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William Schuyler Jones

Professor of Medicine
Medicine, Cardiology
Duke Box 3330, Durham, NC 27710
2400 Pratt Street, 7037, Durham, NC 27705

Overview


I am an interventional cardiologist with a specific focus on the diagnosis and treatment of patients with cardiovascular disease. As a clinician, I see patients in the office and do coronary and peripheral vascular procedures (angiography and interventions) in the Duke Cardiac Catheterization Laboratory. I have served as the Medical Director of the cath lab at Duke since 2016. Alongside my partners in the cath lab, we collaborate with our cardiothoracic surgeons to hold Heart Team meetings each week, and we frequently are asked to address complex cardiovascular issues as a multidisciplinary team.

I also have a broad background in cardiovascular site-based research, multicenter clinical trials, clinical event classification, and observational analyses. I have helped to lead clinical trial efforts at the Duke Clinical Research Institute (DCRI) by designing and conducting studies evaluating new and existing treatments for patients with coronary artery disease and peripheral artery disease. My specific research interests include examining access to care and disparities in care for patients with peripheral artery disease and the design and conduct of pragmatic clinical trials in cardiovascular disease.

Current Appointments & Affiliations


Professor of Medicine · 2024 - Present Medicine, Cardiology, Medicine
Professor in Population Health Sciences · 2024 - Present Population Health Sciences, Basic Science Departments
Member in the Duke Clinical Research Institute · 2013 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


Associations of common antipsychotic medications with weight gain in youth and adults: a target trial emulation study.

Journal Article J Psychiatr Res · May 2026 BACKGROUND: Few real-world studies have estimated differences in weight gain between antipsychotic medications. This study estimated effects of initiating 4 first-line antipsychotic medications on weight change in adults and children/adolescents. METHODS: ... Full text Link to item Cite

Secondary prevention strategies for patients with lower extremity peripheral artery disease after successful peripheral vascular intervention.

Journal Article Am Heart J · April 30, 2026 BACKGROUND: Individuals with lower extremity peripheral artery disease (LE PAD) represent a subset of patients with atherosclerotic cardiovascular disease that are among the highest risk for major adverse cardiovascular and limb events. Despite this, LE PA ... Full text Link to item Cite

2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal Article J Am Coll Cardiol · April 7, 2026 AIM: The "2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults" is a de novo guideline that provides comprehensive recommendations for the evaluation, management, and follow-up ... Full text Link to item Cite
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Recent Grants


1/3 CTSA UM1 at Duke University

ResearchFaculty Member · Awarded by National Institutes of Health · 2025 - 2032

1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2030

View All Grants

Education


University of Arkansas, Little Rock · 2001 M.D.