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Sandip Madhusudan Swain

Assistant Professor in Medicine
Medicine, Gastroenterology

Overview


Dr. Swain is an Assistant Professor of Medicine and a basic research scientist. He has expertise in ion channel biology and is interested in understanding the molecular mechanisms of mechanically activated ion channels in regulating pancreatic and intestinal pathophysiology. Mechanical ion channels regulate critical physiological processes such as cell migration, growth, and tissue repair. However, altered channel activities lead to fibrosis and cancer. His long-term goal is to understand how mechanosensing regulates pancreatic and intestinal function and regeneration and how targeting these channels could be a checkpoint to pancreatic and intestinal fibrosis. Dr. Swain works with Dr. Rodger Liddle on the following areas: (1) mechanisms of mechanically induced acute pancreatitis (2) mechanisms of pancreatic fibrosis (3) gut neuroendocrine cell signaling and (4) pancreatic regeneration and cancer.

Current Appointments & Affiliations


Assistant Professor in Medicine · 2022 - Present Medicine, Gastroenterology, Medicine

Recent Publications


Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels.

Journal Article J Cell Sci · April 15, 2025 Pancreatic stellate cells (PSCs) are primarily responsible for producing the stiff tumor tissue in pancreatic ductal adenocarcinoma (PDAC). Thereby, PSCs generate a stiffness gradient between the healthy pancreas and the tumor. This gradient induces durota ... Full text Link to item Cite

LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt.

Journal Article Theranostics · 2025 Rationale: Acute pancreatitis (AP) is a common gastrointestinal disease affecting nearly 3 million people annually worldwide. Although AP is typically self-limiting, up to 20% of patients may develop life-threatening complications. Individuals who suffer f ... Full text Link to item Cite
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Recent Grants


Mechanisms of mechanically-induced acute pancreatitis

ResearchResearch Associate · Awarded by National Institutes of Health · 2019 - 2025

Mechanisms of Pancreatic Fibrosis

ResearchResearch Scientist · Awarded by National Institutes of Health · 2020 - 2025

Metabolic regulation of pancreatitis

ResearchResearch Associate · Awarded by National Institutes of Health · 2020 - 2025

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Education, Training & Certifications


Indian Institute of Technology, Madras (India) · 2013 Ph.D.