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William Schuyler Jones

Professor of Medicine
Medicine, Cardiology
Duke Box 3330, Durham, NC 27710
2400 Pratt Street, 7037, Durham, NC 27705

Overview


I am an interventional cardiologist with a specific focus on the diagnosis and treatment of patients with cardiovascular disease. As a clinician, I see patients in the office and do coronary and peripheral vascular procedures (angiography and interventions) in the Duke Cardiac Catheterization Laboratory. I have served as the Medical Director of the cath lab at Duke since 2016. Alongside my partners in the cath lab, we collaborate with our cardiothoracic surgeons to hold Heart Team meetings each week, and we frequently are asked to address complex cardiovascular issues as a multidisciplinary team.

I also have a broad background in cardiovascular site-based research, multicenter clinical trials, clinical event classification, and observational analyses. I have helped to lead clinical trial efforts at the Duke Clinical Research Institute (DCRI) by designing and conducting studies evaluating new and existing treatments for patients with coronary artery disease and peripheral artery disease. My specific research interests include examining access to care and disparities in care for patients with peripheral artery disease and the design and conduct of pragmatic clinical trials in cardiovascular disease.

Current Appointments & Affiliations


Professor of Medicine · 2024 - Present Medicine, Cardiology, Medicine
Professor in Population Health Sciences · 2024 - Present Population Health Sciences, Basic Science Departments
Member in the Duke Clinical Research Institute · 2013 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


Investigating the Use of the Fast Health Care Interoperability Resources (FHIR) Standard to Support Data Activities Across the PCORnet® Infrastructure: Lessons Learned From the FHIR Pilots of the Coordinating Center for PCORnet®.

Journal Article Med Care · February 1, 2026 BACKGROUND: Institutions that participate in PCORnet® transform their local electronic health record (EHR) data into the PCORnet® Common Data Model (CDM), which is then used to generate data extracts for PCORnet® Studies. PCORnet® Studies can also include ... Full text Link to item Cite

Dual versus monotherapy with SGLT2 inhibitor and GLP-1 receptor agonist: PRECIDENTD pragmatic randomized trial.

Journal Article Am Heart J · December 26, 2025 BACKGROUND: Dual therapy with sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) is frequently recommended. We compared rates of medication initiation and discontinuation between participants assigne ... Full text Link to item Cite

Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE.

Journal Article J Am Heart Assoc · December 2, 2025 BACKGROUND: Guidelines recommend aspirin (75-100 mg daily) for the secondary prevention of atherosclerotic cardiovascular disease (ASCVD). However, it is unknown if people with a history of ASCVD and chronic obstructive pulmonary disease (COPD) or asthma, ... Full text Link to item Cite
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Recent Grants


1/3 CTSA UM1 at Duke University

ResearchFaculty Member · Awarded by National Institutes of Health · 2025 - 2032

1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2030

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Education, Training & Certifications


University of Arkansas, Little Rock · 2001 M.D.