Satish K. Chitneni | Scholars@Duke

Satish K. Chitneni
Assistant Professor of Radiology

The major focus of my research is on the design, development and evaluation of novel radiotracers based on small molecules for imaging of specific molecular targets by positron emission tomography (PET). The imaging targets are usually enzymes, cell surface receptors or transporters that are strongly implicated in or markers of diseases. Fluorine-18, which has a half-life of about 110 min, is ideally suited for radiolabeling of small molecules, and permits PET imaging studies for up to 4 h after injection in vivo. Other radioisotopes of interest for PET radiotracer development include carbon-11 and iodine-124, the latter one has a longer half-life (4.2 days) and enables imaging at late time points. Another major area of interest is the use of PET imaging in conjunction with suitable radiotracers for evaluation of novel therapeutics in preclinical studies.

Utilizing the wealth of information available from the cancer genome sequencing studies and The Cancer Genome Atlas (TCGA) studies, efforts are underway to develop radiolabeled probes for PET imaging of isocitrate dehydrogenase 1 (IDH1) mutations, which are present in the vast majority of patients with lower-grade gliomas and secondary higher-grade gliomas. Successful development of imaging methods for mutant IDH1 and other important genetic alterations in gliomas can help in molecular and genetic classification of gliomas noninvasively and in developing novel therapeutics.

Current Appointments & Affiliations

Assistant Professor of Radiology, Radiology, Clinical Science Departments 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Faculty Network Member of Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2017

Contact Information

311 Research Drive, 161-I Bryan Research Building, Durham, NC 27710
Box 3949 Med Ctr, Durham, NC 27710
satish.chitneni@duke.edu (919) 684-7809

Background
Education, Training, & Certifications
- Ph.D., Katholieke Universiteit Leuven (Belgium) 2007
Expertise
Subject Headings
Research
Selected Grants
- EGFRvIII-targeted Bispecific T cell Engagers for brain tumors awarded by National Institutes of Health 2013 - 2019
- Novel Approach to Quantify Nicotinic Receptor Upregulation in Smokers awarded by National Institutes of Health 2014 - 2017
- Imaging IDH1 Mutations in Glioma and Other Malignancies awarded by National Institutes of Health 2014 - 2016
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Chitneni, S, Reitman, Z, Yan, H, and Zalutsky, M. "Radioiodinated AGI-5198 for in vivo imaging of isocitrate dehydrogenase 1 (IDH1) mutation in gliomas." May 2014. Link to Item
  - Celen, S, Koole, M, De Angelis, M, Sannen, I, Chitneni, SK, Alcazar, J, Dedeurwaerdere, S, Moechars, D, Schmidt, M, Verbruggen, A, Xavier, L, Van Laere, K, Ignacio Andres, J, and Bormans, G. "[18F]JNJ41510417 a potential PET radioligand for imaging phosphodiesterase-10A in the brain." August 2010. Full Text Link to Item
  - Chitneni, SK, Balzarini, J, Verbruggen, A, and Bormans, G. "Synthesis and biological evaluation of C-11-labeled acyclic- and furo[2,3-d] pyrimidine derivative of bicyclic nucleoside analogs (BCNAs) for structure-brain uptake relationship study of BCNA tracers." October 2007. Link to Item
  - Chitneni, SK, Govaerts, C, Adams, E, Van Schepdael, A, and Hoogmartens, J. "Identification of impurities in erythromycin by liquid chromatography-mass spectrometric detection." November 12, 2004. Full Text Link to Item
- Journal Articles
  - Zhou, Z, Chitneni, SK, Devoogdt, N, Zalutsky, MR, and Vaidyanathan, G. "Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. (Accepted)" Bioorganic & medicinal chemistry 26, no. 8 (May 2018): 1939-1949. Full Text
  - Chitneni, SK, Reitman, ZJ, Spicehandler, R, Gooden, DM, Yan, H, and Zalutsky, MR. "Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors." Bioorganic & medicinal chemistry letters 28, no. 4 (February 2018): 694-699. Full Text
  - Chitneni, SK, Reitman, ZJ, Gooden, DM, Yan, H, and Zalutsky, MR. "Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs." European journal of medicinal chemistry 119 (August 2016): 218-230. Full Text Open Access Copy
  - Chitneni, SK. "IDH1 Mutations in Glioma: Considerations for Radiotracer Development." SM radiology journal 2, no. 1 (January 2016). Open Access Copy
  - Chitneni, SK, Bida, GT, Zalutsky, MR, and Dewhirst, MW. "Reply: Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding." Journal of nuclear medicine : official publication, Society of Nuclear Medicine 56, no. 4 (April 2015): 653-654. (Letter) Full Text
  - Pruszynski, M, Koumarianou, E, Vaidyanathan, G, Chitneni, S, and Zalutsky, MR. "D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination." Nuclear medicine and biology 42, no. 1 (January 2015): 19-27. Full Text Open Access Copy
  - Safi, R, Nelson, ER, Chitneni, SK, Franz, KJ, George, DJ, Zalutsky, MR, and McDonnell, DP. "Copper signaling axis as a target for prostate cancer therapeutics." Cancer research 74, no. 20 (October 2014): 5819-5831. Full Text Open Access Copy
  - Chitneni, SK, Bida, GT, Zalutsky, MR, and Dewhirst, MW. "Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models." Journal of nuclear medicine : official publication, Society of Nuclear Medicine 55, no. 7 (July 2014): 1192-1197. Full Text
  - Akurathi, V, Dubois, L, Celen, S, Lieuwes, NG, Chitneni, SK, Cleynhens, BJ, Innocenti, A, Supuran, CT, Verbruggen, AM, Lambin, P, and Bormans, GM. "Development and biological evaluation of ⁹⁹mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers." Eur J Med Chem 71 (January 2014): 374-384. Full Text Link to Item
  - Chitneni, SK, Bida, GT, Yuan, H, Palmer, GM, Hay, MP, Melcher, T, Wilson, WR, Zalutsky, MR, and Dewhirst, MW. "18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model." J Nucl Med 54, no. 8 (August 2013): 1339-1346. Full Text Link to Item
  - Deroose, CM, Chitneni, SK, Gijsbers, R, Vermaelen, P, Ibrahimi, A, Balzarini, J, Baekelandt, V, Verbruggen, A, Nuyts, J, Debyser, Z, Bormans, GM, and Mortelmans, L. "Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET." Nucl Med Biol 39, no. 8 (November 2012): 1266-1274. Full Text Link to Item
  - Chitneni, SK, Bida, GT, Dewhirst, MW, and Zalutsky, MR. "A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5)." Nucl Med Biol 39, no. 7 (October 2012): 1012-1018. Full Text Link to Item
  - Chitneni, SK, Bida, GT, Hay, MP, Zalutsky, MR, Melcher, T, Wilson, WR, and Dewhirst, MW. "Abstract 5306: 18 F-EF5 microPET imaging of treatment response from a novel, hypoxia-selective cytotoxin SN30000 in a human lung cancer xenograft model." Cancer Research 71, no. 8 Supplement (April 15, 2011): 5306-5306. Full Text
  - Chitneni, SK, Palmer, GM, Zalutsky, MR, and Dewhirst, MW. "Molecular imaging of hypoxia." J Nucl Med 52, no. 2 (February 2011): 165-168. (Review) Full Text Link to Item
  - Celen, S, Koole, M, De Angelis, M, Sannen, I, Chitneni, SK, Alcazar, J, Dedeurwaerdere, S, Moechars, D, Schmidt, M, Verbruggen, A, Langlois, X, Van Laere, K, Andrés, JI, and Bormans, G. "Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain." J Nucl Med 51, no. 10 (October 2010): 1584-1591. Full Text Link to Item
  - Akurathi, V, Dubois, L, Lieuwes, NG, Chitneni, SK, Cleynhens, BJ, Vullo, D, Supuran, CT, Verbruggen, AM, Lambin, P, and Bormans, GM. "Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia." Nucl Med Biol 37, no. 5 (July 2010): 557-564. Full Text Link to Item
  - Akurathi, V, Dubois, L, Lieuwes, NG, Chitneni, SK, Cleynhens, BJ, Verbruggen, AM, Lambin, P, and Bormans, G. "Synthesis and Biological Evaluation of 99mTc-Labelled Aminoethylbenzenesulfonamide Conjugate for In vivo Visualisation of Carbonic Anhydrase IX (CAIX) Expression in Tumor Hypoxia." EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 36 (September 2009): S309-S309. Link to Item
  - Celen, S, De Angelis, M, Chitneni, SK, Alcazar, J, Koole, M, Dedeurwaerdere, S, Steckler, T, Schmidt, M, Van Laere, K, Verbruggen, A, Langlois, X, Andres, JI, and Bormans, G. "Synthesis and preliminary biological evaluation of [F-18]JNJ41510417as a radioligand for positron emission tomography imaging of phosphodiesterase-10A in the brain." EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 36 (September 2009): S236-S236. Link to Item
  - Akurathi, V, Chitneni, S, Cleynhens, B, Verbruggen, A, and Bormans, G. "DEVELOPMENT AND PRELIMINARY EVALUATION OF A 11C LABELED SULFONAMIDE DERIVATES AS POTENTIAL PET TRACER FOR BLOOD POOL IMAGING." JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 52 (2009): S341-S341. Link to Item
  - Akurathi, V, Dubois, L, Lieuwes, N, Chitneni, SK, Cleynhens, B, Verbruggen, A, Lambin, P, and Bormans, G. "SYNTHESIS AND BIOLOGICAL EVALUATION OF A NEGATIVELY CHARGED 99mTc-LABELLED AMINOETHYLBENZENE SULFONAMIDE CONJUGATE FOR IN VIVO VISUALISATION OF CARBONIC ANHYDRASE IX (CA IX) EXPRESSION AS A SURROGATE MARKER OF TUMOR HYPOXIA." JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 52 (2009): S135-S135. Link to Item
  - Chitneni, SK, Serdons, K, Evens, N, Fonge, H, Celen, S, Deroose, CM, Debyser, Z, Mortelmans, L, Verbruggen, AM, and Bormans, GM. "Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction." J Chromatogr A 1189, no. 1-2 (May 2, 2008): 323-331. Full Text Link to Item
  - Celen, S, Deroose, C, de Groot, T, Chitneni, SK, Gijsbers, R, Debyser, Z, Mortelmans, L, Verbruggen, A, and Bormans, G. "Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography." Bioconjug Chem 19, no. 2 (February 2008): 441-449. Full Text Link to Item
  - Chitneni, SK, Balzarini, J, Celen, S, Dyubankova, N, Verbruggen, AM, and Bormans, GM. "Synthesis and biological evaluation of carbon-11-labeled acyclic and furo[2,3-d]pyrimidine derivatives of bicyclic nucleoside analogues (BCNAs) for structure-brain uptake relationship study of BCNA tracers." Journal of Labelled Compounds and Radiopharmaceuticals 51, no. 3 (2008): 159-166. Full Text
  - Chitneni, SK, Garreau, L, Cleynhens, B, Evens, N, Bex, M, Vermaelen, P, Chalon, S, Busson, R, Guilloteau, D, Van Laere, K, Verbruggen, A, and Bormans, G. "Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT." Nucl Med Biol 35, no. 1 (January 2008): 75-82. Full Text Link to Item
  - Chitneni, SK, Deroose, CM, Balzarini, J, Gijsbers, R, Celen, S, Debyser, Z, Mortelmans, L, Verbruggen, AM, and Bormans, GM. "A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression." J Med Chem 50, no. 26 (December 27, 2007): 6627-6637. Full Text Link to Item
  - Fonge, H, Chitneni, SK, Lixin, J, Vunckx, K, Prinsen, K, Nuyts, J, Mortelmans, L, Bormans, G, Ni, Y, and Verbruggen, A. "Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis." Bioconjug Chem 18, no. 6 (November 2007): 1924-1934. Full Text Link to Item
  - Chitneni, SK, Deroose, CM, Fonge, H, Gijsbers, R, Dyubankova, N, Balzarini, J, Debyser, Z, Mortelmans, L, Verbruggen, AM, and Bormans, GM. "Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging." Bioorg Med Chem Lett 17, no. 12 (June 15, 2007): 3458-3462. Full Text Link to Item
  - Toelen, J, Deroose, CM, Gijsbers, R, Reumers, V, Sbragia, LN, Vets, S, Chitneni, SK, Bormans, G, Mortelmans, L, Deprest, JA, and Debyser, Z. "Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model." Am J Obstet Gynecol 196, no. 4 (April 2007): 352.e1-352.e6. Full Text Link to Item
  - Chitneni, SK, Deroose, CM, Balzarini, J, Gijsbers, R, Celen, SJL, de Groot, TJ, Debyser, Z, Mortelmans, L, Verbruggen, AM, and Bormans, GM. "Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography." J Med Chem 50, no. 5 (March 8, 2007): 1041-1049. Full Text Link to Item
  - Chitneni, SK, Ruymaeker, TD, Balzarini, J, Verbruggen, AM, and Bormans, GM. "Synthesis and biological evaluation of a lipophilic, fluorine-18-labeled 5-ethynyl-2′-deoxyuridine derivative." Journal of Labelled Compounds and Radiopharmaceuticals 50, no. 7 (2007): 649-655. Full Text
  - Chitneni, S, Deroose, C, Balzarini, J, Verbruggen, A, and Bormans, G. "Synthesis and preliminary evaluation of F-18 and C-11 labeled bi-cyclic nucleoside analogues (BCNAs) as potential PET reporter probes for imaging varicella-zoster virus thymidine kinase (VZV-tk) gene expression." EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 33 (September 2006): S175-S175. Link to Item
  - Chitneni, S, Cleynhens, B, de Groot, T, Verbruggen, A, and Bormans, G. "A New Precursor for a High Yield Synthesis of[F-18]FHBG." EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 32 (September 2005): S268-S269. Link to Item

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Education, Training, & Certifications

Subject Headings

Selected Grants

Selected Publications

Conference Papers

Journal Articles