Scholars@Duke
Shara Reihani

Shara Reihani

Research Program Leader, Sr
Duke Cancer Institute
2400 Pratt Street Suite 5000, DUMC 3961, ABMT Team, Durham, NC 27710

Selected Publications

MnTnBuOE-2-PyP5+ Ascorbate in the Treatment of Ovarian Cancer

Conference Free Radical Biology and Medicine · November 2020 Full text Cite

Mn porphyrin/ascorbate sensitizes serous epithelial ovarian cancer to chemotherapy

Conference Free Radical Biology and Medicine · November 2018 Full text Cite

Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.

Journal Article Radiat Res · August 2017 Breast cancer is the most common malignancy diagnosed among women and represents a heterogeneous group of subtypes. Radiation therapy is a critical component of treatment for breast cancer patients. However, little is known about radiation response among t ... Full text Link to item Cite

Angiogenesis

Chapter · February 22, 2017 Angiogenesis is a complex multifaceted process essential for cancer growth and progression. The underlying biology regulating angiogenesis is incredibly complicated, involving interaction between cancer cells and the tumor microenvironment. Angiogenic grow ... Full text Cite

Abstract 1656: Subtype-specific radiation response in human breast cancer and potential therapeutic effect of FAS death receptor modulation

Conference Cancer Research · July 15, 2016 AbstractBreast cancer is the most common malignancy diagnosed among women worldwide and represents a heterogeneous group of subtypes. Radiation therapy is an important component of multimodal treatment for w ... Full text Cite

FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.

Journal Article Radiat Res · November 2015 Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes. We hypothesized that this clini ... Full text Link to item Cite

Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

Journal Article Gynecol Oncol · October 2015 OBJECTIVES: To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS: 51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts ... Full text Link to item Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.

Journal Article Int J Hyperthermia · June 2015 PURPOSE: We have previously reported that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion patterns obtained from locally advanced breast cancer (LABC) patients prior to neoadjuvant therapy predicted pathologic clinical response. Ge ... Full text Link to item Cite

Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Radiation therapy is associated with acute treatment-related complications that can lead to decreased quality of life (QOL). Exercise has been shown in other cancer treatment settings to improve negative outcomes. We conducted a prospective pilot ... Full text Link to item Cite

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines.

Journal Article Front Oncol · 2014 OBJECTIVES: Underlying mechanisms regulating angiogenesis in ovarian cancer have not been completely elucidated. Evidence suggests that the TP53 tumor suppressor pathway and tumor microenvironment play integral roles. We utilized microarray technology to s ... Full text Link to item Cite

Abstract 3732: Inflammatory breast cancer rates among different ethnic and racial groups in the United States

Conference Cancer Research · April 15, 2011 AbstractInflammatory breast cancer (IBC) is considered to be the most aggressive form of breast cancer. In the US, the proportion of incidences of IBC cases ranges from 2% to 5%. Understanding the determinan ... Full text Cite

Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.

Journal Article Journal of molecular recognition : JMR · March 2011 Adaptor proteins mediate signal transduction from cell surface receptors to downstream signaling pathways. The Grb7 protein family of adaptor proteins is constituted by Grb7, Grb10, and Grb14. This protein family has been shown to be overexpressed in certa ... Full text Cite

Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.

Journal Article Cancer research · June 2009 Secreted frizzle-related protein 2 (SFRP2), a modulator of Wnt signaling, has recently been found to be overexpressed in the vasculature of 85% of human breast tumors; however, its role in angiogenesis is unknown. We found that SFRP2 induced angiogenesis i ... Full text Cite