Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1994
  • M.D., Columbia University 1987
• 

  Duke Appointment History

  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1987 - 2014
  • Associate Professor of Surgery, Surgical Oncology, Surgery 2008 - 2013
  • Associate Professor of Surgery, Surgery, Clinical Science Departments 2005 - 2008
  • Assistant Professor of Surgery, Surgery, Clinical Science Departments 1997 - 2005
  • Instructor, Temporary in the Department of Surgery, Surgery, Clinical Science Departments 1997
• Research
• 

  Selected Grants

  • Large Scale Antibody and TCell Epitope Discovery awarded by National Institutes of Health 2004 - 2011
  • Novel Strategies to Broaden the Impact of HIFU Therapy in Cancer Management awarded by National Institutes of Health 2008 - 2011
  • IPA - Jens Dannull awarded by Veterans Administration Medical Center 2008 - 2010
  • Immune Response to Breast Ductal Carcinoma In Situ awarded by National Institutes of Health 1992 - 2000
  • Modulation Of Hyperacute Xenograft Rejection awarded by National Institutes of Health 1993 - 1999
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Marabelle, Aurelien, Dung T. Le, Paolo A. Ascierto, Anna Maria Di Giacomo, Ana De Jesus-Acosta, Jean-Pierre Delord, Ravit Geva, et al. “Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.” J Clin Oncol 38, no. 1 (January 1, 2020): 1–10. https://doi.org/10.1200/JCO.19.02105.
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    • Chung, Hyun Cheol, Willeke Ros, Jean-Pierre Delord, Ruth Perets, Antoine Italiano, Ronnie Shapira-Frommer, Lyudmila Manzuk, et al. “Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study.” J Clin Oncol 37, no. 17 (June 10, 2019): 1470–78. https://doi.org/10.1200/JCO.18.01265.
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    • Steiniche, T., M. Ladekarl, J. Bæhr Georgsen, S. Andreasen, M. Busch-Sørensen, W. Zhou, S. K. Pruitt, A. K. Joe, and K. L. Liaw. “Association of PD-L1 expression with prognosis among patients with 10 select cancers.” Annals of Oncology : Official Journal of the European Society for Medical Oncology 29 (October 1, 2018): viii15. https://doi.org/10.1093/annonc/mdy269.051.
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    • Singh, U., Y. Cui, N. Dimaano, S. Mehta, S. K. Pruitt, J. Yearley, O. F. Laterza, J. W. Juco, and B. Dogdas. “Analytical validation of quantitative immunohistochemical assays of tumor infiltrating lymphocyte biomarkers.” Biotech Histochem 93, no. 6 (2018): 411–23. https://doi.org/10.1080/10520295.2018.1445290.
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    • Wang, Hanghang, Karissa Heck, Scott K. Pruitt, Terence Z. Wong, Randall P. Scheri, Gregory S. Georgiade, Ikwunze Ichite, and E Shelley Hwang. “Impact of delayed lymphoscintigraphy for sentinel lymphnode biopsy for breast cancer.” J Surg Oncol 111, no. 8 (June 2015): 931–34. https://doi.org/10.1002/jso.23915.
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    • Dannull, Jens, Chunrui Tan, Christine Farrell, Cynthia Wang, Scott Pruitt, Smita K. Nair, and Walter T. Lee. “Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy.” J Immunol Res 2015 (2015): 789136. https://doi.org/10.1155/2015/789136.
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    • Phua, Kyle K. L., David Boczkowski, Jens Dannull, Scott Pruitt, Kam W. Leong, and Smita K. Nair. “Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.” Advanced Healthcare Materials 3, no. 6 (June 2014): 837–42. https://doi.org/10.1002/adhm.201300512.
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    • Nair, Smita K., Georgia D. Tomaras, Ana Paula Sales, David Boczkowski, Cliburn Chan, Kelly Plonk, Yongting Cai, et al. “High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.” Scientific Reports 4 (April 23, 2014): 4632. https://doi.org/10.1038/srep04632.
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    • Tan, Chunrui, Jens Dannull, Smita K. Nair, Enyu Ding, Douglas S. Tyler, Scott K. Pruitt, and Walter T. Lee. “Local secretion of IL-12 augments the therapeutic impact of dendritic cell-tumor cell fusion vaccination.” J Surg Res 185, no. 2 (December 2013): 904–11. https://doi.org/10.1016/j.jss.2013.06.045.
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    • Dannull, Jens, N Rebecca Haley, Gary Archer, Smita Nair, David Boczkowski, Mark Harper, Nicole De Rosa, et al. “Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.” J Clin Invest 123, no. 7 (July 2013): 3135–45. https://doi.org/10.1172/JCI67544.
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    • Tan, Chunrui, Varun Reddy, Jens Dannull, Enyu Ding, Smita K. Nair, Douglas S. Tyler, Scott K. Pruitt, and Walter T. Lee. “Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model.” J Transl Med 11 (June 17, 2013): 148. https://doi.org/10.1186/1479-5876-11-148.
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    • Coit, Daniel G., Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson, Adil Daud, Dominick Dimaio, et al. “Melanoma, version 2.2013: featured updates to the NCCN guidelines.” J Natl Compr Canc Netw 11, no. 4 (April 1, 2013): 395–407. https://doi.org/10.6004/jnccn.2013.0055.
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    • Lyman, Gary H., Jay Baker, Joseph Geradts, Janet Horton, Gretchen Kimmick, Jeffrey Peppercorn, Scott Pruitt, Randall P. Scheri, and E Shelley Hwang. “Multidisciplinary care of patients with early-stage breast cancer.” Surgical Oncology Clinics of North America 22, no. 2 (April 2013): 299–317. https://doi.org/10.1016/j.soc.2012.12.005.
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    • Shetty, Gina, Georgia M. Beasley, Sara Sparks, Michael Barfield, Melanie Masoud, Paul J. Mosca, Scott K. Pruitt, et al. “Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion.” Ann Surg Oncol 20, no. 4 (April 2013): 1128–35. https://doi.org/10.1245/s10434-012-2785-5.
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    • Salama, April K. S., Nicole de Rosa, Randall P. Scheri, Scott K. Pruitt, James E. Herndon, Jennifer Marcello, Douglas S. Tyler, and Amy P. Abernethy. “Hazard-rate analysis and patterns of recurrence in early stage melanoma: moving towards a rationally designed surveillance strategy.” Plos One 8, no. 3 (2013): e57665. https://doi.org/10.1371/journal.pone.0057665.
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    • Salama, April K. S., Nicole de Rosa, Randall P. Scheri, James E. Herndon, Douglas S. Tyler, Jennifer Marcello, Scott K. Pruitt, and Amy P. Abernethy. “The effect of metastatic site and decade of diagnosis on the individual burden of metastatic melanoma: contemporary estimates of average years of life lost.” Cancer Invest 30, no. 9 (November 2012): 637–41. https://doi.org/10.3109/07357907.2012.726387.
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    • Dannull, Jens, N Rebecca Haley, Gary Archer, Smita Nair, Nicole De Rosa, Maria Selim, Douglas S. Tyler, John Sampson, and Scott K. Pruitt. “Abstract 5373: Altering the composition of the proteasome of melanoma antigen RNA-transfected dendritic cells enhances vaccination-induced anti-melanoma immunity: results of a Phase I trial.” Immunology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-5373.
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    • Tan, Chunrui, Varun Reddy, Enyu Ding, Jens Dannull, Smita Nair, Scott K. Pruitt, and Walter T. Lee. “Abstract 4389: Impact of regulatory T cell depletion on dendritic cell-tumor fusion vaccine immunotherapy.” Immunology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-4389.
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    • Dannull, Jens, Tristan Schneider, Walter T. Lee, Nicole de Rosa, Douglas S. Tyler, and Scott K. Pruitt. “Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function.” Blood 119, no. 13 (March 29, 2012): 3113–22. https://doi.org/10.1182/blood-2011-10-385930.
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    • Coit, Daniel G., Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson, Adil Daud, Raza A. Dilawari, et al. “Melanoma.” J Natl Compr Canc Netw 10, no. 3 (March 2012): 366–400. https://doi.org/10.6004/jnccn.2012.0036.
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    • Pruitt, Scott K., David Boczkowski, Nicole de Rosa, N Rebecca Haley, Michael A. Morse, Douglas S. Tyler, Jens Dannull, and Smita Nair. “Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.” Eur J Immunol 41, no. 12 (December 2011): 3553–63. https://doi.org/10.1002/eji.201141383.
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    • Pruitt, S. K., D. Boczkowski, N. de Rosa, N. R. Haley, M. A. Morse, D. S. Tyler, J. Dannull, and S. Nair. “Enhancement of Anti-Tumor Immunity Through Local Modulation of CTLA-4 and GITR by Dendritic Cells.” Eur J Immunol, September 9, 2011. https://doi.org/10.1002/eji.201041383.
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    • Rosa, Nicole de, Gary H. Lyman, Damian Silbermins, Matias E. Valsecchi, Scott K. Pruitt, Douglas M. Tyler, and Walter T. Lee. “Sentinel node biopsy for head and neck melanoma: a systematic review.” Otolaryngol Head Neck Surg 145, no. 3 (September 2011): 375–82. https://doi.org/10.1177/0194599811408554.
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    • Raymond, Amanda K., Georgia M. Beasley, Gloria Broadwater, Christina K. Augustine, James C. Padussis, Ryan Turley, Bercedis Peterson, Hilliard Seigler, Scott K. Pruitt, and Douglas S. Tyler. “Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution.” J Am Coll Surg 213, no. 2 (August 2011): 306–16. https://doi.org/10.1016/j.jamcollsurg.2011.03.013.
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    • Toshimitsu, Hiroaki, Yasunori Yoshimoto, Christina K. Augustine, James C. Padussis, Jin S. Yoo, M. Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.” Ann Surg Oncol 17, no. 8 (August 2010): 2247–54. https://doi.org/10.1245/s10434-010-0971-x.
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    • Augustine, Christina K., Hiroaki Toshimitsu, Sin-Ho Jung, Patricia A. Zipfel, Jin S. Yoo, Yasunori Yoshimoto, M Angelica Selim, et al. “Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.” Mol Cancer Ther 9, no. 7 (July 2010): 2090–2101. https://doi.org/10.1158/1535-7163.MCT-10-0073.
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    • Boczkowski, D., J. Lee, S. Pruitt, and S. Nair. “Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.” Cancer Gene Therapy 16, no. 12 (December 2009): 900–911. https://doi.org/10.1038/cgt.2009.39.
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    • Aldrink, Jennifer H., M Angelica Selim, Diana L. Diesen, Jeffrey Johnson, Scott K. Pruitt, Douglas S. Tyler, and Hilliard F. Seigler. “Pediatric melanoma: a single-institution experience of 150 patients.” J Pediatr Surg 44, no. 8 (August 2009): 1514–21. https://doi.org/10.1016/j.jpedsurg.2008.12.003.
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    • Beasley, Georgia M., Abigail Caudle, Rebecca P. Petersen, Nicole S. McMahon, James Padussis, Paul J. Mosca, Jonathan S. Zager, et al. “A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.” J Am Coll Surg 208, no. 5 (May 2009): 706–15. https://doi.org/10.1016/j.jamcollsurg.2008.12.019.
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    • Coit, Daniel G., Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick Dimaio, Valerie Guild, Allan C. Halpern, et al. “Melanoma.” J Natl Compr Canc Netw 7, no. 3 (March 2009): 250–75. https://doi.org/10.6004/jnccn.2009.0020.
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    • Beasley, Georgia M., Rebecca P. Petersen, Jin Yoo, Nicole McMahon, Thomas Aloia, William Petros, Gretchen Sanders, et al. “Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.” Ann Surg Oncol 15, no. 8 (August 2008): 2195–2205. https://doi.org/10.1245/s10434-008-9988-9.
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    • Dannull, Jens, Diem-Thu Lesher, Robert Holzknecht, Wenning Qi, Gabi Hanna, Hilliard Seigler, Douglas S. Tyler, and Scott K. Pruitt. “Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity.” Blood 110, no. 13 (December 15, 2007): 4341–50. https://doi.org/10.1182/blood-2007-04-083188.
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    • Yoshimoto, Yasunori, Christina K. Augustine, Jin S. Yoo, Patricia A. Zipfel, M Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler. “Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.” Mol Cancer Ther 6, no. 5 (May 2007): 1492–1500. https://doi.org/10.1158/1535-7163.MCT-06-0718.
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    • Grubbs, Elizabeth G., Zeinab Abdel-Wahab, Douglas S. Tyler, and Scott K. Pruitt. “Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer.” Ann Surg Oncol 13, no. 12 (December 2006): 1645–54. https://doi.org/10.1245/s10434-006-9029-5.
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    • Ueno, Tomio, Sae Hee Ko, Elizabeth Grubbs, Yasunori Yoshimoto, Christi Augustine, Zeinab Abdel-Wahab, Tsung-Yen Cheng, et al. “Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine.” Mol Cancer Ther 5, no. 3 (March 2006): 732–38. https://doi.org/10.1158/1535-7163.MCT-05-0098.
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    • Ko, Sae Hee, Tomio Ueno, Yasunori Yoshimoto, Jin Soo Yoo, Omar I. Abdel-Wahab, Zeinab Abdel-Wahab, Edward Chu, et al. “Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.” Clin Cancer Res 12, no. 1 (January 1, 2006): 289–97. https://doi.org/10.1158/1078-0432.CCR-05-0210.
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    • Abdel-Wahab, Zeinab, Robin Cisco, Jens Dannull, Tomio Ueno, Omar Abdel-Wahab, Matthew F. Kalady, Mark W. Onaitis, Douglas S. Tyler, and Scott K. Pruitt. “Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses.” J Surg Res 124, no. 2 (April 2005): 264–73. https://doi.org/10.1016/j.jss.2004.10.002.
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    • Ueno, Tomio, Sae Hee Ko, Elizabeth Grubbs, Scott K. Pruitt, Henry S. Friedman, and Douglas S. Tyler. “Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma.” Am J Surg 188, no. 5 (November 2004): 532–37. https://doi.org/10.1016/j.amjsurg.2004.07.014.
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    • Abdel-Wahab, Omar I., Elizabeth Grubbs, Benjamin L. Viglianti, Tsung-Yen Cheng, Tomio Ueno, SaeHee Ko, Zahid Rabbani, et al. “The role of hyperthermia in regional alkylating agent chemotherapy.” Clin Cancer Res 10, no. 17 (September 1, 2004): 5919–29. https://doi.org/10.1158/1078-0432.CCR-04-0096.
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    • Grubbs, Elizabeth G., Omar Abdel-Wahab, Tsung-Yen Cheng, Zeinab Abdel-Wahab, Bercedis Peterson, Scott K. Pruitt, O Michael Colvin, Henry S. Friedman, and Douglas S. Tyler. “In-transit melanoma: the role of alkylating-agent resistance in regional therapy.” J Am Coll Surg 199, no. 3 (September 2004): 419–27. https://doi.org/10.1016/j.jamcollsurg.2004.05.271.
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    • Grubbs, Elizabeth G., Tomio Ueno, Omar Abdel-Wahab, Tsung-Yen Cheng, Scott K. Pruitt, O. Michael Colvin, Henry S. Friedman, and Douglas S. Tyler. “Modulation of resistance to regional chemotherapy in the extremity melanoma model.” Surgery 136, no. 2 (August 2004): 210–18. https://doi.org/10.1016/j.surg.2004.04.021.
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    • Cisco, Robin M., Zeinab Abdel-Wahab, Jens Dannull, Smita Nair, Douglas S. Tyler, Eli Gilboa, Johannes Vieweg, Yehia Daaka, and Scott K. Pruitt. “Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4.” Journal of Immunology (Baltimore, Md. : 1950) 172, no. 11 (June 2004): 7162–68. https://doi.org/10.4049/jimmunol.172.11.7162.
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    • Kalady, Matthew F., Mark W. Onaitis, Sirisha Emani, Zeinab Abdul-Wahab, Scott K. Pruitt, and Douglas S. Tyler. “Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells.” J Gastrointest Surg 8, no. 2 (February 2004): 175–81. https://doi.org/10.1016/j.gassur.2003.11.003.
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    • Kalady, Matthew F., Mark W. Onaitis, Sirisha Emani, Zeinab Abdel-Wahab, Douglas S. Tyler, and Scott K. Pruitt. “Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.” J Surg Res 116, no. 1 (January 2004): 24–31. https://doi.org/10.1016/j.jss.2003.09.003.
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    • Cheng, Tsung-Yen, Elizabeth Grubbs, Omar Abdul-Wahab, Szu-Yun Leu, Chen-Fang Hung, William Petros, Thomas Aloia, et al. “Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion.” Am J Surg 186, no. 5 (November 2003): 460–67. https://doi.org/10.1016/j.amjsurg.2003.07.019.
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    • Abdel-Wahab, Zeinab, Matthew F. Kalady, Sirisha Emani, Mark W. Onaitis, Omar I. Abdel-Wahab, Robin Cisco, Lee Wheless, Tsung-Yen Cheng, Douglas S. Tyler, and Scott K. Pruitt. “Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution.” Cell Immunol 224, no. 2 (August 2003): 86–97. https://doi.org/10.1016/j.cellimm.2003.08.005.
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    • Onaitis, Mark W., Matthew F. Kalady, Sirisha Emani, Zeinab Abdel-Wahab, Douglas S. Tyler, and Scott K. Pruitt. “CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy.” Surgery 134, no. 2 (August 2003): 300–305. https://doi.org/10.1067/msy.2003.240.
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    • Su, Zhen, Jens Dannull, Axel Heiser, Donna Yancey, Scott Pruitt, John Madden, Doris Coleman, Donna Niedzwiecki, Eli Gilboa, and Johannes Vieweg. “Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells.” Cancer Res 63, no. 9 (May 1, 2003): 2127–33.
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    • Onaitis, Mark, Matthew F. Kalady, Scott Pruitt, and Douglas S. Tyler. “Dendritic cell gene therapy.” Surg Oncol Clin N Am 11, no. 3 (July 2002): 645–60. https://doi.org/10.1016/s1055-3207(02)00027-3.
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    • Kalady, Matthew F., Mark W. Onaitis, Karen M. Padilla, Sirisha Emani, Douglas S. Tyler, and Scott K. Pruitt. “Enhanced dendritic cell antigen presentation in RNA-based immunotherapy.” J Surg Res 105, no. 1 (June 1, 2002): 17–24. https://doi.org/10.1006/jsre.2002.6435.
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    • Bartlett, John A., G Diego Miralles, Anne D. Sevin, Martha Silberman, Scott K. Pruitt, Janet Ottinger, Victoria Gryszowska, Susan A. Fiscus, R Pat Bucy, and R Pat ACTG 380 Study Team. “Addition of cyclophosphamide to antiretroviral therapy does not diminish the cellular reservoir in HIV-infected persons.” Aids Res Hum Retroviruses 18, no. 8 (May 20, 2002): 535–43. https://doi.org/10.1089/088922202753747888.
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    • Raj, G. V., S. K. Pruitt, S. Lilly, J. T. Madden, and D. T. Price. “Multimodal therapy for stage IV adult Wilms tumor.” The Journal of Urology 165, no. 4 (April 2001): 1202. https://doi.org/10.1097/00005392-200104000-00035.
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    • Heiser, A., M. A. Maurice, D. R. Yancey, N. Z. Wu, P. Dahm, S. K. Pruitt, D. Boczkowski, et al. “Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA.” Journal of Immunology (Baltimore, Md. : 1950) 166, no. 5 (March 2001): 2953–60. https://doi.org/10.4049/jimmunol.166.5.2953.
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    • White, D. C., F. R. Schuler, S. K. Pruitt, D. K. Culhane, H. F. Seigler, R. E. Coleman, and D. Tyler. “Timing of sentinel lymph node mapping after lymphoscintigraphy.” Surgery 126, no. 2 (August 1999): 156–61.
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    • Dong, X. D., Z. Abdel-Wahab, P. Dematos, T. Fong, S. K. Pruitt, and H. F. Seigler. “MCA106 fibrosarcoma cells transduced with granulocyte/macrophage colony-stimulating factor are not superior to the wild-type cells in suppressing the growth of hepatic metastases.” J Surg Oncol 71, no. 1 (May 1999): 36–45. https://doi.org/10.1002/(sici)1096-9098(199905)71:1<36::aid-jso8>3.0.co;2-x.
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    • Pruitt, S. K., R. R. Bollinger, B. H. Collins, H. C. Marsh, J. L. Levin, A. R. Rudolph, W. M. Baldwin, and F. Sanfilippo. “Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.” Transplantation 63, no. 6 (March 27, 1997): 900–902. https://doi.org/10.1097/00007890-199703270-00017.
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    • Davis, E. A., F. Jakobs, S. K. Pruitt, P. S. Greene, Z. Qian, T. T. Lam, E. Tseng, J. L. Levin, W. M. Baldwin, and F. Sanfilippo. “Overcoming rejection in pig-to-primate cardiac xenotransplantation.” Transplantation Proceedings 29, no. 1–2 (February 1997): 938–39. https://doi.org/10.1016/s0041-1345(96)00259-x.
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    • Davis, E. A., S. K. Pruitt, P. S. Greene, S. Ibrahim, T. T. Lam, J. L. Levin, W. M. Baldwin, and F. Sanfilippo. “Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts.” Transplantation 62, no. 7 (October 15, 1996): 1018–23. https://doi.org/10.1097/00007890-199610150-00022.
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    • Pruitt, S. K., R. R. Bollinger, B. H. Collins, H. C. Marsh, J. L. Levin, A. R. Rudolph, W. M. Baldwin, and F. Sanfilippo. “Continuous complement (C) inhibition using soluble C receptor type 1 (sCR1): effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts.” Transplant Proc 28, no. 2 (April 1996): 756.
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    • Pruitt, S. K., W. M. Baldwin, and F. Sanfilippo. “The role of C3a and C5a in hyperacute rejection of guinea pig-to-rat cardiac xenografts.” Transplant Proc 28, no. 2 (April 1996): 596.
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    • Brauer, R. B., W. M. Baldwin, D. Wang, S. K. Pruitt, A. S. Klein, and F. Sanfilippo. “Functional activity of anti-C6 antibodies elicited in C6-deficient rats reconstituted by liver allografts. Ability to inhibit hyperacute rejection of discordant cardiac xenografts.” Transplantation 61, no. 4 (February 27, 1996): 588–94. https://doi.org/10.1097/00007890-199602270-00013.
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    • Baldwin, W. M., S. K. Pruitt, R. B. Brauer, M. R. Daha, and F. Sanfilippo. “Complement in organ transplantation. Contributions to inflammation, injury, and rejection.” Transplantation 59, no. 6 (March 27, 1995): 797–808.
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    • Brauer, R. B., W. M. Baldwin, S. K. Pruitt, and F. Sanfilippo. “Survival of guinea pig cardiac xenografts in C6-deficient PVG rats treated with monoclonal antibody to CD18.” Transplant Proc 26, no. 3 (June 1994): 1251.
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    • Pruitt, S. K., A. D. Kirk, R. R. Bollinger, H. C. Marsh, B. H. Collins, J. L. Levin, J. R. Mault, J. S. Heinle, S. Ibrahim, and A. R. Rudolph. “The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts.” Transplantation 57, no. 3 (February 1994): 363–70. https://doi.org/10.1097/00007890-199402150-00009.
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    • Brauer, R. B., W. M. Baldwin, M. R. Daha, S. K. Pruitt, and F. Sanfilippo. “Use of C6-deficient rats to evaluate the mechanism of hyperacute rejection of discordant cardiac xenografts.” J Immunol 151, no. 12 (December 15, 1993): 7240–48.
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    • Pruitt, S. K., W. M. Baldwin, R. N. Barth, and F. Sanfilippo. “The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts.” Transplantation 56, no. 6 (December 1993): 1318–24. https://doi.org/10.1097/00007890-199312000-00006.
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    • Brauer, R. B., W. M. Baldwin, S. K. Pruitt, and F. Sanfilippo. “Rat strain differences in complement activity correlate with hyperacute rejection of guinea pig cardiac xenografts.” Transplant Proc 25, no. 5 (October 1993): 2848–49.
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    • Pruitt, S. K., D. Weinstock, M. M. Suyemoto, F. Sanfilippo, and W. M. Baldwin. “The effect of bursectomy on natural xenoreactive antibodies and vascularized rat cardiac xenograft rejection in the chicken.” Transplantation 55, no. 5 (May 1993): 1139–44. https://doi.org/10.1097/00007890-199305000-00039.
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    • Pruitt, S. K., D. Weinstock, M. M. Suyemoto, F. Sanfilippo, and W. M. Baldwin. “Effect of bursectomy on deposition of natural xenoreactive antibodies and complement within rat cardiac xenografts in the chicken.” Transplant Proc 25, no. 1 Pt 1 (February 1993): 435–37.
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    • Pruitt, S. K., D. Weinstock, M. M. Suyemoto, F. Sanfilippo, and W. M. Baldwin. “Effect of bursectomy on deposition of natural xenoreactive antibodies and complement within rat cardiac xenografts in the chicken.” Transplantation Proceedings 25, no. 1 (January 1, 1993): 435–37.
    • Baldwin, W. M., D. Weinstock, M. M. Suyemoto, S. K. Pruitt, S. S. Lin, L. R. Jones, and F. Sanfilippo. “Effects of bursectomy and rat skin xenografts on natural antibodies in chickens.” Transplant Proc 24, no. 2 (April 1992): 472–73.
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    • Pruitt, S. K., W. M. Baldwin, H. C. Marsh, S. S. Lin, C. G. Yeh, and R. R. Bollinger. “Effect of soluble complement receptor type 1 on natural antibody levels during xenograft rejection.” Transplant Proc 24, no. 2 (April 1992): 477–78.
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    • Pruitt, S. K., W. M. Baldwin, H. C. Marsh, S. S. Lin, C. G. Yeh, and R. R. Bollinger. “The effect of soluble complement receptor type 1 on hyperacute xenograft rejection.” Transplantation 52, no. 5 (November 1991): 868–73. https://doi.org/10.1097/00007890-199111000-00022.
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    • Pruitt, S. K., and R. R. Bollinger. “The effect of soluble complement receptor type 1 on hyperacute allograft rejection.” J Surg Res 50, no. 4 (April 1991): 350–55. https://doi.org/10.1016/0022-4804(91)90202-w.
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    • Pruitt, S. K., E. C. Halperin, and R. R. Bollinger. “The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival.” Transplant Proc 23, no. 1 Pt 1 (February 1991): 585–86.
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    • Baldwin, W. M., S. K. Pruitt, and F. Sanfilippo. “Alloantibodies: Basic and clinical concepts.” Transplantation Reviews 5, no. 2 (January 1, 1991): 100–119. https://doi.org/10.1016/S0955-470X(10)80036-9.
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    • Pruitt, S. K., E. C. Halperin, and R. R. Bollinger. “The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival.” Transplantation Proceedings 23, no. 1 I (January 1, 1991): 585–86.
    • Bessey, P. Q., S. K. Pruitt, and D. W. Wilmore. “The effect of free fatty acids on insulin-mediated glucose uptake.” J Surg Res 36, no. 5 (May 1984): 462–69. https://doi.org/10.1016/0022-4804(84)90127-6.
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  • Other Articles

    • Zhong, P., F. Xing, X. Huang, H. Zhu, H. W. Lo, X. Zhong, S. Pruitt, and C. Robertson. “HIFU as a neoadjuvant therapy in cancer treatment.” Aip Conference Proceedings, October 13, 2011. https://doi.org/10.1063/1.3607920.
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    • Quigley, R. L., S. K. Pruitt, T. N. Pappas, and O. Akwari. “Primary hypertrophic pyloric stenosis in the adult.” Arch Surg, September 1990. https://doi.org/10.1001/archsurg.1990.01410210145025.
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  • Conference Papers

    • De Rosa, N., G. H. Lyman, D. Silbermins, M. E. Valsecchi, S. Wong, S. K. Pruitt, and W. T. Lee. “Systematic review of ^99mTc human serum albumin and ^99mTc sulfur colloid studies of sentinel lymph node biopsy of cutaneous melanoma of the head and neck.” In Laryngoscope, Vol. 121, 2011. https://doi.org/10.1002/lary.21983.
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    • Beasley, G. M., A. Selim, N. S. McMahon, A. Coleman, A. P. Abernethy, K. Nelson, S. K. Pruitt, et al. “Prospective Evaluation of PET/CT as a Surveillance Tool to Define Response to Therapy and Identify New Recurrent Disease in Patients with Locally Advanced Melanoma Undergoing Regional Chemotherapy Treatment with Melphalan.” In Annals of Surgical Oncology, 17:S115–S115. SPRINGER, 2010.
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    • De Rosa, N., J. E. Herndon, J. Marcello, D. S. Tyler, R. P. Scheri, S. K. Pruitt, J. L. Wheeler, and A. P. Abernethy. “Patterns of Recurrence in Melanoma and the Impact on Survival.” In Annals of Surgical Oncology, 17:S104–5. SPRINGER, 2010.
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    • Dannull, Jens, Douglas S. Tyler, and Scott K. Pruitt. “Immunostimulatory and migratory properties of human monocyte-derived dendritic cells (DC) matured in the presence of the cysteinyl leukotrienes (cysLTs) LTC4 and LTD4.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.
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    • Grubbs, E., K. Bennett, R. Westlund, F. Schuler, R. Bentley, L. G. Wilke, G. Georgaide, J. A. Olson, and S. K. Pruitt. “Sentinel lymph node biopsy in breast cancer: How many nodes need to be removed?” In Annals of Surgical Oncology, 14:41–41. SPRINGER, 2007.
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    • Yoo, J., C. K. Augustine, Y. Yoshimoto, R. P. Petersen, S. K. Pruitt, F. Ali-Osman, and D. S. Tyler. “Role of BAY 43-9006 in combination with temozolomide and melphalan in metastatic melanoma.” In Annals of Surgical Oncology, 13:12–12. SPRINGER, 2006.
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    • Yoshimoto, Y., J. S. Yoo, C. K. Augustine, S. K. Pruitt, H. S. Friedman, and D. S. Tyler. “The role of chemoresistance in regional infusion therapy for melanoma.” In Annals of Surgical Oncology, 13:82–82. SPRINGER, 2006.
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    • Yoo, Jin S., Yasunori Yoshimoto, Rebecca P. Petersen, Scott K. Pruitt, Francis Ali-Osman, and Douglas S. Tyler. “Glutathione S-transferase as a marker of metastatic potential in malignant melanoma.” In Journal of the American College of Surgeons, 201:S84–S84. Elsevier BV, 2005. https://doi.org/10.1016/j.jamcollsurg.2005.06.197.
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    • Abdel-Wahab, O. I., E. Grubbs, T. Y. Cheng, B. Viglianti, T. Ueno, S. Curtiss, S. K. Pruitt, M. W. Dewhirst, and D. S. Tyler. “Role of hyperthermia in regional alkylating agent chemotherapy.” In Annals of Surgical Oncology, 11:S79–80. Springer Science and Business Media LLC, 2004. https://doi.org/10.1007/bf02524061.
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    • Cisco, R. M., Z. Abdel-Wahab, J. Dannull, D. S. Tyler, and S. K. Pruitt. “Transfection with RNA encoding a dominant positive toll-like receptor 4 (TLR4) construct induces maturation of human monocyte-derived dendritic cells (DC) in the absence of exogenous maturation stimuli.” In Journal of the American College of Surgeons, 197:S75–S75. ELSEVIER SCIENCE INC, 2003.
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    • Kalady, Mathhew F., Mark W. Onaitis, Zeinab Abdul-Wahab, Sirisha Emani, Scott K. Pruitt, and Douglas S. Tyler. “Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific anti-pancreatic cancer T cells.” In Gastroenterology, 124:A788–A788. Elsevier BV, 2003. https://doi.org/10.1016/s0016-5085(03)83977-x.
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    • Grubbs, E. G., S. K. Pruitt, and D. S. Tyler. “Quantitative PCR: Identifying novel tumor markers in pancreatic cancer.” In Annals of Surgical Oncology, 10:S9–S9. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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    • White, D. C., A. Hamza, K. Nielson, H. K. Lyerly, S. M. Steele, S. K. Pruitt, G. S. Leight, and J. A. Olson. “Thoracic paravertebral blockade for breast sentinel lymph node biopsy: Experience in 137 patients.” In Annals of Surgical Oncology, 9:S56–57. LIPPINCOTT WILLIAMS & WILKINS, 2002.
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    • Pruitt, S. K., W. M. Baldwin, R. Bollinger, H. C. March, and F. Sanfillippo. “Soluble complement receptor and hyperacute rejection.” In Vascular Endothelium, edited by J. D. Catravas, A. D. Callow, and U. A. Ryan, 281:3–10. PLENUM PRESS DIV PLENUM PUBLISHING CORP, 1996.
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    • PRUITT, S. K., E. C. HALPERIN, and R. R. BOLLINGER. “THE EFFECT OF 15-DEOXYSPERGUALIN ON HAMSTER-TO-RAT CARDIAC XENOGRAFT SURVIVAL.” In Transplantation Proceedings, 23:585–86. ELSEVIER SCIENCE INC, 1991.
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