Scholars@Duke
Sean Michael O'Brien

Sean Michael O'Brien

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
sean.m.obrien@duke.edu
Duke Box 3850, Durham, NC 27710
200 Morris Street, 7816 200 Morris, Durham, NC 27701

Overview

Statistical methods for healthcare provider profiling; observational studies; Bayesian data analysis.

Current Appointments & Affiliations

Associate Professor of Biostatistics & Bioinformatics · 2014 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics
Member in the Duke Clinical Research Institute · 2004 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications

Development of a Novel Society of Thoracic Surgeons Aortic Surgery Mortality and Morbidity Risk Model.

Journal Article Ann Thorac Surg · January 2025 BACKGROUND: The Society of Thoracic Surgeons Adult Cardiac Surgery Database (STS ACSD) was expanded in 2017 to include more granular detail on thoracic aortic surgeries. We describe the first validated risk model in thoracic aortic surgery from the STS ACS ... Full text Link to item Cite

Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Journal Article Circ Cardiovasc Interv · December 2024 BACKGROUND: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, ... Full text Link to item Cite

Outcomes with revascularisation versus conservative management of participants with 3-vessel coronary artery disease in the ISCHEMIA trial.

Journal Article EuroIntervention · October 21, 2024 BACKGROUND: Whether revascularisation (REV) improves outcomes in patients with three-vessel coronary artery disease (3V-CAD) is uncertain. AIMS: Our objective was to evaluate outcomes with REV (percutaneous coronary intervention [PCI] or coronary artery by ... Full text Link to item Cite
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Recent Grants

2/2 IMPRroving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2030

Integrated Biostatistical Training for CVD Research

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by North Carolina State University · 2022 - 2027

ISCHEMIA-Extend_Resubmission

ResearchPrincipal Investigator · Awarded by New York University · 2022 - 2026

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Education, Training & Certifications

University of North Carolina, Chapel Hill · 2002 Ph.D.