Scholars@Duke
Shamitha Shetty

Selected Publications

Anti-Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL-1β-Mediated Inflammation.

Journal Article Advanced healthcare materials · August 2024 IL-1β is a principal proinflammatory cytokine underlying multiple local and systemic chronic inflammatory conditions including psoriasis, rheumatoid arthritis, inflammatory bowel disease, and type 2 diabetes. Passive immunotherapies and biologic drugs targ ... Full text Open Access Cite

Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges.

Journal Article Annual review of biomedical engineering · July 2024 Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate trafficking through various tissues, complement or augment adjuvant activiti ... Full text Open Access Cite

Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses.

Journal Article ACS biomaterials science & engineering · March 2024 Allergen immunotherapies are often successful at desensitizing allergic patients but can require life-long dosing and suffer from frequent adverse events including instances of systemic anaphylaxis, leading to poor patient compliance and high cost. Allerge ... Full text Cite

Data from: Self-assembling allergen vaccine platform raises therapeutic allergen-specific IgG responses without induction of systemic allergic responses

Dataset · February 28, 2024 Allergen immunotherapies are often successful at desensitizing allergic patients but can require life-long dosing and suffer from frequent adverse events including instances of systemic anaphylaxis, leading to poor patient compliance and high cost. Allerge ... Full text Cite

Immune-active polymeric materials for the treatment of inflammatory diseases

Journal Article Current Opinion in Colloid and Interface Science · October 1, 2023 In recent years, a growing understanding of the underlying mechanisms of autoinflammatory and autoimmune disease has enabled significant advances in biomaterial therapeutics for their treatment and prevention. Drug-free or immune-active polymeric materials ... Full text Cite

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial.

Journal Article The Lancet. Infectious diseases · May 2023 BackgroundHuman monoclonal antibodies might offer an important new approach to reduce malaria morbidity and mortality. In the first two parts of a three-part clinical trial, the antimalarial monoclonal antibody CIS43LS conferred high protection ag ... Full text Open Access Cite

A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · April 2023 Microporous annealed particle scaffolds (MAPS) are a new class of granular materials generated through the interlinking of tunable microgels, which produce an interconnected network of void space. These microgel building blocks can be designed with differe ... Full text Open Access Cite

A sublingual nanofiber vaccine to prevent urinary tract infections.

Journal Article Science advances · November 2022 Urinary tract infections (UTIs) are a major public health problem affecting millions of individuals each year. Recurrent UTIs are managed by long-term antibiotic use, making the alarming rise of antibiotic resistance a substantial threat to future UTI trea ... Full text Open Access Cite

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria.

Journal Article The New England journal of medicine · August 2022 BackgroundNew approaches for the prevention and elimination of malaria, a leading cause of illness and death among infants and young children globally, are needed.MethodsWe conducted a phase 1 clinical trial to assess the safety and pharm ... Full text Open Access Cite

A Monoclonal Antibody for Malaria Prevention.

Journal Article The New England journal of medicine · August 2021 BackgroundAdditional interventions are needed to reduce the morbidity and mortality caused by malaria.MethodsWe conducted a two-part, phase 1 clinical trial to assess the safety and pharmacokinetics of CIS43LS, an antimalarial monoclonal ... Full text Open Access Cite

A non-affinity purification process for GMP production of prefusion-closed HIV-1 envelope trimers from clades A and C for clinical evaluation.

Journal Article Vaccine · June 2021 Metastable glycosylated immunogens present challenges for GMP manufacturing. The HIV-1 envelope (Env) glycoprotein trimer is covered by N-linked glycan comprising half its mass and requires both trimer assembly and subunit cleavage to fold into a prefusion ... Full text Open Access Cite

Comprehensive Flow Cytometry Analysis of PEI-Based Transfections for Virus-Like Particle Production.

Journal Article Research (Washington, D.C.) · January 2020 The generation of stable clones for biomolecule production is a common but lengthy and labor-intensive process. For complex molecules, such as viruses or virus-like particles (VLPs), the timeline becomes even more cumbersome. Thus, in the early stages of d ... Full text Cite