Current Appointments & Affiliations
Associate Professor in Medicine
·
2024 - Present
Medicine, Cardiology,
Medicine
Recent Publications
Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection.
Journal Article J Clin Invest · March 2, 2026 While current antivirals primarily target viral proteins, host-directed strategies remain underexplored. Here, we performed a genome-wide CRISPR inhibition (CRISPRi) screening to identify the host protein, hepatocyte growth factor-regulated tyrosine kinase ... Full text Link to item CiteMechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.
Journal Article Nat Commun · February 20, 2026 Beta-arrestins (βarrs) are key regulators and transducers of G-protein coupled receptor signaling; however, little is known of how βarrs communicate with their downstream effectors. Here, we delineate structural mechanisms underlying βarr-mediated signal t ... Full text Link to item CiteA positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia.
Journal Article J Clin Invest · December 15, 2025 Orthosteric beta blockers represent the leading pharmacological intervention for managing heart diseases owing to their ability to competitively antagonize β-adrenergic receptors (βARs). However, their use is often limited by adverse effects such as fatigu ... Full text Link to item CiteRecent Grants
Molecular Regulation of Cardiovascular 7 TM Receptors
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 1976 - 2027B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function
ResearchResearch Professional · Awarded by National Institutes of Health · 2002 - 2012View All Grants
Education
Duke University ·
2002
Ph.D.