Scholars@Duke
Bryony Hawgood

Selected Publications

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer.

Journal Article bioRxiv · November 15, 2024 Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively1,2. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets ... Full text Link to item Cite

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.

Journal Article Cancer Cell · June 10, 2024 The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse m ... Full text Link to item Cite