Current Duke Appointments & Affiliations
Associate Professor in Medicine
·
2024 - Present
Medicine, Cardiology,
Medicine
Recent Scholarly Works
Small-molecule modulation of β-arrestins.
Journal article Nature · August 2026 β-Arrestins are multifunctional regulators of G-protein-coupled receptor (GPCR) signalling and orchestrate diverse downstream signalling events and physiological responses across the GPCR superfamily1-3. Although GPCR pharmacology has advanced to target or ... Full text Link to item CiteConformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules.
Journal article bioRxiv · July 16, 2026 Blockade of signaling through the angiotensin II type 1 receptor (AT1R), a prototypical G protein-coupled receptor (GPCR), by angiotensin receptor blockers (ARBs) is a major therapeutic approach to treating a wide variety of cardiovascular and renal diseas ... Full text Link to item CiteTargeting the host factor HGS-viral membrane protein interaction in coronavirus infection.
Journal article J Clin Invest · March 2, 2026 While current antivirals primarily target viral proteins, host-directed strategies remain underexplored. Here, we performed a genome-wide CRISPR inhibition (CRISPRi) screening to identify the host protein, hepatocyte growth factor-regulated tyrosine kinase ... Full text Link to item CiteRecent Grants
Molecular Regulation of Cardiovascular 7 TM Receptors
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 1976 - 2027B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function
ResearchResearch Professional · Awarded by National Institutes of Health · 2002 - 2012View All Grants
Education
Duke University ·
2002
Ph.D.