Samantha Shaltz

Journal Article DNA repair · May 2024 The type IB topoisomerase of budding yeast (yTop1) generates small deletions in tandem repeats through a sequential cleavage mechanism and larger deletions with random endpoints through the nonhomologous end-joining (NHEJ) pathway. Vaccinia virus Top1 (vTo ... Full text Cite

Genetic control of the error-prone repair of a chromosomal double-strand break with 5' overhangs in yeast.

Journal Article Genetics · August 2023 A targeted double-strand break introduced into the genome of Saccharomyces cerevisiae is repaired by the relatively error-prone nonhomologous end joining (NHEJ) pathway when homologous recombination is not an option. A zinc finger nuclease cleavage site wa ... Full text Cite

Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast.

Journal Article DNA Repair (Amst) · June 2023 Transcription in Saccharomyces cerevisiae is associated with elevated mutation and this partially reflects enhanced damage of the corresponding DNA. Spontaneous deamination of cytosine to uracil leads to CG>TA mutations that provide a strand-specific read- ... Full text Open Access Link to item Cite

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Samantha Shaltz

Current Appointments & Affiliations

Recent Publications

Deletions initiated by the vaccinia virus TopIB protein in yeast.

Genetic control of the error-prone repair of a chromosomal double-strand break with 5' overhangs in yeast.

Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast.

Recent Grants

Regulation of mitotic genome stability in yeast.

Temperature-dependent transposon mobilization in Cryptococcus neoformans

Mitotic recombination mechanisms in yeast