Scholars@Duke
Sarah Angle

Scholarly Works

An Engineered Prodrug Selectively Suppresses β-Lactam-Resistant Bacteria in a Mixed Microbial Setting.

Journal article ACS Infect Dis · July 11, 2025 The rise of β-lactam resistance necessitates new strategies to combat bacterial infections. We purposefully engineered the β-lactam prodrug AcephPT to exploit β-lactamase activity to selectively suppress resistant bacteria producing extended-spectrum-β-lac ... Full text Link to item Cite

Cobalt(III) Schiff Base Complexes as Irreversible Inhibitors of the Metallo-β-Lactamase NDM-1

Preprint · June 21, 2025 Antibiotic resistance is a critical global health concern. Roughly 2.8 million Americans are infected with antibiotic-resistant bacteria each year, leading to over 35,000 deaths. Of particular concern are Enterobacterales that express metallo-β-lac ... Full text Cite

An engineered prodrug selectively suppresses β-lactam resistant bacteria in a mixed microbial setting.

Journal article bioRxiv · August 3, 2024 The rise of β-lactam resistance necessitates new strategies to combat bacterial infections. We purposefully engineered the β-lactam prodrug AcephPT to exploit β-lactamase activity to selectively suppress resistant bacteria producing extended-spectrum-β-lac ... Full text Link to item Cite

Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors.

Journal article Journal of medicinal chemistry · July 2024 Targeting the S1P pathway has resulted in the development of S1P1 receptor modulators for the treatment of multiple sclerosis and ulcerative colitis. We hypothesize that targeting an upstream node of the S1P pathway may provide an improved adverse event pr ... Full text Cite

Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients.

Journal article Clinical and translational science · October 2023 Tacrolimus, the most common immunosuppressant for organ transplant, has a narrow therapeutic range and is metabolized by CYP3A4/5. Trough concentration monitoring and dosing adjustments are used to reach a therapeutic range. CYP3A5 intermediate and normal ... Full text Cite