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Sean Michael O'Brien

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 3850, Durham, NC 27710
200 Morris Street, 7816 200 Morris, Durham, NC 27701

Overview


Statistical methods for healthcare provider profiling; observational studies; Bayesian data analysis.

Current Appointments & Affiliations


Associate Professor of Biostatistics & Bioinformatics · 2014 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics
Member in the Duke Clinical Research Institute · 2004 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


Use of Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Intervention and Associated Outcomes in the ISCHEMIA Trial.

Journal Article Am Heart J · May 20, 2025 BACKGROUND: In the ISCHEMIA Trial, 5179 patients with stable coronary disease were randomized to initial invasive or conservative management. METHODS: PCI was recommended with a SYNTAX score 0-22 (low) and CABG with a SYNTAX score ≥33 (high). Either could ... Full text Link to item Cite

Invasive vs Conservative Management of Patients With Chronic Total Occlusion: Results From the ISCHEMIA Trial.

Journal Article J Am Coll Cardiol · April 1, 2025 BACKGROUND: Randomized trials of chronic total occlusion (CTO) revascularization vs medical therapy have yielded inconsistent results. OBJECTIVES: The aim of this study was to evaluate outcomes with an initial invasive strategy (INV) vs an initial conserva ... Full text Link to item Cite

Stress Echocardiography in Patients With Moderate or Severe Myocardial Ischemia: Insights From the ISCHEMIA Trial.

Journal Article J Am Soc Echocardiogr · March 18, 2025 BACKGROUND: This study examined stress echocardiography in relation to coronary artery anatomy and outcome in subjects randomized in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial. METHODS: ... Full text Link to item Cite
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Recent Grants


2/2 IMPRroving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2030

Integrated Biostatistical Training for CVD Research

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by North Carolina State University · 2022 - 2027

ISCHEMIA-Extend_Resubmission

ResearchPrincipal Investigator · Awarded by New York University · 2022 - 2026

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2002 Ph.D.