2018 - 2023
- Improving identification and healthcare for patients with Inherited Cancer Syndromes: Evidence-based EMR implementation using a web-based computer platform awarded by Vanderbilt University Medical Center 2019 - 2022
- Implementation, Adoption, and Utility of Family History in Diverse Care Settings awarded by National Institutes of Health 2013 - 2019
External Relationships
- Duke-NUS Medical school
- GlaxoSmithKline
- MeTree&You
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Dong, Olivia M., Megan C. Roberts, R Ryanne Wu, Corrine I. Voils, Nina Sperber, Kara L. Gavin, Jill Bates, et al. “Evaluation of the Veterans Affairs Pharmacogenomic Testing for Veterans (PHASER) clinical program at initial test sites.” Pharmacogenomics 22, no. 17 (November 2021): 1121–33. https://doi.org/10.2217/pgs-2021-0089.
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  - Yoon, Sungwon, Hendra Goh, Si Ming Fung, Shihui Tang, David Matchar, Geoffrey S. Ginsburg, Lori A. Orlando, Joanne Ngeow, and Rebekah Ryanne Wu. “Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients.” J Pers Med 11, no. 10 (October 19, 2021). https://doi.org/10.3390/jpm11101046.
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  - Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Daisuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med 23, no. 10 (October 2021): 2020. https://doi.org/10.1038/s41436-020-01054-0.
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  - Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (July 5, 2021): 109. https://doi.org/10.1186/s13073-021-00916-9.
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  - Ginsburg, Geoffrey S., Larisa H. Cavallari, Hrishikesh Chakraborty, Rhonda M. Cooper-DeHoff, Paul R. Dexter, Michael T. Eadon, Bart S. Ferket, et al. “Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.” Genet Med 23, no. 7 (July 2021): 1185–91. https://doi.org/10.1038/s41436-021-01118-9.
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  - Fung, Si Ming, R Ryanne Wu, Rachel A. Myers, Jasper Goh, Geoffrey S. Ginsburg, David Matchar, Lori A. Orlando, and Joanne Ngeow. “Clinical implementation of an oncology-specific family health history risk assessment tool.” Hered Cancer Clin Pract 19, no. 1 (March 20, 2021): 20. https://doi.org/10.1186/s13053-021-00177-y.
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  - Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Family history assessment significantly enhances delivery of precision medicine in the genomics era.” Genome Med 13, no. 1 (January 7, 2021): 3. https://doi.org/10.1186/s13073-020-00819-1.
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  - Orlando, Lori A., R Ryanne Wu, Rachel A. Myers, Joan Neuner, Catherine McCarty, Irina V. Haller, Melissa Harry, et al. “At the intersection of precision medicine and population health: an implementation-effectiveness study of family health history based systematic risk assessment in primary care.” Bmc Health Serv Res 20, no. 1 (November 7, 2020): 1015. https://doi.org/10.1186/s12913-020-05868-1.
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  - Wu, R Ryanne, Rehena Sultana, Yasmin Bylstra, Saumya Jamuar, Sonia Davila, Weng Khong Lim, Geoffrey S. Ginsburg, et al. “Evaluation of family health history collection methods impact on data and risk assessment outcomes.” Prev Med Rep 18 (June 2020): 101072. https://doi.org/10.1016/j.pmedr.2020.101072.
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  - Bylstra, Y., S. Davila, W. K. Lim, R. Wu, J. X. Teo, S. Kam, T. Lysaght, et al. “Implementation of genomics in medical practice to deliver precision medicine for an Asian population.” Npj Genomic Medicine 4, no. 1 (December 1, 2019). https://doi.org/10.1038/s41525-019-0085-8.
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  - Goldstein, Karen M., Deborah A. Fisher, R Ryanne Wu, Lori A. Orlando, Cynthia J. Coffman, Janet M. Grubber, Tejinder Rakhra-Burris, et al. “An electronic family health history tool to identify and manage patients at increased risk for colorectal cancer: protocol for a randomized controlled trial.” Trials 20, no. 1 (October 7, 2019): 576. https://doi.org/10.1186/s13063-019-3659-y.
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  - Weitzel, Kristin Wiisanen, Benjamin Q. Duong, Meghan J. Arwood, Aniwaa Owusu-Obeng, Noura S. Abul-Husn, Barbara A. Bernhardt, Brian Decker, et al. “A stepwise approach to implementing pharmacogenetic testing in the primary care setting.” Pharmacogenomics 20, no. 15 (October 2019): 1103–12. https://doi.org/10.2217/pgs-2019-0053.
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  - Ginsburg, Geoffrey S., R Ryanne Wu, and Lori A. Orlando. “Family health history: underused for actionable risk assessment.” Lancet 394, no. 10198 (August 17, 2019): 596–603. https://doi.org/10.1016/S0140-6736(19)31275-9.
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  - Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Diasuke Goto, James K. Hicks, Ann M. Holmes, et al. “Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med 21, no. 7 (July 2019): 1670. https://doi.org/10.1038/s41436-018-0280-5.
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  - Levy, Kenneth D., Kathryn Blake, Colette Fletcher-Hoppe, James Franciosi, Daisuke Goto, James K. Hicks, Ann M. Holmes, et al. “Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.” Genet Med 21, no. 3 (March 2019): 743–47. https://doi.org/10.1038/s41436-018-0080-y.
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  - Wu, R Ryanne, Rachel A. Myers, Adam H. Buchanan, David Dimmock, Kimberly G. Fulda, Irina V. Haller, Susanne B. Haga, et al. “Effect of Sociodemographic Factors on Uptake of a Patient-Facing Information Technology Family Health History Risk Assessment Platform.” Appl Clin Inform 10, no. 2 (March 2019): 180–88. https://doi.org/10.1055/s-0039-1679926.
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  - Wu, R Ryanne, Rachel A. Myers, Nina Sperber, Corrine I. Voils, Joan Neuner, Catherine A. McCarty, Irina V. Haller, et al. “Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework.” Genet Med 21, no. 2 (February 2019): 331–38. https://doi.org/10.1038/s41436-018-0049-x.
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  - Orlando, Lori A., Nina R. Sperber, Corrine Voils, Marshall Nichols, Rachel A. Myers, R Ryanne Wu, Tejinder Rakhra-Burris, et al. “Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group.” Genet Med 20, no. 6 (June 2018): 655–63. https://doi.org/10.1038/gim.2017.144.
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  - Sperber, Nina R., Janet S. Carpenter, Larisa H. Cavallari, Laura J Damschroder, Rhonda M. Cooper-DeHoff, Joshua C. Denny, Geoffrey S. Ginsburg, et al. “Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.” Bmc Med Genomics 10, no. 1 (May 22, 2017): 35. https://doi.org/10.1186/s12920-017-0273-2.
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  - Kinsinger, Linda S., Charles Anderson, Jane Kim, Martha Larson, Stephanie H. Chan, Heather A. King, Kathryn L. Rice, et al. “Implementation of Lung Cancer Screening in the Veterans Health Administration.” Jama Internal Medicine 177, no. 3 (March 2017): 399–406. https://doi.org/10.1001/jamainternmed.2016.9022.
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  - Wu, R Ryanne, Rachel A. Myers, Elizabeth R. Hauser, Allison Vorderstrasse, Alex Cho, Geoffrey S. Ginsburg, and Lori A. Orlando. “Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes.” J Genet Couns 26, no. 1 (February 2017): 133–40. https://doi.org/10.1007/s10897-016-9988-z.
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  - Orlando, Lori A., R Ryanne Wu, Rachel A. Myers, Adam H. Buchanan, Vincent C. Henrich, Elizabeth R. Hauser, and Geoffrey S. Ginsburg. “Clinical utility of a Web-enabled risk-assessment and clinical decision support program.” Genet Med 18, no. 10 (October 2016): 1020–28. https://doi.org/10.1038/gim.2015.210.
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  - Weitzel, Kristin Wiisanen, Madeline Alexander, Barbara A. Bernhardt, Neil Calman, David J. Carey, Larisa H. Cavallari, Julie R. Field, et al. “The IGNITE network: a model for genomic medicine implementation and research.” Bmc Med Genomics 9 (January 5, 2016): 1. https://doi.org/10.1186/s12920-015-0162-5.
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  - Wu, R Ryanne, Rachel A. Myers, Catherine A. McCarty, David Dimmock, Michael Farrell, Deanna Cross, Troy D. Chinevere, Geoffrey S. Ginsburg, Lori A. Orlando, and Lori A. Family Health History Network. “Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study.” Implement Sci 10 (November 24, 2015): 163. https://doi.org/10.1186/s13012-015-0352-8.
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  - Wu, R Ryanne, and Lori A. Orlando. “Implementation of health risk assessments with family health history: barriers and benefits.” Postgrad Med J 91, no. 1079 (September 2015): 508–13. https://doi.org/10.1136/postgradmedj-2014-133195.
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  - McVay, Megan A., Christopher Beadles, Ryanne Wu, Janet Grubber, Cynthia J. Coffman, William S. Yancy, Isaac Lipkus Reiner, and Corrine I. Voils. “Effects of provision of type 2 diabetes genetic risk feedback on patient perceptions of diabetes control and diet and physical activity self-efficacy.” Patient Educ Couns, June 30, 2015. https://doi.org/10.1016/j.pec.2015.06.016.
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  - Wu, R Ryanne, Linda S. Kinsinger, Dawn Provenzale, Heather A. King, Patricia Akerly, Lottie K. Barnes, Santanu K. Datta, et al. “Implementation of new clinical programs in the VHA healthcare system: the importance of early collaboration between clinical leadership and research.” J Gen Intern Med 29 Suppl 4 (December 2014): 825–30. https://doi.org/10.1007/s11606-014-3026-3.
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  - Beadles, Chris A., R. Ryanne Wu, Tiffany Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth Hauser, Vincent C. Henrich, Geoffrey S. Ginsburg, and Lori A. Orlando. “Providing patient education: impact on quantity and quality of family health history collection.” Fam Cancer 13, no. 2 (June 2014): 325–32. https://doi.org/10.1007/s10689-014-9701-z.
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  - Orlando, Lori A., R Ryanne Wu, Chris Beadles, Tiffany Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Vincent C. Henrich, and Geoffrey S. Ginsburg. “Implementing family health history risk stratification in primary care: impact of guideline criteria on populations and resource demand.” Am J Med Genet C Semin Med Genet 166C, no. 1 (March 2014): 24–33. https://doi.org/10.1002/ajmg.c.31388.
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  - Wu, R Ryanne, Tiffany L. Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Geoffrey S. Ginsburg, Vincent C. Henrich, and Lori A. Orlando. “Quality of family history collection with use of a patient facing family history assessment tool.” Bmc Fam Pract 15 (February 13, 2014): 31. https://doi.org/10.1186/1471-2296-15-31.
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  - Wu, R. R., T. L. Himmel, A. H. Buchanan, K. P. Powell, E. R. Hauser, G. S. Ginsburg, V. C. Henrich, and L. A. Orlando. “Quality of family history collection with use of a patient facing family history assessment tool.” Bmc Family Practice 15, no. 1 (2014). https://doi.org/10.1186/1471-2296-15-31.
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  - Wu, R Ryanne, Lori A. Orlando, Tiffany L. Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey S. Ginsburg. “Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial.” Bmc Fam Pract 14 (August 6, 2013): 111. https://doi.org/10.1186/1471-2296-14-111.
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  - Sun, J. F., R. R. Wu, C. Norris, A. M. Noone, M. Amankwa-Sakyi, R. Slack, and J. L. Marshall. “Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers.” Gastrointestinal Cancer Research 3, no. 4 (July 1, 2010): 134–40.
  - Ryanne Wu, Rebekah, Peter A. Lindenberg, Rebecca Slack, Anne-Michelle Noone, John L. Marshall, and Aiwu R. He. “Evaluation of hypertension as a marker of bevacizumab efficacy.” J Gastrointest Cancer 40, no. 3–4 (2009): 101–8. https://doi.org/10.1007/s12029-009-9104-9.
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  - Bylstra, Yasmin, Weng Khong Lim, Sylvia Kam, Koei Wan Tham, R Ryanne Wu, Jing Xian Teo, Sonia Davila, et al. “Family History Assessment Significantly Enhances Delivery of Precision Medicine in the Genomics Era,” n.d. https://doi.org/10.1101/2020.01.29.926139.
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- Book Sections
  - Orlando, L. A., and R. R. Wu. “Family Health History and Health Risk Assessment For Cardiovascular Disease in Health Care.” In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition, 1–16, 2018. https://doi.org/10.1016/B978-0-12-801812-5.00016-0.
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  - Orlando, L. A., and R. R. Wu. “Family Health History and Health Risk Assessment in Health Care.” In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition, 189–204, 2017. https://doi.org/10.1016/B978-0-12-800681-8.00013-X.
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- Conference Papers
  - Orlando, Lori A., R. R. Wu, Adam Buchanan, Rachel A. Myers, and Geoffrey S. Ginsburg. “THE INTERSECTION OF POPULATION HEALTH AND PRECISION MEDICINE: EMPLOYING TECHNOLOGY TO OPTIMIZE RISK ASSESSMENT IN PRIMARY CARE.” In Journal of General Internal Medicine, 33:S362–S362. SPRINGER, 2018.
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  - Wu, R. R., Tiffany Himmel, Rachel A. Myers, Elizabeth Hauser, Allison Vorderstrasse, Geoffrey Ginsburg, and Lori A. Orlando. “EFFECT OF FAMILY HISTORY AND GENETIC RISK COUNSELLING FOR TYPE 2 DIABETES ON PERCEPTIONS OF RISK AND CONTROL: SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL.” In Journal of General Internal Medicine, 30:S55–S55. SPRINGER, 2015.
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  - Wu, Rebekah R., Tiffany Himmel, Adam Buchanan, Karen Powell, Elizabeth Hauser, Astrid B. Agbaje, Geoffrey S. Ginsburg, Vincent Henrich, and Lori A. Orlando. “IMPACT OF A FAMILY HISTORY COLLECTION TOOL, METREE (c), IN IDENTIFYING INDIVIDUALS AT HIGH-RISK FOR CANCER AND THROMBOSIS.” In Journal of General Internal Medicine, 28:S101–S101. SPRINGER, 2013.
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  - Wu, Rebekah R., Tiffany Himmel, Karen Powell, Elizabeth Hauser, Astrid B. Agbaje, Vincent Henrich, Geoffrey S. Ginsburg, and Lori A. Orlando. “USABILITY OF A FAMILY HEALTH HISTORY AND CLINICAL DECISION SUPPORT TOOL FOR PATIENTS AND PRIMARY CARE PROVIDERS.” In Journal of General Internal Medicine, 28:S233–S233. SPRINGER, 2013.
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  - Wu, R. R., T. Himmel, K. Powell, E. Hauser, A. Agbaje, G. Ginsburg, V. Henrich, and L. Orlando. “USABILITYOF A FAMILY HEALTH HISTORY AND CLINICAL DECISION SUPPORT TOOL FOR PATIENTS AND PRIMARY CARE PROVIDERS.” In Journal of Investigative Medicine, 61:523–523. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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Teaching & Mentoring
Teaching Activities
- Faculty attending preceptor in VA Internal Medicine Resident Primary Care clinic

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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Teaching Activities