Bryony Hawgood

Journal article Cancer Res · June 18, 2026 Lung squamous cell carcinoma (LUSC) is a basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, further work is needed to elucidate the broader landscape of in ... Full text Link to item Cite

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer.

Journal article Nature · November 2025 Neuroendocrine and tuft cells are rare chemosensory epithelial lineages defined by the expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets ... Full text Link to item Cite

KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer.

Preprint · March 13, 2025 Lung squamous cell carcinoma (LUSC) is basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, the broader landscape of intra-tumoral heterogeneity within LUSC ... Full text Link to item Cite

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer.

Journal article bioRxiv · November 15, 2024 Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively1,2. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets ... Full text Link to item Cite

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.

Journal article Cancer Cell · June 10, 2024 The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse m ... Full text Open Access Link to item Cite