Scott Leigh Shofer | Scholars@Duke

Scott Leigh Shofer
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2017

Contact Information

112 Hanes Bldg, Box 102356, Durham, NC 27710
Duke Box 102356, Durham, NC 27710
scott.shofer@duke.edu (919) 668-2402

Background
Education, Training, & Certifications
- Fellow in Pulmonary Medicine, Medicine, Duke University 2004 - 2007
- Medical Resident, Medicine, Stanford University 2001 - 2004
- M.D., Boston University 2001
- Ph.D., University of California at Santa Cruz 1997
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2009 - 2017
- Medical Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007 - 2009
- Instructor, Temporary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007
Research
Selected Grants
- IPA for Melissa Wagner awarded by Durham Veterans Affairs Medical Center 2018 - 2020
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- PSA for Mona Malik awarded by Institute for Medical Research, Inc. 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hong, JC, Boyer, MJ, Spiegel, DY, Williams, CD, Tong, BC, Shofer, SL, Moravan, MJ, Kelley, MJ, and Salama, JK. "Increasing PET Use in Small Cell Lung Cancer: Survival Improvement and Stage Migration in the VA Central Cancer Registry." Journal of the National Comprehensive Cancer Network : Jnccn 17, no. 2 (February 2019): 127-139. Full Text
  - Davidson, KR, Elmasri, M, Wahidi, MM, Shofer, SL, Cheng, GZ, and Mahmood, K. "Management of Lung Transplant Bronchial Stenosis With Mitomycin C." Journal of Bronchology & Interventional Pulmonology (August 22, 2018). Full Text
  - DeMaio, A, Clarke, JM, Dash, R, Sebastian, S, Wahidi, MM, Shofer, SL, Cheng, GZ, Li, X, Wang, X, and Mahmood, K. "Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma." Journal of Bronchology & Interventional Pulmonology (July 25, 2018). Full Text
  - Argento, AC, Gilstrap, DL, Shofer, S, Mahmood, K, Blackwell, K, and Wahidi, MM. "Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in the Diagnosis of Breast Cancer Thoracic Metastases and Detection of Receptor Discordance." Journal of Bronchology & Interventional Pulmonology 25, no. 3 (July 2018): 176-180. Full Text
  - Bedoya, A, Glisinski, K, Clarke, J, Lind, RN, Buckley, CE, and Shofer, S. "Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases." The American Journal of Case Reports 18 (July 31, 2017): 842-846. Full Text
  - Mahmood, K, Ebner, L, He, M, Robertson, SH, Wang, Z, McAdams, HP, Wahidi, MM, Shofer, SL, Huang, YT, and Driehuys, B. "Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 7 (July 2017): 1895-1904. Full Text
  - Wahidi, MM, Reddy, C, Yarmus, L, Feller-Kopman, D, Musani, A, Shepherd, RW, Lee, H, Bechara, R, Lamb, C, Shofer, S, Mahmood, K, Michaud, G, Puchalski, J, Rafeq, S, Cattaneo, SM, Mullon, J, Leh, S, Mayse, M, Thomas, SM, Peterson, B, and Light, RW. "Randomized Trial of Pleural Fluid Drainage Frequency in Patients with Malignant Pleural Effusions. The ASAP Trial." American Journal of Respiratory and Critical Care Medicine 195, no. 8 (April 2017): 1050-1057. Full Text
  - Frush, BW, Li, Z, Stiles, JV, Cotter, SF, Shofer, SL, Foster, WM, Hollingsworth, JW, and Tighe, RM. "Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects." The Journal of Allergy and Clinical Immunology 138, no. 4 (October 2016): 1213-1215.e1. (Letter) Full Text
  - Mahmood, K, Kraft, BD, Glisinski, K, Hartwig, MG, Harlan, NP, Piantadosi, CA, and Shofer, SL. "Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant." Clinical Transplantation 30, no. 9 (September 2016): 1134-1139. Full Text
  - Sciurba, FC, Criner, GJ, Strange, C, Shah, PL, Michaud, G, Connolly, TA, Deslée, G, Tillis, WP, Delage, A, Marquette, C-H, Krishna, G, Kalhan, R, Ferguson, JS, Jantz, M, Maldonado, F, McKenna, R, Majid, A, Rai, N, Gay, S, Dransfield, MT, Angel, L, Maxfield, R, Herth, FJF, Wahidi, MM, Mehta, A, Slebos, D-J, and RENEW Study Research Group, . "Effect of Endobronchial Coils vs Usual Care on Exercise Tolerance in Patients With Severe Emphysema: The RENEW Randomized Clinical Trial." Jama 315, no. 20 (May 2016): 2178-2189. Full Text
  - Mahmood, K, Wahidi, MM, Osann, KE, Coles, K, Shofer, SL, Volker, EE, and Davoudi, M. "Development of a Tool to Assess Basic Competency in the Performance of Rigid Bronchoscopy." Annals of the American Thoracic Society 13, no. 4 (April 2016): 502-511. Full Text
  - Kraft, BD, Suliman, HB, Colman, EC, Mahmood, K, Hartwig, MG, Piantadosi, CA, and Shofer, SL. "Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation." American Journal of Respiratory and Critical Care Medicine 193, no. 5 (March 2016): 552-560. Full Text
  - Argento, AC, Wolfe, CR, Wahidi, MM, Shofer, SL, and Mahmood, K. "Bronchomediastinal fistula caused by endobronchial aspergilloma." Annals of the American Thoracic Society 12, no. 1 (January 2015): 91-95. Full Text
  - Mahmood, K, Wahidi, MM, Thomas, S, Argento, AC, Ninan, NA, Smathers, EC, and Shofer, SL. "Therapeutic bronchoscopy improves spirometry, quality of life, and survival in central airway obstruction." Respiration; International Review of Thoracic Diseases 89, no. 5 (January 2015): 404-413. Full Text
  - Stevenson, M, Christensen, J, Shoemaker, D, Foster, T, Barry, WT, Tong, BC, Wahidi, M, Shofer, S, Datto, M, Ginsburg, G, Crawford, J, D'Amico, T, and Ready, N. "Tumor acquisition for biomarker research in lung cancer." Cancer investigation 32, no. 6 (July 2014): 291-298. Full Text
  - Pathak, V, Welsby, I, Mahmood, K, Wahidi, M, MacIntyre, N, and Shofer, S. "Ventilation and anesthetic approaches for rigid bronchoscopy." Annals of the American Thoracic Society 11, no. 4 (May 2014): 628-634. (Review) Full Text
  - Wahidi, MM, Hulett, C, Pastis, N, Shepherd, RW, Shofer, SL, Mahmood, K, Lee, H, Malhotra, R, Moser, B, and Silvestri, GA. "Learning experience of linear endobronchial ultrasound among pulmonary trainees." Chest 145, no. 3 (March 2014): 574-578. Full Text
  - Mahmood, K, Shofer, SL, Moser, BK, Argento, AC, Smathers, EC, and Wahidi, MM. "Hemorrhagic complications of thoracentesis and small-bore chest tube placement in patients taking clopidogrel." Annals of the American Thoracic Society 11, no. 1 (January 2014): 73-79. Full Text
  - Shofer, S, Beyea, M, Li, S, Bastian, LA, Wahidi, MM, Kelley, M, and Lipkus, IM. "Feasibility of using an epigenetic marker of risk for lung cancer, methylation of p16, to promote smoking cessation among US veterans." BMJ open respiratory research 1, no. 1 (January 2014): e000032-. Full Text
  - Castleberry, AW, Worni, M, Kuchibhatla, M, Lin, SS, Snyder, LD, Shofer, SL, Palmer, SM, Pietrobon, R, Davis, RD, and Hartwig, MG. "A comparative analysis of bronchial stricture after lung transplantation in recipients with and without early acute rejection." The Annals of Thoracic Surgery 96, no. 3 (September 2013): 1008-1017. Full Text
  - Shofer, SL, Dunphy, F, Mahmood, K, Wahidi, MM, and Yoo, D. "Endobronchial fiducial to guide stereotactic body radiotherapy." J Bronchology Interv Pulmonol 20, no. 3 (July 2013): 274-275. Full Text Link to Item
  - Mahmood, K, Koubar, S, Shofer, SL, Ninan, NA, and Wahidi, MM. "Alendronate tracheobronchitis." Ann Am Thorac Soc 10, no. 1 (February 2013): 64-66. Full Text Link to Item
  - Shofer, SL, Wahidi, MM, Davis, WA, Palmer, SM, Hartwig, MG, Lu, Y, and Snyder, LD. "Significance of and risk factors for the development of central airway stenosis after lung transplantation." Am J Transplant 13, no. 2 (February 2013): 383-389. Full Text Link to Item
  - Castleberry, AW, Worni, M, Kuchibhatla, M, Lin, SS, Snyder, LD, Shofer, SL, Palmer, SM, Pietrobon, R, Davis, RD, and Hartwig, MG. "A comparative analysis of bronchial stricture after lung transplantation in recipients with and without early acute rejection." Annals of Thoracic Surgery 96, no. 3 (2013): 1008-1018. Full Text
  - Heyman, BM, Chung, MM, Lark, AL, and Shofer, S. "Endobronchial metastasis from primary anorectal melanoma." The American Journal of Case Reports 14 (January 2013): 253-257. Full Text
  - Shofer, SL, Wahidi, MM, Davis, WA, Palmer, SM, Hartwig, MG, Lu, Y, and Snyder, LD. "Significance of and risk factors for the development of central airway stenosis after lung transplantation." American Journal of Transplantation 13, no. 2 (2013): 383-389. Full Text
  - Piantadosi, CA, Bartz, RR, Carraway, MS, Ghio, AJ, McMahon, TJ, Murdoch, DM, Roggli, VL, Shofer, SL, Tighe, RM, Welty-Wolf, KE, and Young, SL. "The opprobrium of Big Tobacco." Am J Respir Crit Care Med 185, no. 9 (May 1, 2012): 1030-. (Letter) Full Text Link to Item
  - "Flexible Bronchoscopy Training." (January 5, 2012): 63-69. (Chapter) Full Text
  - Wahidi, MM, Unroe, MA, Adlakha, N, Beyea, M, and Shofer, SL. "The use of electrocautery as the primary ablation modality for malignant and benign airway obstruction." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 6, no. 9 (September 2011): 1516-1520. Full Text
  - Unroe, MA, Shofer, SL, and Wahidi, MM. "Training for endobronchial ultrasound: methods for proper training in new bronchoscopic techniques." Curr Opin Pulm Med 16, no. 4 (July 2010): 295-300. (Review) Full Text Link to Item
  - Wahidi, MM, Shofer, SL, Sporn, TA, and Ernst, A. "Comparison of transbronchial lung biopsy yield between standard forceps and electrocautery hot forceps in swine." Respiration 79, no. 2 (2010): 137-140. Full Text Link to Item
  - Meyer, J, Wahidi, M, Shofer, S, Evans, J, Crawford, J, and Kelsey, CR. "Formation of a bronchoesophageal fistula following concurrent radiation and chemotherapy for lung cancer in the setting of Behçet's disease." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 3, no. 11 (November 2008): 1361-1362. (Letter) Full Text
  - Shofer, S, Badea, C, Qi, Y, Potts, E, Foster, WM, and Johnson, GA. "A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury." Journal of Applied Physiology (Bethesda, Md. : 1985) 105, no. 2 (August 2008): 669-677. Full Text
  - Hollingsworth, JW, Shofer, S, and Zaas, A. "Successful treatment of Ochroconis gallopavum infection in an immunocompetent host." Infection 35, no. 5 (October 2007): 367-369. Full Text Link to Item
  - Chen, T-M, Gokhale, J, Shofer, S, and Kuschner, WG. "Outdoor air pollution: nitrogen dioxide, sulfur dioxide, and carbon monoxide health effects." The American Journal of the Medical Sciences 333, no. 4 (April 2007): 249-256. Full Text
  - Shofer, S, Badea, C, Auerbach, S, Schwartz, DA, and Johnson, GA. "A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice." Experimental Lung Research 33, no. 3-4 (April 2007): 169-183. Full Text
  - Chen, T-M, Gokhale, J, Shofer, S, and Kuschner, WG. "Outdoor air pollution: Particulate matter health effects." American Journal of the Medical Sciences 333, no. 4 (2007): 235-243. Full Text
  - Chen, T-M, Gokhale, J, Shofer, S, and Kuschner, WG. "Outdoor air pollution: Ozone health effects." American Journal of the Medical Sciences 333, no. 4 (2007): 244-248. Full Text
  - Chen, T-M, Shofer, S, Gokhale, J, and Kuschner, WG. "Outdoor air pollution: Overview and historical perspective." American Journal of the Medical Sciences 333, no. 4 (2007): 230-234. Full Text
  - Shofer, S, Chen, T-M, Gokhale, J, and Kuschner, WG. "Outdoor air pollution: Counseling and exposure risk reduction." American Journal of the Medical Sciences 333, no. 4 (2007): 257-260. Full Text
  - Shofer, S, Haus, BM, and Kuschner, WG. "Quality of occupational history assessments in working age adults with newly diagnosed asthma." Chest 130, no. 2 (2006): 455-462. Full Text
  - Haus, BM, Stark, P, Shofer, SL, and Kuschner, WG. "Massive pulmonary pseudotumor." Chest 124, no. 2 (August 2003): 758-760. Link to Item
  - Shofer, SL, and Tjeerdema, RS. "Sublethal effects of pentachlorophenol in abalone (Haliotis rufescens) veliger larvae as measured by (31)P-NMR." Ecotoxicol Environ Saf 51, no. 3 (March 2002): 155-160. Full Text Link to Item
  - Stucchi, AF, Shofer, S, Leeman, S, Materne, O, Beer, E, McClung, J, Shebani, K, Moore, F, O'Brien, M, and Becker, JM. "NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats." American Journal of Physiology. Gastrointestinal and Liver Physiology 279, no. 6 (December 2000): G1298-G1306. Full Text
  - Shofer, SL, and Tjeerdema, RS. "Effects of hypoxia and toxicant exposure on adenylate energy charge and cytosolic ADP concentrations in abalone." Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119, no. 1 (January 1998): 51-57. Link to Item
  - Shofer, SL, Willis, JA, and Tjeerdema, RS. "Effects of hypoxia and toxicant exposure on arginine kinase function as measured by³¹P-NMR magnetization transfer in living abalone." Comparative Biochemistry and Physiology C Pharmacology Toxicology and Endocrinology 117, no. 3 (July 1, 1997): 283-289. Full Text
  - Shofer, SL, Willis, JA, and Tjeerdema, RS. "Effects of hypoxia and toxicant exposure on phosphoarginine, intracellular pH, and free Mg²⁺ in abalone as measured by ³¹P-NMR." Comparative Biochemistry and Physiology a Physiology 118, no. 4 (January 1, 1997): 1183-1191. Full Text
  - Shofer, SL, Willis, JA, and Tjeerdema, RS. "Sublethal effects of pentachlorophenol and hypoxia on rates of arginine kinase flux in red abalone (Haliotis rufescens) as measured by³¹P magnetization saturation transfer NMR." Marine Environmental Research 42, no. 1-4 (January 1, 1996): 363-367.
  - Williamson, KC, Shofer, SL, and Tjeerdema, RS. "Toxicokinetics and biotransformation of p-nitrophenol in the black turban snail (Tegula funebralis)." Aquatic Toxicology 33, no. 2 (January 1, 1995): 113-123. Full Text
  - Shofer, SL, and Tjeerdema, RS. "Comparative disposition and biotransformation of pentachlorophenol in the oyster (crassostrea gigas) and abalone (haliotis fulgens)." Pesticide Biochemistry and Physiology 46, no. 2 (January 1, 1993): 85-95. Full Text
- Book Sections
  - Shofer, S, and Wahidi, MM. "Transbronchial lung biopsy." In Introduction to Bronchoscopy: Second Edition, 118-128. September 7, 2017. Full Text
  - Shofer, S, and Wahidi, MM. "Transbronchial lung biopsy." In Introduction to Bronchoscopy, 98-106. January 1, 2009. Full Text
- Conference Papers
  - Ali, HA, Snyder, LD, Mahmood, K, Wahidi, MM, Argento, AC, Larrier, NA, and Shofer, SL. "High Dose Brachytherapy For Bronchial Stenosis In Lung Transplant Recipients." 2015. Link to Item
  - Lehr, CJ, Snyder, LD, and Shofer, SL. "Pleural Effusions Underlying Rejection After Lung Transplantation." 2015. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers