Samantha Shaltz

Journal Article Cell · October 2, 2025 Despite the remarkable fidelity of eukaryotic DNA replication, nucleotide misincorporation errors occur in every replication cycle, generating mutations that drive genetic diseases and genome evolution. Here, we show that transcription factor (TF) proteins ... Full text Link to item Cite

Deletions initiated by the vaccinia virus TopIB protein in yeast.

Journal Article DNA repair · May 2024 The type IB topoisomerase of budding yeast (yTop1) generates small deletions in tandem repeats through a sequential cleavage mechanism and larger deletions with random endpoints through the nonhomologous end-joining (NHEJ) pathway. Vaccinia virus Top1 (vTo ... Full text Cite

Genetic control of the error-prone repair of a chromosomal double-strand break with 5' overhangs in yeast.

Journal Article Genetics · August 2023 A targeted double-strand break introduced into the genome of Saccharomyces cerevisiae is repaired by the relatively error-prone nonhomologous end joining (NHEJ) pathway when homologous recombination is not an option. A zinc finger nuclease cleavage site wa ... Full text Cite

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Samantha Shaltz

Current Appointments & Affiliations

Recent Publications

DNA mutagenesis driven by transcription factor competition with mismatch repair.

Deletions initiated by the vaccinia virus TopIB protein in yeast.

Genetic control of the error-prone repair of a chromosomal double-strand break with 5' overhangs in yeast.

Recent Grants

Regulation of mitotic genome stability in yeast.

Temperature-dependent transposon mobilization in Cryptococcus neoformans

Mitotic recombination mechanisms in yeast