Shawn K. Acheson | Scholars@Duke

Shawn K. Acheson
Assistant Professor in Psychiatry and Behavioral Sciences

In collaboration with Dr. Scott Swartzwelder, research in our lab has focused on the neurodevelopmental effects of alcohol and other drugs of abuse. In particular, we have been interested in how and why adolescents are more sensitive to some effects of ethanol and THC (e.g., learning and memory) and less sensitive to other effects (e.g., sedation). Beginning in Fall 2011, my lab will begin a new line of research focused on potential pharmacotherapies for TBI and the basic underlying mechanisms of recovery of function following acquired brain injury. This work is funded by a Career Development Award from the Veterans Administration Biomedical Laboratory Research & Development service.

Current Appointments & Affiliations

Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2013
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2012

Contact Information

1260 Betty's Creek Rd., Sylva, NC 28779
1260 Betty's Creek Rd., Sylva, NC 28779
shawn.acheson@duke.edu (919) 768-2243

Background
Education, Training, & Certifications
- Ph.D., Southern Illinois University 1997
Duke Appointment History
- Assistant Professor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2009 - 2013
Expertise
Subject Headings
Research
Selected Grants
- 1/8 NADIA UO1 Adolescent Alcohol Effects on Learning and Hippocampal Function awarded by National Institutes of Health 2010 - 2020
- IPA - Shawn Acheson awarded by Durham Veterans Affairs Medical Center 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Swartzwelder, HS, Park, M-H, & Acheson, S. (2017, October 13). Adolescent Ethanol Exposure Enhances NMDA Receptor-Mediated Currents in Hippocampal Neurons: Reversal by Gabapentin. Scientific reports , 7 (1), 13133-. Full Text
  - Miller, KM, Risher, M-L, Acheson, SK, Darlow, M, Sexton, HG, Schramm-Sapyta, N, & Swartzwelder, HS. (2017, July 5). Behavioral Inefficiency on a Risky Decision-Making Task in Adulthood after Adolescent Intermittent Ethanol Exposure in Rats. Scientific Reports , 7 (1), 4680-null. Full Text
  - Sharma, R, Rosenberg, A, Bennett, ER, Laskowitz, DT, & Acheson, SK. (2017, January). A blood-based biomarker panel to risk-stratify mild traumatic brain injury. PloS one , 12 (3), e0173798-. Full Text
  - Lei, B, James, ML, Liu, J, Zhou, G, Venkatraman, TN, Lascola, CD, Acheson, SK, Dubois, LG, Laskowitz, DT, & Wang, H. (2016, October 7). Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. Scientific Reports , 6 , 34834-null. Full Text Open Access Copy
  - Klein, RC, Acheson, SK, Qadri, LH, Dawson, AA, Rodriguiz, RM, Wetsel, WC, Moore, SD, Laskowitz, DT, & Dawson, HN. (2016, June). Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress. Journal of neuroscience research , 94 (6), 579-589. Full Text
  - Risher, ML, Fleming, RL, Risher, WC, Miller, KM, Klein, RC, Wills, T, Acheson, SK, Moore, SD, Wilson, WA, Eroglu, C, & Swartzwelder, HS. (2015, June). Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. Alcoholism, Clinical and Experimental Research , 39 (6), 989-997.
  - Swartzwelder, HS, Acheson, SK, Miller, KM, Sexton, HG, Liu, W, Crews, FT, & Risher, ML. (2015, January). Adolescent Intermittent Alcohol Exposure: Deficits in Object Recognition Memory and Forebrain Cholinergic Markers. Plos One , 10 (11), e0140042-e0140042.
  - Centanni, SW, Teppen, T, Risher, ML, Fleming, RL, Moss, JL, Acheson, SK, Mulholland, PJ, Pandey, SC, Chandler, LJ, & Swartzwelder, HS. (2014, November). Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. Alcoholism, Clinical and Experimental Research , 38 (11), 2800-2808.
  - Klein, RC, Acheson, SK, Mace, BE, Sullivan, PM, & Moore, SD. (2014, September). Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. Neurobiology of aging , 35 (9), 2046-2052. Full Text
  - Swartzwelder, HS, Hogan, A, Risher, M-L, Swartzwelder, RA, Wilson, WA, & Acheson, SK. (2014, June). Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats. Alcohol (Fayetteville, N.Y.) , 48 (4), 353-360. Full Text
  - Klein, RC, Acheson, SK, Mace, BE, Sullivan, PM, & Moore, SD. (2014, January 1). Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. Neurobiology of Aging , 35 (9), 2046-2052. Full Text
  - Klein, RC, Saini, S, Risher, M-L, Acheson, SK, Fleming, RL, Sexton, HG, Swartzwelder, HS, & Moore, SD. (2014, January). Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. PLoS ONE , 9 (4), e94071-. Full Text
  - Swartzwelder, HS, Hogan, A, Risher, ML, Swartzwelder, RA, Wilson, WA, & Acheson, SK. (2014, January 1). Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats. Alcohol , 48 (4), 353-360. Full Text
  - Li, Q, Fleming, RL, Acheson, SK, Madison, RD, Moore, SD, Risher, M-L, Wilson, WA, & Swartzwelder, HS. (2013, December). Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood. Alcohol Clin Exp Res , 37 (12), 2074-2085. Full Text Link to Item
  - Fleming, RL, Li, Q, Risher, M-L, Sexton, HG, Moore, SD, Wilson, WA, Acheson, SK, & Swartzwelder, HS. (2013, July). Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells. Alcohol Clin Exp Res , 37 (7), 1154-1160. Full Text Link to Item
  - Wang, H, Anderson, LG, Lascola, CD, James, ML, Venkatraman, TN, Bennett, ER, Acheson, SK, Vitek, MP, & Laskowitz, DT. (2013, March). ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Experimental Neurology , 241 , 67-74. Full Text
  - Acheson, SK, Bearison, C, Risher, ML, Abdelwahab, SH, Wilson, WA, & Swartzwelder, HS. (2013, January). Effects of acute or chronic ethanol exposure during adolescence on behavioral inhibition and efficiency in a modified water maze task. Plos One , 8 (10), e77768-null. Full Text
  - Fleming, RL, Li, Q, Risher, M-L, Sexton, HG, Moore, SD, Wilson, WA, Acheson, SK, & Swartzwelder, HS. (2013). Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABA_A receptor-mediated tonic inhibition in dentate granule cells. Alcoholism: Clinical and Experimental Research , 37 (7), 1154-1160. Full Text
  - Li, Q, Fleming, RL, Acheson, SK, Madison, RD, Moore, SD, Risher, ML, Wilson, WA, & Swartzwelder, HS. (2013, January 1). Long-Term Modulation of A-Type K⁺ Conductances in Hippocampal CA1 Interneurons in Rats After Chronic Intermittent Ethanol Exposure During Adolescence or Adulthood. Alcoholism: Clinical and Experimental Research , 37 (12), 2074-2085. Full Text
  - Risher, M-L, Fleming, RL, Boutros, N, Semenova, S, Wilson, WA, Levin, ED, Markou, A, Swartzwelder, HS, & Acheson, SK. (2013, January). Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding. Plos One , 8 (5), e62940-null. Full Text
  - Swartzwelder, NA, Risher, ML, Abdelwahab, SH, D'Abo, A, Rezvani, AH, Levin, ED, Wilson, WA, Swartzwelder, HS, & Acheson, SK. (2012, October 3). Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats. Neurosci Lett , 527 (1), 11-15. Full Text Link to Item
  - Fleming, RL, Acheson, SK, Moore, SD, Wilson, WA, & Swartzwelder, HS. (2012, February). In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood. Alcohol Clin Exp Res , 36 (2), 279-285. Full Text Link to Item
  - Gierisch, JM, Straits-Tröster, K, Calhoun, PS, Beckham, JC, Acheson, S, & Hamlett-Berry, K. (2012). Tobacco use among Iraq- and Afghanistan-era veterans: a qualitative study of barriers, facilitators, and treatment preferences. Prev Chronic Dis , 9 , E58-. Link to Item
  - Fleming, RL, Acheson, SK, Moore, SD, Wilson, WA, & Swartzwelder, HS. (2011, September). GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus. Alcohol , 45 (6), 577-583. Full Text Link to Item
  - Acheson, SK, Straits-Tröster, K, Calhoun, PS, Beckham, JC, & Hamlett-Berry, K. (2011, May 1). Characteristics and correlates of cigarette use among recent U.S. veterans. Military Psychology , 23 (3), 297-314. Full Text
  - Zaborowski, DE, Dedert, EA, Straits-Troster, K, Lee, S, Wilson, SM, Calhoun, PS, Moore, SD, Acheson, S, Hamlett-Berry, KW, & Beckham, JC. (2011, March). Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001. Journal of Addiction Medicine , 5 (1), 79-83. Full Text
  - Acheson, SK, Moore, NLT, Kuhn, CM, Wilson, WA, & Swartzwelder, HS. (2011, January 10). The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals. Neurosci Lett , 487 (3), 411-414. Full Text Link to Item
  - Moore, NLT, Greenleaf, ALR, Acheson, SK, Wilson, WA, Swartzwelder, HS, & Kuhn, CM. (2010, November). Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats. The Journal of Pharmacology and Experimental Therapeutics , 335 (2), 294-301. Full Text
  - White, AM, Jordan, JD, Schroeder, KM, Acheson, SK, Georgi, BD, Sauls, G, Ellington, RR, & Swartzwelder, HS. (2004, March). Predictors of relapse during treatment and treatment completion among marijuana-dependent adolescents in an intensive outpatient substance abuse program. Substance abuse , 25 (1), 53-59. Full Text
  - Acheson, SK, Ross, EL, & Swartzwelder, HS. (2001, April). Age-independent and dose-response effects of ethanol on spatial memory in rats. Alcohol , 23 (3), 167-175. Link to Item
  - Abou-Donia, MB, Abdel-Rahman, AA, Kishk, AM, Walker, D, Markwiese, BJ, Acheson, SK, Reagan, KE, Swartzwelder, S, & Jensen, KF. (2000, January 28). Neurotoxicity of ethyl methacrylate in rats. J Toxicol Environ Health A , 59 (2), 97-118. Link to Item
  - Acheson, SK, Richardson, R, & Swartzwelder, HS. (1999, May). Developmental changes in seizure susceptibility during ethanol withdrawal. Alcohol , 18 (1), 23-26. Link to Item
  - Acheson, SK, Stein, RM, & Swartzwelder, HS. (1998, October). Impairment of semantic and figural memory by acute ethanol: age-dependent effects. Alcohol Clin Exp Res , 22 (7), 1437-1442. Link to Item
  - Markwiese, BJ, Acheson, SK, Levin, ED, Wilson, WA, & Swartzwelder, HS. (1998, April). Differential effects of ethanol on memory in adolescent and adult rats. Alcoholism, Clinical and Experimental Research , 22 (2), 416-421. Full Text
  - Molfese, VJ, & Acheson, S. (1997, January 1). Infant and preschool mental and verbal abilities: How are infant scores related to preschool scores?. International Journal of Behavioral Development , 20 (4), 595-607. Full Text
  - Gilbert, ME, Acheson, SK, Mack, CM, & Crofton, KM. (1990). An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models. NeuroToxicology , 11 (1), 73-86.
- Book Sections
  - Marx, CE, Naylor, JC, Kilts, JD, Dunn, CE, Tupler, LA, Szabo, ST, Capehart, BP, Morey, RA, Shampine, LJ, & Acheson, SK. (2016, April 21). Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veterans. In Translational Research in Traumatic Brain Injury (pp. 145-161).
- Conference Papers
  - Fleming, RL, Acheson, SK, Risher, ML, Li, Q, Wilson, WA, Moore, SD, & Swartzwelder, HS. (2012, June). IN THE RAT, CHRONIC INTERMITTENT ETHANOL EXPOSURE DURING ADOLESCENCE, BUT NOT LATER, ALTERS THE ETHANOL SENSITIVITY OF TONIC INHIBITION IN ADULTHOOD. Link to Item
Teaching & Mentoring
Advising & Mentoring
Available to mentor:
- Undergraduate

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Advising & Mentoring

Available to mentor: