Sandip Madhusudan Swain | Scholars@Duke

Sandip Madhusudan Swain
Assistant Professor in Medicine

Dr. Swain is an Assistant Professor of Medicine and a basic research scientist. He has expertise in ion channel biology and is interested in understanding the molecular mechanisms of mechanically activated ion channels in regulating pancreatic and intestinal pathophysiology. Mechanical ion channels regulate critical physiological processes such as cell migration, growth, and tissue repair. However, altered channel activities lead to fibrosis and cancer. His long-term goal is to understand how mechanosensing regulates pancreatic and intestinal function and regeneration and how targeting these channels could be a checkpoint to pancreatic and intestinal fibrosis. Dr. Swain works with Dr. Rodger Liddle on the following areas: (1) mechanisms of mechanically induced acute pancreatitis (2) mechanisms of pancreatic fibrosis (3) gut neuroendocrine cell signaling and (4) pancreatic regeneration and cancer.

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Gastroenterology, Medicine 2022

Contact Information

sandip.swain@duke.edu

Background
Education, Training, & Certifications
- Ph.D., Indian Institute of Technology (India) 2013
Recognition
Awards & Honors
Research
Selected Grants
- Mechanisms of Pancreatic Fibrosis awarded by National Institutes of Health 2020 - 2025
- Metabolic regulation of pancreatitis awarded by National Institutes of Health 2020 - 2024
- Mechanisms of mechanically-induced acute pancreatitis awarded by National Institutes of Health 2019 - 2023
- Mechanosensing in Pancreatic Regeneration and Development awarded by National Pancreas Foundation 2022 - 2023
- IPA - Sandip M Swain awarded by Durham Veterans Affairs Medical Center 2018 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Sahoo, Nirakar, Kefan Yang, Ina Coburger, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, et al. “Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.” Sci Rep 12, no. 1 (August 27, 2022): 14645. https://doi.org/10.1038/s41598-022-18975-2.
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  - Farooq, Ahmad, Liliana Hernandez, Sandip M. Swain, Rafiq A. Shahid, Joelle M-J Romac, Steven R. Vigna, and Rodger A. Liddle. “Initiation and severity of experimental pancreatitis are modified by phosphate.” Am J Physiol Gastrointest Liver Physiol 322, no. 6 (June 1, 2022): G561–70. https://doi.org/10.1152/ajpgi.00022.2022.
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  - Swain, Sandip M., Joelle M-J Romac, Steven R. Vigna, and Rodger A. Liddle. “Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice.” Jci Insight 7, no. 8 (April 22, 2022). https://doi.org/10.1172/jci.insight.158288.
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  - Farooq, Ahmad, Courtney M. Richman, Sandip M. Swain, Rafiq A. Shahid, Steven R. Vigna, and Rodger A. Liddle. “The Role of Phosphate in Alcohol-Induced Experimental Pancreatitis.” Gastroenterology 161, no. 3 (September 2021): 982-995.e2. https://doi.org/10.1053/j.gastro.2021.05.048.
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  - Sokratian, Arpine, Julia Ziaee, Kaela Kelly, Allison Chang, Nicole Bryant, Shijie Wang, Enquan Xu, et al. “Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.” Acta Neuropathol 141, no. 4 (April 2021): 547–64. https://doi.org/10.1007/s00401-021-02288-1.
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  - Swain, Sandip M., and Rodger A. Liddle. “Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.” J Biol Chem 296 (January 2021): 100171. https://doi.org/10.1074/jbc.RA120.015059.
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  - Swain, Sandip M., and Rodger A. Liddle. “Pressure-sensing Piezo1: the eyes have it.” J Physiol 599, no. 2 (January 2021): 365–66. https://doi.org/10.1113/JP281122.
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  - Coburger, Ina, Kefan Yang, Alisa Bernert, Eric Wiesel, Nirakar Sahoo, Sandip M. Swain, Toshinori Hoshi, Roland Schönherr, and Stefan H. Heinemann. “Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels.” Pflugers Arch 472, no. 5 (May 2020): 551–60. https://doi.org/10.1007/s00424-020-02386-1.
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  - Swain, Sandip M., Joelle M-J Romac, Rafiq A. Shahid, Stephen J. Pandol, Wolfgang Liedtke, Steven R. Vigna, and Rodger A. Liddle. “TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.” J Clin Invest 130, no. 5 (May 1, 2020): 2527–41. https://doi.org/10.1172/JCI134111.
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  - Swain, Sandip M., Joelle Romac, Rafiq A. Shahid, Stephen J. Pandol, Steven Vigna, and Rodger A. Liddle. “421 – Pathological Activation of Piezo1 is the Initial Step in Pressure-Induced Pancreatitis.” Gastroenterology 156, no. 6 (May 2019): S-82. https://doi.org/10.1016/s0016-5085(19)36994-x.
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  - Swain, Sandip M., Joelle Romac, Rafiq A. Shahid, Stephen J. Pandol, and Rodger A. Liddle. “318 - The Pressure Sensitive Ion Channel, PIEZO1, Induces Enzyme Activation through Sustained Cytosolic Calcium Elevation in Pancreatic Acinar Cells.” Gastroenterology 154, no. 6 (May 2018): S-79. https://doi.org/10.1016/s0016-5085(18)30713-3.
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  - Romac, Joelle M-J, Rafiq A. Shahid, Sandip M. Swain, Steven R. Vigna, and Rodger A. Liddle. “Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.” Nat Commun 9, no. 1 (April 30, 2018): 1715. https://doi.org/10.1038/s41467-018-04194-9.
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  - Gessner, Guido, Nirakar Sahoo, Sandip M. Swain, Gianna Hirth, Roland Schönherr, Ralf Mede, Matthias Westerhausen, et al. “CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).” Eur J Pharmacol 815 (November 15, 2017): 33–41. https://doi.org/10.1016/j.ejphar.2017.10.006.
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  - Swain, Sandip M., Nirakar Sahoo, Sophie Dennhardt, Roland Schönherr, and Stefan H. Heinemann. “Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels.” Sci Rep 5 (October 21, 2015): 15509. https://doi.org/10.1038/srep15509.
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  - Swain, Sandip Madhusudan, and Amal Kanti Bera. “Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel.” J Mol Neurosci 51, no. 1 (September 2013): 199–207. https://doi.org/10.1007/s12031-013-9991-x.
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  - Swain, Sandip Madhusudan, Sreejit Parameswaran, Giriraj Sahu, Rama Shanker Verma, and Amal Kanti Bera. “Proton-gated ion channels in mouse bone marrow stromal cells.” Stem Cell Res 9, no. 2 (September 2012): 59–68. https://doi.org/10.1016/j.scr.2012.04.005.
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  - Bolshakov, Konstantin, Natalia Dorofeeva, Sandip Swain, Maxim Nikolaev, Natalia Potapjeva, and Amal Kanti Bera. “NO donors subunit and state‐dependently increase desensitization of acid sensitive ion channels.” The Faseb Journal 26, no. S1 (April 2012). https://doi.org/10.1096/fasebj.26.1_supplement.1048.12.
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  - Jetti, Suresh Kumar, Sandip Madhusudan Swain, Syamantak Majumder, Suvro Chatterjee, V. Poornima, and Amal Kanti Bera. “Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.” Nitric Oxide 22, no. 3 (April 1, 2010): 213–19. https://doi.org/10.1016/j.niox.2009.12.006.
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  - Swain, S. M., C. Singh, and V. Arul. “Inhibitory activity of probiotics Streptococcus phocae PI80 and Enterococcus faecium MC13 against Vibriosis in shrimp Penaeus monodon.” World Journal of Microbiology and Biotechnology 25, no. 4 (April 1, 2009): 697–703. https://doi.org/10.1007/s11274-008-9939-4.
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- Conference Papers
  - Farooq, Ahmad, Liliana C. Hernandez, Sandip M. Swain, Joelle Romac, Steven Vigna, and Rodger A. Liddle. “INITIATION AND SEVERITY OF EXPERIMENTAL PANCREATITIS ARE MODIFIED BY PHOSPHATE.” In Gastroenterology, 162:S910–11, 2022.
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Education, Training, & Certifications

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Conference Papers